Journal of the International AIDS Society最新文献

{"title":"The association between adherence to antiretroviral therapy and viral suppression under dolutegravir-based regimens: an observational cohort study from Uganda","authors":"Zachary Wagner,&nbsp;Zetianyu Wang,&nbsp;Chad Stecher,&nbsp;Yvonne Karamagi,&nbsp;Mary Odiit,&nbsp;Jessica E. Haberer,&nbsp;Sebastian Linnemayr","doi":"10.1002/jia2.26350","DOIUrl":"10.1002/jia2.26350","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Millions of people living with HIV (PLWH) take oral antiretroviral therapy (ART), which requires a lifetime of consistent medication adherence. The relationship between adherence and poor HIV outcomes is well documented. Newer ART regimens that include dolutegravir (DTG) could be more forgiving, but empirical evidence on the relationship between adherence and viral suppression under DTG is only emerging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this observational cohort study (secondary analysis of data from a randomized trial), we used data from 313 ART clients from a large HIV clinic in Kampala, Uganda. Over the 4-year study period (January 2018–January 2022), 91% switched from non-DTG regimens to DTG regimens. We measured adherence using Medication Event Monitoring Systems-caps and extracted prescription information and viral load measures from electronic health records. We estimated unadjusted linear regressions and adjusted models that included individual and time fixed-effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Under non-DTG regimens, 96% of participants were virally suppressed (defined as viral load &lt; 200 copies/ml) when adherence was 90% or higher in the 3 months before viral load measurement. Viral suppression was 32 percentage points lower when adherence was between 0% and 49% (95% CI −0.44, −0.20, <i>p</i> &lt; 0.01), 12 percentage points lower when adherence was between 50% and 79% (95% CI −0.23, −0.02, <i>p</i> &lt; 0.01), and not significantly different when adherence was between 80% and 89% (effect of 0.00, 95% CI −0.06, 0.07, <i>p</i> = 0.81). In contrast, for participants taking DTG, there was no statistically significant difference in viral suppression among any of the four adherence levels; more than 95% were virally suppressed at each adherence level. On average, switching to DTG increased viral suppression by 6 percentage points in our adjusted models (95% CI 0.00, 0.13, <i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There was no significant association between adherence levels and viral suppression among PLWH taking DTG regimens, suggesting a high degree of forgiveness for missed doses. The use of DTG should be prioritized over older regimens, particularly for those with low adherence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trial Number</h3>\u0000 \u0000 <p>NCT03494777.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jia2.26350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing private sector strategies for family planning to deliver the Dual Prevention Pill, the first multipurpose prevention technology with pre-exposure prophylaxis, in an expanding HIV prevention landscape","authors":"Catherine Verde Hashim,&nbsp;Emma Llewellyn,&nbsp;Rob Wood,&nbsp;Tracey Brett,&nbsp;Tinashe Chinyanga,&nbsp;Karen Webb,&nbsp;Kate Segal","doi":"10.1002/jia2.26346","DOIUrl":"10.1002/jia2.26346","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The Dual Prevention Pill (DPP) combines oral pre-exposure prophylaxis (PrEP) with oral contraception (OC) to prevent HIV and pregnancy. Noting the significant role played by the private sector in delivering family planning (FP) services in countries with high HIV burden, high level of private sector OC uptake, and the recent growth in self-care and technology-based private sector channels, we undertook qualitative research in Kenya, South Africa and Zimbabwe to prioritize private sector service delivery approaches for the introduction of the DPP.