Proceedings for Annual Meeting of The Japanese Pharmacological Society最新文献

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Involvement in the development of Alzheimer's disease through activation of systemic immune response. 通过激活全身免疫反应参与阿尔茨海默病的发展。
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_3-s36-1
Ito Minako, R. Kaneko
{"title":"Involvement in the development of Alzheimer's disease through activation of systemic immune response.","authors":"Ito Minako, R. Kaneko","doi":"10.1254/jpssuppl.95.0_3-s36-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-s36-1","url":null,"abstract":"In neurodegenerative diseases such as Alzheimer's disease (AD), the appearance and accumulation of aggregates of Amyloid beta (Aβ) and phosphorylated Tau is triggered by some stimulus such as an immune response. Inflammatory bowel disease was also reported to be a risk factor for dementia in humans, but the mechanism remains unclear. The aim of this study is to develop novel therapeutic strategies by clarifying the immune responses that regulate the expansion of cells expressing Aβ and phosphorylated Tau. We found that colitis enhanced the pathogenesis of AD, and immune cells were infiltrated in the brains and dura maters of mice models of AD by using scRNAseq, suggesting the involvement of immune responses in the development of neurological diseases. Symposium 36","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76800858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of α-synuclein uptake at the blood-brain barrier α-突触核蛋白在血脑屏障的摄取特性
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_3-b-p-230
S. Dohgu, Miki Yokoya, F. Takata, T. Iwao, Junichi Matsumoto, Kazunori Sano
{"title":"Characteristics of α-synuclein uptake at the blood-brain barrier","authors":"S. Dohgu, Miki Yokoya, F. Takata, T. Iwao, Junichi Matsumoto, Kazunori Sano","doi":"10.1254/jpssuppl.96.0_3-b-p-230","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-p-230","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82152156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural analysis of the ABC transporter which transports long chain fatty acid CoA. 运输长链脂肪酸CoA的ABC转运蛋白的结构分析。
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-ss-67
Shinichiro Aiba, H. Okamoto, A. Tomita, T. Kusakizako, O. Nureki
{"title":"Structural analysis of the ABC transporter which transports long chain fatty acid CoA.","authors":"Shinichiro Aiba, H. Okamoto, A. Tomita, T. Kusakizako, O. Nureki","doi":"10.1254/jpssuppl.95.0_1-ss-67","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-ss-67","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81402271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of fast-dissociating recombinant antibody probes for multiplexed super-resolution molecular mapping 用于多路超分辨率分子定位的快速解离重组抗体探针的研制
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-ss02-6
Qianli Zhang, Akitoshi Miyamoto, T. Arimori, J. Takagi, Naoki Watanabe
{"title":"Development of fast-dissociating recombinant antibody probes for multiplexed super-resolution molecular mapping","authors":"Qianli Zhang, Akitoshi Miyamoto, T. Arimori, J. Takagi, Naoki Watanabe","doi":"10.1254/jpssuppl.96.0_2-b-ss02-6","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-ss02-6","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81772643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRPA channel plays ubiquitous roles in O2 sensing TRPA通道在O2传感中起着无处不在的作用
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-s40-2
Y. Mori, Akito Nakao, Kenneth Liu, N. Takahashi
{"title":"TRPA channel plays ubiquitous roles in O2 sensing","authors":"Y. Mori, Akito Nakao, Kenneth Liu, N. Takahashi","doi":"10.1254/jpssuppl.96.0_4-b-s40-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-s40-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81784841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of weak-interacting proteins with Sav1 using BioID2 method 利用BioID2方法鉴定与Sav1弱相互作用的蛋白
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-p-180
Uchida Kazuhiko, Nobuya Sakai, K. Shibata
{"title":"Identification of weak-interacting proteins with Sav1 using BioID2 method","authors":"Uchida Kazuhiko, Nobuya Sakai, K. Shibata","doi":"10.1254/jpssuppl.95.0_2-p-180","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-180","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82322103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of endotoxic death by a nociceptor-derived anti-microbial peptide. 由伤害感受器衍生的抗微生物肽预防内毒素死亡。
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_3-b-p-196
T. Kondo, Erika Sugisawa, Kenta Maruyama
{"title":"Prevention of endotoxic death by a nociceptor-derived anti-microbial peptide.","authors":"T. Kondo, Erika Sugisawa, Kenta Maruyama","doi":"10.1254/jpssuppl.96.0_3-b-p-196","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_3-b-p-196","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82496963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The interaction between MMP-9 and TNF-α contributes to the exacerbation of capillary degeneration in a rat model of NMDA-induced retinal injury MMP-9和TNF-α的相互作用加剧了nmda诱导的大鼠视网膜损伤模型的毛细血管变性
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-p-274
Mihoka Kojima, Daiki Asano, Akane Morita, T. Kashihara, T. Nakahara
{"title":"The interaction between MMP-9 and TNF-α contributes to the exacerbation of capillary degeneration in a rat model of NMDA-induced retinal injury","authors":"Mihoka Kojima, Daiki Asano, Akane Morita, T. Kashihara, T. Nakahara","doi":"10.1254/jpssuppl.96.0_4-b-p-274","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-p-274","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78870645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a novel causative gene for dilated cardiomyopathy requiring heart transplantation and elucidation of the mechanism of protein homeostasis in cardiomyocytes 需要心脏移植的扩张型心肌病新致病基因的鉴定和心肌细胞蛋白稳态机制的阐明
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-s02-1
Hideyuki Hakui
{"title":"Identification of a novel causative gene for dilated cardiomyopathy requiring heart transplantation and elucidation of the mechanism of protein homeostasis in cardiomyocytes","authors":"Hideyuki Hakui","doi":"10.1254/jpssuppl.96.0_1-b-s02-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-s02-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76327135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of ALS-related mutation on lipid binding of sigma-1 receptor and its relationship with agonist action 肌萎缩侧索硬化症相关突变对sigma-1受体脂质结合的影响及其与激动剂作用的关系
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_3-p-204
Yasuharu Shinoda, Yudai Haga, Takuya Sasaki, K. Fukunaga
{"title":"The effect of ALS-related mutation on lipid binding of sigma-1 receptor and its relationship with agonist action","authors":"Yasuharu Shinoda, Yudai Haga, Takuya Sasaki, K. Fukunaga","doi":"10.1254/jpssuppl.95.0_3-p-204","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_3-p-204","url":null,"abstract":"Sigma-1 receptor (σ1R) is a chaperone protein localized in ER membrane. Intrinsic molecules like cholesterol and some clinical drugs are known to bind and regulate the receptor. In this decade, twelve mutations of σ1R were discovered in motor neuron diseases like ALS and dHMN. We previously reported that the mutant (E102Q) which was identified in ALS shows abnormal resistant to detergents, intracellular aggregation, and toxicity in NSC-34 cells, a motor neuron-like cultured cells. However, it is fully unknown how the mutation alters the feature of σ1R. We transfected the cells with wildtype and the mutant and performed pulldown assay using cholesterol-beads. Cells were treated with the agonist SA4503 to investigate if the agonist changes the formation of σ1R and lipid complex. Moreover, cells were treated with BODIPY-Cholesterol to analyze cellular distribution of the lipid. As a result, the mutant but not wildtype σ1R binds with cholesterol in NSC-34 cells. SA4503 inhibited the binding of the mutant and cholesterol. BODIPY-Cholesterol was accumulated in the mutant aggregation. These results suggest that ALS-related mutation causes σ1R to bind with cholesterol, leading to aberrant aggregations and toxicity. Moreover, modulations by the agonist can inhibit the binding with the lipid and aggregation. Poster Session","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76425888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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