Macromolecular Rapid Communications最新文献_第4页

Fish Gelatin-Carbohydrate Composite Nanofibers: High-Yield Electrospinning and In Vitro Performance.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-08 DOI: 10.1002/marc.202500036

Amanda Kennell, Olivia Shivers, Ranoah Chatterton, Andrei Stanishevsky

{"title":"Fish Gelatin-Carbohydrate Composite Nanofibers: High-Yield Electrospinning and In Vitro Performance.","authors":"Amanda Kennell, Olivia Shivers, Ranoah Chatterton, Andrei Stanishevsky","doi":"10.1002/marc.202500036","DOIUrl":"https://doi.org/10.1002/marc.202500036","url":null,"abstract":"Electrospun fish gelatin (FGel) nanofibers (NF) mimic the natural bodies extracellular matrix's (ECM) structure and are an attractive material for many biomedical applications. However, FGel poor mechanical properties and rapid dissolution in an aqueous media paired with usually low productivity of the typical electrospinning process necessitate further effort in overcoming these issues. In this study, alternating field electrospinning (AFES) fabricates cold water fish skin gelatin nanofibrous materials (FGel NFM) with up to 10 wt.% Dextran (DEX) or acetyl glucosamine (AGA) from pure aqueous solutions at process productivity of 7.92-8.90 g∙h-1. Thermal crosslinking of as-spun materials resulted in FGel-based NFM with 125-325 nm fiber diameters. DEX (MW500k and MW75k) and AGA additives cause different effects on FGel fiber diameters, structure, tensile and degradation behavior, and in vitro performance. All tested materials reveal favorable, but not the same, cellular response through the formation of a confluent layer on the NFM surface regardless of the fibers' composition despite the significant difference in FGel NFM structure and properties. Results show that AFES and thermal crosslinking of FGel-based NFM can lead to a sustainable \"green\" fabrication technology of mono- and polysaccharide modified FGel-based NFM scaffolds with the parameters attuned to targeted biomedical applications.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500036"},"PeriodicalIF":4.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiadhesive and Antibacterial Coatings for Short-Term Titanium Implants.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-08 DOI: 10.1002/marc.202400989

Fiona Wiesner, Karl G M Schönewald, Kira Vogel, Niklas Jung, Barbara Schwierz, Maren Kipping, Aliia Ibragimova, Joshua Schumacher, Christian Pritzel, Clinton R V Thiagarajan, Ulrike Ritz, Ulrich Jonas

{"title":"Antiadhesive and Antibacterial Coatings for Short-Term Titanium Implants.","authors":"Fiona Wiesner, Karl G M Schönewald, Kira Vogel, Niklas Jung, Barbara Schwierz, Maren Kipping, Aliia Ibragimova, Joshua Schumacher, Christian Pritzel, Clinton R V Thiagarajan, Ulrike Ritz, Ulrich Jonas","doi":"10.1002/marc.202400989","DOIUrl":"https://doi.org/10.1002/marc.202400989","url":null,"abstract":"This study presents a novel approach for the development of antifouling and antibacterial hydrogel coatings for short-term titanium implants to treat bone defects. Such implants provide temporary stabilization during bone healing and are intended to be explanted within a period of 12 months. The novel surface modification prevents complications during implant removal, like injury to tissue, nerves, or tendons due to adhesion to the untreated titanium surface. The coatings combine acrylamide-based hydrogels with photocrosslinkers possessing intrinsic antibacterial properties and anchor groups designed for titanium substrates. Comprehensive in vitro evaluations are conducted to assess the biocompatibility and efficacy of these coatings. The results demonstrate that the water-swellable polymer networks effectively prevent cell and tissue adhesion by their antifouling characteristics without inducing cytotoxicity. Importantly, these coatings also exhibit an intrinsic and non-leaching antibacterial effect covalently incorporated into the molecular framework, which addresses the limitations of current implant coating technologies that often rely on the incorporation of antibiotics or bactericidal agents. As the experimental data conclusively verify the effectiveness of the coatings in inhibiting cell adhesion and bacterial colonization, this technology shows great potential to significantly advance the field of short-term titanium implants.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2400989"},"PeriodicalIF":4.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetically Driven Cooperative Supramolecular Polymerization of Bisterpyridine Ligands in Aqueous Solution.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-08 DOI: 10.1002/marc.202401004

