Porphyrin Science by Women最新文献_第3页

Propentdyopents: Brief history of a family of dipyrrolic pigments 前驱色素:一类二吡啶类色素的简史

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619300210

E. Tomat

{"title":"Propentdyopents: Brief history of a family of dipyrrolic pigments","authors":"E. Tomat","doi":"10.1142/s1088424619300210","DOIUrl":"https://doi.org/10.1142/s1088424619300210","url":null,"abstract":"Propentdyopents are naturally occurring dipyrroles deriving from the metabolism of heme and characterized by a dipyrrin-1,9-dione motif. The unusual name propentdyopent is due to the first colorimetric method (the Stokvis reaction) for the detection of these compounds, which were initially isolated from urine samples. Upon reduction in alkaline solutions, they produced red species that were termed pentdyopents to describe with Greek numerals their absorption maximum (525 nm) in the visible range. The precursors to the red pentdyopents were thus indicated as propentdyopents.Over the course of several decades, these dipyrrolic compounds have appeared in several studies of human physiology, typically associated to conditions of abnormal heme metabolism and/or oxidative stress. Concurrently, synthetic investigations have confirmed their chemical structure, reactivity, and ability to coordinate metals as bidentate monoanionic ligands. Notably, the planar dipyrrindione platform can undergo reversible one-electron redox processes and thereby act as an electron reservoir in metal complexes. In combination with the documented ability of the carbonyl groups to act as hydrogen-bonding acceptors, the coordination chemistry of propentdyopents could lead to new applications for this old class of pigments. Furthermore, the observation of these pigments in several clinical contexts could potentially delineate a role of propentdyopents as diagnostic biomarkers. This mini-review summarizes both the chemistry and biology of propentdyopents while highlighting the ample space for new discoveries.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78394010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hexylsulfanyl-substituted CoPc and GO-CoPc on Ni foam as electroactive material for supercapacitors 已基磺胺基取代CoPc和GO-CoPc在泡沫镍上作为超级电容器的电活性材料

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501955

N. Taşaltın, Cihat Tasaltin, H. Aydın, U. Şahintürk, A. Gürek

引用次数: 0

Mitochondria-targeted porphyrin-based photosensitizers containing triphenylphosphonium cations showing efficient in vitro photodynamic therapy effects 含三苯基磷阳离子的线粒体靶向卟啉光敏剂显示出有效的体外光动力治疗效果

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501682

Xing Guo, Hao Wu, W. Miao, Yangchun Wu, Erhong Hao, Lijuan Jiao

引用次数: 3

Application of photodynamic therapy drugs for management of glioma 光动力治疗药物在胶质瘤治疗中的应用

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619300192

S. Dubey, Sai K. Pradyuth, R. Saha, Gautam Singhvi, A. Alexander, Mukta Agrawal, B. Shapiro, A. Puri

{"title":"Application of photodynamic therapy drugs for management of glioma","authors":"S. Dubey, Sai K. Pradyuth, R. Saha, Gautam Singhvi, A. Alexander, Mukta Agrawal, B. Shapiro, A. Puri","doi":"10.1142/s1088424619300192","DOIUrl":"https://doi.org/10.1142/s1088424619300192","url":null,"abstract":"Human gliomas are one of the most prevalent and challenging-to-treat adult brain tumors, and thus result in high morbidity and mortality rates worldwide. Current research and treatments of gliomas include surgery associated with conventional chemotherapy, use of biologicals, radiotherapy, and medical device applications. The selected treatment options are often guided by the category and aggressiveness of this deadly disease and the patient’s conditions. However, the effectiveness of these approaches is still limited due to poor drug efficacy (including delivery to desired sites), undesirable side effects, and high costs associated with therapies. In addition, the degree of leakiness of the blood–brain barrier (BBB) that regulates trafficking of molecules in and out of the brain also modulates accumulation of adequate drug levels to tumor sites. Active research is being pursued to overcome these limitations to obtain a superior therapeutic index and enhanced patient survival. One area of development in this direction focuses on the localized application of photodynamic therapy (PDT) drugs to cure brain cancers. PDT molecules potentially utilize multiple pathways based on their ability to generate reactive oxygen species (ROS) upon photoactivation by a suitable light source. In this communication, we have attempted to provide a brief overview of PDT and cancer, photoactivation pathways, mechanism of tumor destruction, effect of PDT on tumor cell viability, immune activation, various research attempted by applying PDT in combination with novel strategies to treat glioma, role of BBB and clinical status of PDT therapy for glioma treatment.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84921129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Selective guest recognition by a metallo-organic phthalocyanine-based host 金属有机酞菁基宿主的选择性客体识别

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501712

E. Fazio, M. J. Vicente-Arana, M. Alonso, T. Torres, G. Torre

引用次数: 0

Enhancement of PDT-cytotoxicity via ROS induced by indomethacin in metastatic breast cancer 吲哚美辛诱导的ROS增强转移性乳腺癌pdt细胞毒性

