Postgraduate Medical Journal最新文献

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Revisiting Ronald Ross: inspiration for pioneering research in resource-limited settings. 重访罗纳德·罗斯:资源有限环境下开创性研究的启示。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2025-01-09 DOI: 10.1093/postmj/qgae199
Rupak Chatterjee, Atanu Chandra, Sugata Dasgupta
{"title":"Revisiting Ronald Ross: inspiration for pioneering research in resource-limited settings.","authors":"Rupak Chatterjee, Atanu Chandra, Sugata Dasgupta","doi":"10.1093/postmj/qgae199","DOIUrl":"https://doi.org/10.1093/postmj/qgae199","url":null,"abstract":"","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When trimethoprim-sulfamethoxazole goes rogue. 当甲氧苄啶-磺胺甲恶唑失控时。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2025-01-07 DOI: 10.1093/postmj/qgae192
Tina H Dao, Christopher D Jackson
{"title":"When trimethoprim-sulfamethoxazole goes rogue.","authors":"Tina H Dao, Christopher D Jackson","doi":"10.1093/postmj/qgae192","DOIUrl":"https://doi.org/10.1093/postmj/qgae192","url":null,"abstract":"","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between diabetes mellitus and fetal and maternal outcomes during and after pregnancy-a nationwide study. 妊娠期间和妊娠后糖尿病与胎儿和母体结局的关系——一项全国性研究。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2025-01-06 DOI: 10.1093/postmj/qgae191
Binita Neupane, Sunita Karki, Monica Sharma, Umer Farooq
{"title":"Association between diabetes mellitus and fetal and maternal outcomes during and after pregnancy-a nationwide study.","authors":"Binita Neupane, Sunita Karki, Monica Sharma, Umer Farooq","doi":"10.1093/postmj/qgae191","DOIUrl":"https://doi.org/10.1093/postmj/qgae191","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes Mellitus (DM) affects both the mother and fetus during and after pregnancy. Multiple studies have shown the prognostic impact of DM on maternal and fetal outcomes, but studies at the national level are limited. Therefore, we aimed to conduct this nationwide study.</p><p><strong>Materials and methods: </strong>This retrospective study used a Nationwide Inpatient Sample 2020 (NIS) using International Classification of Diseases (ICD-10) codes for adult pregnant patients. STATA version MP14.2 was used mainly for analysis. We used Fischer's exact test to compare proportions, the student's t-test to compare continuous variables, and multivariate regression analysis to calculate the adjusted odds ratio.</p><p><strong>Results: </strong>The total number of pregnant patients included in the study was 3 436 671; 36 350 (1.05%) had DM. Patients with DM had longer hospital lengths of stay than non-diabetic patients (3.93 days vs. 2.5 days, P < .01). Other significant outcomes were higher cost of hospital stay ($37 079 vs. $23 371, P < .01), preeclampsia (7.17% vs. 2.02%, P < .01), intrauterine fetal death (0.63% vs. 0.13%, P < .01), stillbirth (2.89% vs. 0.75%, P < .01), gestational hypertension (7.07% vs. 3.07%, P < .01) and preterm labor (5.8% vs. 1.94%, P < .01). There were no differences in the two groups regarding pre-existing hypertension, abortion, large for gestational age, eclampsia, placenta previa, abruptio placenta, postpartum anemia, prolonged labor, intrapartum, and postpartum hemorrhage. We conducted a trend analysis from 2016 to 2020 for mortality, length of stay, total charges, and significant maternal and fetal outcomes.</p><p><strong>Conclusion: </strong>DM is associated with greater maternal and fetal adverse outcomes, resource utilization, and length of stay.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abortion in evolution, caesarean scar pregnancy, and cervical ectopic: discerning the triplets on ultrasound. 进化流产、瘢痕妊娠、宫颈异位:超声鉴别三胞胎。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-27 DOI: 10.1093/postmj/qgae189
Akaninyene Eseme Ubom, Engelbert Hanzal, Petra Kohlberger
