Pneumologie最新文献_第5页

[Neoadjuvant therapy for resectable non-small cell lung cancer]. 可切除的非小细胞肺癌的新辅助治疗。

IF 1.2

Pneumologie Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1055/a-2465-4830

Katrin Welcker, Danny Jonigk, Cornelia Kropf-Sanchen, Amanda Tufman, Andreas Draube, Albrecht Stenzinger, Mohamed Zaatar, Michael Thomas

{"title":"[Neoadjuvant therapy for resectable non-small cell lung cancer].","authors":"Katrin Welcker, Danny Jonigk, Cornelia Kropf-Sanchen, Amanda Tufman, Andreas Draube, Albrecht Stenzinger, Mohamed Zaatar, Michael Thomas","doi":"10.1055/a-2465-4830","DOIUrl":"10.1055/a-2465-4830","url":null,"abstract":"Treatment perspectives for non-small cell lung cancer (NSCLC) have been significantly expanded by the integration of immune checkpoint inhibitors into multimodal therapy concepts. Currently, combined, immune checkpoint-inhibitor-based therapy concepts are also advancing into early, resectable stages of NSCLC. Neoadjuvant and perioperative chemoimmunotherapy opened up a promising new preoperative treatment approach, but also raises some new questions and challenges. With the expanded perioperative treatment options and the perspective on a further improvement in the absence of recurrence after tumor resection, there is push towards comprehensively collecting therapy-relevant findings for imaging, molecular and histopathological diagnostics at an early stage. All patients with lung carcinoma, regardless of the therapy intention, should be presented to an interdisciplinary tumor board with thoracic oncological expertise. This is regularly given in certified lung cancer centers.A standardized procedure contributes to optimized pre-therapeutic diagnostics and facilitates coordination for the best possible multimodal approach in the interdisciplinary tumor board. In the case of centrally located resectable tumors, for example, neoadjuvant treatment increases the chances of a procedure that is as parenchymal sparing as possible. Some questions cannot yet be answered conclusively. Perioperative systemic therapy with molecular-targeted and immune checkpoint inhibitors is the subject of numerous ongoing studies. The considerable dynamics in newly approved therapies and the development of perioperative therapy concepts require continuous adaptation of diagnostic algorithms and standards. Integration into standard pre-surgical routine makes rapid classification of the relevant findings as well as close coordination between the diagnostic and interventional disciplines essential.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":"16-24"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Everything under control?] [一切尽在掌握？ ]

IF 1.2

Pneumologie Pub Date : 2025-01-01 Epub Date: 2024-05-23 DOI: 10.1055/a-2313-4137

Johanna Eggeling, Barbara Kalsdorf, Dagmar Schaub, Stefanie Schierholz, Peter Hammerl, Dennis Nowak, Christoph Lange

引用次数: 0

Sekretolyse – mögliche Vorgehensweisen. 分泌溶解--可能的程序。

IF 1.2

Pneumologie Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1055/a-1935-2240

Thomas Hillmann

引用次数: 0

[Cannabis and nicotine in German music videos]. [德国音乐录影带中的大麻和尼古丁]。

IF 1.2

Pneumologie Pub Date : 2024-12-13 DOI: 10.1055/a-2486-6646

Reiner Hanewinkel, Clemens Neumann, Matthis Morgenstern

{"title":"[Cannabis and nicotine in German music videos].","authors":"Reiner Hanewinkel, Clemens Neumann, Matthis Morgenstern","doi":"10.1055/a-2486-6646","DOIUrl":"https://doi.org/10.1055/a-2486-6646","url":null,"abstract":"Background: Smoking of tobacco and cannabis is widespread in Germany. Preventing children and adolescents from starting to use these products is an important goal of prevention. The aim of the present study was to examine how often depiction or mention of cannabis and nicotine use occurs in German-language music videos, which can be seen as advertising for smoking.Method: The sample, which comprised the population of all German-language music videos listed in the YouTube Top 100 Charts in 2023, included 600 music videos. Using a coding scheme, the music videos were categorised as 'smoke-free' or 'not smoke-free' and the depiction or mention of consumption was counted.Results: Of the videos examined, 54.7% (n=328) contained at least one depiction or mention of cannabis or tobacco use; 31.7% of the videos (n=190) were exclusively about tobacco use, 12.5% of the videos (n=75) were exclusively about cannabis use, and 10.5% (n=63) were about both. While tobacco or cannabis use was shown or mentioned in 67.0% of the videos from the 'German rap' genre, the average for the other genres was 20.6% (OR=7.83; p<0.001). When considering cannabis use alone, the difference between the genres was even more pronounced. The proportion of videos in which cannabis was shown or mentioned was 29.7% in the 'German rap' genre and 4.4% in the other genres (OR=9.27; p<0.001). The 328 videos in which tobacco or cannabis use was shown received 3.2 billion clicks (64.5% of clicks). This means that these 328 videos generated a total of 9.7 trillion impressions. Of these, 5.8 trillion impressions were about nicotine use and 3.9 trillion about cannabis use.Discussion: Music videos expose children and adolescents to a wide range of scenes of nicotine and cannabis use, which remains largely unregulated.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pneumonia due to silent aspiration: a diagnostic and therapeutic challenge]. 【无声吸入性肺炎：诊断和治疗的挑战】。

