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Journal of Japan Society of Immunology & Allergology in Otolaryngology最新文献

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Sublingual immunotherapy for pediatric allergic rhinitis 儿童变应性鼻炎的舌下免疫治疗
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.65
K. Kawashima
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引用次数: 1
Allergic rhinitis associated with bronchial asthma: The importance and management of rhinitis 过敏性鼻炎与支气管哮喘:鼻炎的重要性和管理
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.1
S. Masuda
{"title":"Allergic rhinitis associated with bronchial asthma: The importance and management of rhinitis","authors":"S. Masuda","doi":"10.5648/jjiao.38.1","DOIUrl":"https://doi.org/10.5648/jjiao.38.1","url":null,"abstract":"The prevalence of allergic rhinitis in asthmatic patients is high. It is also known that allergic rhinitis could be a risk factor for the onset and exacerbation of asthma. Many oral and topical medicines for allergic rhinitis are expected to ameliorate symptoms of asthma indirectly by improving allergic inflammation in the nose. However, some first-generation antihistamines are contraindicated for asthma. When administering intranasal corticosteroids to patients using inhaled steroids, those with low systemic bioavailability should be chosen. Leukotrienes receptor antagonists are used not only for treatment of allergic rhinitis but also for control of asthma. Anti-human IgE antibodies with expanded indications for some of severe Japanese cedar pollinosis are also expected to be effective in the patients with asthma caused by IgE-related allergic inflammation. In Japan, the subcutaneous allergen immunotherapy is indicated for allergic rhinitis and asthma, and the sublingual method is indicated only for allergic rhinitis. It is recommended for the patients with allergic rhinitis accompanied by asthma related to house dust mite antigens. It is necessary to understand the indication of immunotherapy for asthma, to share information about patients with other physicians, and to control asthma.","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124352798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Educational Lecture 教育讲座
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.37.30
{"title":"Educational Lecture","authors":"","doi":"10.5648/jjiao.37.30","DOIUrl":"https://doi.org/10.5648/jjiao.37.30","url":null,"abstract":"","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124202186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergic rhinitis and clock gene 过敏性鼻炎与时钟基因
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.13
A. Honma
{"title":"Allergic rhinitis and clock gene","authors":"A. Honma","doi":"10.5648/jjiao.38.13","DOIUrl":"https://doi.org/10.5648/jjiao.38.13","url":null,"abstract":"血圧や体温,ホルモン分泌の変動といった生理機能にみ られる概日リズムは,脳視床下部視交叉上核にある中枢時 計と全身の組織に存在する末梢時計により制御されてい る。アレルギー性鼻炎の症状にも日内変動が見られ,夜 間から早朝にかけて増悪する。この鼻炎症状の日内変動も 体内時計により制御されており,ホルモン分泌や自律神経 系の概日リズムが,夜間の鼻腔抵抗増加やマスト細胞脱顆 粒反応亢進など,アレルギー性鼻炎の病態に影響を及ぼす と考えられている。一方で,炎症性ストレスや炎症性サ イトカインが時計遺伝子発現に影響を及ぼすことが報告さ れており,慢性炎症が体内時計を狂わす可能性も示唆され る。このように,近年,慢性炎症性疾患の病態や免疫反 応における時計遺伝子の関与が注目されつつある。 本稿では,筆者らが行ってきた鼻粘膜の時計遺伝子の研 究成果を中心に,体内時計の役割と,体内時計の制御に着 目したアレルギー性鼻炎の治療に対する展望について言及 したい。なお,全ての実験は国立大学法人北海道大学動物 実験に関する規程第 7条第 1項の規定に基づき,総長より 承認をうけた動物実験計画「概日振動の分子・細胞メカニ ズム:中枢時計の同調と末梢時計の統合」(承認番号:130064)および「アレルギー性鼻炎に対するステロイド点鼻 薬の時間治療法の開発」(承認番号:16-0098)の一環とし て行われた。","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132966082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of inhaled antigen sensitization in children with food allergy 食物过敏儿童吸入抗原致敏的检查
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/JJIAO.37.3
K. Kawashima, Takahiro Sasaki, Y. Takaoka, Yukinori Yoshida, M. Kameda
{"title":"Examination of inhaled antigen sensitization in children with food allergy","authors":"K. Kawashima, Takahiro Sasaki, Y. Takaoka, Yukinori Yoshida, M. Kameda","doi":"10.5648/JJIAO.37.3","DOIUrl":"https://doi.org/10.5648/JJIAO.37.3","url":null,"abstract":"","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134407861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Refractory chronic rhinosinusitis of IgG4-related disease igg4相关疾病的难治性慢性鼻窦炎
