Journal of the International AIDS Society最新文献

{"title":"Assessing the HIV care continuum among transgender women during 11 years of follow-up: results from the Netherlands’ ATHENA observational cohort","authors":"Vita W. Jongen,&nbsp;Ceranza Daans,&nbsp;Ard van Sighem,&nbsp;Maarten Schim van der Loeff,&nbsp;Kris Hage,&nbsp;Camiel Welling,&nbsp;Alex von Vaupel-Klein,&nbsp;Martin den Heijer,&nbsp;Edgar J. G. Peters,&nbsp;Marc van der Valk,&nbsp;Peter Reiss,&nbsp;Maria Prins,&nbsp;Elske Hoornenborg,&nbsp;the ATHENA observational HIV cohort","doi":"10.1002/jia2.26317","DOIUrl":"10.1002/jia2.26317","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Transgender women are at increased risk of acquiring HIV. Earlier studies reported lower retention in HIV care, antiretroviral therapy uptake, adherence and viral suppression. We assessed the stages of the HIV care continuum of transgender women in the Netherlands over an 11-year period. In addition, we assessed new HIV diagnoses and late presentation, as well as disengagement from care, between 2011 and 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the Dutch national ATHENA cohort, we separately assessed viral suppression, as well as time to achieving viral suppression, among transgender women for each year between 2011 and 2021. We also assessed trends in new HIV diagnoses and late presentation (CD4 count of &lt;350 cells/µl and/or AIDS at diagnosis), and disengagement from care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2011 and 2021, a total of 260 transgender women attended at least one HIV clinical visit. Across all years, &lt;90% of transgender women were virally suppressed (207/239 [87%] in 2021). The number of new HIV diagnoses fluctuated for transgender women (<i>p</i>_trend = 0.053) and late presentation was common (ranging between 10% and 67% of new HIV diagnoses). Of the 260 transgender women, 26 (10%) disengaged from care between 2011 and 2021 (incidence rate = 1.10 per 100 person-years, 95% confidence interval = 0.75−1.61).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Between 2011 and 2021, less than 90% of transgender women linked to HIV care were virally suppressed. Late presentation at the time of diagnosis and disengagement from care were common. Efforts are needed to identify barriers to early HIV diagnosis and to optimize the different steps across the care continuum for transgender women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability, usability, and willingness to pay for HIV self-test kits distributed through community-based, PLHIV network-led and private practitioners models in India: Results from the STAR III Initiative","authors":"Chinmay Laxmeshwar,&nbsp;Asha Hegde,&nbsp;Alpana Dange,&nbsp;Kannan Mariyappan,&nbsp;Manish Soosai,&nbsp;Sandeep Mane,&nbsp;Murugesan Sivasubramanian,&nbsp;Mahesh Doddamane,&nbsp;Madhuri Mukherjee,&nbsp;G. S. Shreenivas,&nbsp;Manoj Pardesi,&nbsp;Vinod Jambhale,&nbsp;Venkateswara Rao Pakkela,&nbsp;Vijayaraman Arumugam,&nbsp;Vedant Rungta,&nbsp;Yashika Bansal,&nbsp;Jatin Chaudary,&nbsp;Vijay Yeldandi,&nbsp;Mahalingam Periasamy,&nbsp;Chengappa Uthappa,&nbsp;Sudhir Chawla,&nbsp;Sunita Upadhyaya,&nbsp;Melissa Nyendak,&nbsp;Venkatesan Chakrapani,&nbsp;Sheela Godbole,&nbsp;Vinita Verma,&nbsp;Bhawani Singh Kushwaha,&nbsp;Chinmoyee Das,&nbsp;Shobini Rajan,&nbsp;Anoop Kumar Puri,&nbsp;J. V. R. Prasada Rao,&nbsp;Tarun Bhatnagar,&nbsp;D. C. S. Reddy,&nbsp;Kimberly Green","doi":"10.1002/jia2.26348","DOIUrl":"10.1002/jia2.26348","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>HIV self-testing (HIVST) has been shown to increase the uptake of HIV testing and help achieve the UNAIDS 95-95-95 targets. This study assessed the acceptability, usability (ease of use and result interpretation) and the willingness to pay for HIVST kits distributed through three distribution models, namely the community-based, PLHIV network-led and private practitioners models, in India.