Yumi Park, Juyeong Kim, Jong Hwa Jung

引用次数: 0

On-Resin Recycling of Acid-Labile Linker Enables the Reuse of Solid Support for Fmoc-Based Solid Phase Synthesis.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-08 DOI: 10.1002/marc.202500073

Nicholas Jäck, Laura Hartmann

{"title":"On-Resin Recycling of Acid-Labile Linker Enables the Reuse of Solid Support for Fmoc-Based Solid Phase Synthesis.","authors":"Nicholas Jäck, Laura Hartmann","doi":"10.1002/marc.202500073","DOIUrl":"https://doi.org/10.1002/marc.202500073","url":null,"abstract":"In this study, the first recyclable and reusable polystyrene solid support (resin with functional linker) for Fmoc-based solid phase synthesis (SPS) for the synthesis of sequence-defined oligoamides and peptides is presented. By introducing an acid-labile cyclic acetal linker, efficient oligomer cleavage under mildly acidic conditions comparable to conventional linkers is achieve while also enabling efficient on-resin regeneration of the linker. This regeneration ability allows the support to be reused for multiple synthesis cycles without compromising the flexibility, high reproducibility, and structural control inherent to solid-phase synthesis. As a proof of concept, the robustness of this approach is demonstrated by synthesizing different dimeric structures in an alternating manner on the same resin. For each cycle, the oligomer is first elongated through building block coupling, followed by cleavage from the solid support to release the product. The linker is then regenerated on the functionalized solid support, allowing the cycle to be repeated for the synthesis of subsequent oligomers. This approach maintains high yields and purity across multiple cycles, illustrating the potential as a versatile and more sustainable methodology for Fmoc-based solid phase synthesis.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500073"},"PeriodicalIF":4.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Macromol. Rapid Commun. 5/2025

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-06 DOI: 10.1002/marc.202570016

引用次数: 0

The Core-Shell Approach for Thermally Conductive and Electrically Insulating Polymer Nanocomposites: A Review.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-06 DOI: 10.1002/marc.202500078

Antoine Bodin, Anne Coloigner, Thomas Pietri, Jean-Pierre Simonato

{"title":"The Core-Shell Approach for Thermally Conductive and Electrically Insulating Polymer Nanocomposites: A Review.","authors":"Antoine Bodin, Anne Coloigner, Thomas Pietri, Jean-Pierre Simonato","doi":"10.1002/marc.202500078","DOIUrl":"https://doi.org/10.1002/marc.202500078","url":null,"abstract":"The development of new high-performance materials in the field of polymer composites is becoming increasingly challenging as the requirements for real-life applications evolve rapidly. In particular, the issue of heat dissipation in a multitude of devices has become a matter of critical importance due to the ever-increasing compaction of electronic devices and the significant growth in power density stored in batteries. This calls for the development of novel solutions to enhance heat dissipation while preserving electrical insulation properties, particularly in light of safety concerns. In this context, polymer nanocomposites can play a significant role, as the incorporation of specific fillers can markedly improve their intrinsic properties, namely, low electrical conductivity, lightweightness, processability, and low cost. New fillers based on a core-shell structure have recently emerged. They are typically nanoscopic in size and synthesized through fine chemical processes to optimize their performance and ensure optimal cohesion with the polymer matrix. Nanocomposites based on core-shell nanofiller yield remarkable and highly promising outcomes, often exceeding the state of the art. This review article presents a comprehensive overview of these nanostructures and their applications, elucidating their significance and results, and discusses their role in achieving optimal heat dissipation.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2500078"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymatic Synthesis of Poly(β-Amino Ester) Copolymer With High Potency in Eliminating Gram-Negative Bacteria.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-06 DOI: 10.1002/marc.202400885

Peng Dong, Wei Xiong, Jin Feng, Beibei Wang, Caizhen Liang, Huijuan Wang, Tingli Sun, Ming Wei, Qingshan Shi, Xiaobao Xie

