Problemy endokrinologii最新文献

{"title":"[What newly brought endocrinology by the past 2022?]","authors":"G A Melnichenko, M V Shestakova","doi":"10.14341/probl13261","DOIUrl":"10.14341/probl13261","url":null,"abstract":"<p><p>In the past year, the Federal Project \"Fight against Diabetes\" 2023-2030 was developed in detail and submitted in detail and submitted to the Government of the Russian Federation, which will significantly improve the practice of working with patients with diabetes, providing them with maximum availability of medical care, including in updated and technologically re -equipped regional endocrinological centers, reviving the active work of \"Diabetes schools\", \"Diabetic foot\" rooms, diagnostic laboratories, introducing new forms of communication with patients, including using personal assistants of a doctor, continuous technologies for monitoring glycemia, etc.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10822876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathogenic <i>TSHR</i> variants in children with thyroid dysgenesis].","authors":"E V Shreder,&nbsp;T A Vadina,&nbsp;E N Solodovnikova,&nbsp;V V Zakharova,&nbsp;M V Degtyarev,&nbsp;M B Konyukhova,&nbsp;N V Sergeeva,&nbsp;O B Bezlepkina","doi":"10.14341/probl13210","DOIUrl":"https://doi.org/10.14341/probl13210","url":null,"abstract":"<p><strong>Background: </strong>Loss-of-function mutations in the TSH receptor gene (TSHR) (NP_000360.2) are the potential causes of thyroid dysgenesis in patients with congenital hypothyroidism. Heterozygous variants of the TSHR gene lead to partial resistance to TSH, homozygous and compound heterozygous variants have been shown to cause CH due to thyroid hypoplasia or TSH resistance. Recently more and more articles in this field have appeared in the international literature sources, while local publications are limited. The studies are necessary to understand the etiology, pathogenesis of the disease, to improve the management of these patients.</p><p><strong>Aim: </strong>To assess the frequency of incidence of pathogenic variants of the TSHR gene in children with CH due to thyroid dysgenesis. To study inheritance and phenotypic patterns of CH in families.</p><p><strong>Materials and methods: </strong>In this single-center interventional one-stage non-comparative study a group of CH patients was examined. The patients underwent neck ultrasound and radionuclide imaging. The examination was performed 14 days after hormone replacement therapy suspension or prior to its initiation. The structure of thyroid dysgenesis was estimated, genetic testing for mutations in the TSHR gene was performed using the NGS method.</p><p><strong>Results: </strong>The study included 95 children with primary CH (75 girls; 20 boys). The patients' median age at the time of examination was 6.2 years [4.5; 8.9], the median level of neonatal TSH was 157.5 mU/l [60.9; 257.2]. Ectopic thyroid was found in 52% of children, aplasia in 36%, hypoplasia and hemiagenesis in 10% and 2%, respectively. In 5.4% of cases (in 5 out of 95 patients), different variants of the TSH gene were detected. Two children had heterozygous p.R450H and p.D487N variants in TSHR gene, two patients was homozygous for the p.S49Afs * 9 variant, one child had compound heterozygous variants (p.A485D and p.R450H). According to ultrasound imaging, all patients had thyroid hypoplasia of varying severity. Three children underwent thyroid scintigraphy, which revealed decreased 99mТc pertechnetate uptake (0.3-0.9%).</p><p><strong>Conclusion: </strong>In our study, the incidence of different variants in the TSHR gene in children with CH was 5.3%. Our analysis uncovered two previously undescribed variants. Genetic testing may be able to help with making the diagnosis, patient's management, and genetic counseling.