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Between March 2022 and February 2023, we conducted a literature review and key informant interviews with 34 donors and implementing partners, 19 government representatives, 17 private sector organizations, 13 pharmacy and drug shop representatives, and 12 telehealth agencies to assess the feasibility of DPP introduction in private sector channels. Channels were analysed thematically based on policies, level of coordination with the public sector, data systems, supply chain, need for subsidy, scalability, sustainability and geographic coverage.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Wide geographic reach, ongoing pharmacy-administered PrEP pilots in Kenya and South Africa, and over-the-counter OC availability in Zimbabwe make pharmacies a priority for DPP delivery, in addition to private networked clinics, already trusted for FP and HIV services. In Kenya and South Africa, newer, technology-based channels such as e-pharmacies, telehealth and telemedicine are prioritized as they have rapidly grown in popularity due to nationwide accessibility, convenience and privacy. Findings are limited by a lack of standardized data on service uptake in newer channels and gaps in information on commodity pricing and willingness-to-pay for all channels.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The private sector provides a significant proportion of FP services in countries with high HIV burden yet is an untapped delivery source for PrEP. Offering users a range of access options for the DPP in non-traditional channels that minimize stigma, enhance discretion and increase convenience could increase uptake and continuation. Preparing these channels for PrEP provision requires engagement with Ministries of Health and providers and further research on pricing and willingness-to-pay. Aligning FP and PrEP delivery to meet the needs of those who want both HIV and pregnancy prevention will facilitate integrated service delivery a","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jia2.26346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scaling person-centred psycho-socioeconomic support for people living with HIV experiencing homelessness and unemployment in the Philippines: lessons learnt from the Open-Doors Home programme","authors":"Rodenie A. Olete,&nbsp;Joseph S. Cadelina,&nbsp;Charmaine Faye M. Chu,&nbsp;Emerson A. Arriola,&nbsp;Inad Q. Rendon","doi":"10.1002/jia2.26347","DOIUrl":"10.1002/jia2.26347","url":null,"abstract":"&lt;p&gt;Founded in 2018, &lt;i&gt;Gabay sa Pulang Laso Inc&lt;/i&gt;. (GPLI) (in English, “Guide to the Red Ribbon”) is a non-for-profit organization providing non-biomedical interventions to support people living with HIV (PLHIV) in the Philippines. As a response to a nationwide survey showing significant associations between unemployment, homelessness and mental distress among PLHIV during the COVID-19 pandemic [&lt;span&gt;1&lt;/span&gt;], GPLI established the flagship programme, “Open Doors Home” (ODH). ODH is a temporary shelter programme with the main goal of addressing psychosocial and socioeconomic needs (also termed “psycho-socioeconomic” or “PsySE”) among PLHIV experiencing mental distress because of homelessness, unemployment, disrupted education, domestic violence or discrimination.