Plastic and reconstructive surgery最新文献

{"title":"Improving Speech Outcomes in Low- and Middle-Income Countries for Patients Born with Cleft Palate.","authors":"Catherine J Crowley","doi":"10.1097/PRS.0000000000012374","DOIUrl":"https://doi.org/10.1097/PRS.0000000000012374","url":null,"abstract":"<p><strong>Summary: </strong>This article reviews the research and current practices aimed at building cleft speech therapy capacity in low- and middle-income countries (LMICs), given the paucity of qualified speech-language pathologists with cleft palate expertise. The importance of a successful initial palate repair is emphasized, as well as the more specialized training and skills needed for speech clinicians working with patients requiring secondary procedures. Intensive short-term cleft speech clinics (ISSCs), which incorporate both didactic learning and hands-on clinical experiences, are introduced. Outcomes, advantages, and limitations of ISSCs are discussed. Resources for ongoing support of cleft speech therapy in local languages in LMICs are described, including online classes with accompanying assessments in 5 languages, cleft speech assessment screeners in 30 languages, and cleft therapy word games in almost 40 languages, covering more than 200 different sounds. Recommendations for building capacity for cleft speech therapy are provided, including (1) identifying and addressing factors leading to a greater likelihood of velopharyngeal insufficiency or fistulas after primary palate repair; (2) expanding the use of ISSCs to build capacity in cleft palate speech therapy in LMICs, where more traditional weekly or biweekly therapy sessions are challenging due to long distances between the patient homes and the speech providers; and (3) continuing to create and disseminate speech care courses, trainings, and mentorship opportunities for cleft speech therapy. These recommendations are meant to implement the current research to meet the goal of improving speech outcomes for all children born with cleft palate, especially those born in LMICs.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":"156 4S-2","pages":"14S-22S"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the (Lymph-)Angiogenic Potential of Regenerative Scaffolds and the Impact of Adipose-Derived Mesenchymal Stem Cells.","authors":"Katja K Koll, Donna A Klevansky, Dimitri Kasakovski, Nima Ahmadzadeh, Patrick A Will, Ulrich Kneser, Christoph Hirche","doi":"10.1097/PRS.0000000000012131","DOIUrl":"10.1097/PRS.0000000000012131","url":null,"abstract":"<p><strong>Background: </strong>Regenerative matrices are essential in the therapy of complex wounds, where lymphangiogenesis and angiogenesis play crucial roles. This work investigates the lymph and angiogenic potential of regenerative scaffolds and the influence of adipose-derived mesenchymal stem cells (ADSC) in a rodent wound model.</p><p><strong>Methods: </strong>In a wound model, the authors administered different acellular dermal matrices (ADMs) to 2 wounds on each rat-enriching 1 with ADSCs and leaving the other without. ADSCs were isolated from rodent inguinal fat tissue, characterized using fluorescence-activated cell sorting and their viability confirmed in vitro on different matrices. Tissue samples were collected on days 7, 14, 21, and 28 postoperatively. Six different ADMs, including 2 synthetic and 4 biological variants, were compared using histologic, immunofluorescence staining, and molecular biological analyses.</p><p><strong>Results: </strong>ADM integration varied, with collagen (COL)-elastin-ADM showing the highest integration (95%) and polyurethane (PU)-ADM, the lowest (23%) after 7 days. Synthetic ADMs, particularly PU-ADM, exhibited the highest mRNA expression of angiogenesis and lymphangiogenesis markers at 7 and 28 days. Protein analysis showed that synthetic ADMs had the highest CD31 levels from 14 to 28 days, whereas COL-ADM had the highest LYVE1 and PROX1 levels at 21 and 28 days. Immunofluorescence revealed polylactide-ADM consistently had the highest CD31 and LYVE1 signals at various times, with PU-ADM and COL-ADM peaking at 28 days. The application of ADSCs did not enhance lymphangiogenesis or angiogenesis.</p><p><strong>Conclusions: </strong>ADM material properties impact lymphangiogenesis and angiogenesis, guiding therapeutic selection and tissue regeneration. This study highlights COL-, polylactide-, and PU-ADMs as the most effective in promoting these processes.</p><p><strong>Clinical relevance statement: </strong>This study provides valuable insights into the unique material properties of ADMs, highlighting COL-, polylactide-, and PU-ADMs as exhibiting the most robust effects on lymphangiogenesis and angiogenesis.