A G Arutyunov, E I Tarlovskaya, G R Galstyan, T I Batluk, R A Bashkinov, G G Arutyunov, Yu N Belenkov, A O Konradi, Yu M Lopatin, A P Rebrov, S N Tereshchenko, A I Chesnikova, H G Hayrapetyan, A P Babin, I G Bakulin, N V Bakulina, L A Balykova, A S Blagonravova, M V Boldina, M I Butomo, A R Vaisberg, A S Galyavich, V V Gomonova, N Yu Grigoryeva, I V Gubareva, I V Demko, A V Evzerikhina, A V Zharkov, A A Zateishchikova, U K Kamilova, Z F Kim, T Yu Kuznetsova, A N Kulikov, N A V Lareva, E V Makarova, S V Malchikova, S V Nedogoda, M M Petrova, I G Pochinka, K V Protasov, D N Protsenko, D Yu Ruzanov, S A Saiganov, A Sh Sarybaev, N M Selezneva, A B Sugraliev, I V Fomin, O V Khlynova, O Yu Chizhova, I I Shaposhnik, D A Schukarev, A K Abdrakhmanova, S A Avetisyan, H G Avoyan, K K Azaryan, G T Aimakhanova, D A Ayypova, A Ch Akunov, M K Alieva, A R Almukhambedova, A V Aparkina, O R Aruslanova, E Yu Ashina, O Na Yu Badina, O Yu Barysheva, A S Batchaeva, A M Bitieva, I U Bikhteev, N A Borodulina, M V Bragin, V A Brazhnik, A M Budu, G A Bykova, K R Vagapova, D D Varlamova, N N Vezikova, E A Verbitskaya, O E Vilkova, E A Vinnikova, V V Vustina, E A Galova, V V Genkel, D B Giller, E I Gorshenina, E V Grigoryeva, E Yu Gubareva, G M Dabylova, A I Demchenko, O Yu Dolgikh, M Y Duishobaev, D S Evdokimov, K E Egorova, A N Ermilova, A E Zheldybaeva, N V Zarechnova, Yu D Zimina, S Yu Ivanova, E Yu Ivanchenko, M V Ilina, M V Kazakovtseva, E V Kazymova, Yu S Kalinina, N A Kamardina, A M Karachenova, I A Karetnikov, N A Karoli, M Kh Karsiev, D S Kaskaeva, K F Kasymova, Zh B Kerimbekova, E S Kim, N V Kiseleva, D A Klimenko, A V Klimova, O V Kovalishena, S V Kozlov, E V Kolmakova, T P Kolchinskaya, M I Kolyadich, O V Kondryakova, M P Konoval, D Yu Konstantinov, E A Konstantinova, V A Kordyukova, E V Koroleva, A Yu Kraposhina, T V Kryukova, A S Kuznetsova, T Yu Kuzmina, K V Kuzmichev, Ch K Kulchoroeva, T V Kuprina, I A M Kuranova, L Va V Kurenkova, N Yu Kurchugina, N A Kushubakova, V I Levankova, A A Ledyaeva, T V Lisun, V E Lisyanskaya, N A Lyubavina, N A Magdeeva, K V Mazalov, V I Mayseenko, A S Makarova, A M Maripov, N V Markov, A A Marusina, E S Melnikov, A I Metlinskaya, N B Moiseenko, F N Muradova, R G Muradyan, Sh N Musaelyan, E S Nekaeva, N M Nikitina, S E Nifontov, E Yu Obolentseva, A A Obukhova, B B Ogurlieva, A A Odegova, Yu V Omarova, N A Omurzakova, Sh O Ospanova, V A Pavlova, E V Pakhomova Pakhomova, L D Petrov, S S Plastinina, D A Platonov, V Aya A Pogrebetskaya, D V Polyakov, D S Polyakov, E Enko V Ponomarenko, L L Popova, A A Potanin, N A Prokofieva, Yu D Rabik, N A Rakov, A N Rakhimov, N A Rozanova, I V Samus, S Serikbolkyzy, Ya A Sidorkina, A A Simonov, V V Skachkova, R D Skvortsova, D S Skuridin, D V Solovieva, I A Solovieva, I M Sukhomlinova, A G Sushilova, D R Tagaeva, Yu V Titoykina, E P Tikhonova, D S Tokmin, A A Tolmacheva, M S Torgunakova, K V Trenogina, N Aya A Trostyanetskaya, D A Trofimov, M A Trubnikova, A A Tulichev, A T Tursunova, N D Ulanova, O V Fatenkov, O V Fedorishina, T S Fil, I Yu Fomina, I S Fominova, I A Frolova, S M Tsvinger, V V Tsoma, M B Cholponbaeva, T Skikh I Chudinovskikh, I V Shavrin, O A Shevchenko, D R Shikhaliev, E A Shishkina, K Yu Shishkov, S Yu Shcherbakov, G V Shcherbakova, E A Yausheva