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10814932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of the structure of the glucocorticoid receptor and single nucleotide <i>NR3C1</i> gene polymorphisms with metabolic disorders].","authors":"S S Brovkina,&nbsp;I S Dzherieva,&nbsp;N I Volkova,&nbsp;T P Shkurat,&nbsp;Z A Goncharova,&nbsp;E V Mashkina,&nbsp;I B Reshetnikov","doi":"10.14341/probl13160","DOIUrl":"https://doi.org/10.14341/probl13160","url":null,"abstract":"<p><p>Glucocorticoid therapy is widely used in the treatment of various pathologies. Sensitivity to glucocorticoids  (GC) has a serious impact not only on the effectiveness of their action, but also on the severity of side effects, the formation of risk factors and the development  of cardiovascular diseases (CVD). Variability of sensitivity to GC causes different phenotypes and severity of metabolic disorders underlying  CVD. Among  them, one can distinguish  a decrease in muscle mass and strength, obesity, glucose and lipid metabolism impairment, and others. Glucocorticoids carry out their effects by binding to the glucocorticoid receptor (GR), and therefore this is considered a critical point in their action. This review presents data on the significance of the glucocorticoid  receptor structure, examines the main single nucleotide polymorphisms (SNP) of the NR3C1 gene associated with hypersensitivity  or relative resistance to glucocorticoids  in the context of metabolic disorders and the development of CVD. The association of the four most studied SNP of the GR gene with metabolic risks is described in detail: BclI (rs41423247), N363S (rs56149945), ER22/23EK (rs6189/rs6190), GR-9ß (rs6198). Their determination can contribute to clarifying the prognosis of both the effectiveness of GC and the development of metabolic disorders, and subsequent early correction of CVD risk factors.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10814931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Casuistic cases of parathyroid carcinoma with a verified mutation in the <i>MEN1</i> gene].","authors":"S V Pylina,&nbsp;E I Kim,&nbsp;E V Bondarenko,&nbsp;J A Krupinova,&nbsp;A K Eremkina,&nbsp;N G Mokrysheva","doi":"10.14341/probl13176","DOIUrl":"https://doi.org/10.14341/probl13176","url":null,"abstract":"<p><p>Parathyroid cancer (PTC) is usually sporadic; however, it could be presented as a component of hereditary syndromes. The prevalence of PTC among patients with primary hyperparathyroidism (PHPT) is about 1% cases. The lack of reliable preoperative predictors significantly complicates the diagnosis of PTC. The clinical course is non-specific and in most cases is determined by severe hypercalcemia. The final diagnosis can only be made on the basis of invasive histopathologic features, while an analysis immunohistochemical (IHC) one can be used only as an additional method. Given the rarity the diagnosis of MEN1-related PTC a challenge. We present two clinical cases of patients with PTC and a verified heterozygous mutation in the MEN1 gene. The described cases demonstrate the complexity of morphological diagnosis for PTC, the heterogeneity of clinical manifestations in patients with the MEN1 mutation, as well as the need for timely screening to identify other components of MEN1 syndrome and mutations of the MEN1 gene among first-line relatives.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10822877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries].","authors":"V V Salukhov,&nbsp;G P Arutyunov,&nbsp;E I Tarlovskaya,&nbsp;T I Batluk,&nbsp;R A Bashkinov,&nbsp;I V Samus,&nbsp;E S Melnikov,&nbsp;M A Trubnikova,&nbsp;A G Arutyunov","doi":"10.14341/probl13175","DOIUrl":"https://doi.org/10.14341/probl13175","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies indicate a high incidence of various disorders of carbohydrate metabolism against the new coronavirus infection. These disorders aggravate the course of infection and increase mortality. Thereby, analysis of risk factors for unfavorable outcomes and assessment of the long-term consequences of COVID-19 in patients with impaired carbohydrate metabolism is of great importance.</p><p><strong>Aim: </strong>To investigate the association between carbohydrate metabolism disorders in COVID-19 patients and mortality, course of infection, long-term consequences, as well as to identify risk factors for an unfavorable disease course.</p><p><strong>Materials and methods: </strong>A retrospective analysis of data from the combined multicenter non-interventional real-world AKTIV and AKTIV 2 registries was performed. The sample included 9290 patients who had COVID-19 with varying severity from June 29, 2020, to November 29, 2020 (AKTIV) and from October 01, 2020, to March 30, 2021 (AKTIV 2). The patients were divided into 3 groups: Group 1 - patients with intact carbohydrate metabolism, n=6606; Group 2 - patients with newly diagnosed hyperglycemia (NDH), n=1073; Group 3 - patients with a history of type 2 diabetes mellitus (DM2), n=1611. The groups were assessed for clinical and laboratory parameters, comorbidities, mortality, carbohydrate metabolic status, and well-being during the infection and at 12 months.