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was implemented across 14 states in India between September 2021 and June 2022. All participants could choose between blood-based or oral-fluid-based test kits. Participants were shown a test-kit usage demonstration video, and pre- and post-test counselling was provided for all. Participants were followed-up after testing, and if reported reactive, were further supported for linkage to confirmatory testing and antiretroviral therapy (ART) initiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 90,605 participants found eligible, 88,080 (97%) accepted an HIVST kit. Among the 87,976 who reported using an HIVST kit, 45,207 (51%) preferred a blood-based kit, and 42,120 (48%) reported testing for the first time. For future testing, 77,064 (88%) reported preferring HIVST over other HIV testing methods. Among those who used the kit, 83,308 (95%) found the kit easy to use, and 83,237 (95%) reported that the test results were easy to interpret. Among those who preferred HIVST for future use, 52,136 (69%) were willing to pay for the kit, with 35,854 (69%) of those willing to pay less than US$ 1.20. Only one instance of social harm was reported, with a participant reporting suicidal tendencies due to discord with their partner.</p>\u0000 \u0000 <p>Out of 328 participants (0.4%) who tested reactive with HIVST, 291 (89%) were linked to confirmatory testing; of these, 254 were confirmed HIV positive, and 216 (85%) successfully initiated ART.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, we report that nearly all participants were willing to accept HIVST, found the test kits easy to use and interpret, and about two-thirds were willing to pay for HIVST. Given the high levels of acceptance and the ability to reach a large proportion of first-time testers, HIVST in India could contribute to achieving the UNAIDS first 95 and ending the HIV epidemic.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eliminating perinatal transmission of hepatitis B virus: it is time for action","authors":"Rania A. Tohme,&nbsp;Su Wang,&nbsp;Benjamin Cowie,&nbsp;Sandra Dudareva,&nbsp;Carolyn Wester","doi":"10.1002/jia2.26337","DOIUrl":"10.1002/jia2.26337","url":null,"abstract":"&lt;p&gt;Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and liver cancer causing 1.1 million deaths globally in 2022 [&lt;span&gt;1&lt;/span&gt;]. In 2022, an estimated 254 million persons were living with chronic HBV infection. Globally, HBV is mainly acquired through mother-to-child transmission (MTCT) at birth (vertical or perinatal transmission), and during early childhood (horizontal transmission). Up to 90% of newborns who acquire HBV through MTCT will develop chronic hepatitis B compared to 30%–50% of children infected between the ages of 1–5 years, while &lt;5% of those infected in adulthood develop chronic hepatitis B [&lt;span&gt;2&lt;/span&gt;]. The hepatitis B vaccine is &gt;90% effective at preventing infections and is given as a series starting with a dose of monovalent vaccine within 24 hours of birth (hepatitis B-birth dose [hepB-BD]) (70%–95% effective in preventing perinatal HBV infection), followed by two or three additional doses during infancy [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Elimination targets for MTCT of HBV include achieving ≤0.1% prevalence of hepatitis B surface antigen (HBsAg) in children ≤5 years of age, and ≥90% coverage with timely HepB-BD and three doses of hepatitis B vaccine (HepB3) [&lt;span&gt;3&lt;/span&gt;]. In addition, countries that provide selective HepB-BD (e.g. only to infants with known exposure) need to screen ≥90% of pregnant women for hepatitis B and treat ≥90% of those eligible [&lt;span&gt;3&lt;/span&gt;]. Prevention of HBV infection in infancy and childhood through vaccination and treatment of pregnant women would be the most impactful interventions to reduce the prevalence of chronic hepatitis B in the population.