&lt;/p&gt;&lt;p&gt;The ODH programme complements biomedical interventions by providing PsySE support (i.e. shelter, nutrition, education, individualized psychosocial counselling, career guidance and livelihood trainings) as social determinants of the HIV care cascade. Guided by the person-centred care (PCC) framework [&lt;span&gt;2&lt;/span&gt;], individualized physical, mental, and socioeconomic needs assessments are done to ensure that the PsySE support is aligned with clients’ preferences and priorities. Clients, termed “housemates,” receive tailored PsySE support based on the individual needs assessment and individualized PCC plan. For example, if the intake interview shows that unemployment is the housemate's main concern, PsySE support will prioritize career path enhancement and referral to GPLI's network of entrepreneurs for hiring while also addressing other basic needs. ODH emphasizes empowerment, with healthcare providers serving only as facilitators to improve the housemates’ problem-solving capacities.&lt;/p&gt;&lt;p&gt;Due to limited shelter capacity, a passive intake process is used where potential clients reach out via social media (Twitter/X or Facebook) or through partner organizations (e.g. HIV &amp; AIDS Support House, Positive Action Foundation of the Philippines Inc. and other social hygiene clinics). The requirements for ODH intake are: (a) a summative case study from their medical doctor or a referral letter from the social welfare department or a community-based organization; (b) HIV confirmatory test result; (c) a medical abstract from the last 6 months showing no concurrent opportunistic infections; and (d) copies of two valid identifications for proper coordination with their respective HIV care facilities.&lt;/p&gt;&lt;p&gt;Based on a previous study, SEGT demonstrated improved mental health after engagement within a mutually supportive group environment [&lt;span&gt;3&lt;/span&gt;]. In ODH, SEGT was designed into four domains with 12 modules that guide housemates in expressing their emotions through focused group discussions. The modules adapted the Filipino core values of social psychology [&lt;span&gt;4&lt;/span&gt;]. Conducted weekly over 3 months, these sessions incorporated activities like journal writing, catharsis trainin","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the HIV care continuum among transgender women during 11 years of follow-up: results from the Netherlands’ ATHENA observational cohort","authors":"Vita W. Jongen,&nbsp;Ceranza Daans,&nbsp;Ard van Sighem,&nbsp;Maarten Schim van der Loeff,&nbsp;Kris Hage,&nbsp;Camiel Welling,&nbsp;Alex von Vaupel-Klein,&nbsp;Martin den Heijer,&nbsp;Edgar J. G. Peters,&nbsp;Marc van der Valk,&nbsp;Peter Reiss,&nbsp;Maria Prins,&nbsp;Elske Hoornenborg,&nbsp;the ATHENA observational HIV cohort","doi":"10.1002/jia2.26317","DOIUrl":"10.1002/jia2.26317","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Transgender women are at increased risk of acquiring HIV. Earlier studies reported lower retention in HIV care, antiretroviral therapy uptake, adherence and viral suppression. We assessed the stages of the HIV care continuum of transgender women in the Netherlands over an 11-year period. In addition, we assessed new HIV diagnoses and late presentation, as well as disengagement from care, between 2011 and 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the Dutch national ATHENA cohort, we separately assessed viral suppression, as well as time to achieving viral suppression, among transgender women for each year between 2011 and 2021. We also assessed trends in new HIV diagnoses and late presentation (CD4 count of &lt;350 cells/µl and/or AIDS at diagnosis), and disengagement from care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2011 and 2021, a total of 260 transgender women attended at least one HIV clinical visit. Across all years, &lt;90% of transgender women were virally suppressed (207/239 [87%] in 2021). The number of new HIV diagnoses fluctuated for transgender women (<i>p</i>_trend = 0.053) and late presentation was common (ranging between 10% and 67% of new HIV diagnoses). Of the 260 transgender women, 26 (10%) disengaged from care between 2011 and 2021 (incidence rate = 1.10 per 100 person-years, 95% confidence interval = 0.75−1.61).