绝经过渡期的认知和心理情绪变化:医学矫正的可能性。

Q4 Medicine
S A Gasparyan, A M Chotchaeva, S M Karpov
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引用次数: 0

摘要

人口中老年群体的增加决定了年龄相关疾病的研究和这一领域新调查的出现。在女性体内,进入更年期是生殖功能“衰老”的开始,与性激素水平下降有关。揭示了雌激素、孕激素、雄激素比值变化与女性认知功能的直接联系。性激素受体的解剖定位、激素与这些受体的相互作用机制决定了类固醇在中枢神经系统中发挥生物学作用的途径。"健康的神经细胞"和"雌性激素不足"的现代理论解释了诸如无神经疾病史和雌性激素不足持续时间等附加标准对绝经期激素治疗结果的作用。可影响MHT作用的其他因素包括:激素治疗的组成、给药方法、方案(循环、连续)、治疗持续时间、内分泌疾病史、糖尿病、妇科史(胎次、初潮年龄、COC使用)、遗传。这些章节介绍了更年期过渡对抑郁症、情绪变化、睡眠障碍和精神残疾的发展的影响。更年期激素治疗对认知健康的负面影响也从现代观点进行了解释。研究人员的矛盾意见,对早期研究结果的新阅读的潜力,证实了继续研究这一主题的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction].

The increasing of older age group in the population determines studying of age related diseases and emergence of new investigations in this area. In Female body, entering the menopausal transition is the start of «aging» of reproductive function and linked with decreasing of sex hormons levels. A direct connection between changes of estrogen, progesterone, androgen ratios and cognitive function of women was revealed. The anatomical localization of sex hormone receptors, the mechanisms of interaction of hormones with these receptors determine the ways of implementing biological effects of steroids on the CNS. Modern theories of «healthy nerve cells» and «eu-estrogenemia» explains the role of additional criteria, such as the absence of neurological diseases history and the duration of hypoestrogenia, to the outcome of menopausal hormone therapy. Additional factors that can affect to MHT action include: the composition of hormone therapy, administration methods, regimens (cyclic, continuous), duration of treatment, history of endocrine diseases, diabetes mellitus, gynecological history (parity, menarche age, COC use), heredity. The sections present the effect of menopausal transition on the development of depression, mood changes, sleep disturbances and mental disabilities. The explanation of negative effects of menopausal hormone therapy to cognitive health is also described by modern point of view. The ambivalent opinions of researchers, the potential of new reading of the results of earlier studies, confirms the necessity of continuing study of this topic.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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