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.87
Y. Ota
{"title":"Refractory chronic rhinosinusitis of IgG4-related disease","authors":"Y. Ota","doi":"10.5648/jjiao.38.87","DOIUrl":"https://doi.org/10.5648/jjiao.38.87","url":null,"abstract":"症例 1は 47歳男性である。2年前より慢性的に鼻閉,鼻 漏,咳嗽症状を認めた。1年ほど保存的に加療したが症状 改善を認めず,当科紹介受診となった。気管支喘息の既往 は無い。初診時鼻内視鏡所見では,両側下鼻甲介粘膜蒼白 であったが,鼻茸などは認められず,中等度の鼻漏,後鼻 漏を認めた。副鼻腔Computed Tomography (CT) では,両 上顎洞の軟部陰影,両篩骨洞の軟部組織陰影を認めた (図 1)。血液検査所見では,IgE 100 IU/mlと正常であり, 血中好酸球は 3.7%と正常範囲であった。鼻症状の改善を なかなか認めないため,IgG4を測定したところ,血清 IgG 1473 mg/dl, IgG4 306 mg/dlと,IgG4高値を示していた。 診断および治療目的に全身麻酔下に両側鼻内視鏡下鼻副 鼻腔手術を施行したところ,左上顎洞には膿汁の貯留を認 めたが,篩骨洞上顎洞の粘膜腫脹は両側とも軽度であっ た。手術検体による病理組織検査では,Hematoxylin Eosin (HE)染色でリンパ球,形質細胞や繊維化病変を認め,好 酸球浸潤は少数のみであった。免疫組織染色では IgG/IgG4 比 40%以上,強拡大で 10個以上の IgGおよび IgG4陽性形 質細胞を認め(図 2:1–3),IgG4関連疾患の包括的診断基 準を満たした。IgG4関連疾患が考えられたため,全身検 索を行ったが,眼窩外側部の腫脹や唾液腺腫脹の出現はな く,全身 CTでも他臓器に IgG4関連疾患を示唆する所見 もなく,病変は鼻副鼻腔だけであった。手術後鼻閉症状は 軽快したが,鼻腔分泌物の多さは遷延し,後鼻漏,咳嗽症 状が継続した。現在鼻洗浄や鼻噴霧型ステロイド,吸入ス テロイド /長時間作用型 β刺激薬(ICS/LABA)配合剤, CAMの少量長期投与などで外来経過観察中である。 症例 2は 42歳男性。両側鼻閉,嗅覚消失,両側顎下部 の腫脹で当科を受診した。初診時両側鼻腔に鼻茸が認めら れ(図3),両側の顎下部,眼窩外側部の腫脹も認められた。 CTでは両側の汎副鼻腔炎,両側顎下腺,涙腺の腫脹が認 められた(図 4)。血液検査では,血清総 IgE 380 IU/mL, IgG4 383 mg/dL, と高値を示し,血中好酸球は 6.3%と正常 範囲内であった。血清抗デスモグレイン 3抗体は 4390 U/ml と高値を示した。 2020年 10月 18日受稿 別冊請求先:太田 康 〒285-8741 千葉県佐倉市下志津 564-1 東邦大学医学部耳鼻咽喉科学講座(佐倉) TEL: 043-462-8811 E-mail: Yasushiota5610@yahoo.co.jp IgG4関連の難治性慢性鼻副鼻腔炎","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122754866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical and medical treatment for intractable eosinophilic chronic rhinosinusitis 顽固性嗜酸性慢性鼻窦炎的外科与内科治疗
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.37.261
K. Nomura
{"title":"Surgical and medical treatment for intractable eosinophilic chronic rhinosinusitis","authors":"K. Nomura","doi":"10.5648/jjiao.37.261","DOIUrl":"https://doi.org/10.5648/jjiao.37.261","url":null,"abstract":"好酸球性副鼻腔炎とは,鼻ポリープ組織中の顕微鏡 400 倍視野において,好酸球数が 70個以上存在する慢性副鼻 腔炎である。アスピリン不耐症,NSAIDsアレルギー, 気管支喘息,末梢血好酸球増多,篩骨洞中心病変を伴うと 内視鏡手術後の再発が起こりやすい。 好酸球性副鼻腔炎の治療は鼻内内視鏡手術(Endoscopic Sinus Surgery, ESS) と術後の鼻洗浄, ステロイド点鼻, モンテルカストの内服である。ポリープはしばしば再発 し,確実な治療法は存在しない。 今回報告するのは,長期間の好酸球性副鼻腔炎罹患によ り前頭洞のう胞を発症した症例である。両側 ESSとDraf type III手術(Draf III) を行うも,術後経過中,鼻ポリープ が再増大したため,ステロイド,生物学的製剤などを投与 した。 本稿では通常の好酸球性副鼻腔炎の治療方針に加え,難 治性好酸球性副鼻腔炎に対するDraf IIIの適応,内服ステ ロイドの投与量・投与期間,生物学的製剤の投与につき解 説する。 症 例","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115590735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JIAO Award Nominees' Presentation 焦炭奖提名者颁奖典礼
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.131
{"title":"JIAO Award Nominees' Presentation","authors":"","doi":"10.5648/jjiao.38.131","DOIUrl":"https://doi.org/10.5648/jjiao.38.131","url":null,"abstract":"","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121035428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morning Seminar 早上研讨会
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5631/jibirinsuppl.150.66
{"title":"Morning Seminar","authors":"","doi":"10.5631/jibirinsuppl.150.66","DOIUrl":"https://doi.org/10.5631/jibirinsuppl.150.66","url":null,"abstract":"","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129212254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
「日本耳鼻咽喉科免疫アレルギー学会を振り返る　～そして発展へ～」 “回顾日本耳鼻咽喉科免疫过敏学会~然后发展~”
Journal of Japan Society of Immunology & Allergology in Otolaryngology Pub Date : 1900-01-01 DOI: 10.5648/jjiao.38.s22
{"title":"「日本耳鼻咽喉科免疫アレルギー学会を振り返る　～そして発展へ～」","authors":"","doi":"10.5648/jjiao.38.s22","DOIUrl":"https://doi.org/10.5648/jjiao.38.s22","url":null,"abstract":"","PeriodicalId":204414,"journal":{"name":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127696628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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