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Between 2011 and 2021, less than 90% of transgender women linked to HIV care were virally suppressed. Late presentation at the time of diagnosis and disengagement from care were common. Efforts are needed to identify barriers to early HIV diagnosis and to optimize the different steps across the care continuum for transgender women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability, usability, and willingness to pay for HIV self-test kits distributed through community-based, PLHIV network-led and private practitioners models in India: Results from the STAR III Initiative","authors":"Chinmay Laxmeshwar,&nbsp;Asha Hegde,&nbsp;Alpana Dange,&nbsp;Kannan Mariyappan,&nbsp;Manish Soosai,&nbsp;Sandeep Mane,&nbsp;Murugesan Sivasubramanian,&nbsp;Mahesh Doddamane,&nbsp;Madhuri Mukherjee,&nbsp;G. S. Shreenivas,&nbsp;Manoj Pardesi,&nbsp;Vinod Jambhale,&nbsp;Venkateswara Rao Pakkela,&nbsp;Vijayaraman Arumugam,&nbsp;Vedant Rungta,&nbsp;Yashika Bansal,&nbsp;Jatin Chaudary,&nbsp;Vijay Yeldandi,&nbsp;Mahalingam Periasamy,&nbsp;Chengappa Uthappa,&nbsp;Sudhir Chawla,&nbsp;Sunita Upadhyaya,&nbsp;Melissa Nyendak,&nbsp;Venkatesan Chakrapani,&nbsp;Sheela Godbole,&nbsp;Vinita Verma,&nbsp;Bhawani Singh Kushwaha,&nbsp;Chinmoyee Das,&nbsp;Shobini Rajan,&nbsp;Anoop Kumar Puri,&nbsp;J. V. R. Prasada Rao,&nbsp;Tarun Bhatnagar,&nbsp;D. C. S. Reddy,&nbsp;Kimberly Green","doi":"10.1002/jia2.26348","DOIUrl":"10.1002/jia2.26348","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>HIV self-testing (HIVST) has been shown to increase the uptake of HIV testing and help achieve the UNAIDS 95-95-95 targets. This study assessed the acceptability, usability (ease of use and result interpretation) and the willingness to pay for HIVST kits distributed through three distribution models, namely the community-based, PLHIV network-led and private practitioners models, in India.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was implemented across 14 states in India between September 2021 and June 2022. All participants could choose between blood-based or oral-fluid-based test kits. Participants were shown a test-kit usage demonstration video, and pre- and post-test counselling was provided for all. Participants were followed-up after testing, and if reported reactive, were further supported for linkage to confirmatory testing and antiretroviral therapy (ART) initiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 90,605 participants found eligible, 88,080 (97%) accepted an HIVST kit. Among the 87,976 who reported using an HIVST kit, 45,207 (51%) preferred a blood-based kit, and 42,120 (48%) reported testing for the first time. For future testing, 77,064 (88%) reported preferring HIVST over other HIV testing methods. Among those who used the kit, 83,308 (95%) found the kit easy to use, and 83,237 (95%) reported that the test results were easy to interpret. Among those who preferred HIVST for future use, 52,136 (69%) were willing to pay for the kit, with 35,854 (69%) of those willing to pay less than US$ 1.20. Only one instance of social harm was reported, with a participant reporting suicidal tendencies due to discord with their partner.