Macromolecular Rapid Communications最新文献

{"title":"Issue Information: Macromol. Rapid Commun. 18/2026","authors":"","doi":"10.1002/marc.70440","DOIUrl":"https://doi.org/10.1002/marc.70440","url":null,"abstract":"","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/marc.70440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Machine Learning-Assisted Design and Development of Polymer Materials","authors":"Longyu Ma,&nbsp;Wenjing Li,&nbsp;Jian Yuan,&nbsp;Jian Zhu,&nbsp;Yan Wu,&nbsp;Hanliang He,&nbsp;Xiangqiang Pan","doi":"10.1002/marc.202500361","DOIUrl":"10.1002/marc.202500361","url":null,"abstract":"<div>\u0000 \u0000 <p>The traditional research paradigm for polymer materials relies heavily on time-consuming and inefficient trial-and-error methods, which are no longer sufficient to meet the demands of modern research and development. With the rapid advancement of big data and artificial intelligence technologies, machine learning has emerged as a powerful data analysis tool, revolutionizing polymer material research and development. This paper provides an overview of machine learning techniques, summarizes common machine learning algorithms, and reviews recent progress in machine learning-assisted polymer material design and development. Key areas include polymer sequence design, material property prediction, classification and identification, and applications leveraging computer vision technologies. Furthermore, this study discusses several critical challenges currently faced by the field and offers perspectives on future directions\u0000.</p>\u0000 </div>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macromolecular Design Principles for Polymer-Lipid Hybrid Nanoparticles in RNA Delivery","authors":"Bing Shao,&nbsp;Minglong Chen,&nbsp;Shiyong Liu","doi":"10.1002/marc.70402","DOIUrl":"10.1002/marc.70402","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of nonviral RNA delivery has been shaped by the chemistry of cationic materials and their capacity to organize nucleic acids through multivalent electrostatic interactions. Before ionizable lipid nanoparticle (LNP) formulations became central to clinically translated RNA therapeutics, nonviral nucleic acid delivery relied largely on cationic liposomes, cationic polymers, and polymer-lipid complexes that condensed anionic DNA or RNA into nanoscale assemblies. These systems established principles that continue to guide RNA nanomedicine, including electrostatic complexation, colloidal assembly, endosomal trafficking, charge-associated toxicity, degradable carrier design, and intracellular cargo release. Over the past decade, the clinical success of mRNA vaccines has consolidated small-molecule ionizable lipid LNPs as a major formulation platform, owing to their ability to combine efficient RNA encapsulation with improved tolerability, manufacturability, and in vivo expression. This Perspective revisits cationic polymer-lipid nanoparticles not as historical precursors to ionizable lipid LNPs, but as a macromolecular materials space that can clarify and extend current RNA delivery design. We discuss these systems within a structure-assembly-biointerface framework, emphasizing how polymer architecture, charge distribution, degradability, topology, and polymer-lipid interfacial organization govern RNA packaging, nanoparticle formation, intracellular release, tissue-selective interactions, and biological identity.</p>\u0000 </div>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen Initiated Crosslinking of Electronically Optimized Catechols","authors":"Animesh Ghosh,&nbsp;Vicki X. Wu,&nbsp;Konrad Kozlowski,&nbsp;Darien Kwek,&nbsp;Terry W. J. Steele","doi":"10.1002/marc.70391","DOIUrl":"10.1002/marc.70391","url":null,"abstract":"<div>\u0000 \u0000 <p>Catechol grafted macromolecules have attributes that overlap what's needed within non-toxic bioadhesives. However, decades of research have failed to make commercial progress as a general tissue adhesive. The major impediments include reliance on harmful crosslinking additives, long-term shelf-stability, and variability in preparation (e.g. two component mixing). This can arguably be assigned to the over-reliance on just one catechol crosslinker based on L-dopamine. Herein, we evaluate catechol scaffolds