</p><p><strong>Results: </strong>The prevalence of carbohydrate metabolism disorders (CMD) was 28,9%, with DM2 patients accounting for 17,3% and patients with newly diagnosed hyperglycemia (NDH) for 11,6%. The mortality rate of patients with hyperglycemia of any origin was 10.6%, which was significantly higher compared to patients without hyperglycemia (3,9%). The probability of lethal outcome increased 2,48-fold in the group of patients with DM2 and 2,04-fold in the group of patients with NDH. At the same time, the probability of a lethal outcome decreased 2,94-fold in patients without CMD. At 12 months, patients with CMD showed a significantly higher frequency and longer persistence of complaints. This trend was more pronounced in patients with DM2 than in those with NDH. Only 1,7% of patients from the NDH group had type 2 diabetes and were receiving oral hypoglycemic medications one year after the infection. A prognostic model was developed to determine the risk of lethal outcome. The model included such known predictors as concomitant ischemic heart disease, history of myocardial infarction or stroke, blood glucose level, and age.</p><p><strong>Conclusion: </strong>Carbohydrate metabolism disorders aggravate the course of COVID-19 and increase mortality. One year after infection, patients with DM2 and NDH were more likely to have symptoms typical for post-COVID syndrome, and NDH resolved in most cases after the infection.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10822878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Electroencephalogram features in children with congenital hyperinsulinism treated according to the international protocol in Russian Federation].","authors":"L R Sarakaeva,&nbsp;D V Ryzhkova,&nbsp;L B Mitrofanova,&nbsp;V G Bairov,&nbsp;A A Sukhotskaya,&nbsp;A P Smorodin,&nbsp;E A Eftich,&nbsp;I A Kelmanson,&nbsp;I L Nikitina","doi":"10.14341/probl13174","DOIUrl":"https://doi.org/10.14341/probl13174","url":null,"abstract":"<p><strong>Background: </strong>Congenital hyperinsulinism (CHI) is a rare life-threatening disease characterised by persistent hypoglycaemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.</p><p><strong>Aim: </strong>To evaluate neurophysiological characteristics of central nervous system in children with congenital hyperinsulinism treated according to the international protocol in Russian Federation.</p><p><strong>Materials and methods: </strong>Our retrospective, prospective cohort study included 73 patients who received treatment for CHI according to the current international protocol at different departments of the Almazov National Medical Research Centre from 2017 to 2022. All patients underwent a comprehensive examination, including electroencephalography (EEG).</p><p><strong>Results: </strong>Among 73 patients with CHI, 35% (23) had focal form of the disease, 65% had non-focal form (49% (39) - diffuse form, 16% (11) - atypical form). All patients with focal form of CHI had a recovery as an outcome.Analysing the EEG data we found that paroxysmal activity was recorded in 23 patients (32%), 50 patients did not have paroxysmal activity (68%). Diffuse changes were observed in 47 patients (64%), whereas 26 patients (36%) were absent of it. By constructing Kaplan-Meier curves we found that the alpha rhythm is formed significantly (p=0.026) earlier in patients with a focal form of CHI.</p><p><strong>Conclusion: </strong>CHI patients treated according to the international guidelines in Russian Federation show rather positive neurological outcome. We established that alpha rhythm earliest formation is associated with focal form of CHI.