{"title":"[体重指数对急性 SARS-COV-2 感染过程的影响以及出院后第一年出现的风险。AKTIV 和 AKTIV 2 登记的子分析证据]。","authors":"A G Arutyunov, E I Tarlovskaya, G R Galstyan, T I Batluk, R A Bashkinov, G G Arutyunov, Yu N Belenkov, A O Konradi, Yu M Lopatin, A P Rebrov, S N Tereshchenko, A I Chesnikova, H G Hayrapetyan, A P Babin, I G Bakulin, N V Bakulina, L A Balykova, A S Blagonravova, M V Boldina, M I Butomo, A R Vaisberg, A S Galyavich, V V Gomonova, N Yu Grigoryeva, I V Gubareva, I V Demko, A V Evzerikhina, A V Zharkov, A A Zateishchikova, U K Kamilova, Z F Kim, T Yu Kuznetsova, A N Kulikov, N A V Lareva, E V Makarova, S V Malchikova, S V Nedogoda, M M Petrova, I G Pochinka, K V Protasov, D N Protsenko, D Yu Ruzanov, S A Saiganov, A Sh Sarybaev, N M Selezneva, A B Sugraliev, I V Fomin, O V Khlynova, O Yu Chizhova, I I Shaposhnik, D A Schukarev, A K Abdrakhmanova, S A Avetisyan, H G Avoyan, K K Azaryan, G T Aimakhanova, D A Ayypova, A Ch Akunov, M K Alieva, A R Almukhambedova, A V Aparkina, O R Aruslanova, E Yu Ashina, O Na Yu Badina, O Yu Barysheva, A S Batchaeva, A M Bitieva, I U Bikhteev, N A Borodulina, M V Bragin, V A Brazhnik, A M Budu, G A Bykova, K R Vagapova, D D Varlamova, N N Vezikova, E A Verbitskaya, O E Vilkova, E A Vinnikova, V V Vustina, E A Galova, V V Genkel, D B Giller, E I Gorshenina, E V Grigoryeva, E Yu Gubareva, G M Dabylova, A I Demchenko, O Yu Dolgikh, M Y Duishobaev, D S Evdokimov, K E Egorova, A N Ermilova, A E Zheldybaeva, N V Zarechnova, Yu D Zimina, S Yu Ivanova, E Yu Ivanchenko, M V Ilina, M V Kazakovtseva, E V Kazymova, Yu S Kalinina, N A Kamardina, A M Karachenova, I A Karetnikov, N A Karoli, M Kh Karsiev, D S Kaskaeva, K F Kasymova, Zh B Kerimbekova, E S Kim, N V Kiseleva, D A Klimenko, A V Klimova, O V Kovalishena, S V Kozlov, E V Kolmakova, T P Kolchinskaya, M I Kolyadich, O V Kondryakova, M P Konoval, D Yu Konstantinov, E A Konstantinova, V A Kordyukova, E V Koroleva, A Yu Kraposhina, T V Kryukova, A S Kuznetsova, T Yu Kuzmina, K V Kuzmichev, Ch K Kulchoroeva, T V Kuprina, I A M Kuranova, L Va V Kurenkova, N Yu Kurchugina, N A Kushubakova, V I Levankova, A A Ledyaeva, T V Lisun, V E Lisyanskaya, N A Lyubavina, N A Magdeeva, K V Mazalov, V I Mayseenko, A S Makarova, A M Maripov, N V Markov, A A Marusina, E S Melnikov, A I Metlinskaya, N B Moiseenko, F N Muradova, R G Muradyan, Sh N Musaelyan, E S Nekaeva, N M Nikitina, S E Nifontov, E Yu Obolentseva, A A Obukhova, B B Ogurlieva, A A Odegova, Yu V Omarova, N A Omurzakova, Sh O Ospanova, V A Pavlova, E V Pakhomova Pakhomova, L D Petrov, S S Plastinina, D A Platonov, V Aya A Pogrebetskaya, D V Polyakov, D S Polyakov, E Enko V Ponomarenko, L L Popova, A A Potanin, N A Prokofieva, Yu D Rabik, N A Rakov, A N Rakhimov, N A Rozanova, I V Samus, S Serikbolkyzy, Ya A Sidorkina, A A Simonov, V V Skachkova, R D Skvortsova, D S Skuridin, D V Solovieva, I