&lt;/p&gt;&lt;p&gt;An analysis of the impact of childhood vaccination in 98 low- and middle-income countries showed that hepatitis B vaccination will have prevented 38 million (range: 25–52 million) deaths over the lifetime of those born from 2000 to 2030, which was second only to measles vaccine [&lt;span&gt;4&lt;/span&gt;]. Yet, despite the availability of safe and effective hepatitis B vaccines since 1982, coverage with timely hepB-BD has been suboptimal in most regions (Figure 1). By 2023, 140 of 195 (72%) countries have introduced either universal or selective HepB-BD, with 115 (59%) countries providing HepB-BD to all newborns [&lt;span&gt;5&lt;/span&gt;]. In 2022, almost 5.6 million children aged ≤5 years were living with HBV infection [&lt;span&gt;6&lt;/span&gt;]. In the World Health Organization (WHO) African region where the burden of HBV infection in children is the highest, only 16 of 47 (34%) countries have introduced HepB-BD mainly due to lack of financial support from Gavi, the Vaccine Alliance [&lt;span&gt;7&lt;/span&gt;]. In 2020, Gavi approved funding for HepB-BD introduction; however, this was put on hold due to the COVID-19 pandemic. In June 2024, Gavi launched official funding support for eligible countries for HepB-BD introduction [&lt;span&gt;8&lt;/span&gt;]. Countries must now take urgent action to introduce HepB-BD, including submitting applications for Gavi fund","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social network strategies to distribute HIV self-testing kits: a global systematic review and network meta-analysis","authors":"Siyue Hu,&nbsp;Fengshi Jing,&nbsp;Chengxin Fan,&nbsp;Yifan Dai,&nbsp;Yewei Xie,&nbsp;Yi Zhou,&nbsp;Hang Lv,&nbsp;Xi He,&nbsp;Dan Wu,&nbsp;Joseph D. Tucker,&nbsp;Weiming Tang","doi":"10.1002/jia2.26342","DOIUrl":"10.1002/jia2.26342","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Social network strategies, in which social networks are utilized to influence individuals or communities, are increasingly being used to deliver human immunodeficiency virus (HIV) interventions to key populations. We summarized and critically assessed existing research on the effectiveness of social network strategies in promoting HIV self-testing (HIVST).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Using search terms related to social network interventions and HIVST, we searched five databases for trials published between 1st January 2010 and 30th June 2023. Outcomes included uptake of HIV testing, HIV prevalence and linkage to antiretroviral therapy (ART) or HIV care. We used network meta-analysis to assess the uptake of HIV testing through social network strategies compared with control methods. A pairwise meta-analysis of studies with a comparison arm that reported outcomes was performed to assess relative risks (RR) and their corresponding 95% confidence intervals (CI).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among the 4496 manuscripts identified, 39 studies fulfilled the inclusion criteria, including one quasi-experimental study, 22 randomized controlled trials and 16 observational studies. Networks HIVST testing was organized by peers (distributed to known peers, 15 studies), partners (distributed to their sexual partners, 16 studies) and peer educators (distributed to unknown peers, 8 studies). Among social networks, simulating the possibilities of ranking position, peer distribution had the highest uptake of HIV testing (84% probability), followed by partner distribution (80% probability) and peer educator distribution (74% probability). Pairwise meta-analysis showed that peer distribution (RR 2.29, 95% CI 1.54−3.39, 5 studies) and partner distribution (RR 1.76, 95% CI 1.50−2.07, 10 studies) also increased the probability of detecting HIV reactivity during testing within the key population when compared to the control.