{"title":"Abortion in evolution, caesarean scar pregnancy, and cervical ectopic: discerning the triplets on ultrasound.","authors":"Akaninyene Eseme Ubom, Engelbert Hanzal, Petra Kohlberger","doi":"10.1093/postmj/qgae189","DOIUrl":"https://doi.org/10.1093/postmj/qgae189","url":null,"abstract":"<p><strong>Background: </strong>On the second day of my clinical observership in the Obgyn Department of the Vienna University Hospital, I saw a suspected case of caesarean scar pregnancy on follow-up, with one of my very senior professors, in the gynaecology outpatient clinic.</p><p><strong>Methods: </strong>The 29-year-old multigravida with a previous caesarean section had earlier presented to the emergency room with vaginal bleeding at 7 weeks of gestation.</p><p><strong>Results: </strong>Ultrasound scan revealed a non-viable low-lying gestational sac located near the caesarean section scar, with a myometrial thickness of 0.96 cm. There was minimal vascular flow during the Doppler interrogation. Her quantitative serum beta-human chorionic gonadotropin was 687 IU/l at presentation. This had dropped to 344 IU/l after 48 h, with a further drop to 39 IU/l after a week. Repeat ultrasound scan 1 week after revealed an empty uterus with no visible gestational sac, and vaginal bleeding had resolved. My professor made a final diagnosis of a spontaneous complete abortion.</p><p><strong>Conclusions: </strong>On reflection, this experience further reinforced the diagnostic dilemma that many clinical conditions can present, the need for a high index of suspicion in diagnosing and differentiating clinical conditions that present similar features, as well as the need for younger clinicians to leverage the better knowledge and experience of more senior colleagues to unknot knotty clinical dilemmas.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating UK internal medicine training applications: 10 essential tips. 浏览英国内科培训申请:10个基本提示。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-27 DOI: 10.1093/postmj/qgae190
Sara Khalid, Thomas Heather, Victoria Palin, Oliver I Brown, Michael Drozd
{"title":"Navigating UK internal medicine training applications: 10 essential tips.","authors":"Sara Khalid, Thomas Heather, Victoria Palin, Oliver I Brown, Michael Drozd","doi":"10.1093/postmj/qgae190","DOIUrl":"https://doi.org/10.1093/postmj/qgae190","url":null,"abstract":"<p><p>Internal medicine training applications in the UK have become increasingly competitive. This article provides ten tips for optimizing internal medicine training applications covering portfolio development, teaching experience, project selection, and interview preparation. We outline strategies for maximizing application scores through efficient resource allocation, effective project selection, and structured interview preparation. These tips are designed to help candidates navigate the competitive selection process while developing skills valuable for their future medical careers.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new strategy for drug delivery systems in oral diseases using stem cell-derived extracellular vesicles: review and new perspectives. 利用干细胞来源的细胞外囊泡作为口腔疾病药物输送系统的新策略:综述和新观点。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-26 DOI: 10.1093/postmj/qgae187
Ruyang Xia, Maojiao Li, Bo Huang
{"title":"A new strategy for drug delivery systems in oral diseases using stem cell-derived extracellular vesicles: review and new perspectives.","authors":"Ruyang Xia, Maojiao Li, Bo Huang","doi":"10.1093/postmj/qgae187","DOIUrl":"https://doi.org/10.1093/postmj/qgae187","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) are membrane vesicles derived from cells and serve as an endogenous mechanism for intercellular communication. Since the discovery of their capacity to effectively transfer biological information, their potential as drug delivery vehicles has garnered significant scientific interest. Particularly, EVs derived from mesenchymal cells (MSC-EVs) have emerged as a highly promising method for drug delivery. They can transport bioactive molecules, such as nucleic acids, lipids, and proteins, and possess the ability to modulate immune responses, transmit information, and target specific cells. EVs offer several advantages over conventional drug delivery systems, including their capacity to traverse natural barriers, inherent cell targeting capabilities, and stability in circulation. Compared to their parent cells, EVs exhibit low