Plastic and Reconstructive Surgery Global Open最新文献

Plant-based Exosome Injections for Skin Wound Healing: Experimental Study.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-10 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006949

Noury Adel, Nenad Stankovic, Gerardo Cervantes, Amira Gindi, Lamiaa Mohamed Shawky

{"title":"Plant-based Exosome Injections for Skin Wound Healing: Experimental Study.","authors":"Noury Adel, Nenad Stankovic, Gerardo Cervantes, Amira Gindi, Lamiaa Mohamed Shawky","doi":"10.1097/GOX.0000000000006949","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006949","url":null,"abstract":"Background: This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds.Methods: A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration.Results: The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics.Conclusions: The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6949"},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilot Study: Investigating the Local Breast Microbiome in Implant-based Breast Reconstruction Using 16S rRNA Sequencing.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-10 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006928

Laura L Barnes, Nisha Parmeshwar, Michael Campbell, Laura Esserman, Merisa Piper

{"title":"Pilot Study: Investigating the Local Breast Microbiome in Implant-based Breast Reconstruction Using 16S rRNA Sequencing.","authors":"Laura L Barnes, Nisha Parmeshwar, Michael Campbell, Laura Esserman, Merisa Piper","doi":"10.1097/GOX.0000000000006928","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006928","url":null,"abstract":"Background: Prior studies have used 16S rRNA sequencing to examine and define the local breast microbiome, but this has not been investigated with respect to breast reconstruction. Periexpander fluid can be readily collected in patients with a dual-port tissue expander, which could allow us to define the local breast microbiome at any given time point. This study aimed to determine the feasibility of obtaining microbiome data from periexpander fluid and explore its potential relevance for clinical implant infections.Methods: We designed a pilot study including patients undergoing mastectomy with 2-stage implant-based reconstruction using dual-port tissue expanders. The periexpander fluid was obtained by accessing the aspiration port during standard postoperative visits, and this fluid was stored in a 1:1 ratio with DNA/RNA shield at -20°C. The microbiome of each sample was defined using 16S rRNA microbiome sequencing.Results: Intraoperative and postoperative samples from 10 patients were sequenced to determine the feasibility of obtaining microbiome data from the periexpander aspirates. We were successful in obtaining microbiome data from all aspirates. Our results indicate that there are a large range of genera represented, but several genera appear to be more pervasive, including Pseudomonas, Corynebacterium, Phenylobacterium, Acinetobacter, and Staphylococcus.Conclusions: We found that it is feasible to perform microbiome sequencing of breast tissue and periexpander aspirates to define the local breast environment. Rather than focusing on eliminating bacteria, it is critical to learn more about how we can optimize the balance of microorganisms in the breast microbiome to minimize infection risk.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6928"},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buttock Augmentation Using Doppler Ultrasound-guided Cannulation for Patient Safety.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006940

Luis F Reyes, Nicole G Echeverry, Hugo A Aguilar, Juan M Velasco, Brian Ramírez, Silvia Villabona, Hector M Serrano, Agustina Varela

{"title":"Buttock Augmentation Using Doppler Ultrasound-guided Cannulation for Patient Safety.","authors":"Luis F Reyes, Nicole G Echeverry, Hugo A Aguilar, Juan M Velasco, Brian Ramírez, Silvia Villabona, Hector M Serrano, Agustina Varela","doi":"10.1097/GOX.0000000000006940","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006940","url":null,"abstract":"Background: Augmentation gluteoplasty performed through autologous fat grafting is a surgical technique that volumizes the buttock and shapes the gluteal region according to the patient's expectations, but it is one of the most dangerous aesthetic surgical procedures due to the high rate of the complication and mortality. The aim of the study was to assess the safety of subcutaneous gluteal fat grafting using ultrasound-guided cannulation.Methods: A retrospective study of the clinical outcomes of gluteal augmentation with Doppler ultrasound-assisted fat grafting was conducted. The medical records of 177 patients who underwent gluteal augmentation between February and May 2024 were analyzed.Results: In a sample of 177 patients who received gluteal fat grafting, we found that the visualization of perforating arteries had a median of 9 arteries (interquartile range: 2) per buttock. Distribution by quadrants varied among patients. The use of Doppler ultrasound-guided fat grafting was shown to be safe; related complications included 5 patients with hematomas, 2 with seromas, and 1 with suture dehiscence; no cases of infection, deep vein thrombosis, pulmonary embolism, or death were reported.Conclusions: Subcutaneous gluteal lipoinjection with Doppler ultrasound indirect vision is a procedure that meets patient safety standards. It allows visualization of the tissue where the fat is grafted, reducing the risk of developing thrombotic events by identifying risk structures such as the intramuscular plane and vascular structures. Achieving a good aesthetic result and a low complication rate requires prior training in the use of ultrasound specifically for gluteal lipoinjection using Doppler.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6940"},"PeriodicalIF":1.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Intestinal Fistulization Managed With Vacuum Therapy.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006874