</p>\u0000 \u0000 <p>Out of 328 participants (0.4%) who tested reactive with HIVST, 291 (89%) were linked to confirmatory testing; of these, 254 were confirmed HIV positive, and 216 (85%) successfully initiated ART.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, we report that nearly all participants were willing to accept HIVST, found the test kits easy to use and interpret, and about two-thirds were willing to pay for HIVST. Given the high levels of acceptance and the ability to reach a large proportion of first-time testers, HIVST in India could contribute to achieving the UNAIDS first 95 and ending the HIV epidemic.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eliminating perinatal transmission of hepatitis B virus: it is time for action","authors":"Rania A. Tohme,&nbsp;Su Wang,&nbsp;Benjamin Cowie,&nbsp;Sandra Dudareva,&nbsp;Carolyn Wester","doi":"10.1002/jia2.26337","DOIUrl":"10.1002/jia2.26337","url":null,"abstract":"&lt;p&gt;Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and liver cancer causing 1.1 million deaths globally in 2022 [&lt;span&gt;1&lt;/span&gt;]. In 2022, an estimated 254 million persons were living with chronic HBV infection. Globally, HBV is mainly acquired through mother-to-child transmission (MTCT) at birth (vertical or perinatal transmission), and during early childhood (horizontal transmission). Up to 90% of newborns who acquire HBV through MTCT will develop chronic hepatitis B compared to 30%–50% of children infected between the ages of 1–5 years, while &lt;5% of those infected in adulthood develop chronic hepatitis B [&lt;span&gt;2&lt;/span&gt;]. The hepatitis B vaccine is &gt;90% effective at preventing infections and is given as a series starting with a dose of monovalent vaccine within 24 hours of birth (hepatitis B-birth dose [hepB-BD]) (70%–95% effective in preventing perinatal HBV infection), followed by two or three additional doses during infancy [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Elimination targets for MTCT of HBV include achieving ≤0.1% prevalence of hepatitis B surface antigen (HBsAg) in children ≤5 years of age, and ≥90% coverage with timely HepB-BD and three doses of hepatitis B vaccine (HepB3) [&lt;span&gt;3&lt;/span&gt;]. In addition, countries that provide selective HepB-BD (e.g. only to infants with known exposure) need to screen ≥90% of pregnant women for hepatitis B and treat ≥90% of those eligible [&lt;span&gt;3&lt;/span&gt;]. Prevention of HBV infection in infancy and childhood through vaccination and treatment of pregnant women would be the most impactful interventions to reduce the prevalence of chronic hepatitis B in the population.&lt;/p&gt;&lt;p&gt;An analysis of the impact of childhood vaccination in 98 low- and middle-income countries showed that hepatitis B vaccination will have prevented 38 million (range: 25–52 million) deaths over the lifetime of those born from 2000 to 2030, which was second only to measles vaccine [&lt;span&gt;4&lt;/span&gt;]. Yet, despite the availability of safe and effective hepatitis B vaccines since 1982, coverage with timely hepB-BD has been suboptimal in most regions (Figure 1). By 2023, 140 of 195 (72%) countries have introduced either universal or selective HepB-BD, with 115 (59%) countries providing HepB-BD to all newborns [&lt;span&gt;5&lt;/span&gt;]. In 2022, almost 5.6 million children aged ≤5 years were living with HBV infection [&lt;span&gt;6&lt;/span&gt;]. In the World Health Organization (WHO) African region where the burden of HBV infection in children is the highest, only 16 of 47 (34%) countries have introduced HepB-BD mainly due to lack of financial support from Gavi, the Vaccine Alliance [&lt;span&gt;7&lt;/span&gt;]. In 2020, Gavi approved funding for HepB-BD introduction; however, this was put on hold due to