Ophthalmic Technologies XXIX最新文献_第3页

Handheld OCT-A using spectrally encoded coherence tomography and reflectometry (Conference Presentation) 手持OCT-A使用频谱编码相干层析成像和反射测量(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2510340

Joseph D. Malone, Mohamed T. El-Haddad, Yuankai K. Tao

{"title":"Handheld OCT-A using spectrally encoded coherence tomography and reflectometry (Conference Presentation)","authors":"Joseph D. Malone, Mohamed T. El-Haddad, Yuankai K. Tao","doi":"10.1117/12.2510340","DOIUrl":"https://doi.org/10.1117/12.2510340","url":null,"abstract":"Optical coherence tomographic angiography (OCT-A) technologies have been primarily demonstrated on slit-lamp systems, which preclude imaging in infants, bedridden patients, or patients who are otherwise unable to be imaged upright. Current-generation OCT-A requires densely-sampled volumetric datasets for high vascular resolution imaging, but bulk motion artifacts, resulting from saccades or eye drifts, often distort anatomic features during long acquisitions. Here, we demonstrate handheld motion-artifact corrected OCT-A using spectrally encoded coherence tomography and reflectometry (SECTR). SECTR has advantageous over previously demonstrated handheld ophthalmic imagers by acquiring spatiotemporally co-registered, high-speed en face images of the retinal fundus using spectrally encoded reflectometry (SER) concurrently with OCT. The orthogonal priority acquisition axes of SER and OCT enables volumetric registration and motion-artifact compensation. We have incorporated several optomechanical improvements including novel snap-fit lens mounts for reduced size and weight and improved optical stability over our previous design. Additionally, we developed a method for reducing back reflections from a double-clad fiber by fusion-splicing a no-core fiber segment with a predefined geometry. Lastly, we demonstrate in vivo human OCT-A imaging of the optic nerve head and fovea. OCT and OCT-A images were motion-corrected using complementary motion information extracted from en face SER and cross-sectional OCT images. Here, OCT-A volumetric datasets were densely-sampled in small regions-of-interest within a large SER field-of-view to achieve high vascular resolution OCT-A while maintaining sufficient fiducials within SER images for motion registration. We believe our probe will enable point-of-care functional ophthalmic imaging.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133920162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Jones-matrix OCT for diagnosis of macular disease (Conference Presentation) 临床琼斯矩阵OCT诊断黄斑病变(会议报告)

Ophthalmic Technologies XXIX Pub Date : 2019-03-13 DOI: 10.1117/12.2507800

Shinnosuke Azuma, S. Makita, M. Miura, Toshihiro Mino, Tatsuo Yamaguchi, Y. Yasuno

{"title":"Clinical Jones-matrix OCT for diagnosis of macular disease (Conference Presentation)","authors":"Shinnosuke Azuma, S. Makita, M. Miura, Toshihiro Mino, Tatsuo Yamaguchi, Y. Yasuno","doi":"10.1117/12.2507800","DOIUrl":"https://doi.org/10.1117/12.2507800","url":null,"abstract":"Jones matrix optical coherence tomography (JM-OCT) is a functional extension of OCT. However, the clinical utility of JM-OCT is not widely accepted. Because of its hardware complexity and poorly established methods for clinical interpretation.\u0000In this study, we propose the approaches to solve the above-mentioned problems. To reduce the hardware complexity, we employ encapsulated passive polarization delay module (PPD) and encapsulated polarization diversity detection module (PDD), and develop full-function JM-OCT and simplified JM-OCT. In addition, we developed a pixel wise segmentation method for JM-OCT. \u0000The full-function JM-OCT which uses both PDD and PPD measures OCT, OCT angiography (OCTA), degree-of-polarization-uniformity (DOPU) and birefringence. The simplified JM-OCT which uses only PDD measures OCT, OCTA, and DOPU but not birefringence. In both JM-OCT systems, all the optical components are packed in a standard-sized retinal scanner.\u0000A pixel-wise segmentation method for retinal pigment epithelium (RPE) and choroidal stroma exploits multiple types of images obtained by the JM-OCT. Attenuation coefficient, OCTA, and DOPU are combined to synthesize a new artificial contrast. By applying a simple threshold to it, the target tissue is segmented. After segmenting the RPE, an en face “melano-layer thickness map” is created. \u0000A Normal subject and a pigment epithelial detachment (PED) subject are obtained by full-function JM-OCT and simplified JM-OCT. In PED subject, thickened RPE, hyper-reflective foci, and damaged RPE are correctly detected by RPE segmentation. In addition, created melano-layer thickness map has similar patterns to infrared fundus autofluorescence (NIR-AF), and it can contribute further interpretation of the NIR-AF.","PeriodicalId":204875,"journal":{"name":"Ophthalmic Technologies XXIX","volume":"439 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115613511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follow-up of accelerated-crosslinking non-invasively and label-free using multiphoton tomography 多光子断层扫描无创无标记加速交联的随访研究

Ophthalmic Technologies XXIX Pub Date : 2019-02-28 DOI: 10.22028/D291-28846

A. Batista, H. Breunig, T. Hager, B. Seitz, K. König

引用次数: 0

Artery and vein differentiation in retinal optical coherence tomography angiography of macular region 视网膜黄斑区光学相干断层血管造影的动静脉分化

Ophthalmic Technologies XXIX Pub Date : 2019-02-28 DOI: 10.1117/12.2508918

T. Son, Minha Alam, Changgeng Liu, D. Toslak, Xincheng Yao

引用次数: 1