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"509e-520e"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Diagnostic Criteria for Cubital Tunnel Syndrome.","authors":"Kevin R Cuneo, Devin W Collins, Constance M Sullivan, Nina Suh, Eric R Wagner, Michael B Gottschalk","doi":"10.1097/PRS.0000000000012169","DOIUrl":"10.1097/PRS.0000000000012169","url":null,"abstract":"<p><strong>Background: </strong>Cubital tunnel syndrome (CuTS) is the second most common compressive neuropathy of the upper extremity. The authors aimed to determine the importance of diagnostic criteria for CuTS.</p><p><strong>Methods: </strong>Expert opinion previously reached a consensus on the 6 most important criteria for CuTS diagnosis using Delphi. These criteria were used to create 64 unique CuTS vignettes. Two groups of 8 hand surgeons evaluated these vignettes. One group made a binary diagnosis of CuTS; the second group used a 10-cm visual analog scale (VAS) to rate the likelihood of CuTS. The results were used to develop a logistic regression model and a multiple linear regression model, respectively, to predict the probability of CuTS from the weighted criteria. Correlation between the logistic regression model probabilities and the panelist VAS scores was calculated. The probabilities produced by these models were correlated with the number of criteria in each case.</p><p><strong>Results: </strong>The correlation between the probabilities of CuTS predicted by the logistic regression with the panelists' VAS scores was 0.291. The correlation between the number of criteria present and the predicted probabilities of the logistic and the multiple regression models were 0.638 and 0.923, respectively.</p><p><strong>Conclusions: </strong>This study found that there is no agreement on the relative importance of the 6 diagnostic criteria for CuTS among experts. However, the sum of the number of criteria present is a good predictor of the probability of CuTS. Furthermore, a threshold of 3 positive criteria can help clinicians diagnose CuTS with high confidence.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"583-589"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRS Journal Club: Deep Plane Rhytidectomy, Pollybeak Prevention in Open Rhinoplasty, and Private Equity in Aesthetic Surgery.","authors":"Amanda R Sergesketter, Ilana G Margulies, Christopher L Kalmar","doi":"10.1097/PRS.0000000000012267","DOIUrl":"10.1097/PRS.0000000000012267","url":null,"abstract":"","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":"156 4","pages":"674-675"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plastic and Reconstructive Surgery Best Paper Awards 2025.","authors":"Kevin C Chung, Aaron Weinstein, Joseph J Disa, Bernard L Markowitz, Samuel J Lin, Amy S Colwell, Justine C Lee, Kyle R Eberlin, Larry Hollier, Edward I Chang, John P Fischer, Matthew M Hanasono, Ash Patel, John Y S Kim","doi":"10.1097/PRS.0000000000012340","DOIUrl":"https://doi.org/10.1097/PRS.0000000000012340","url":null,"abstract":"","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":"156 4","pages":"663-669"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the Impact of C7 Spinal Nerve Harvest on Spontaneous, Patient-Initiated Movement of the Donor Upper Extremity.","authors":"Whitney E Muhlestein, Tommy Nai-Jen Chang, Rachel N Logue Cook, Kate W-C Chang, Johnny Chuieng-Yi Lu, Kevin C Chung, Lynda J-S Yang, Susan H Brown, David Chwei-Chin Chuang","doi":"10.1097/PRS.0000000000011825","DOIUrl":"10.1097/PRS.0000000000011825","url":null,"abstract":"<p><strong>Background: </strong>Transfer of a healthy C7 spinal nerve is a tool for upper extremity reanimation in patients with severe brachial plexus injury (BPI). Its use remains controversial because of concern for neurologic injury to the donor arm. Using wearable motion-sensor technology, the authors aimed to quantify donor arm morbidity after C7 spinal nerve harvest in patients with pan-BPI, reporting both the time and magnitude of donor arm movement in a real-world setting compared with healthy controls.</p><p><strong>Methods: </strong>Seventeen patients who underwent contralateral C7 (CC7) transfer for traumatic pan-BPI at least 2 years prior were compared with 14 healthy controls. Each participant wore an accelerometer on both arms for 7 consecutive days. The vector time (VT) (or time of movement measured in hours per day) and the vector magnitude (VM) (or magnitude of arm movement measured as a single vector magnitude per second) were collected and compared between groups. The correlation between VT and VM and time from C7 spinal nerve harvest was also calculated.</p><p><strong>Results: </strong>At a mean of 7.7 years after C7 spinal nerve harvest, there was no difference between donor and control arms for VT (5.76 ± 1.55 versus 5.45 ± 1.22 hours; P = 0.56) or VM (2,242,236 ± 753,853 versus 1,919,223 ± 579,723 activity counts; P = 0.20), regardless of donor arm dominance. The C7 harvest cohort used the injured arm 53% of the time and with 27% of the power of the donor arm.