the COVID-19 pandemic. In June 2024, Gavi launched official funding support for eligible countries for HepB-BD introduction [&lt;span&gt;8&lt;/span&gt;]. Countries must now take urgent action to introduce HepB-BD, including submitting applications for Gavi fund","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social network strategies to distribute HIV self-testing kits: a global systematic review and network meta-analysis","authors":"Siyue Hu,&nbsp;Fengshi Jing,&nbsp;Chengxin Fan,&nbsp;Yifan Dai,&nbsp;Yewei Xie,&nbsp;Yi Zhou,&nbsp;Hang Lv,&nbsp;Xi He,&nbsp;Dan Wu,&nbsp;Joseph D. Tucker,&nbsp;Weiming Tang","doi":"10.1002/jia2.26342","DOIUrl":"10.1002/jia2.26342","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Social network strategies, in which social networks are utilized to influence individuals or communities, are increasingly being used to deliver human immunodeficiency virus (HIV) interventions to key populations. We summarized and critically assessed existing research on the effectiveness of social network strategies in promoting HIV self-testing (HIVST).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Using search terms related to social network interventions and HIVST, we searched five databases for trials published between 1st January 2010 and 30th June 2023. Outcomes included uptake of HIV testing, HIV prevalence and linkage to antiretroviral therapy (ART) or HIV care. We used network meta-analysis to assess the uptake of HIV testing through social network strategies compared with control methods. A pairwise meta-analysis of studies with a comparison arm that reported outcomes was performed to assess relative risks (RR) and their corresponding 95% confidence intervals (CI).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among the 4496 manuscripts identified, 39 studies fulfilled the inclusion criteria, including one quasi-experimental study, 22 randomized controlled trials and 16 observational studies. Networks HIVST testing was organized by peers (distributed to known peers, 15 studies), partners (distributed to their sexual partners, 16 studies) and peer educators (distributed to unknown peers, 8 studies). Among social networks, simulating the possibilities of ranking position, peer distribution had the highest uptake of HIV testing (84% probability), followed by partner distribution (80% probability) and peer educator distribution (74% probability). Pairwise meta-analysis showed that peer distribution (RR 2.29, 95% CI 1.54−3.39, 5 studies) and partner distribution (RR 1.76, 95% CI 1.50−2.07, 10 studies) also increased the probability of detecting HIV reactivity during testing within the key population when compared to the control.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Discussion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All of the three social network distribution strategies enhanced the uptake of HIV testing compared to standard facility-based testing. Linkage to ART or HIV care remained comparable to facility-based testing across the three HIVST distribution strategies.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Network-based HIVST distribution is considered effective in augmenting HIV testing rates and reaching marginalized populatio","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thank you note to our peer reviewers (2023)","authors":"Kenneth H. Mayer,&nbsp;Annette H. Sohn,&nbsp;Marlène Bras","doi":"10.1002/jia2.26335","DOIUrl":"10.1002/jia2.26335","url":null,"abstract":"&lt;p&gt;The &lt;i&gt;Journal of the International AIDS Society&lt;/i&gt; (JIAS) would like to express our gratitude to the peer reviewers who contributed to reviewing articles for the journal in 2023. Their time and expertise are crucial to upholding the quality of this publication, and we are thankful for their engagement.