Ophthalmic Technologies XXIX最新文献

Ophthalmic Technologies XXIX Pub Date : 2019-05-23 DOI: 10.1117/12.2531204

引用次数: 0

First clinical application of low cost portable OCT system (Conference Presentation) 低成本便携式OCT系统的首次临床应用(会议介绍)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2507936

Ge Song, Sanghoon Kim, Michael Crose, Brian Cox, Evan T. Jelly, J. N. Ulrich, Adam Wax

引用次数: 0

Spherical aberration of the crystalline lens measured in-vitro using an LRT-OCT system (Conference Presentation) 用LRT-OCT系统体外测量晶状体的球差(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2508664

Siobhan Williams, M. Ruggeri, Bianca Maceo Heilman, Yu-Cherng Chang, Ashik Mohamed, G. Sravani, C. Rowaan, Alex Gonzalez, A. Ho, J. Parel, F. Manns

{"title":"Spherical aberration of the crystalline lens measured in-vitro using an LRT-OCT system (Conference Presentation)","authors":"Siobhan Williams, M. Ruggeri, Bianca Maceo Heilman, Yu-Cherng Chang, Ashik Mohamed, G. Sravani, C. Rowaan, Alex Gonzalez, A. Ho, J. Parel, F. Manns","doi":"10.1117/12.2508664","DOIUrl":"https://doi.org/10.1117/12.2508664","url":null,"abstract":"Anatomical changes of the growing crystalline lens influence its refractive development, including power and spherical aberration. We have recently developed a new instrument that characterizes both the optical and biometric properties of the lens in-vitro by merging Ray-Tracing Aberrometry (RTA) with three-dimensional OCT imaging. In this abstract, we describe the application of the RTA to the measurement of lens spherical aberration.\u0000\u0000Experiments were performed on 54 isolated human lenses (age: 0.25 to 56 years). The system was programmed to sequentially deliver the probing beam through the lens using a raster scan pattern of 13 × 13 transversal positions spaced 0.5 mm apart. Exit rays were imaged after exiting the tissue chamber at 9 different axial positions (ΔZ = 0 mm to 8 mm) in 1 mm intervals. A total of 1,521 spot images were acquired per lens. All data was automatically analyzed using custom software we developed in MATLAB. Exit ray slopes over a 6 mm pupil were used to determine Zernike wavefront coefficients up to the sixth order. The 4th order Zernike coefficient Z[4,0] was used to measure primary spherical aberration (SA). The results suggest that spherical aberration of the growing lens becomes more negative before adulthood and less negative after around age 30. The data is consistent with results from in-vivo studies that suggest the lens spherical aberration becomes less negative in older lenses (>30 years).","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115844298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel ergonomic optical coherence tomography probe optimized for supine handheld angiography of young children and infants (Conference Presentation) 一种新型的符合人体工程学的光学相干断层扫描探头，用于婴幼儿仰卧位手持式血管造影(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2508034

C. Viehland, Xi Chen, Du Tran-Viet, G. Waterman, Moseph Jackson-Atogi, C. Toth, J. Izatt

{"title":"A novel ergonomic optical coherence tomography probe optimized for supine handheld angiography of young children and infants (Conference Presentation)","authors":"C. Viehland, Xi Chen, Du Tran-Viet, G. Waterman, Moseph Jackson-Atogi, C. Toth, J. Izatt","doi":"10.1117/12.2508034","DOIUrl":"https://doi.org/10.1117/12.2508034","url":null,"abstract":"Optical coherence tomography angiography (OCTA) is an extension of OCTA that allows for non-invasive imaging of the retinal microvasculature. OCTA imaging of adult retinal diseases is area of active research in ophthalmology as OCTA can provide insight into the pathogenesis of many retinal diseases. Like these adult diseases, pediatric diseases such as retinopathy of prematurity (ROP) have a primarily vascular pathogenesis. However, table top OCTA systems require compliant, seated subjects and cannot be used on infants and young children. In this manuscript we describe the development of a non-contact handheld OCTA (HH-OCTA) probe for imaging of young children and infants in the operating room. The probe utilizes a novel, diverging light on the scanner optical design that provides improved performance over a traditional OCT scanner design. While most handheld OCT probes are designed to be held by the side of the case or by a handle, our operators tend to prefer to grip probes by the tip of the probe for supine imagine. The ergonomics of the HH-OCTA probe were designed to match this grip. The HH-OCTA probe used a 200 kHz OCT engine, has a motorized stage that provides +10 to -10 D refractive error correction, and weighs 700g. Initial OCTA imaging was performed in 9 children or infants during exam under anesthesia. The HH-OCTA images provide visualization of the retinal microvasculature in both normal and pathological eyes.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133474574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular fundus imaging with transmitted light (Conference Presentation) 眼底透射光成像(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2507989

