Journal of Japan Society of Immunology & Allergology in Otolaryngology最新文献_第5页

How to use NSAIDs for patients with nasal polyps 鼻息肉患者如何使用非甾体抗炎药

Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.37.229

T. Matsuyama, Hiroe Tada, K. Chikamatsu

{"title":"How to use NSAIDs for patients with nasal polyps","authors":"T. Matsuyama, Hiroe Tada, K. Chikamatsu","doi":"10.5648/jjiao.37.229","DOIUrl":"https://doi.org/10.5648/jjiao.37.229","url":null,"abstract":"2000年代に入り, 成人発症, 両側鼻茸, 嗅覚障害, 末梢血中好酸球の高値,気管支喘息の合併を主徴とする慢性副鼻腔炎がみつかり,春名らにより好酸球性副鼻腔炎と提唱された。2014年に診断基準が確立し,2015年 7月には厚生労働省の指定難病として登録されている。この上気道の慢性炎症である好酸球性副鼻腔炎と下気道の慢性炎症である気管支喘息は,one airway one diseaseという病態が共通する気道炎症疾患であるとの概念が確立され,互いの疾患は高率に合併する。その病態の一つとして,獲得免疫応答である 2型ヘルパー T細胞 (Th2),自然免疫応答である 2型自然リンパ球(innate lymphoid cells type 2: ILC2) による IL-5の好酸球誘導が気道炎症を引き起こすことが考えられているが,その全貌は明らかになっていない。また, 好酸球性副鼻腔炎に合併する気管支喘息はアスピリン喘息であることが多いことが知られているが,そのアスピリン不耐との関連性に関してもいまだ明確にされていない。対して,アスピリン喘息では早くから鼻茸や嗅覚障害が合併することがわかっており,アスピリン喘息と診断された患者のほぼ全例に好酸球性副鼻腔炎を合併している。アスピリン喘息患者のアスピリン発作は時に意識障害を伴うほどの大発作となり,死につながる例も珍しくない。そのため,アスピリン不耐のない通常の気管支喘息患者に対しても薬剤アレルギー歴の有無に関係なく,NSAIDsを投与しないことは現在医療界全体で通例となっている。しかし,反対にアスピリン喘息を合併しやすい好酸球性副鼻腔炎の患者に対してNSAIDsを投与しないことは広く周知されていない。鼻茸を有する症例の中には好酸球性副鼻腔炎が含まれることが多く,また,好酸球性副鼻腔炎の中にアスピリン喘息患者が多いことが知られている。このため, 鼻茸を有する症例に対してはNSAIDsの取り扱いに慎重を期する必要がある。今回,NSAIDsアレルギー歴がなく,気管支喘息も合併していない好酸球性副鼻腔炎の患者のアスピリン喘息発作を経験した。上述のように,アスピリン喘息発作の気管支狭窄は重症であり,時に死につながる可能性もある。鼻茸を有する患者の中には,潜在的にアスピリン不耐の患者が存在することを念頭に置くことは,喘息死の予防の一翼を担うと考えられる。症例報告と共に,鼻茸患者に対する NSAIDsの取り扱い方に関して注意喚起を行う。","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114684118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization to insects in urban or rural area, and their clinical and immunological features 城乡昆虫致敏情况及其临床和免疫学特征

Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.57

Aiko Oka, Shougo Oyamada, Shinichiro Oka, Sakiko Hurutate, Masahiro Takahashi, S. Iwasaki, Maki Akamatsu, Y. Noguchi, S. Kariya, Kengo Kanai, S. Makihara, K. Nishizaki, M. Okano

{"title":"Sensitization to insects in urban or rural area, and their clinical and immunological features","authors":"Aiko Oka, Shougo Oyamada, Shinichiro Oka, Sakiko Hurutate, Masahiro Takahashi, S. Iwasaki, Maki Akamatsu, Y. Noguchi, S. Kariya, Kengo Kanai, S. Makihara, K. Nishizaki, M. Okano","doi":"10.5648/jjiao.38.57","DOIUrl":"https://doi.org/10.5648/jjiao.38.57","url":null,"abstract":"Background: Prevalence of sensitization to insects and its clinical and immunological features remains largely unclear in Japan. Patients and methods: The study includes 524 patients (316 from International University of Health and Welfare (IUHW) Mita Hospital in Tokyo and 208 from IUHW Hospital in Tochigi) who complained of nasal symptoms and underwent ImmunoCAP IgE tests. We compared the ratio of insect sensitization (moth, chironomid and cockroach) in Tokyo and Tochigi and investigated the clinical and immunological features of the patients, focusing particularly on those with sensitization to insects alone. Results: The ratio of sensitization to moth, chironomid and cockroach were 30.7%, 10.0% and 10.6% in Tokyo, and 26.4%, 10.6% and 12.5% in Tochigi, respectively. The geographical comparison showed no significant difference. Among the insect allergic patients, 95.1% were sensitized to the moth. In comparison to those insensitive to arthropods, the group of patients sensitized to insects was male dominant and indicated higher total IgE. The group of those sensitized only to insects was relatively older than that of those sensitive to not only insects but also other inhaled allergens. Conclusion: The study showed the high ratio of sensitization to the moth carried significance of the moth as an allergen in allergic rhinitis. The ratio of insect sensitization showed no significant different between urban and rural area. Patients sensitized to insects alone were dominated by elderly male with high total IgE.","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117300942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arachidonic acid metabolites-induced activation of group 2 innate lymphoid cell in eosinophilic upper airway inflammation 花生四烯酸代谢物诱导嗜酸性上呼吸道炎症中2组先天淋巴样细胞的活化

Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.37.217

I. Tojima, Takeshi Shimizu

引用次数: 0

挨拶挨拶

Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.s1

引用次数: 0