Sandro Cilindro de Souza, Diego de Almeida Meneses

引用次数: 0

Complex Nasal Reconstruction With Free Superficial Circumflex Iliac Artery/Inferior Epigastric Artery Flaps and Exteriorized Skin-grafted Pedicles.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006953

Alberto Franchi, Ioannis Kyriazidis, Marc Baltensperger, Florian Jung, Abdul Rahman Jandali

{"title":"Complex Nasal Reconstruction With Free Superficial Circumflex Iliac Artery/Inferior Epigastric Artery Flaps and Exteriorized Skin-grafted Pedicles.","authors":"Alberto Franchi, Ioannis Kyriazidis, Marc Baltensperger, Florian Jung, Abdul Rahman Jandali","doi":"10.1097/GOX.0000000000006953","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006953","url":null,"abstract":"Reconstruction of extensive nasal defects is technically demanding due to the nose's aesthetic importance and intricate 3-dimensional structure. The gold standard for nasal reconstruction typically involves local flaps, with or without the addition of free flaps, depending on the defect's extent and complexity. In cases where conventional reconstructive options are unavailable, innovative approaches may be considered. A 79-year-old woman presented with a large nasal defect following the excision of an extensive basal cell carcinoma and multiple failed reconstruction attempts. Due to the unavailability of pedicled forehead flaps, an alternative approach was adopted using abdominal free skin flaps, specifically, a flap based on the superficial branch of the superficial circumflex iliac artery, followed by a flap based on the superficial inferior epigastric artery, incorporating an exteriorized skin-grafted pedicle to minimize further damage to facial tissues. This approach achieved nasal reconstruction with satisfactory aesthetic and functional outcomes by using redundant abdominal skin, while avoiding the use of large local facial flaps that could have resulted in additional tissue injury and distortion. Abdominal skin represents a promising donor site for flaps in the reconstruction of complex nasal defects. Although the exteriorized skin-grafted pedicle technique carries inherent risks, it warrants further investigation as a potentially valuable advancement in the reconstructive armamentarium.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6953"},"PeriodicalIF":1.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Breast Reconstruction With Concurrent Profunda Artery Perforator Flap and Autologous Fat Grafting.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006956

Pacifico Armando M Cruz, Hironobu Aoki, Mariko Inoue, Rei Ogawa

{"title":"Immediate Breast Reconstruction With Concurrent Profunda Artery Perforator Flap and Autologous Fat Grafting.","authors":"Pacifico Armando M Cruz, Hironobu Aoki, Mariko Inoue, Rei Ogawa","doi":"10.1097/GOX.0000000000006956","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006956","url":null,"abstract":"The profunda artery perforator (PAP) flap has become an important option in breast reconstruction, particularly for patients with prior abdominal surgery, insufficient abdominal tissue, or those who prefer to avoid abdominal scars. Despite its advantages, the PAP flap may be limited by insufficient volume relative to the size of the mastectomy defect. We present the case of a 64-year-old woman with scleroderma and a body mass index of 20.9 kg/m² who was diagnosed with right breast cancer. She underwent a nipple-sparing mastectomy and sentinel lymph node biopsy, followed by immediate reconstruction using a PAP flap harvested from the left posteromedial thigh. To complement the flap, fat was harvested from the flap periphery and injected into the pectoralis muscle and subcutaneous space to enhance contour and shape. Postoperatively, the patient experienced no complications, with no evidence of flap compromise, necrosis, or donor site issues. She expressed satisfaction with the reconstructed breast volume and contour, and the unnoticeable donor site scar. This case demonstrated the benefits of combining PAP flap reconstruction with autologous fat grafting to achieve sufficient breast volume and contour, particularly in patients with low body mass index or challenging tissue conditions. The synchronous use of microvascular reconstruction and regenerative techniques maximizes outcomes, avoids secondary procedures, and provides a viable solution for immediate breast reconstruction. Further research is needed to validate the long-term efficacy of this combined approach.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6956"},"PeriodicalIF":1.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Reconstruction in Becker Nevus Syndrome.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006957