Timothy D. Weber, J. Mertz

{"title":"Ocular fundus imaging with transmitted light (Conference Presentation)","authors":"Timothy D. Weber, J. Mertz","doi":"10.1117/12.2507989","DOIUrl":"https://doi.org/10.1117/12.2507989","url":null,"abstract":"Widefield ocular fundus imaging is conventionally performed in a reflection geometry. In this configuration, back-reflections from inner retinal layers, such as the nerve fiber layer, the inner limiting membrane, or even the anterior walls of large blood vessels, are often encountered, and may obscure the visibility of deeper features. Moreover, spectroscopic quantification of endogenous chromophores is complicated since the final image is a summation of reflections from several fundus layers (i.e. no single absorption pathlength can safely be assumed). Researchers have sought to model the fundus reflections, however the models are sensitive to the populations used and particular imaging platform. In theory, unwanted superficial reflections could be avoided and light path modeling could be simplified by adopting a transmission imaging geometry. We present an alternative transillumination fundus imaging strategy based on deeply penetrating near-infrared (NIR) light delivered transcranial near the subject’s temple. A portion of this light diffuses through bone and illuminates the posterior eye not from the front, as with conventional methods, but rather mostly from behind. As such, we image light transmitted through the fundus rather than back-reflected off multiple fundus layers. This single-pass measurement geometry simplifies absorption pathlength considerations and provides complementary information to fundus reflectometry. The use of NIR light enables imaging as deep as the choroid. Importantly, the technique is compatible with reflection-based techniques and we have shown that it works well with a commercial non-mydriatic fundus camera. Combining information from these two illumination approaches should improve spectroscopic analysis of the fundus.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115366052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Axial motion corrected constant linear velocity spiral scan OCT with dynamic focusing for high resolution wide field corneal and anterior chamber imaging (Conference Presentation) 轴向运动校正恒线速度螺旋扫描OCT动态聚焦用于高分辨率宽视场角膜和前房成像(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2510164

R. McNabb, Yuxiao Wei, Moseph Jackson-Atogi, Alice S Liu, O. Carrasco-Zevallos, J. Izatt, A. Kuo

{"title":"Axial motion corrected constant linear velocity spiral scan OCT with dynamic focusing for high resolution wide field corneal and anterior chamber imaging (Conference Presentation)","authors":"R. McNabb, Yuxiao Wei, Moseph Jackson-Atogi, Alice S Liu, O. Carrasco-Zevallos, J. Izatt, A. Kuo","doi":"10.1117/12.2510164","DOIUrl":"https://doi.org/10.1117/12.2510164","url":null,"abstract":"Imaging the entire human cornea with a conventional OCT system configuration requires trade-offs between resolution and depth-of-focus because the cornea is curved over a depth of approximately 4 mm. These system trade-offs result in image quality variations in the corneal image such as a bright apex surrounded by decreasing intensity as the cornea curves away from the apex. These intensity changes cause non-biological ambiguities in interpreting the image, make it difficult to see anatomy in the dim areas, and make automated surface detection difficult in the periphery. To address this problem, we developed a continuously focusing corneal OCT system coupled with a constant linear velocity (CLV) spiral scan pattern that is able to better maintain focus from the apex to the deeper cornea during a scan. The continuous focusing was implemented by introducing a focusing telescope on a motorized stage into the sample arm and matching the translation of the telescope with the CLV scan as it spiraled from the corneal apex outwards. Orthogonal B-scans prior to volume acquisition were used as a reference to estimate and correct motion that occurred during the subsequent CLV scan. A consented subject was imaged, and the resultant image showed increased intensity in the peripheral and deeper cornea and anterior chamber. Continuous focusing with CLV spiral scanning is a promising design change to OCT systems allowing adequate focus over relatively large depths such as for scanning the human cornea.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116244883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards in vivo imaging of the mouse cone photoreceptors (Conference Presentation) 小鼠视锥细胞光感受器的体内成像研究(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2508864