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501542

A. Terasaki, Hiromi Kurokawa, H. Indo, H. Bando, H. Hara, H. Majima, H. Matsui, H. Ito

{"title":"Enhancement of PDT-cytotoxicity via ROS induced by indomethacin in metastatic breast cancer","authors":"A. Terasaki, Hiromi Kurokawa, H. Indo, H. Bando, H. Hara, H. Majima, H. Matsui, H. Ito","doi":"10.1142/s1088424619501542","DOIUrl":"https://doi.org/10.1142/s1088424619501542","url":null,"abstract":"Breast cancer is one of the most common types of cancers prevalent in women. Several types of breast cancers can easily metastasize to bone and cause disease complications such as hypercalcemia and pathologic fracture, thus compromising the quality of life of people affected by it. Bisphosphonate drugs are often used for the treatment of bone metastasis to suppress osteoclastic bone resorption. However, bisphosphonate has adverse effects on the gastrointestinal tract and kidneys and also induces osteonecrosis of the jaw. Photodynamic therapy (PDT) is an alternative cancer treatment approach with minimal invasiveness. It is a combination treatment that uses photosensitizers, which accumulate in tumor cells, followed by laser irradiation. We previously reported that the cellular incorporation of 5-aminolevulinic acid (5-ALA), which was a precursor of protoporphyrin IX (PpIX), was regulated by reactive oxygen species derived from mitochondria (mitROS). In this study, we investigated the incorporation of 5-ALA, accumulation of PpIX, and subsequent effects on cell viability after laser irradiation of two different breast cancer cell lines with different metastaticites. The highly metastatic breast cancer cell line 4T1E/M3 showed a significant increase in ROS production after treatment with indomethacin (IND). In addition, IND treatment enhanced the cellular uptake of 5-ALA via PEPT1 upregulation in 4T1E/M3, but not in the non-metastatic cell line. Overall, metastatic breast cancer is likely to be sensitive to ROS and activate signaling pathways associated with 5-ALA transportation, suggesting that ALA-PDT could be an effective treatment with low invasiveness for metastatic breast cancer.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83538711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Synthesis, characterization and modeling of self-assembled porphyrin nanorods 自组装卟啉纳米棒的合成、表征和建模

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501451

D. Laurencin, P. Yot, C. Gervais, Y. Guari, S. Clément, E. Elkaim, M. Paillet, D. Cot, Sébastien Richeter

引用次数: 2

Heterocomponent ternary supramolecular complexes of porphyrins: A review 卟啉异组分三元超分子配合物的研究进展

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s108842461930026x

Elena Prigorchenko, Lukas Ustrnul, V. Borovkov, R. Aav

引用次数: 6

Peripherally substituted soluble nickel phthalocyanines: Synthesis, characterization, aggregation behavior and antioxidant properties 外周取代可溶性酞菁镍:合成、表征、聚集行为和抗氧化性能

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501645

S. Yazici, S. Kahraman, S. Yıldız, M. D. Yilmaz

引用次数: 1

Increasing the complexity of oxoporphyrinogen colorimetric sensing chromophores: N-alkylation and β-substitution 增加氧卟啉原比色传感发色团的复杂性:n -烷基化和β-取代

Porphyrin Science by Women Pub Date : 2019-12-01 DOI: 10.1142/s1088424619501463

M. Chahal, N. Velychkivska, Whitney A Webre, J. Labuta, Shinsuke Ishihara, K. Ariga, F. D’Souza, Jonathan P. Hill

{"title":"Increasing the complexity of oxoporphyrinogen colorimetric sensing chromophores: N-alkylation and β-substitution","authors":"M. Chahal, N. Velychkivska, Whitney A Webre, J. Labuta, Shinsuke Ishihara, K. Ariga, F. D’Souza, Jonathan P. Hill","doi":"10.1142/s1088424619501463","DOIUrl":"https://doi.org/10.1142/s1088424619501463","url":null,"abstract":"Meso-5,10,15,20-tetrakis-3,5-di-tert-butyl-4-oxocyclohexadienylideneporphyrinogen, OxP, is a versatile, highly colored chromophore derived from meso-5,10,15,20-tetrakis(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin. It exhibits a wide range of chromogenic responses to solvents (solvatochromism), anions and acidic media (halochromism) making it potentially useful as an analytical reagent. The chromogenic responses of OxP can be modulated by varying its chemical structure, and this is reviewed here based on the introduction of substituents at central nitrogen atoms or pyrrolic [Formula: see text]-positions. OxP and its N-alkylated derivates Bn2OxP and Bn4OxP have been used to estimate acidity in non-polar solvents. Bn2OxP can also be used to determine enantiomeric excesses of chiral substances. N-alkylation has also been used to introduce higher functional groups such as porphyrins to prepare self-assembling systems. [Formula: see text]-Substitution has been used to introduce selectivity of anion interactions including towards basic anions (fluoride, cyanide) and polyoxoanions (nitrate, perchlorate, etc.). These aspects make OxP a highly adaptable tetrapyrrole molecule for sensing and other applications.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77360221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2