immunogenicity, ease of storage and transport, and a reduced risk of tumorigenesis. The diagnosis and treatment of oral diseases often involve invasive measures, and MSC-EVs have demonstrated initial efficacy in oral disease treatment. This review explores the application of MSC-EVs in maxillofacial tissue regeneration, periodontitis, temporomandibular joint osteoarthritis, Sjögren's Syndrome, oral cancer, and other oral diseases. Additionally, it outlines potential future directions for the development of MSC-EVs. This review aims to provide a comprehensive understanding of MSC-EVs in oral disease treatment and to stimulate interest in their applications for targeted drug delivery.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum uric acid and prediabetes progression and regression: a retrospective cohort study. 血清尿酸与前驱糖尿病进展与回归:一项回顾性队列研究。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-26 DOI: 10.1093/postmj/qgae183
Yijia He, Miaomin Ye, Yin Xia, Ziyi Zhong, Qian Li
{"title":"Serum uric acid and prediabetes progression and regression: a retrospective cohort study.","authors":"Yijia He, Miaomin Ye, Yin Xia, Ziyi Zhong, Qian Li","doi":"10.1093/postmj/qgae183","DOIUrl":"https://doi.org/10.1093/postmj/qgae183","url":null,"abstract":"<p><strong>Background: </strong>The impact of serum uric acid (SUA) levels on metabolic disorders, particularly concerning the development or reversal of prediabetes, is not well understood. While high uric acid is recognized for its association with metabolic disturbances, its specific influence on prediabetes progression and regression has been insufficiently explored. This study investigates how SUA levels correlate with the natural course of prediabetes, shedding light on its management.</p><p><strong>Methods: </strong>A cohort of 3659 individuals diagnosed with prediabetes at Nanjing First Hospital was tracked over three years. Follow-up assessments included fasting plasma glucose and hemoglobin A1c (HbA1c) measurements. Serum uric acid was measured initially and categorized into quartiles (Q1 through Q4). To assess the impact of uric acid levels on shifting prediabetes status, methods such as restricted cubic spline, segmented regression, stratified analysis, and receiver operating characteristic curves were utilized in a multinomial logistic regression framework.</p><p><strong>Results: </strong>At baseline, all 3659 participants had prediabetes; by the three-year mark, 2626 remained in this category, 523 reverted to normal fasting glucose (NFG), and 510 advanced to diabetes. After adjustment for potential confounders, a positive correlation was found between higher SUA levels and progression to diabetes (Odds ratio [OR] 1.182, 95% confidence interval [CI]: 1.095-1.276), with no significant link to reversion to NFG (OR: 0.987, 95% CI: 0.909-1.073).</p><p><strong>Conclusion: </strong>Elevated SUA levels are linked with a higher likelihood of progressing from prediabetes to diabetes but do not significantly forecast a regression to NFG.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of traumatic brain injury on visual processing: a neuro-ophthalmological perspective. 外伤性脑损伤对视觉加工的影响:神经-眼科学视角。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-26 DOI: 10.1093/postmj/qgae188
Hajar Nasir Tukur, Olivier Uwishema, Dalal Sheikhah, Hatice Akbay, Tarek Emir Chehab, Jack Wellington
{"title":"The impact of traumatic brain injury on visual processing: a neuro-ophthalmological perspective.","authors":"Hajar Nasir Tukur, Olivier Uwishema, Dalal Sheikhah, Hatice Akbay, Tarek Emir Chehab, Jack Wellington","doi":"10.1093/postmj/qgae188","DOIUrl":"https://doi.org/10.1093/postmj/qgae188","url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic brain injury (TBI) is a critical global health issue characterized by perturbance in cerebral function attributed to mechanical force. TBI often precipitates significant visual impairment that negatively impacts the patients' quality of life. This review examines the effects of TBI on visual function from a neuro-ophthalmological perspective, focusing on the assessment, diagnostics, and management of associated sequelae.