&lt;/p&gt;&lt;p&gt;We also wish to extend our appreciation to the JIAS Editorial Board members, Deputy Editors, statistical experts and Ethical Committee members for their valuable contributions in assessing and reviewing articles submitted to the journal.&lt;/p&gt;&lt;p&gt;Kenneth Mayer, co-Editors-in-Chief&lt;/p&gt;&lt;p&gt;Annette Sohn, co-Editors-in-Chief&lt;/p&gt;&lt;p&gt;Marlène Bras, Executive Editor&lt;/p&gt;&lt;p&gt;Aaloke Mody&lt;/p&gt;&lt;p&gt;Adam Trickey&lt;/p&gt;&lt;p&gt;Adekemi Sekoni&lt;/p&gt;&lt;p&gt;Aditi Ramakrishnan&lt;/p&gt;&lt;p&gt;Aditya Subhash Khanna&lt;/p&gt;&lt;p&gt;Alana T. Brennan&lt;/p&gt;&lt;p&gt;Albert Liu&lt;/p&gt;&lt;p&gt;Alex Dubov&lt;/p&gt;&lt;p&gt;Alex Keuroghlian&lt;/p&gt;&lt;p&gt;Alex Viguerie&lt;/p&gt;&lt;p&gt;Alexander Adia&lt;/p&gt;&lt;p&gt;Alexandra C. Vrazo&lt;/p&gt;&lt;p&gt;Allan Maleche&lt;/p&gt;&lt;p&gt;Allanise Cloete&lt;/p&gt;&lt;p&gt;Allison McFall&lt;/p&gt;&lt;p&gt;Amelia M. Stanton&lt;/p&gt;&lt;p&gt;Amy Zheng&lt;/p&gt;&lt;p&gt;Anatole Menon-Johansson&lt;/p&gt;&lt;p&gt;Andrea Jane Low&lt;/p&gt;&lt;p&gt;Andrew Hill&lt;/p&gt;&lt;p&gt;Andrew McAuley&lt;/p&gt;&lt;p&gt;Andrew Prendergast&lt;/p&gt;&lt;p&gt;Angela Bengtson&lt;/p&gt;&lt;p&gt;Aniruddha Hazra&lt;/p&gt;&lt;p&gt;Ann Gottert&lt;/p&gt;&lt;p&gt;Anna Bershteyn&lt;/p&gt;&lt;p&gt;Anna Grimsrud&lt;/p&gt;&lt;p&gt;Anthony Fojo&lt;/p&gt;&lt;p&gt;Antons Mozalevskis&lt;/p&gt;&lt;p&gt;Anupam Garrib&lt;/p&gt;&lt;p&gt;Aoife Doyle&lt;/p&gt;&lt;p&gt;April D. Kimmel&lt;/p&gt;&lt;p&gt;Ariane van der Straten&lt;/p&gt;&lt;p&gt;Ashley Lacombe-Duncan&lt;/p&gt;&lt;p&gt;Augustine Talumba Choko&lt;/p&gt;&lt;p&gt;Bankole Olatosi&lt;/p&gt;&lt;p&gt;Benjamin Brown&lt;/p&gt;&lt;p&gt;Benjamin H. Chi&lt;/p&gt;&lt;p&gt;Bernadette Kina Kombo&lt;/p&gt;&lt;p&gt;Bernard Surial&lt;/p&gt;&lt;p&gt;Bill G. Kapogiannis&lt;/p&gt;&lt;p&gt;Bindiya Meggi&lt;/p&gt;&lt;p&gt;Brandon Guthrie&lt;/p&gt;&lt;p&gt;Brenda Hoagland&lt;/p&gt;&lt;p&gt;Brennan Cebula&lt;/p&gt;&lt;p&gt;Brian Zanoni&lt;/p&gt;&lt;p&gt;Bronwyn Elizabeth Bosch&lt;/p&gt;&lt;p&gt;Brooke E. Nichols&lt;/p&gt;&lt;p&gt;Bruce Richman&lt;/p&gt;&lt;p&gt;Caitlin Dugdale&lt;/p&gt;&lt;p&gt;Camille Cioffi&lt;/p&gt;&lt;p&gt;Carla Pires&lt;/p&gt;&lt;p&gt;Carmen Logie&lt;/p&gt;&lt;p&gt;Carol S. Camlin&lt;/p&gt;&lt;p&gt;Carol Strong&lt;/p&gt;&lt;p&gt;Caroline De Schacht&lt;/p&gt;&lt;p&gt;Caroline Foster&lt;/p&gt;&lt;p&gt;Carolyn Bolton-Moore&lt;/p&gt;&lt;p&gt;Carolyn Lauckner&lt;/p&gt;&lt;p&gt;Catherine Godfrey&lt;/p&gt;&lt;p&gt;Catherine Lesko&lt;/p&gt;&lt;p&gt;Cheryl Case Johnson&lt;/p&gt;&lt;p&gt;Chris Collins&lt;/p&gt;&lt;p&gt;Christian Kraef&lt;/p&gt;&lt;p&gt;Christina Psaros&lt;/p&gt;&lt;p&gt;Chutima Suraratdecha&lt;/p&gt;&lt;p&gt;Claudia Estcourt&lt;/p&gt;&lt;p&gt;Clemens Benedikt&lt;/p&gt;&lt;p&gt;Collins Iwuji&lt;/p&gt;&lt;p&gt;Daisuke Mizushima&lt;/p&gt;&lt;p&gt;Daniel Fierer&lt;/p&gt;&lt;p&gt;Danielle Resar&lt;/p&gt;&lt;p&gt;Darrell Tan&lt;/p&gt;&lt;p&gt;David Allen Roberts&lt;/p&gt;&lt;p&gt;David B. Hanna&lt;/p&gt;&lt;p&gt;David Dunn&lt;/p&gt;&lt;p&gt;David Hoos&lt;/p&gt;&lt;p&gt;David V. Glidden&lt;/p&gt;&lt;p&gt;Dean Murphy&lt;/p&gt;&lt;p&gt;Deanna Kerrigan&lt;/p&gt;&lt;p&gt;Debrah Boeras&lt;/p&gt;&lt;p&gt;Denis Nash&lt;/p&gt;&lt;p&gt;Denise Jacobson&lt;/p&gt;&lt;p&gt;Didier Ekouevi&lt;/p&gt;&lt;p&gt;Dobromir Dimitrov&lt;/p&gt;&lt;p&gt;Donn Colby&lt;/p&gt;&lt;p&gt;Doris Chibo&lt;/p&gt;&lt;p&gt;Dorlim Antonio Moiana Uetela&lt;/p&gt;&lt;p&gt;Dvora Joseph Davey&lt;/p&gt;&lt;p&gt;Edinah Mudimu&lt;/p&gt;&lt;p&gt;Elaine J. Abrams&lt;/p&gt;&lt;p&gt;Elenore P. Bhatraju&lt;/p&gt;&lt;p&gt;Elijah Kakande&lt;/p&gt;&lt;p&gt;Elizabeth T. Knippler&lt;/p&gt;&lt;p&gt;Elliot