Pengfei Zhang, Eric B. Miller, Suman K. Manna, R. Meleppat, E. Pugh, R. Zawadzki

{"title":"Towards in vivo imaging of the mouse cone photoreceptors (Conference Presentation)","authors":"Pengfei Zhang, Eric B. Miller, Suman K. Manna, R. Meleppat, E. Pugh, R. Zawadzki","doi":"10.1117/12.2508864","DOIUrl":"https://doi.org/10.1117/12.2508864","url":null,"abstract":"Vision is the most important sense organ of human, more than 80% of the information from outside world is acquired by vision. Vision starts at the photoreceptors in the retina capturing the visible light photons. There are two general types of photoreceptors, called rods and cones. Rods allow us to see in dim and dark light, cones allow us to perceive fine visual detail and color. To understand physiology of cones, researchers developed many model organisms that allow them to study in details different aspects of photoreceptors function. Specifically, mice play a central role in basic vision science research. However, one should keep in mind that mice have rod dominant retinas which is different from human cone dominant retinas near fovea. \u0000As one of the consequence in vivo imaging of cones in humans is relatively easy in periphery, and cone mosaic was the first cellular structure that was reported to be seen by optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), especially with implementation of adaptive optics (AO)[1]. However, just recently researchers started to visualize human rods which are smaller than cones [2, 3]. In case of mouse retinal imaging, it is quite the opposite situation. There have been recent reports of imaging rods mosaic [4-6], but up to date no reports on identifying cones in the images. Given that the cones are twice as big as rods in mice, it is very interesting why one can visualize rods but cannot visualize cones.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117318045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vivo imaging of vitreous opacities with full-eye-length SS-OCT (Conference Presentation) 全眼SS-OCT在体内成像玻璃体混浊(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2509474

I. Grulkowski, Ana Rodríguez-Aramendía, S. Manzanera, Yiwei Chen, Juan Mompeán, F. Díaz-Doutón, J. Pujol, J. Sebag, P. Artal

{"title":"In vivo imaging of vitreous opacities with full-eye-length SS-OCT\u0000 (Conference Presentation)","authors":"I. Grulkowski, Ana Rodríguez-Aramendía, S. Manzanera, Yiwei Chen, Juan Mompeán, F. Díaz-Doutón, J. Pujol, J. Sebag, P. Artal","doi":"10.1117/12.2509474","DOIUrl":"https://doi.org/10.1117/12.2509474","url":null,"abstract":"Transparency of ocular structures is an important factor determining contrast in the retinal image. Although opacities are most commonly formed in the crystalline lens of aging eye (cataract formation), visual function can be also altered by the opacities in the vitreous body. Therefore, macro- and micro-scale visualization of vitreous is clinically relevant since alterations of vitreous organization impact retinal diseases and affect vision. However, optical imaging of the vitreous body is challenging due to its transparency. We demonstrate visualization of vitreous and its opacities in vivo using optical coherence tomography (OCT). We developed a prototype long-depth-range Swept-Source OCT instrument operating at the speed of 30 kA-scans/second and at the central wavelength of 1 μm to perform high-resolution imaging through the entire vitreous depth. The interface with focus-tunable optics has been used to optimize the field of view. 2-D and 3-D OCT data sets of eyes with vitreous opacities were acquired and processed to obtain contrast-enhanced high-resolution images of vitreous. The results demonstrate the ability of the OCT imaging to characterize the opacities that cause floaters. In conclusion, long-depth-range SS-OCT enables volumetric visualization of in vivo microstructural changes in the vitreous body. This instrument might be a useful tool in high-resolution evaluation and surgical management of vitreous opacities.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122386963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive and high temporal resolution choroidal and retinal blood flow imaging using laser Doppler holography (Conference Presentation) 激光多普勒全息成像无创、高时间分辨率脉络膜和视网膜血流成像(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2506157