{"title":"Enzymatic Synthesis of Poly(β-Amino Ester) Copolymer With High Potency in Eliminating Gram-Negative Bacteria.","authors":"Peng Dong, Wei Xiong, Jin Feng, Beibei Wang, Caizhen Liang, Huijuan Wang, Tingli Sun, Ming Wei, Qingshan Shi, Xiaobao Xie","doi":"10.1002/marc.202400885","DOIUrl":"https://doi.org/10.1002/marc.202400885","url":null,"abstract":"The functional lactone 2-Methyl-2-propanyl-7-oxo-1,4-oxazepane-4-carboxylate (BocOP), containing a protected secondary amino group, is synthesized through oxone-mediated Baeyer-Villiger oxidation. After that, the homopolymerization kinetics of BocOP catalyzed by immobilized Candida antarctia lipase B (Novozym 435, N435) are investigated. The N435 can efficiently catalyze the conversion of BocOP into poly(β-amino ester) (PAE). Then, the N435 is subsequently employed to synthesize copolymers of BocOP and ε-caprolactone (CL) using methoxypolyethylene glycols (mPEG) as initiators. The study shows that BocOP copolymerized with CL to produce a random PAE copolymer. Following deprotection, the PAE copolymers containing discoverable secondary amino groups demonstrate a preferent bactericidal effect against Gram-negative bacteria. The preference arises from the capacity of PAE copolymers to permeabilize the bacterial outer membrane, subsequently slightly compromising the inner membrane and resulting in the death of Gram-negative bacteria. Furthermore, the PAE copolymers exhibit a comparatively low hemolysis and cytotoxicity.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2400885"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoselective Polymerization of 1-Vinylcyclohexene (VCH) and a Terpene Derived Monomer S-4-Isopropenyl-1-vinyl-1-cyclohexene (IVC), and Its Binary Copolymerization with Linear Terpenes

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-06 DOI: 10.1002/marc.202570015

Ilaria Grimaldi, Assunta D'Amato, Mariarosaria C. Gambardella, Antonio Buonerba, Raffaele Marzocchi, Finizia Auriemma, Carmine Capacchione

引用次数: 0

Synthesis and Binding Properties of High-Affinity Histidine-Bearing Polymers for Wood Lignin

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-06 DOI: 10.1002/marc.202570014

Nanami Aoki, Yumin Tang, Xiangbing Zeng, Takahiro Ichikawa

引用次数: 0

Nanocomposites from Au-Doped Vinylogous Urethane Vitrimers Based on Different Block Copolymers and Their Recyclability in Combination with Plasmonic Heating.

IF 4.2 3区化学

Macromolecular Rapid Communications Pub Date : 2025-03-06 DOI: 10.1002/marc.202401027

Patrick Schütz, Siraphat Weerathaworn, Clas Jürgensen, Birgit Hankiewicz, Volker Abetz

{"title":"Nanocomposites from Au-Doped Vinylogous Urethane Vitrimers Based on Different Block Copolymers and Their Recyclability in Combination with Plasmonic Heating.","authors":"Patrick Schütz, Siraphat Weerathaworn, Clas Jürgensen, Birgit Hankiewicz, Volker Abetz","doi":"10.1002/marc.202401027","DOIUrl":"https://doi.org/10.1002/marc.202401027","url":null,"abstract":"The combination of gold nanoparticles (Au-NPs) and block copolymer (BCP)-based vinylogous urethane vitrimers leads to advanced nanocomposites where the thermal, mechanical, and thermo-mechanical properties are enhanced without interfering with the formation of vinylogous urethane groups and the transamination in the dynamic polymer network. Photoiniferter reversible addition-fragmentation chain transfer polymerization (photoRAFT) and inverse Turkevich synthesis are used in this work to fabricate the desired BCPs and spherical Au-NPs. The key feature of this synthesis is the integration of Au-NPs into the polymer matrix as fixed parts of the hybrid network, ensuring full recyclability. A wide range of properties can be tuned by variations of gold content, monomers, and BCP architecture. After ligand exchange, network formation, and reprocessing through heat compression, the unique optical properties of Au-NPs are retained, allowing plasmonic heating to trigger the transamination exchange reaction within the materials. As a result, the Au-doped vitrimers can self-heal and exhibit shape-memory shortly after exposure to not only heat but also light. This incorporation of Au-NPs into vitrimers could provide a versatile platform for the development of hybrid materials offering potential applications in coatings, sensors, electronic devices, etc.","PeriodicalId":205,"journal":{"name":"Macromolecular Rapid Communications","volume":" ","pages":"e2401027"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0