Raizes&lt;/p&gt;&lt;p&gt;Elona Toska&lt;/p&gt;&lt;p&gt;Emily Chasco&lt;/p&gt;&lt;p&gt;Emily Hyle&lt;/p&gt;&lt;p&gt;Emma Kalk&lt;/p&gt;&lt;p&gt;Erica N. Browne&lt;/p&gt;&lt;p&gt;Erin Graves&lt;/p&gt;&lt;p&gt;Erin Wilson&lt;/p&gt;&lt;p&gt;Estevão P. Nunes&lt;/p&gt;&lt;p&gt;Esther C. Atukunda&lt;/p&gt;&lt;p&gt;Fiona Burns&lt;/p&gt;&lt;p&gt;Florence Anabwani&lt;/p&gt;&lt;p&gt;Fran","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jia2.26335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract Supplement Abstracts from AIDS 2024, the 25th International AIDS Conference, 22 – 26 July, Munich, Germany & Virtual","authors":"","doi":"10.1002/jia2.26279","DOIUrl":"10.1002/jia2.26279","url":null,"abstract":"","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 S4","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jia2.26279","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV vulnerabilities and psychosocial health among young transgender women in Lima, Peru: results from a bio-behavioural survey","authors":"Alfonso Silva-Santisteban,&nbsp;Dorothy Apedaile,&nbsp;Amaya Perez-Brumer,&nbsp;Segundo R. Leon,&nbsp;Leyla Huerta,&nbsp;Francezka Leon,&nbsp;Rodrigo Aguayo-Romero,&nbsp;Sari L. Reisner","doi":"10.1002/jia2.26299","DOIUrl":"10.1002/jia2.26299","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Peruvian young transgender women (YTW) ages 16−24 years are a critical but understudied group for primary HIV prevention efforts, due to sharp increases in HIV prevalence among TW ages 25 years and older.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between February and July 2022, a cross-sectional quantitative study with YTW ages 16−24 years in Peru (<i>N</i> = 211) was conducted consisting of a bio-behavioural survey accompanied by laboratory-based testing for HIV and sexually transmitted infections (STIs). Bivariate and multivariable Poisson regression models were used to estimate prevalence ratios between socio-demographic and behavioural characteristics and HIV status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HIV prevalence was 41.5% (95% CI: 33.9−49.4%), recent syphilis acquisition 19.4% (95% CI: 12.7−28.4), chlamydia 6.3% (95% CI: 3.1−11.1) and gonorrhoea 12.3% (95% CI: 7.9−18.7). Almost half (47.9%) reported condomless anal sex in the past 6 months, 50.7% reported sex work in the past 30 days and 13.7% reported accepting more money for condomless sex. There were no significant differences in reported sexual behaviours by HIV status. Only 60.8% of participants reported ever having been tested for HIV, and 25.6% reported a past 6-month STI test. More than two-thirds (67.8%) had not heard of antiretroviral pre-exposure prophylaxis (PrEP) and only 4.7% had taken PrEP in the past month. Current moderate-to-severe psychological distress was endorsed by 20.3%, 10.0% reported attempting suicide in the past 6 months and 85.4% reported alcohol misuse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings show that the HIV epidemic for YTW in Lima, Peru is situated in the context of widespread social exclusion, including economic vulnerabilities, violence victimization and the mental health sequelae of transphobic stigma that starts early in life. Future research should aim to further understand the intersection of these vulnerabilities. Moreover, there is an urgent necessity to design and evaluate HIV prevention programmes that address the root systems driving HIV vulnerabilities in YTW and that focus on developmentally specific clusters of stigma-related conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":201,"journal":{"name":"Journal of the International AIDS Society","volume":"27 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}