and oxidation processes that side-step these limitations and provide one-component (1C) bioadhesive designs. These 1C designs hypothesize activation via surface contact and oxygen exposure. The branched polyethylenimine (PEI) dendrimer serves as a model macromolecule, easily grafted via Schiff-base click chemistry. One of the optimized formulations, PEI-(5-OMe-3,4-DBA)₂₀, in which 20% of the primary amine groups of PEI are grafted with 5-methoxy-3,4-dihydroxybenzaldehyde (5-OMe-3,4-DBA) through Schiff-base linkages, initiates crosslinking immediately after air/O₂ exposure, but remains stable in anaerobic environments. Structural evaluation confirms PEI-(5-OMe-3,4-DBA)₂₀ undergoes spontaneous conversion to quinones, supported by aromatic CH integration (¹H-NMR) and first order decay of 5-OMe catechol Schiff-base (UV–vis). Gelation time occurs in 〈 1 min with shear strengths of 26 kPa on wetted collagen substrates.</p>\u0000 </div>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid-Promoted Polarity Switch Enables Efficient Radical Polymerization of Vinyl Ethyl Sulfide.","authors":"Dulce M Sánchez-Cerrillo, Kevin Neumann","doi":"10.1002/marc.70439","DOIUrl":"https://doi.org/10.1002/marc.70439","url":null,"abstract":"<p><p>Herein, we report a new concept for the polymerization of electron-rich vinyl sulfides based on an acid-induced polarity switch, termed monomer-Umpolung, resulting in the transient formation of electron-deficient olefins. The polarity switch activates the monomer and facilitates radical formation, thereby enabling both initiation and propagation and resulting in rapid and efficient free radical polymerization with a monomodal molecular weight distribution. We show that the reactivity can be tailored by utilizing a range of readily available acids, including sulfuric acid, acetic acid, and trifluoroacetic acid. We believe that this work will open new possibilities for the polymerization of otherwise less reactive monomers and will have a significant impact on advanced (co)polymerization strategies.</p>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e70439"},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Properties of Diels–Alder-Based Covalent Adaptable Networks from CO2 and 1,3-Butadiene Derived Polyesters","authors":"Shenghao Li,&nbsp;Zhuorui Zhang,&nbsp;Xiao Rao,&nbsp;Xufeng Ni","doi":"10.1002/marc.70398","DOIUrl":"10.1002/marc.70398","url":null,"abstract":"<div>\u0000 \u0000 <p><i>α</i>-Ethylidene-<i>δ</i>-vinyl-<i>δ</i>-valerolactone (EVL), a trifunctional monomer derived from CO₂ and 1,3-butadiene, provides a versatile platform for the construction of functional polyesters. A furan-functionalized monomer (EVL-FML), synthesized via thiol–Michael addition of EVL, exhibits a low ceiling temperature (<i>T</i>_c = −102.4°C) that precludes its homopolymerization. To overcome this thermodynamic limitation, EVL-FML is copolymerized with the Michael adduct of EVL and 1-propanethiol (EVL-SPr), which possesses a higher <i>T</i>_c of −2.4°C. Catalyzed by 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), the ring-opening copolymerization (ROCP) yields polyesters bearing furan groups (PF-x, 0–50 mol%) with number-average molecular weights up to 13.1 kg mol⁻¹, and narrow distributions (<i>Ð</i> &lt; 1.2). Kinetic studies reveal that the ROCP follows pseudo-first-order kinetics, with a reaction order of 0.37 with respect to TBD. The reactivity ratios are determined to be <i>r</i>_EVL-SPr = 0.94 and <i>r</i>_EVL-FML = 0.75. Subsequently, maleimide-functionalized (13–59 mol%) polyesters (PM-y) are prepared via post-polymerization modification of PEVL-SPr. Thermally reversible covalent adaptable networks (CANs) are constructed through the Diels–Alder reaction between PF-x and PM-y, exhibiting cross-link densities ranging from 110 to 572 mol m⁻³ and tensile strengths between 0.42 and 12.45 MPa. These networks demonstrate excellent self-healing, reprocessability, and inherent degradability, offering a promising pathway toward sustainable functional materials.