</p><p><strong>Conclusion: </strong>There was no significant difference in time or magnitude of arm movement between donor arms and the arms of healthy controls.</p><p><strong>Clinical question/level of evidence: </strong>Therapeutic, IV.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"534e-540e"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Lymphedema Duration on Lymphatic Vessel Quality and Outcomes after Super-microsurgical Lymphaticovenous Anastomosis.","authors":"George Taliat, Yu-Che Ou, Yu-Ming Wang, Chad Chang, Shao-Chun Wu, Wei-Che Lin, Peng-Chen Chien, Ching-Hua Hsieh, Johnson Chia-Shen Yang","doi":"10.1097/PRS.0000000000012061","DOIUrl":"10.1097/PRS.0000000000012061","url":null,"abstract":"<p><strong>Background: </strong>Inferior lymphatic vessel (LV) quality was thought to be associated with prolonged lymphedema duration (LD), which can lead to unfavorable lymphaticovenous anastomosis (LVA) outcomes. However, increasing evidence supports the use of LVA in the treatment of advanced lymphedema. Thus, this study aimed to determine the impact of LD on LV quality and outcomes after LVA in patients with secondary lower limb lymphedema.</p><p><strong>Methods: </strong>A total of 189 patients who underwent supermicrosurgical LVA were retrospectively reviewed and enrolled. The study group (LD > 3.6 years) and the control group (LD ≤ 3.6 years) consisted of 94 and 95 patients, respectively. Patients with previous LVA, liposuction, or excisional therapy were excluded. Patient characteristics, intraoperative findings, functional parameters, and volume changes were recorded, and the parameters, except LD, were matched using propensity score matching. The primary endpoint was volume change at 6 and 12 months after LVA.</p><p><strong>Results: </strong>Before matching, the study group had significantly higher ratios of indocyanine green-enhanced, lymph flow-positive, and normal plus ectatic LVs ( P = 0.016, P = 0.035, and P = 0.002, respectively) than the control group. After all parameters except LD were matched, 64 patients were included in each group, with higher median LD in the study group (7.8 years versus 1.1 years; P < 0.001) than the control group. However, no significant intergroup differences were found in postoperative percentage volume reduction at the 6- and 12-month follow-up ( P = 0.813 and P = 0.627, respectively).</p><p><strong>Conclusions: </strong>Contrary to common belief, longer LD did not negatively affect LV quality and outcomes after LVA. Therefore, LVA remains a viable treatment option for patients with longstanding lymphedema.</p><p><strong>Clinical question/level of evidence: </strong>Risk, II.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"593e-603e"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preexpanded Perforator Flaps for Neoesophageal Reconstruction after Bipolar Upper Gastrointestinal Tract Exclusion.","authors":"Nicolas Bertheuil, Damien Bergeat, Bernard Meunier, Maximilien Thoma, Yanis Berkane, Benoit Lengelé","doi":"10.1097/PRS.0000000000012077","DOIUrl":"10.1097/PRS.0000000000012077","url":null,"abstract":"<p><strong>Background: </strong>Total esophageal reconstruction after failure of conventional techniques is a significant surgical challenge, particularly in fragile patients who have undergone multiple surgical procedures. Traditional options, including gastroplasties, colon transfers, and free jejunal flaps, are associated with high morbidity rates, failure rates, or surgical complexity.</p><p><strong>Methods: </strong>The authors report an innovative 4-step strategy for esophageal reconstruction using a presternal skin tube created with tissue expanders and perforator flap techniques. Six patients with previous definitive esophageal exclusion underwent reconstruction between 2009 and 2023. The procedure involved patients with complex medical history and multiple reconstruction failures, including gastroplasties, coloplasties, or ileocoloplasties, and consisted of chest skin expansion with tissue expanders, tubularization of a perforator flap based on internal mammary vessels, anastomosis of the distal skin tube with a jejunal Y loop, and proximal anastomosis to the native cervical esophagus.</p><p><strong>Results: </strong>The entire reconstructive process was completed over 17.5 ± 7.3 months. All patients achieved restoration of digestive tract continuity. Minor complications, including wound dehiscence and fistulas, were observed in all patients, but resolved without major intervention. Functional outcomes were favorable, with a maximum follow-up of 15 years and patients tolerating liquids, semisolids, and solid foods after 2 to 3 months. Imaging and endoscopy confirmed lumen integrity, absence of strictures, and static skin-like epithelium without ulceration.