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar to garner and collate relevant data.</p><p><strong>Results: </strong>TBI may result in visual field defects, ocular motor dysfunction, insufficiency of accommodation, and photosensitivity. Early detection remains a profound challenge, partly due to a dearth of standardized protocols for evaluating visual impairment. Diagnostic methodologies include visual field testing, ocular motility assessments, and fundus photography, while rehabilitation approaches encompass vision therapy and low-vision rehabilitation.</p><p><strong>Conclusion: </strong>Establishing hospital-based multidisciplinary teams is essential for effectively addressing TBI-related visual impairment. Future research should prioritize evidence-based treatment protocols and explore diverse vision rehabilitation strategies through large-scale studies.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PhenoAge and PhenoAgeAccel in the context of dyslipidemia: association with stroke and potential as a new predictor in the US general population. 血脂异常背景下的 PhenoAge 和 PhenoAgeAccel:与中风的关系以及作为美国普通人群新预测指标的潜力。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-23 DOI: 10.1093/postmj/qgae093
Weijie Zhao, Ziyue Wang, Chuanhao Mi, Yu Wang, Xinxin Shao, Xianghua Qi, Xinru Kong
{"title":"PhenoAge and PhenoAgeAccel in the context of dyslipidemia: association with stroke and potential as a new predictor in the US general population.","authors":"Weijie Zhao, Ziyue Wang, Chuanhao Mi, Yu Wang, Xinxin Shao, Xianghua Qi, Xinru Kong","doi":"10.1093/postmj/qgae093","DOIUrl":"10.1093/postmj/qgae093","url":null,"abstract":"<p><strong>Background: </strong>The challenges posed by an aging society are increasingly recognized, particularly regarding the potential impacts of high-fat diets and the trend toward younger ages of disease onset. The purpose of this study was to clarify the relationships between the prevalence of stroke in the general US population and PhenoAge (PA) and PhenoAgeAccel (PAA).</p><p><strong>Methods: </strong>Key methods included a correlation heatmap to explore linear relationships between some of the variables and weighted multivariable logistic regression to assess associations between PA, PAA, and stroke. Restricted cubic spline (RCS) analysis was used to investigate nonlinear relationships and dose-response effects. The ability of the PAA to predict stroke risk was assessed by a nomogram model and a receiver operating characteristic curve.</p><p><strong>Results: </strong>After adjusting for confounding variables, both continuous and categorical PA and PAA were significantly associated with stroke prevalence. RCS analysis revealed a significant nonlinear relationship between PA and stroke prevalence. Further subgroup RCS analysis indicated that maintaining PA below 31.6 could provide greater benefits across all races and genders, specifically for individuals aged 40-80 years and those who are overweight or obese.</p><p><strong>Conclusion: </strong>This study highlights the importance of stroke prevention in overweight and obese populations. Monitoring intermediary factors such as high-density lipoprotein cholesterol and waist circumference may reduce stroke risk. Additionally, PA and PAA may serve as novel markers for stroke, offering new directions for health management in an aging society.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":"17-28"},"PeriodicalIF":3.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex. 线状和网状结痂角化性丘疹脓疱疹:PRIDE(表皮生长因子受体抑制剂引起的丘疹脓疱和/或脓疱疮、毛发生长调节异常、瘙痒和干燥)综合征的罕见表现。
IF 3.6 4区 医学
Postgraduate Medical Journal Pub Date : 2024-12-23 DOI: 10.1093/postmj/qgae104
Shreya K Gowda, Deepak Kumar Sahu, Pavithra Ayyanar, Biswanath Behera
{"title":"A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex.","authors":"Shreya K Gowda, Deepak Kumar Sahu, Pavithra Ayyanar, Biswanath Behera","doi":"10.1093/postmj/qgae104","DOIUrl":"10.1093/postmj/qgae104","url":null,"abstract":"","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":"66-67"},"PeriodicalIF":3.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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