</p>\u0000 </div>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Properties of Liquid Crystalline Elastomer Foams","authors":"Oliver Dai,&nbsp;Andrew Terentjev,&nbsp;Eugene M. Terentjev","doi":"10.1002/marc.70395","DOIUrl":"10.1002/marc.70395","url":null,"abstract":"<p>We investigate how controlled foaming alters the mechanical dissipation of liquid crystalline elastomers (LCEs). Using thermally expandable microspheres, we generate homogeneous foams with precisely tuned bubble volume fractions up to ∼13%, and compare their behavior with non‑mesogenic silicone analogues. We show that microsphere expansion induces a particle‑centered mesogenic interphase, arising from local elastic distortion and preferential alignment of mesogenic units at the inclusion surface. At low bubble volume fractions (≈0.5%–5%), isolated interphases produce a pronounced enhancement of intrinsic viscoelastic loss. Under impact loading, the optimum shifts to moderate bubble fractions because transient compression also engages bubble deformation, pad compliance, and structural integrity. At higher loadings, interphase overlap and mechanical constraint suppress this effect, and the dissipation returns toward baseline elastomeric values. Large‑strain tensile tests and impact experiments exhibit the same non‑monotonic trend, demonstrating that low‑density LCE foams achieve the highest mechanical energy absorption per unit mass. Compared with conventional high‑porosity polymer foams used for acoustic damping, these materials retain sufficient mechanical integrity to sustain impact loads, establishing a microstructural route to engineer high‑performance damping in soft solids.</p>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/marc.70395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Density–Nematic Coupling in Isotropic Solution of DNA: Multiscale Model”","authors":"","doi":"10.1002/marc.70392","DOIUrl":"10.1002/marc.70392","url":null,"abstract":"&lt;p&gt;D. Svenšek, J. Sočan, M. Praprotnik, Density–Nematic Coupling in Isotropic Solution of DNA: Multiscale Model. &lt;i&gt;Macromol. Rapid Commun&lt;/i&gt;. 2024, 45, 2400382. https://doi.org/10.1002/marc.202400382&lt;/p&gt;&lt;p&gt;In caption to Figure 3, the text “&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;ρ&lt;/mi&gt;\u0000 &lt;mn&gt;0&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 &lt;mn&gt;5&lt;/mn&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;ρ&lt;/mi&gt;\u0000 &lt;mn&gt;00&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$rho _0 = 5rho _{00}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; (&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mo&gt;∼&lt;/mo&gt;\u0000 &lt;mn&gt;250000&lt;/mn&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$sim 250000$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; base pairs)” is incorrect and should be replaced by “&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;ρ&lt;/mi&gt;\u0000 &lt;mn&gt;0&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 &lt;mn&gt;5&lt;/mn&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;ρ&lt;/mi&gt;\u0000 &lt;mn&gt;00&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$rho _0 = 5rho _{00}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; (&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mo&gt;∼&lt;/mo&gt;\u0000 &lt;mn&gt;25000&lt;/mn&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$sim 25000$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; base pairs)”. This is solely a typographic error.&lt;/p&gt;&lt;p&gt;In the second paragraph of the “Methods section,” the text “&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;l&lt;/mi&gt;\u0000 &lt;mn&gt;0&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 &lt;mn&gt;0.34&lt;/mn&gt;\u0000 &lt;mspace&gt;&lt;/mspace&gt;\u0000 &lt;mi&gt;nm&lt;/mi&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$l_0 = 0.34 ,{rm nm}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;” is incorrect and should be replaced by “&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;l&lt;/mi&gt;\u0000 &lt;mn&gt;0&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 &lt;mn&gt;0.342&lt;/mn&gt;\u0000 &lt;mspace&gt;&lt;/mspace&gt;\u0000 &lt;mi&gt;nm&lt;/mi&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$l_0 = 0.342 ,{rm nm}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;.” This and the following error are related to the accuracy of the in","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/marc.70392","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate Chemical Aggregation of Phenolated Phosphaphenanthrene Groups via Methylene Bridge Toward Simultaneously Enhanced Flame Retardancy and Toughness of Epoxy Thermosets","authors":"Lunbagen Gao,&nbsp;Biao Cai,&nbsp;Lijun Qian,&nbsp;Yong Qiu,&nbsp;Wei Tang","doi":"10.1002/marc.70390","DOIUrl":"10.1002/marc.70390","url":null,"abstract":"<div>\u0000 \u0000 <p>To validate moderate chemical aggregation of flame-retardant groups as an effective strategy for obtaining advanced flame-retardant molecules, moderate-aggregated linear oligomer B-PDHQ (trimer-dominant) and high-aggregated crosslinked macromolecule C-PDHQ were synthesized via the polymerization between the 10-(2,5-Dihydroxyphenyl)-10H-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO-HQ) monomer and formaldehyde. By propagating linear polymerization aggregation of phenolated phosphaphenanthrene (PDOPO) groups, the moderate-aggregated B-PDHQ exhibits outstanding superiority in combustibility suppression efficiency and toughness enhancement effectiveness of epoxy thermoset (EP), compared with the highly aggregated C-PDHQ and non-aggregated monomer DOPO-HQ. Especially, 3%B-PDHQ/EP passed UL94 V-0 rating, 3%DOPO-HQ/EP only passed UL94 V-2 rating, while 3%C-PDHQ/EP failed to pass any rating of UL94 vertical burning test. Furthermore, moderate-aggregated B-PDHQ also showed leading efficiency in the limited oxygen index, combustion heat inhibition, smoke emission reduction, and char formation enhancement of EP. The behavior of linear oligomer B-PDHQ that triggers the flame-retardant groups aggregation effect was revealed from the condensed-phased char-forming behavior, char layer morphology investigation, and the gas-phased thermal decomposition volatile tracing. In addition, the moderate polymerization aggregation of PDOPO groups in linear oligomer B-PDHQ still enable EP matrix with a higher glass transition temperature and impact toughness. The superiority of moderate-aggregated B-PDHQ provides a practical and efficient route for designing and manufacturing high-performance reactive flame-retardant molecules.</p>\u0000 </div>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide Self-Assembly for Enhanced Cancer Therapy via Immunogenic Programmed Cell Death: Ferroptosis, Pyroptosis, Necroptosis, and Cuproptosis","authors":"Shasha Ning,&nbsp;Xinruo Xing,&nbsp;Yun-Kai Chang,&nbsp;Mengmeng Mao,&nbsp;Hai-Dong Xu,&nbsp;Yu Ma,&nbsp;Guowei Liang,&nbsp;Xianbao Sun,&nbsp;Gaolin Liang","doi":"10.1002/marc.70400","DOIUrl":"10.1002/marc.70400","url":null,"abstract":"<div>\u0000 \u0000 <p>While immunotherapy has revolutionized cancer treatment, its clinical efficacy is still constrained by tumor heterogeneity, acquired drug resistance, and the immunosuppressive tumor microenvironment. Traditional apoptosis-driven cancer therapeutic strategies are often inefficient and immunologically silent. In contrast, non-apoptotic programmed cell death (PCD) pathways (ferroptosis, pyroptosis, necroptosis, and cuproptosis) offer high immunogenicity and the ability to bypass resistance mechanisms, yet their clinical application is limited by poor tumor specificity, off-target toxicity, and delivery inefficiency. Peptide self‑assembly technology has emerged as a powerful platform to address these challenges, enabling enzyme‑responsive morphological transformation, multivalent target binding, subcellular localization, multifunctional co‑assembly, and artificial enzyme mimicry for precise PCD induction. Despite significant progress, a systematic classification of how peptide assemblies trigger distinct PCD pathways is still lacking. This review categorizes peptide self‑assembly‑induced tumor cell death into five major themes, including ferroptosis, pyroptosis, necroptosis, cuproptosis, and combined death. By summarizing the design principles, key evidence, and anti‑tumor outcomes, this review highlights the unique advantages of peptide self‑assembly. It provides a theoretical foundation for developing peptide‑based precision cancer therapies and aims to guide future research toward clinical translation and personalized treatment.</p>\u0000 </div>","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":"47 18","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}