Presse MedicalePub Date : 2022-06-01DOI: 10.1016/j.lpm.2022.104137
Jacques HUGON
{"title":"Author's response to the letter on the article: “Long-COVID: cognitive deficits (brain fog) and brain lesions in non-hospitalized patients”","authors":"Jacques HUGON","doi":"10.1016/j.lpm.2022.104137","DOIUrl":"10.1016/j.lpm.2022.104137","url":null,"abstract":"","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 2","pages":"Article 104137"},"PeriodicalIF":2.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10729347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-06-01DOI: 10.1016/j.lpm.2022.104121
François CHOLLET , Pierre PAYOUX
{"title":"Functional Imaging for Neurodegenerative Diseases","authors":"François CHOLLET , Pierre PAYOUX","doi":"10.1016/j.lpm.2022.104121","DOIUrl":"10.1016/j.lpm.2022.104121","url":null,"abstract":"<div><p><span>Diagnosis and monitoring of neurodegenerative diseases has changed profoundly over the past twenty years. Biomarkers are now included in most diagnostic procedures as well as in </span>clinical trials<span>. Neuroimaging biomarkers provide access to brain structure and function over the course of neurodegenerative diseases. They have brought new insights into a wide range of neurodegenerative diseases and have made it possible to describe some of the imaging challenges in clinical populations. MRI mainly explores brain structure while molecular imaging<span>, functional MRI and electro- and magnetoencephalography examine brain function. In this paper, we describe and analyse the current and potential contribution of MRI and molecular imaging in the field of neurodegenerative diseases.</span></span></p></div>","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 2","pages":"Article 104121"},"PeriodicalIF":2.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10340296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-03-01DOI: 10.1016/j.lpm.2022.104125
Iris Amitay-Laish , Emmilia Hodak
{"title":"New developments in skin-directed treatments of cutaneous T-cell lymphoma","authors":"Iris Amitay-Laish , Emmilia Hodak","doi":"10.1016/j.lpm.2022.104125","DOIUrl":"10.1016/j.lpm.2022.104125","url":null,"abstract":"<div><p>The therapeutic approach for mycosis fungoides<span>, the most common type of primary cutaneous T-cell lymphoma, is based mainly on the stage of the disease, and skin-directed treatment is recommended by all international guidelines as the first-line of treatment for early-stage disease. Skin-directed treatments may be also given in combination with systemic therapies in early-stage mycosis fungoides patients recalcitrant to different types of skin-directed treatments, or in certain patients with high-risk features. Advanced-stage mycosis fungoides is treated mainly with systemic treatments, which may be combined with skin-directed treatments.</span></p><p>Due to the rarity of mycosis fungoides, controlled clinical trials<span> of the different skin-directed treatment modalities are almost non-existent, with a few exceptions, and therefore recommendations are largely based on cohort studies and expert opinion.</span></p><p>This paper reviews the new developments in skin-directed treatments and provides an update on new studies of already well-known therapies, and an update on novel treatments.</p></div>","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 1","pages":"Article 104125"},"PeriodicalIF":2.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75496595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-03-01DOI: 10.1016/j.lpm.2022.104129
M Bagot
{"title":"A new challenge area for cutaneous lymphomas","authors":"M Bagot","doi":"10.1016/j.lpm.2022.104129","DOIUrl":"10.1016/j.lpm.2022.104129","url":null,"abstract":"","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 1","pages":"Article 104129"},"PeriodicalIF":2.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81199533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-03-01DOI: 10.1016/j.lpm.2022.104109
Paolo Fava , Gabriele Roccuzzo , Silvia Alberti-Violetti , Vieri Grandi , Alessandro Pileri , Nicola Pimpinelli , Emilio Berti , Pietro Quaglino