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Discussion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All of the three social network distribution strategies enhanced the uptake of HIV testing compared to standard facility-based testing. Linkage to ART or HIV care remained comparable to facility-based testing across the three HIVST distribution strategies.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Network-based HIVST distribution is considered effective in augmenting HIV testing rates and reaching marginalized populatio","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thank you note to our peer reviewers (2023)","authors":"Kenneth H. Mayer,&nbsp;Annette H. Sohn,&nbsp;Marlène Bras","doi":"10.1002/jia2.26335","DOIUrl":"10.1002/jia2.26335","url":null,"abstract":"&lt;p&gt;The &lt;i&gt;Journal of the International AIDS Society&lt;/i&gt; (JIAS) would like to express our gratitude to the peer reviewers who contributed to reviewing articles for the journal in 2023. Their time and expertise are crucial to upholding the quality of this publication, and we are thankful for their engagement.&lt;/p&gt;&lt;p&gt;We also wish to extend our appreciation to the JIAS Editorial Board members, Deputy Editors, statistical experts and Ethical Committee members for their valuable contributions in assessing and reviewing articles submitted to the journal.&lt;/p&gt;&lt;p&gt;Kenneth Mayer, co-Editors-in-Chief&lt;/p&gt;&lt;p&gt;Annette Sohn, co-Editors-in-Chief&lt;/p&gt;&lt;p&gt;Marlène Bras, Executive Editor&lt;/p&gt;&lt;p&gt;Aaloke Mody&lt;/p&gt;&lt;p&gt;Adam Trickey&lt;/p&gt;&lt;p&gt;Adekemi Sekoni&lt;/p&gt;&lt;p&gt;Aditi Ramakrishnan&lt;/p&gt;&lt;p&gt;Aditya Subhash Khanna&lt;/p&gt;&lt;p&gt;Alana T. Brennan&lt;/p&gt;&lt;p&gt;Albert Liu&lt;/p&gt;&lt;p&gt;Alex Dubov&lt;/p&gt;&lt;p&gt;Alex Keuroghlian&lt;/p&gt;&lt;p&gt;Alex Viguerie&lt;/p&gt;&lt;p&gt;Alexander Adia&lt;/p&gt;&lt;p&gt;Alexandra C. Vrazo&lt;/p&gt;&lt;p&gt;Allan Maleche&lt;/p&gt;&lt;p&gt;Allanise Cloete&lt;/p&gt;&lt;p&gt;Allison McFall&lt;/p&gt;&lt;p&gt;Amelia M. Stanton&lt;/p&gt;&lt;p&gt;Amy Zheng&lt;/p&gt;&lt;p&gt;Anatole Menon-Johansson&lt;/p&gt;&lt;p&gt;Andrea Jane Low&lt;/p&gt;&lt;p&gt;Andrew Hill&lt;/p&gt;&lt;p&gt;Andrew McAuley&lt;/p&gt;&lt;p&gt;Andrew Prendergast&lt;/p&gt;&lt;p&gt;Angela Bengtson&lt;/p&gt;&lt;p&gt;Aniruddha Hazra&lt;/p&gt;&lt;p&gt;Ann Gottert&lt;/p&gt;&lt;p&gt;Anna Bershteyn&lt;/p&gt;&lt;p&gt;Anna Grimsrud&lt;/p&gt;&lt;p&gt;Anthony Fojo&lt;/p&gt;&lt;p&gt;Antons Mozalevskis&lt;/p&gt;&lt;p&gt;Anupam Garrib&lt;/p&gt;&lt;p&gt;Aoife Doyle&lt;/p&gt;&lt;p&gt;April D. Kimmel&lt;/p&gt;&lt;p&gt;Ariane van der Straten&lt;/p&gt;&lt;p&gt;Ashley Lacombe-Duncan&lt;/p&gt;&lt;p&gt;Augustine Talumba Choko&lt;/p&gt;&lt;p&gt;Bankole Olatosi&lt;/p&gt;&lt;p&gt;Benjamin Brown&lt;/p&gt;&lt;p&gt;Benjamin H. Chi&lt;/p&gt;&lt;p&gt;Bernadette Kina Kombo&lt;/p&gt;&lt;p&gt;Bernard Surial&lt;/p&gt;&lt;p&gt;Bill G. Kapogiannis&lt;/p&gt;&lt;p&gt;Bindiya Meggi&lt;/p&gt;&lt;p&gt;Brandon Guthrie&lt;/p&gt;&lt;p&gt;Brenda Hoagland&lt;/p&gt;&lt;p&gt;Brennan Cebula&lt;/p&gt;&lt;p&gt;Brian Zanoni&lt;/p&gt;&lt;p&gt;Bronwyn Elizabeth Bosch&lt;/p&gt;&lt;p&gt;Brooke E. Nichols&lt;/p&gt;&lt;p&gt;Bruce Richman&lt;/p&gt;&lt;p&gt;Caitlin Dugdale&lt;/p&gt;&lt;p&gt;Camille Cioffi&lt;/p&gt;&lt;p&gt;Carla Pires&lt;/p&gt;&lt;p&gt;Carmen