Alexis K Schlosser, Mohammed S Rais, Ruston J Sanchez

{"title":"Breast Reconstruction in Becker Nevus Syndrome.","authors":"Alexis K Schlosser, Mohammed S Rais, Ruston J Sanchez","doi":"10.1097/GOX.0000000000006957","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006957","url":null,"abstract":"Becker nevus syndrome is a rare cutaneous disorder characterized by the presence of a hyperpigmented patch of skin typically occurring on the upper trunk, often associated with hypertrichosis, and sometimes associated with musculoskeletal abnormalities ipsilateral to the nevus. Becker nevus syndrome can lead to breast hypoplasia. Unlike other forms of breast hypoplasia, treatment should begin before the completion of breast development. Due to the rarity of the disease, breast reconstruction in these patients has no gold-standard approach, and treatment is often delayed. Therefore, our case report highlighted the need for early treatment and provided options for reconstruction in this population. Our case reported a single surgeon approach to breast hypoplasia in Becker nevus syndrome. Consent was obtained for medical photography and research purposes. A 37-year-old woman with hypertension presented with concerns regarding drastic breast asymmetry. On examination, she was noted to have significant breast asymmetry with right-sided hypoplasia, left macromastia, and a patchy hyperpigmented lesion along the right chest wall. After a discussion of surgical options, a right breast augmentation and left breast reduction was performed. The patient had no postoperative complications. She was satisfied with her breast size and symmetry at her 6-month postoperative clinic follow-up. Becker nevus syndrome in women may be more frequent than previously described in the literature, as it often goes undiagnosed. Little literature exists on providing surgical options. This article demonstrated a single-stage reconstruction that provided satisfactory results and improvement in symmetry.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6957"},"PeriodicalIF":1.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facial Anatomy Teaching for Aesthetic Surgery: Using 3-dimensional Photogrammetry and Immersive Virtual Reality.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006972

Sara M Hussein, Andrew F Emanuels, Luciano César P C Leonel, Nirusha Lachman, Maria Peris Celda, Jonathan M Morris, Eric M Sheahan, Erick O Martinez, Christian R Hanson, Basel A Sharaf

{"title":"Facial Anatomy Teaching for Aesthetic Surgery: Using 3-dimensional Photogrammetry and Immersive Virtual Reality.","authors":"Sara M Hussein, Andrew F Emanuels, Luciano César P C Leonel, Nirusha Lachman, Maria Peris Celda, Jonathan M Morris, Eric M Sheahan, Erick O Martinez, Christian R Hanson, Basel A Sharaf","doi":"10.1097/GOX.0000000000006972","DOIUrl":"https://doi.org/10.1097/GOX.0000000000006972","url":null,"abstract":"Anatomy is a critical component of surgical training; however, traditional resources-such as Netter's Surgical Anatomy, Gray's Anatomy, and anatomy applications-often fall short in delivering surgically relevant, 3-dimensional (3D) perspectives of facial anatomy. Although cadaveric dissection remains a valuable teaching tool, its accessibility is limited by cost, ethical concerns, and the lack of structured curricula, making it less feasible for ongoing surgical education. To address these limitations, this article introduced a novel educational approach that integrates 3D photogrammetry and virtual reality technology into the surgical anatomy curriculum for craniofacial and aesthetic surgery. Six fresh cadaveric specimens were meticulously dissected by a plastic surgeon to illustrate the intricate layered anatomy of the face and neck. At each stage of the dissection, a photogrammetry technique was used to capture 360-degree images using 5 digital single-lens reflex cameras alongside a 3D handheld camera. This approach not only ensured high-quality imaging but also facilitated the creation of detailed, lifelike virtual 3D models, enhancing the understanding of facial and neck anatomy within a surgical context. Additionally, we present some technical refinements of the 3D volume renderings to capture precise anatomical details during our dissections. Preliminary results from the use of this technology in anatomy courses and workshops indicated trainee engagement, a clearer grasp of the spatial anatomical relationships, and greater confidence in applying this knowledge to hands-on surgical procedures.","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6972"},"PeriodicalIF":1.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surprise Baby: Abdominoplasty Performed During Unknown Pregnancy.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006967

Alisha E Suri, Christyn Mellor, Daniel Murariu

引用次数: 0

CAD/CAM Mandible Reconstruction: Focus on Surgical Access Planning.

IF 1.5

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-07-09 eCollection Date: 2025-07-01 DOI: 10.1097/GOX.0000000000006962

Luca Colombo, Giulia Tirelli, Alessandro R Bolzoni, Alessandro Baj, Giada A Beltramini

引用次数: 0