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10814930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction].","authors":"S A Gasparyan,&nbsp;A M Chotchaeva,&nbsp;S M Karpov","doi":"10.14341/probl13205","DOIUrl":"https://doi.org/10.14341/probl13205","url":null,"abstract":"<p><p>The increasing of older age group in the population determines studying of age related diseases and emergence of new investigations in this area. In Female body, entering the menopausal transition is the start of «aging» of reproductive function and linked with decreasing of sex hormons levels. A direct connection between changes of estrogen, progesterone, androgen ratios and cognitive function of women was revealed. The anatomical localization of sex hormone receptors, the mechanisms of interaction of hormones with these receptors determine the ways of implementing biological effects of steroids on the CNS. Modern theories of «healthy nerve cells» and «eu-estrogenemia» explains the role of additional criteria, such as the absence of neurological diseases history and the duration of hypoestrogenia, to the outcome of menopausal hormone therapy. Additional factors that can affect to MHT action include: the composition of hormone therapy, administration methods, regimens (cyclic, continuous), duration of treatment, history of endocrine diseases, diabetes mellitus, gynecological history (parity, menarche age, COC use), heredity. The sections present the effect of menopausal transition on the development of depression, mood changes, sleep disturbances and mental disabilities. The explanation of negative effects of menopausal hormone therapy to cognitive health is also described by modern point of view. The ambivalent opinions of researchers, the potential of new reading of the results of earlier studies, confirms the necessity of continuing study of this topic.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10814934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].","authors":"A G Arutyunov, E I Tarlovskaya, G R Galstyan, T I Batluk, R A Bashkinov, G G Arutyunov, Yu N Belenkov, A O Konradi, Yu M Lopatin, A P Rebrov, S N Tereshchenko, A I Chesnikova, H G Hayrapetyan, A P Babin, I G Bakulin, N V Bakulina, L A Balykova, A S Blagonravova, M V Boldina, M I Butomo, A R Vaisberg, A S Galyavich, V V Gomonova, N Yu Grigoryeva, I V Gubareva, I V Demko, A V Evzerikhina, A V Zharkov, A A Zateishchikova, U K Kamilova, Z F Kim, T Yu Kuznetsova, A N Kulikov, N A V Lareva, E V Makarova, S V Malchikova, S V Nedogoda, M M Petrova, I G Pochinka, K V Protasov, D N Protsenko, D Yu Ruzanov, S A Saiganov, A Sh Sarybaev, N M Selezneva, A B Sugraliev, I V Fomin, O V Khlynova, O Yu Chizhova, I I Shaposhnik, D A Schukarev, A K Abdrakhmanova, S A Avetisyan, H G Avoyan, K K Azaryan, G T Aimakhanova, D A Ayypova, A Ch Akunov, M K Alieva, A R Almukhambedova, A V Aparkina, O R Aruslanova, E Yu Ashina, O Na Yu Badina, O Yu Barysheva, A S Batchaeva, A M Bitieva, I U Bikhteev, N A Borodulina, M V Bragin, V A Brazhnik, A M Budu, G A Bykova, K R Vagapova, D D Varlamova, N N Vezikova, E A Verbitskaya, O E Vilkova, E A Vinnikova, V V Vustina, E A Galova, V V Genkel, D B Giller, E I Gorshenina, E V Grigoryeva, E Yu Gubareva, G M Dabylova, A I Demchenko, O Yu Dolgikh, M Y Duishobaev, D S Evdokimov, K E Egorova, A N Ermilova, A E Zheldybaeva, N V Zarechnova, Yu D Zimina, S Yu Ivanova, E Yu Ivanchenko, M V Ilina, M V Kazakovtseva, E V Kazymova, Yu S Kalinina, N A Kamardina, A M Karachenova, I A Karetnikov, N A Karoli, M Kh Karsiev, D S Kaskaeva, K F Kasymova, Zh B Kerimbekova, E S Kim, N V Kiseleva, D A Klimenko, A V Klimova, O V Kovalishena, S V Kozlov, E V Kolmakova, T P Kolchinskaya, M I Kolyadich, O V Kondryakova, M P Konoval, D Yu Konstantinov, E A Konstantinova, V A Kordyukova, E V Koroleva, A Yu Kraposhina, T V Kryukova, A S Kuznetsova, T Yu Kuzmina, K V Kuzmichev, Ch K Kulchoroeva, T V Kuprina, I A M Kuranova, L Va V Kurenkova, N Yu Kurchugina, N A Kushubakova, V I Levankova, A A Ledyaeva, T V Lisun, V E Lisyanskaya, N A Lyubavina, N A Magdeeva, K V Mazalov, V I Mayseenko, A S Makarova, A M Maripov, N V Markov, A A Marusina, E S Melnikov, A I Metlinskaya, N B Moiseenko, F N Muradova, R G Muradyan, Sh N Musaelyan, E S Nekaeva, N M Nikitina, S E Nifontov, E Yu Obolentseva, A A Obukhova, B B Ogurlieva, A A Odegova, Yu V Omarova, N A Omurzakova, Sh O Ospanova, V A Pavlova, E V Pakhomova Pakhomova, L D Petrov, S S Plastinina, D A Platonov, V Aya A Pogrebetskaya, D V Polyakov, D S Polyakov, E Enko V Ponomarenko, L L Popova, A A Potanin, N A Prokofieva, Yu D Rabik, N A Rakov, A N Rakhimov, N A Rozanova, I V Samus, S Serikbolkyzy, Ya A Sidorkina, A A Simonov, V V Skachkova, R D Skvortsova, D S Skuridin, D V Solovieva, I A Solovieva, I M Sukhomlinova, A G Sushilova, D R Tagaeva, Yu V Titoykina, E P Tikhonova, D S Tokmin, A A Tolmacheva, M S Torgunakova, K V Trenogina, N Aya A Trostyanetskaya, D A Trofimov, M A Trubnikova, A A Tulichev, A T Tursunova, N D Ulanova, O V Fatenkov, O V Fedorishina, T S Fil, I Yu Fomina, I S Fominova, I A Frolova, S M Tsvinger, V V Tsoma, M B Cholponbaeva, T Skikh I Chudinovskikh, I V Shavrin, O A Shevchenko, D R Shikhaliev, E A Shishkina, K Yu Shishkov, S Yu Shcherbakov, G V Shcherbakova, E A Yausheva","doi":"10.14341/probl13165","DOIUrl":"10.14341/probl13165","url":null,"abstract":"<p><strong>Background: </strong>There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).