Logie&lt;/p&gt;&lt;p&gt;Carol S. Camlin&lt;/p&gt;&lt;p&gt;Carol Strong&lt;/p&gt;&lt;p&gt;Caroline De Schacht&lt;/p&gt;&lt;p&gt;Caroline Foster&lt;/p&gt;&lt;p&gt;Carolyn Bolton-Moore&lt;/p&gt;&lt;p&gt;Carolyn Lauckner&lt;/p&gt;&lt;p&gt;Catherine Godfrey&lt;/p&gt;&lt;p&gt;Catherine Lesko&lt;/p&gt;&lt;p&gt;Cheryl Case Johnson&lt;/p&gt;&lt;p&gt;Chris Collins&lt;/p&gt;&lt;p&gt;Christian Kraef&lt;/p&gt;&lt;p&gt;Christina Psaros&lt;/p&gt;&lt;p&gt;Chutima Suraratdecha&lt;/p&gt;&lt;p&gt;Claudia Estcourt&lt;/p&gt;&lt;p&gt;Clemens Benedikt&lt;/p&gt;&lt;p&gt;Collins Iwuji&lt;/p&gt;&lt;p&gt;Daisuke Mizushima&lt;/p&gt;&lt;p&gt;Daniel Fierer&lt;/p&gt;&lt;p&gt;Danielle Resar&lt;/p&gt;&lt;p&gt;Darrell Tan&lt;/p&gt;&lt;p&gt;David Allen Roberts&lt;/p&gt;&lt;p&gt;David B. Hanna&lt;/p&gt;&lt;p&gt;David Dunn&lt;/p&gt;&lt;p&gt;David Hoos&lt;/p&gt;&lt;p&gt;David V. Glidden&lt;/p&gt;&lt;p&gt;Dean Murphy&lt;/p&gt;&lt;p&gt;Deanna Kerrigan&lt;/p&gt;&lt;p&gt;Debrah Boeras&lt;/p&gt;&lt;p&gt;Denis Nash&lt;/p&gt;&lt;p&gt;Denise Jacobson&lt;/p&gt;&lt;p&gt;Didier Ekouevi&lt;/p&gt;&lt;p&gt;Dobromir Dimitrov&lt;/p&gt;&lt;p&gt;Donn Colby&lt;/p&gt;&lt;p&gt;Doris Chibo&lt;/p&gt;&lt;p&gt;Dorlim Antonio Moiana Uetela&lt;/p&gt;&lt;p&gt;Dvora Joseph Davey&lt;/p&gt;&lt;p&gt;Edinah Mudimu&lt;/p&gt;&lt;p&gt;Elaine J. Abrams&lt;/p&gt;&lt;p&gt;Elenore P. Bhatraju&lt;/p&gt;&lt;p&gt;Elijah Kakande&lt;/p&gt;&lt;p&gt;Elizabeth T. Knippler&lt;/p&gt;&lt;p&gt;Elliot Raizes&lt;/p&gt;&lt;p&gt;Elona Toska&lt;/p&gt;&lt;p&gt;Emily Chasco&lt;/p&gt;&lt;p&gt;Emily Hyle&lt;/p&gt;&lt;p&gt;Emma Kalk&lt;/p&gt;&lt;p&gt;Erica N. Browne&lt;/p&gt;&lt;p&gt;Erin Graves&lt;/p&gt;&lt;p&gt;Erin Wilson&lt;/p&gt;&lt;p&gt;Estevão P. Nunes&lt;/p&gt;&lt;p&gt;Esther C. Atukunda&lt;/p&gt;&lt;p&gt;Fiona Burns&lt;/p&gt;&lt;p&gt;Florence Anabwani&lt;/p&gt;&lt;p&gt;Fran","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jia2.26335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract Supplement Abstracts from AIDS 2024, the 25th International AIDS Conference, 22 – 26 July, Munich, Germany & Virtual","authors":"","doi":"10.1002/jia2.26279","DOIUrl":"10.1002/jia2.26279","url":null,"abstract":"","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 S4","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jia2.26279","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV vulnerabilities and psychosocial health among young transgender women in Lima, Peru: results from a bio-behavioural survey","authors":"Alfonso Silva-Santisteban,&nbsp;Dorothy Apedaile,&nbsp;Amaya Perez-Brumer,&nbsp;Segundo R. Leon,&nbsp;Leyla Huerta,&nbsp;Francezka Leon,&nbsp;Rodrigo Aguayo-Romero,&nbsp;Sari L. Reisner","doi":"10.1002/jia2.26299","DOIUrl":"10.1002/jia2.26299","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Peruvian young transgender women (YTW) ages 16−24 years are a critical but understudied group for primary HIV prevention efforts, due to sharp increases in HIV prevalence among TW ages 25 years and older.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between February and July 2022, a cross-sectional quantitative study with YTW ages 16−24 years in Peru (<i>N</i> = 211) was conducted consisting of a bio-behavioural survey accompanied by laboratory-based testing for HIV and sexually transmitted infections (STIs). Bivariate and multivariable Poisson regression models were used to estimate prevalence ratios between socio-demographic and behavioural characteristics and HIV status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HIV prevalence was 41.5% (95% CI: 33.9−49.4%), recent syphilis acquisition 19.4% (95% CI: 12.7−28.4), chlamydia 6.3% (95% CI: 3.1−11.1) and gonorrhoea 12.3% (95% CI: 7.9−18.7). Almost half (47.9%) reported condomless anal sex in the past 6 months, 50.7% reported