L. Puyo, M. Pâques, M. Fink, J. Sahel, M. Atlan

{"title":"Non-invasive and high temporal resolution choroidal and retinal blood flow imaging using laser Doppler holography (Conference Presentation)","authors":"L. Puyo, M. Pâques, M. Fink, J. Sahel, M. Atlan","doi":"10.1117/12.2506157","DOIUrl":"https://doi.org/10.1117/12.2506157","url":null,"abstract":"Monitoring retinal vascularization is crucial to understand the pathophysiology of major diseases affecting the retina. Laser Doppler holography addresses the problem of temporal resolution in blood flow imaging. The method is conceptually close to laser Doppler flowmetry except it uses digital holography which allows for full-field imaging with a simple Mach–Zehnder interferometer. The light backscattered by the retina is combined with a reference field in order to measure the beat frequency spectrum with a very high acquisition frame rate. Wideband measurements of the optical Doppler broadening were performed with a 75 kHz crash test camera. The power spectrum density of the recorded holograms was analyzed with a short-time Fourier transform analysis to reveal local pulsatile flow. By using laser Doppler holography, we were able to image blood flow in vivo and qualitatively in retinal vessels with a temporal resolution down to a few milliseconds which enabled to investigate blood flow profiles in arteries and veins. Additionally the angiographic contrast in power Doppler images has proved sensitive to lateral flow which made possible to image vessels in en-face planes. Finally we showed that laser Doppler holography allows to reveal non-invasively in young and healthy subjects the large vessels of the choroid. To this end we stitched together multiple power Doppler images to form a wide-field laser Doppler holographic panorama.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132572098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Photovoltaic restoration of sight in age-related macular degeneration (Conference Presentation) 光电恢复老年性黄斑变性的视力(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2508967

D. Palanker, T. Flores, Elton Ho, H. Lorach, Mohajeet B. Bhuckory, T. Kamins, Tiffany W Huang, K. Mathieson

{"title":"Photovoltaic restoration of sight in age-related macular degeneration (Conference Presentation)","authors":"D. Palanker, T. Flores, Elton Ho, H. Lorach, Mohajeet B. Bhuckory, T. Kamins, Tiffany W Huang, K. Mathieson","doi":"10.1117/12.2508967","DOIUrl":"https://doi.org/10.1117/12.2508967","url":null,"abstract":"To restore vision in patients who lost photoreceptors due to retinal degeneration, we developed a photovoltaic subretinal prosthesis which converts light into pulsed electric current, stimulating the inner retinal neurons. Visual information is projected onto the retina by video goggles using pulsed near-infrared (880nm) light. This design avoids the use of bulky electronics and wiring, thereby greatly reducing the surgical complexity and allows scaling the implants to thousands of electrodes.\u0000We found that similarly to normal vision, retinal response to prosthetic stimulation exhibits flicker fusion at high frequencies (>20Hz), adaptation to static images, antagonistic center-surround receptive fields with non-linear summation of its subunits. In rats, photovoltaic arrays with 55um pixels provided grating visual acuity up to a pixel pitch, which corresponds to about 20/200 acuity in a human eye. In patients with geographic atrophy, implants with 100um pixels provided retinotopically correct pattern percepts with resolution matching the pixel size. \u0000With flat pixels of 40um and smaller, stimulation thresholds are becoming prohibitively high. To reduce the pixel size further, we developed a novel honeycomb configuration of the stimulating electrode array with vertical walls separating the active and return electrodes, designed to leverage retinal migration for reducing the subretinal stimulation threshold and electrical cross-talk between neighboring pixels. Scalability, ease of implantation, and high resolution of these arrays open the door to highly functional restoration of sight in retinal degeneration.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132578281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8