{"title":"Cutaneous B-cell lymphomas: Update on diagnosis, risk-stratification, and management","authors":"Paolo Fava , Gabriele Roccuzzo , Silvia Alberti-Violetti , Vieri Grandi , Alessandro Pileri , Nicola Pimpinelli , Emilio Berti , Pietro Quaglino","doi":"10.1016/j.lpm.2022.104109","DOIUrl":"10.1016/j.lpm.2022.104109","url":null,"abstract":"<div><p><span>PCBCLs are a group of Non-Hodgkin's B-cell lymphomas originating in and usually confined to the skin, representing approximately one fourth of primary cutaneous lymphomas<span> (PCL). Their current classification system has been the result of the joint World Health Organization (WHO) - European Organization for Research and Treatment of Cancer (EORTC) consensus in 2018. To date, several types of PCBCLs have been described in the scientific literature, with different clinical presentation and prognosis. Primary cutaneous follicle-center lymphoma (PCFCL) and primary cutaneous </span></span>marginal zone lymphoma (PCMZL) are the most common forms, with a typical indolent course. On the contrary, primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) is less common, yet more aggressive, with a reported 5-year overall survival of approximatively 50%. In this review, we outline the PCBCLs defining diagnostic criteria, report the features of the less common subtypes and summarize the noteworthy therapeutical options currently available in this field.</p></div>","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 1","pages":"Article 104109"},"PeriodicalIF":2.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39818230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-03-01DOI: 10.1016/j.lpm.2022.104118
Vivek P Chavda , Darsh D. Vaghasiya , Aayushi B. Patel
{"title":"Immunoglobulin G4-related disease: Current status","authors":"Vivek P Chavda , Darsh D. Vaghasiya , Aayushi B. Patel","doi":"10.1016/j.lpm.2022.104118","DOIUrl":"10.1016/j.lpm.2022.104118","url":null,"abstract":"","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 1","pages":"Article 104118"},"PeriodicalIF":2.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75193563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-03-01DOI: 10.1016/j.lpm.2022.104110
A. de Masson
{"title":"New biotherapies for the treatment of cutaneous T-cell lymphomas","authors":"A. de Masson","doi":"10.1016/j.lpm.2022.104110","DOIUrl":"10.1016/j.lpm.2022.104110","url":null,"abstract":"<div><p><span><span>Most cutaneous lymphomas<span> are cutaneous T-cell lymphomas, and the most common form is mycosis fungoides. </span></span>Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma which is characterized by </span>erythroderma<span><span><span><span><span><span> and the presence of blood tumor cells. The only potential cure of cutaneous T-cell lymphomas remains allogeneic stem cell transplantation. However, </span>monoclonal antibodies have led to a substantial progress in the </span>treatment of advanced-stage cutaneous T-cell lymphomas. Some of them, such as </span>mogamulizumab (anti-CCR4 monoclobal antibody) or </span>brentuximab vedotin (anti-CD30 coupled to monomethylauristatin E, antibody drug conjugate) have shown efficacy in international randomized controlled studies. Lacutamab, an anti-KIR3DL2 monoclonal antibody, is currently tested in an international, prospective phase 2 trial in cutaneous T-cell lymphomas and peripheral T-cell lymphomas. Finally, </span>immune checkpoint inhibitors have shown clinical benefit in open-label phase 2 studies in cutaneous T-cell lymphomas. This review focuses on the new biotherapies currently used in cutaneous T-cell lymphomas.</span></p></div>","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 1","pages":"Article 104110"},"PeriodicalIF":2.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39818232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Presse MedicalePub Date : 2022-03-01DOI: 10.1016/j.lpm.2022.104108
G. Dobos , M. Miladi , L. Michel , C. Ram-Wolff , M. Battistella , M. Bagot , A. de Masson
{"title":"Recent advances on cutaneous lymphoma epidemiology","authors":"G. Dobos , M. Miladi , L. Michel , C. Ram-Wolff , M. Battistella , M. Bagot , A. de Masson","doi":"10.1016/j.lpm.2022.104108","DOIUrl":"10.1016/j.lpm.2022.104108","url":null,"abstract":"<div><h3>Background</h3><p>Primary cutaneous lymphomas<span><span> are a group of T- (CTCL) and B-cell (CBCL) malignancies. These diseases have different clinical presentations and prognosis. Our knowledge on their </span>epidemiology is limited. Aim of this review was to summarize recent findings on the incidence of CTCL and CBCL, how they change over time, and to describe possible causes and consequences. We found that although there are important differences in the epidemiology of cutaneous lymphomas in different countries, the relative frequency of certain, especially rare lymphomas remains stable. Several studies described growing incidences of both CTCL and CBCL. The emergence of new diagnostic criteria, a more precise definition of the entities and new biomarkers enable a better classification of cases.</span></p></div>","PeriodicalId":20530,"journal":{"name":"Presse Medicale","volume":"51 1","pages":"Article 104108"},"PeriodicalIF":2.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39820139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}