IF 1.2

Pneumologie Pub Date : 2024-12-13 DOI: 10.1055/a-2486-6598

Santiago Ewig, Sören Gatermann, Kai Wiesweg

引用次数: 0

[Combination drug therapy in pulmonary hypertension: switch from selexipaq to intravenous trepostinil]. 肺动脉高压的联合药物治疗：从selexipaq转向静脉注射trepostinil。

IF 1.2

Pneumologie Pub Date : 2024-12-04 DOI: 10.1055/a-2472-0694

Alexander Heine, Anne Obst, Christian F Opitz, Michael Halank, Manuel Richter, Tobias Lange, Ralf Ewert

{"title":"[Combination drug therapy in pulmonary hypertension: switch from selexipaq to intravenous trepostinil].","authors":"Alexander Heine, Anne Obst, Christian F Opitz, Michael Halank, Manuel Richter, Tobias Lange, Ralf Ewert","doi":"10.1055/a-2472-0694","DOIUrl":"https://doi.org/10.1055/a-2472-0694","url":null,"abstract":"A wide range of substances is currently available for the treatment of patients with pulmonary arterial hypertension. The current recommendations for initial drug therapy are based on the patient's risk profile. For patients at high risk, an initial triple combination therapy with different substances including prostanoids is recommended. The aim of the prospective, single-arm, unblinded study was to clarify whether PAH patients on triple therapy benefit from switching from selexipag to intravenous treprostinil. The primary endpoint was the achievement of a \"low-risk\" status after 6 (12) months. 27 PAH patients (45 (37; 61) years, 77.8% women) were included. At study entry they were assigned to low-risk (n=1), intermediate (n=12) or high-risk status (n=14). On average, 22 patients were followed for 8 (range 5-11) months. One patient was successfully transplanted after four months, another four patients died (in one case septic complications of unknown origin; in three cases progressive right heart failure). The primary endpoint (reaching \"low-risk\" status) was achieved in 12/21 (57.1%) patients (one further patient remained in \"low-risk\" status). These data indicate (despite the small number of patients) that even with established triple therapy, clinical improvement in individual patients is possible by switching from selexipag to intravenous treprostinil.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[From vibration trauma to pharyngeal muscle instability: A self-sustaining pathophysiological process (circulus vitiosus) in obstructive sleep apnea]. [从振动损伤到咽肌不稳定：阻塞性睡眠呼吸暂停的自我维持病理生理过程（恶性循环）]。

IF 1.2

Pneumologie Pub Date : 2024-12-04 DOI: 10.1055/a-2438-0479

Ulrich Koehler, Olaf Hildebrandt, Mikail Aykut Degerli, Christian Viniol, Wulf Hildebrandt, Regina Conradt, Richard Birk, Boris Stuck, Janine Sambale, Heike Korbmacher-Steiner

引用次数: 0

[Integration of Palliative Medicine in respiratory care]. [姑息医学在呼吸系统护理中的整合]。

IF 1.2

Pneumologie Pub Date : 2024-12-01 Epub Date: 2024-12-13 DOI: 10.1055/a-2097-5347

Sandra Delis, Rüdiger Karpf-Wissel

引用次数: 0

[Code of conduct for dealing with the tobacco and nicotine industry - Impulse for action for scientific societies - A consensus document by the medical societies and organizations listed below]. [与烟草和尼古丁行业打交道的行为守则--科学协会的行动动力--下列医学协会和组织的共识文件]。

IF 1.2

Pneumologie Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1055/a-2471-1460

引用次数: 0

["Smoke-free in May 2024": concept and description of the participants]. ["2024 年 5 月无烟日"：概念和参与者说明]。

IF 1.2

Pneumologie Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI: 10.1055/a-2405-2840

Reiner Hanewinkel, Friederike Barthels, Barbara Isensee

{"title":"[\"Smoke-free in May 2024\": concept and description of the participants].","authors":"Reiner Hanewinkel, Friederike Barthels, Barbara Isensee","doi":"10.1055/a-2405-2840","DOIUrl":"10.1055/a-2405-2840","url":null,"abstract":"Background: Far too many people smoke in Germany, and the number of serious attempts to stop smoking has been falling for years.Methods: Smoke-free in May 2024 is a low-threshold measure to encourage people to stop smoking. Adults who \"regularly\" consume nicotine products as well as support persons were eligible to take part. As part of the measure, participants and supporters were offered daily support via app notifications, emails and/or WhatsApp. They were also made aware of existing stop-smoking programmes. Finally, prizes were raffled off among the successful participants.Results: A total of 6,386 individuals registered to take part. Of these, 550 individuals registered with a person of their choice to support them. Smokers were predominantly female (56.5%) and on average 42.9 (SD=13.2) years old. They came from all federal states in Germany, with a disproportionately high number from the federal states of Bremen, Schleswig-Holstein, Berlin, North Rhine-Westphalia, Hamburg and Bavaria in relation to the population distribution. Compared to a representative sample from a study by the Robert Koch Institute (2012), they reported a significantly higher subjective socio-economic status. Of the participants, 79.3% categorised their addiction as high. Regular use of more than one nicotine products occurred in 35.3% of the sample; 39.8% of the participants stated that they had not tried to stop smoking during the last 12 months.Conclusions: The number of smokers participating in the program is encouraging. In addition to an efficacy study, it should be examined in subsequent years how more males and individuals with a low subjective social status can be encouraged to initiate smoking cessation.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":"1022-1029"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0