A Solovieva, I M Sukhomlinova, A G Sushilova, D R Tagaeva, Yu V Titoykina, E P Tikhonova, D S Tokmin, A A Tolmacheva, M S Torgunakova, K V Trenogina, N Aya A Trostyanetskaya, D A Trofimov, M A Trubnikova, A A Tulichev, A T Tursunova, N D Ulanova, O V Fatenkov, O V Fedorishina, T S Fil, I Yu Fomina, I S Fominova, I A Frolova, S M Tsvinger, V V Tsoma, M B Cholponbaeva, T Skikh I Chudinovskikh, I V Shavrin, O A Shevchenko, D R Shikhaliev, E A Shishkina, K Yu Shishkov, S Yu Shcherbakov, G V Shcherbakova, E A Yausheva","doi":"10.14341/probl13165","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).</p><p><strong>Aim: </strong>To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.</p><p><strong>Materials and methods: </strong>AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).</p><p><strong>Results: </strong>A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio - 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939974/pdf/","citationCount":"0","resultStr":"{\"title\":\"[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].\",\"authors\":\"A G Arutyunov, E I Tarlovskaya, G R Galstyan, T I Batluk, R A Bashkinov, G G Arutyunov, Yu N Belenkov, A O Konradi, Yu M Lopatin, A P Rebrov, S N Tereshchenko, A I Chesnikova, H G Hayrapetyan, A P Babin, I G Bakulin, N V Bakulina, L A Balykova, A S Blagonravova, M V Boldina, M I Butomo, A R Vaisberg, A S Galyavich, V V Gomonova, N Yu Grigoryeva, I V Gubareva, I V Demko, A V Evzerikhina, A V Zharkov, A A Zateishchikova, U K Kamilova, Z F Kim, T Yu Kuznetsova, A N Kulikov, N A V Lareva, E V Makarova, S V Malchikova, S V Nedogoda, M M Petrova, I G Pochinka, K V Protasov, D N Protsenko, D Yu Ruzanov, S A Saiganov, A Sh Sarybaev, N M Selezneva, A B Sugraliev, I V Fomin, O V Khlynova, O Yu Chizhova, I I Shaposhnik, D A Schukarev, A K Abdrakhmanova, S A Avetisyan, H G Avoyan, K K Azaryan, G T Aimakhanova, D A Ayypova, A Ch Akunov, M K Alieva, A R Almukhambedova, A V Aparkina, O R Aruslanova, E Yu Ashina, O Na Yu Badina, O Yu Barysheva, A S Batchaeva, A M Bitieva, I U Bikhteev, N A Borodulina, M V Bragin, V A Brazhnik, A M Budu, G A Bykova, K R Vagapova, D D Varlamova, N N Vezikova, E A Verbitskaya, O E Vilkova, E A Vinnikova, V V Vustina, E A Galova, V V Genkel, D B Giller, E I Gorshenina, E V Grigoryeva, E Yu Gubareva, G M Dabylova, A I Demchenko, O Yu Dolgikh, M Y Duishobaev, D S Evdokimov, K E Egorova, A N Ermilova, A E Zheldybaeva, N V Zarechnova, Yu D Zimina, S Yu Ivanova, E Yu Ivanchenko, M V Ilina, M V Kazakovtseva, E V Kazymova, Yu S Kalinina, N A Kamardina, A M Karachenova, I A Karetnikov, N A Karoli, M Kh Karsiev, D S Kaskaeva, K F Kasymova, Zh B Kerimbekova, E S Kim, N V Kiseleva, D A Klimenko, A V Klimova, O V Kovalishena, S V Kozlov, E V Kolmakova, T P Kolchinskaya, M I Kolyadich, O V Kondryakova, M P Konoval, D Yu Konstantinov, E A Konstantinova, V A Kordyukova, E V Koroleva, A Yu Kraposhina, T V Kryukova, A S Kuznetsova, T Yu Kuzmina, K V Kuzmichev, Ch K Kulchoroeva, T V Kuprina, I A M Kuranova, L Va V Kurenkova, N Yu Kurchugina, N A Kushubakova, V