sex work in the past 30 days and 13.7% reported accepting more money for condomless sex. There were no significant differences in reported sexual behaviours by HIV status. Only 60.8% of participants reported ever having been tested for HIV, and 25.6% reported a past 6-month STI test. More than two-thirds (67.8%) had not heard of antiretroviral pre-exposure prophylaxis (PrEP) and only 4.7% had taken PrEP in the past month. Current moderate-to-severe psychological distress was endorsed by 20.3%, 10.0% reported attempting suicide in the past 6 months and 85.4% reported alcohol misuse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings show that the HIV epidemic for YTW in Lima, Peru is situated in the context of widespread social exclusion, including economic vulnerabilities, violence victimization and the mental health sequelae of transphobic stigma that starts early in life. Future research should aim to further understand the intersection of these vulnerabilities. Moreover, there is an urgent necessity to design and evaluate HIV prevention programmes that address the root systems driving HIV vulnerabilities in YTW and that focus on developmentally specific clusters of stigma-related conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The audacious goal to end AIDS by 2030: aspiration or reality?","authors":"Quarraisha Abdool Karim,&nbsp;Kenneth H. Mayer,&nbsp;Jivanka Mohan,&nbsp;Carlos del Rio","doi":"10.1002/jia2.26339","DOIUrl":"10.1002/jia2.26339","url":null,"abstract":"&lt;p&gt;In 2015, world leaders pledged to end the AIDS epidemic as a public health threat by 2030 with the goals of zero new acquisitions, zero AIDS-related deaths, and zero stigma and discrimination. It is undeniable that great strides have been made in initiating those living with HIV on antiretroviral medication (7.7 million in 2010 to 29.8 million in 2022) resulting in an estimated 51% reduction in AIDS-related deaths (1.3 million in 2010 to 630,000 in 2022), a 58% decline in perinatal transmissions (310,000 in 2010 to 130,000 in 2022), and a 38% reduction in new acquisitions (2.1 million in 2010 to 1.3 million in 2022) [&lt;span&gt;1&lt;/span&gt;]. However, the path ahead poses multiple challenges, particularly for ending new acquisitions and eliminating stigma and discrimination. The reality is that there is no room for complacency, as much remains to be done to get us to the UNAIDS 2030 goals. Furthermore, achieving these goals has become even more complicated because of disruptions in testing, treatment and support services caused by the COVID-19 pandemic [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The global response to HIV/AIDS has been the most extraordinary and unprecedented public health endeavour in history. From the epidemic's bleakest days in the 1980s and early 90s, through the advent of life-saving antiretroviral therapy in 1996, to global solidarity in the 2000s, we have seen the might of political will, science, activism and empathy [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Unfortunately, the phrase “ending the AIDS epidemic as a public health threat” has been heard by many—including political leaders, decision-makers and the public—as “we have ended the AIDS epidemic,” which has resulted in unintended negative consequences, including threats to end programmes such as the Global Fund to Fight AIDS, Tuberculosis, and Malaria [&lt;span&gt;4&lt;/span&gt;] and the President's Emergency Plan for AIDS Relief (PEPFAR) [&lt;span&gt;5&lt;/span&gt;]. Achieving the 2030 goals will require renewed political commitment, innovative approaches and collaboration across sectors and borders—an all-of-society approach. In the absence of a vaccine and a cure, funding will be necessary beyond 2030 to sustain the gains, maintain 30 million people on treatment, support medication adherence, strengthen primary prevention including pre-exposure prophylaxis (PrEP) and continue research to find effective vaccines and cures. Communicating this message to politicians, decision-makers, funders and the public is a priority imperative.