</p><p><strong>Aim: </strong>To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.</p><p><strong>Materials and methods: </strong>AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected  the  data  of  hospitalized  patients  and  included  3  visits.  All  subjects  were  divided  into  3  groups:  not  overweight  (n=2139), overweight (n=2931) and obese (n=2666).</p><p><strong>Results: </strong>A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p&lt;0.001), serum C-reactive protein over 100 mg/l (p&lt;0.001), and the need for targeted therapy (p&lt;0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The  patients  with  the  1st  and  2nd  degree  obesity,  undergoing  the  inpatient  treatment,  tended  to  have  a  higher  probability  of  a  mortality  rate.  While  in  case  of  morbid  obesity  patients  this  tendency  is  the  most  significant  (odds  ratio  -  1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p&lt;0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION.  Overweight  and/or  obesity  is  a  significant  risk  factor  for severe  course  of  the  new  coronavirus  infection  and  the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10807155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[In Blessed Memory of Alexander Yurievich Mayorov].","authors":"Article Editorial","doi":"10.14341/probl13227","DOIUrl":"https://doi.org/10.14341/probl13227","url":null,"abstract":"<p><p>On January 1, 2023, at the age of 59, the head of the Diabetes Prediction and Innovation Department of the Diabetes Institute of the State Scientific Center-FGBU «NMITs of Endocrinology» of the Ministry of Health of Russia, the president of the All-Russian Public Organization of the Disabled «Russian Diabetes Association» endocrinologist and diabetologist, doctor of medical sciences, died suddenly Professor Mayorov Alexander Yurievich.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10807154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Molecular tumor board and theranostics].","authors":"P O Rumyantsev","doi":"10.14341/probl13220","DOIUrl":"https://doi.org/10.14341/probl13220","url":null,"abstract":"<p><p>Clinical oncology is currently undergoing a period of unprecedented change. Targeted therapy, and subsequently immunotherapy, has revolutionized the clinical course and outcome of many patients with solid cancer. Clinical oncology is inseparable from molecular oncology, the development of which is interconnected. Molecular tumor research proposes the most precise, effective and lesser toxic antitumor therapy regimen is an extremely urgent clinical task, especially in life-threatening and resistant to other types of treatment cases of cancer. Modern technologies of genomic and postgenomic studies, as well as molecular imaging methods (positron and single photon emission computed tomography, PET and SPECT, respectively) make it possible not only to assess the metabolic and receptor status of tumor foci, but also to select the optimal therapeutic tactics as a key to the lock. In the clinical practice of oncology, there is an increasing need for molecular tumor board (MTB). Published real clinical experience with MTB-recommended treatment regimens based on the molecular geno-transcriptomic profile of the tumor indicates better relapse-free and overall patient survival compared to treatment prescribed by a physician without taking into account the molecular profile of the tumor. More experience is needed and randomized controlled clinical trials are needed for more solid and evidence-based conclusions. However, there is no doubt that the MTB is a powerful tool for the development of precision personalized oncology.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9314508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}