I Levankova, A A Ledyaeva, T V Lisun, V E Lisyanskaya, N A Lyubavina, N A Magdeeva, K V Mazalov, V I Mayseenko, A S Makarova, A M Maripov, N V Markov, A A Marusina, E S Melnikov, A I Metlinskaya, N B Moiseenko, F N Muradova, R G Muradyan, Sh N Musaelyan, E S Nekaeva, N M Nikitina, S E Nifontov, E Yu Obolentseva, A A Obukhova, B B Ogurlieva, A A Odegova, Yu V Omarova, N A Omurzakova, Sh O Ospanova, V A Pavlova, E V Pakhomova Pakhomova, L D Petrov, S S Plastinina, D A Platonov, V Aya A Pogrebetskaya, D V Polyakov, D S Polyakov, E Enko V Ponomarenko, L L Popova, A A Potanin, N A Prokofieva, Yu D Rabik, N A Rakov, A N Rakhimov, N A Rozanova, I V Samus, S Serikbolkyzy, Ya A Sidorkina, A A Simonov, V V Skachkova, R D Skvortsova, D S Skuridin, D V Solovieva, I A Solovieva, I M Sukhomlinova, A G Sushilova, D R Tagaeva, Yu V Titoykina, E P Tikhonova, D S Tokmin, A A Tolmacheva, M S Torgunakova, K V Trenogina, N Aya A Trostyanetskaya, D A Trofimov, M A Trubnikova, A A Tulichev, A T Tursunova, N D Ulanova, O V Fatenkov, O V Fedorishina, T S Fil, I Yu Fomina, I S Fominova, I A Frolova, S M Tsvinger, V V Tsoma, M B Cholponbaeva, T Skikh I Chudinovskikh, I V Shavrin, O A Shevchenko, D R Shikhaliev, E A Shishkina, K Yu Shishkov, S Yu Shcherbakov, G V Shcherbakova, E A Yausheva\",\"doi\":\"10.14341/probl13165\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).</p><p><strong>Aim: </strong>To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.</p><p><strong>Materials and methods: </strong>AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).</p><p><strong>Results: </strong>A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio - 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.</p>\",\"PeriodicalId\":20433,\"journal\":{\"name\":\"Problemy endokrinologii\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939974/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Problemy endokrinologii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14341/probl13165\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problemy endokrinologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14341/probl13165","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].
Background: There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).
Aim: To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.
Materials and methods: AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).
Results: A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio - 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
期刊介绍：
Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
![[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].](https://img.booksci.cn/booksciimg/2023-1/2023102778236837584416773346576.jpg)
![[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].](https://img.booksci.cn/booksciimg/2023-1/202310277827283855666909774936.jpg)
![[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].](https://img.booksci.cn/booksciimg/2023-1/2023102778290267048045129595968.jpg)
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