&lt;/p&gt;&lt;p&gt;Significant governmental and foundation investments have been made in research to find a vaccine and a cure for HIV [&lt;span&gt;6&lt;/span&gt;], but more work needs to be done. Additionally, the development of new antiretroviral drugs and long-acting formulations is necessary to improve adherence and clinical outcomes [&lt;span&gt;7&lt;/span&gt;] as well as to increase uptake and persistent use among PrEP users. But the incentives for the industry to continue to innovate are predicated on the assumption that there will b","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing a male-specific ART counselling curriculum: a quality assessment with healthcare workers in Malawi","authors":"Isabella Robson,&nbsp;Misheck Mphande,&nbsp;Jiyoung Lee,&nbsp;Julie Anne Hubbard,&nbsp;Joseph Daniels,&nbsp;Khumbo Phiri,&nbsp;Elijah Chikuse,&nbsp;Thomas J. Coates,&nbsp;Morna Cornell,&nbsp;Kathryn Dovel","doi":"10.1002/jia2.26270","DOIUrl":"10.1002/jia2.26270","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;There is little HIV counselling that directly meets the needs of men in Eastern and Southern Africa, limiting men's knowledge about the benefits of HIV treatment and how to overcome barriers to engagement, contributing to poorer HIV-related outcomes than women. Male-specific approaches are needed to improve men's outcomes but may be difficult for healthcare workers (HCWs) to implement with fidelity and quality in low-resource settings. We developed a male-specific counselling curriculum which was implemented by male HCWs and then conducted a mixed-methods quality assessment.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We audio-recorded counselling sessions to assess the quality of implementation (&lt;i&gt;n&lt;/i&gt; = 50) by male HCWs from two cadres (nurse, &lt;i&gt;n&lt;/i&gt; = 10 and lay cadre, &lt;i&gt;n&lt;/i&gt; = 10) and conducted focus group discussions (FGDs) with HCWs at 6 and 9 months after rollout to understand barriers and facilitators to implementation. Counselling sessions and FGDs were translated, transcribed and analysed using thematic analysis adapted from WHO Quality Counselling Guidelines. We assessed if sessions were respectful, informative, interactive, motivating and included tailored action plans for overcoming barriers to care. All data were collected September 2021−June 2022.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All sessions used respectful, non-judgemental language. Sessions were highly interactive with most HCWs frequently asking open-ended questions (&lt;i&gt;n&lt;/i&gt; = 46, 92%) and often incorporating motivational explanations of how antiretroviral therapy contributes to life goals (&lt;i&gt;n&lt;/i&gt; = 42, 84%). Few sessions included individually tailored action plans for clients to overcome barriers to care (&lt;i&gt;n&lt;/i&gt; = 9, 18%). New counselling themes were well covered; however, occasionally themes of self-compassion and safe sex were not covered during sessions (&lt;i&gt;n&lt;/i&gt; = 16 and &lt;i&gt;n&lt;/i&gt; = 11). HCWs believed that having male HCWs conduct counselling, ongoing professional development and keeping detailed counselling notes facilitated quality implementation. Perceived barriers included curriculum length and client hesitancy to participate in action plan development. Findings were similar across cadres.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Implementing high-quality male-specific counselling using male nurses and/or lay cadre is feasible. Efforts to utilize lay cadres should be prioritized, particularly in low-resource settings. Programmes should provide comprehensive job aids to support HCWs. Ongoing train","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adults with perinatally acquired HIV in low- and middle-income settings: time for a generational shift in HIV care and global guidance","authors":"Annette H. Sohn,&nbsp;Mary-Ann Davies","doi":"10.1002/jia2.26338","DOIUrl":"10.1002/jia2.26338","url":null,"abstract":"&lt;p&gt;Paediatricians caring for children living with HIV started sounding alarm bells about their poorer clinical outcomes from the very beginnings of the HIV epidemic. They were routinely diagnosed late and with advanced disease, lacked appropriate antiretroviral formulations for treatment and their viruses became resistant to these regimens more rapidly, and suffered higher mortality rates [&lt;span&gt;1&lt;/span&gt;]. As those who survived became adolescents, they experienced long-term side effects of their treatment, increased risks for non-communicable diseases, and the social and mental health impacts of stigma, discrimination and orphanhood [&lt;span&gt;2, 3&lt;/span&gt;]. Adults with perinatal HIV are now being managed with limited standards around optimal care delivery.&lt;/p&gt;&lt;p&gt;UNAIDS estimates that there were about 660,000 (560,000–760,000) adults 20–24 years of age living with perinatally acquired HIV in 2023, 88% of whom were in Africa (UNAIDS 2024 epidemiologic estimates). In Asia, Thailand was one of the earliest countries to begin a national HIV treatment programme for children in the mid-2000s, and now ∼1800 adults &gt;18 years of age are estimated to be living with perinatal HIV—with the oldest in their third decade (Thai National AIDS Program, 2022 data). Although many national surveillance systems do not capture the mode of HIV acquisition, data on age at diagnosis are sufficient to identify those with early exposure to HIV and antiretroviral therapy and track them into adulthood. There is an urgent need for evidence-based guidelines for the treatment and care of adults with perinatal HIV that can be implemented in low- and middle-income country (LMIC) settings, as well as standardized provider training to effectively implement them.&lt;/p&gt;&lt;p&gt;In high-income contexts like the United States (US) and the United Kingdom (UK), most of those with perinatal HIV have already transitioned into adult life and HIV care, with some entering their fifth decade [&lt;span&gt;4, 5&lt;/span&gt;]. Data on their outcomes are sobering. In the US, by age 30, the cumulative incidence of type-2 diabetes among those with perinatally acquired HIV was 19%, 22% for hypertension and 25% for chronic kidney disease [&lt;span&gt;6&lt;/span&gt;]. A modelling study estimated that life expectancy in US male youth with perinatal HIV was 10.4 years lower and in female youth 11.8 years lower than their HIV-negative peers [&lt;span&gt;7&lt;/span&gt;]. A UK study showed that a lower nadir CD4 count in early childhood had an ongoing negative impact on CD4 by age 20 [&lt;span&gt;8&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Research from LMICs has reflected increased risks for adolescents with perinatal HIV that similarly bode poorly for their health outcomes as adults. Cohorts from South Africa and Thailand have reported bone, cardiac, neurocognitive or respiratory impairments [&lt;span&gt;2, 9&lt;/span&gt;]. The lack of prior access to human papillomavirus vaccines has put the current generation of young adults at risk for anogenital cancers (e.g. cervical) [&lt;span&gt;10&lt;/span&gt;]. Ear","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}