</p><p><strong>Conclusions: </strong>This staged reconstruction offers a viable and safe alternative for total esophageal replacement in complex, high-risk cases, avoiding additional extensive intrathoracic procedures. The presternal neoesophagus provides acceptable function with manageable complications.</p><p><strong>Clinical question/level of evidence: </strong>Therapeutic, IV.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"576e-584e"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staged Breast Reduction or Mastopexy before Nipple-Sparing Mastectomy: A Systematic Review and Meta-Analysis.","authors":"Ella Gibson, Matthew M Farajzadeh, Ara A Salibian","doi":"10.1097/PRS.0000000000012118","DOIUrl":"10.1097/PRS.0000000000012118","url":null,"abstract":"<p><strong>Background: </strong>Macromastia and breast ptosis have traditionally been considered to be relative contraindications to nipple-sparing mastectomy (NSM) because of concerns regarding nipple and mastectomy flap viability. Staged breast reduction or mastopexy before NSM has demonstrated promising results in decreasing these complications, although data are limited to single-center studies with small sample sizes.</p><p><strong>Methods: </strong>A systematic review of PubMed, Scopus, and Cochrane databases was performed to identify all studies analyzing reconstructive outcomes in patients who underwent staged breast reduction or mastopexy before NSM. Descriptive analyses of surgical techniques and reconstructive outcomes were performed for relevant articles included for analysis. Random-effects model meta-analysis was performed to assess complication rates.</p><p><strong>Results: </strong>Eleven studies, with a pooled total of 542 breasts (288 patients), were identified for analysis. The majority of mastectomies were performed prophylactically (79.2%). Staged breast reduction was performed in 75.2% of patients, and mastopexy was performed in 24.5%. The mean reduction weight per breast was 354.4 ± 64.0 g, and the mean mastectomy specimen weight was 527.5 ± 207.9 g. Autologous techniques were used for reconstruction in 39.7% of breasts, 59.6% had implant-based reconstruction, and 0.7% of cases had hybrid reconstruction. Meta-analysis demonstrated low rates of complications in patients who underwent staged NSM, including nipple-areola complex necrosis (3.1%; 95% CI, 0.8% to 6.3%) and mastectomy flap necrosis (2.4%; 95% CI, 0.1% to 6.3%).</p><p><strong>Conclusions: </strong>Systematic review and meta-analysis of outcomes for staged breast reduction or mastopexy demonstrate low rates of nipple and mastectomy flap necrosis. These data suggest thaprophylactic optimization of breast morphology can improve outcomes and expand candidacy for nipple-sparing procedures.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"461e-471e"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Large Prospective Volumetric and Patient-Reported Outcome Analysis of Hyaluronic Acid Facial Fillers.","authors":"Harrison D Davis, Daniel Mazzaferro, Theodore E Habarth-Morales, Charles A Messa, Ankoor A Talwar, Abhishek A Desai, Phoebe B McAuliffe, Robyn B Broach, Joseph M Serletti, Ivona Percec","doi":"10.1097/PRS.0000000000012135","DOIUrl":"10.1097/PRS.0000000000012135","url":null,"abstract":"<p><strong>Background: </strong>Hyaluronic acid (HA) facial fillers are a nonsurgical treatment for age-related changes. Literature on long-term volumetric results and patient-reported outcomes (PROs) is limited. This prospective study aimed to precisely define and measure objective tissue metrics and PROs of HA fillers in different facial regions over 12 weeks.</p><p><strong>Methods: </strong>Women 40 to 65 years of age received injections in facial regions using HA fillers: Restylane-L in nasolabial folds and marionette lines, Restylane-L Lyft in the malars, and Restylane Silk in the lip border. Patients completed the FACE-Q, and were photographed with 3-dimensional Vectra M3 imaging software before injection, immediately after injection, and at 2, 4, and 12 weeks after injection. Volumes were analyzed from 8 regions: left and right malars and extended midface, upper perioral, lower perioral and jawline, and lips. Tissue displacement factor (TDF) and effective volume (EV) were calculated. Statistical analyses included Mann-Whitney U tests and risk-adjusted linear regression.</p><p><strong>Results: </strong>A total of 101 women participated. Restylane-L Lyft had the highest TDF (1.25), followed by Restylane-L (1.14) and Restylane Silk (0.56). EV for Restylane-L Lyft was highest (89.8%), followed by Restylane-L (89.7%) and Restylane Silk (70%). Volume maintenance was 65.5% (whole face), 79.2% (malars and extended midface), 62.7% (upper perioral), and 37.2% (lips) over 12 weeks. PROs demonstrated improvements in facial appearance, treated regions, and psychologic and social function.</p><p><strong>Conclusions: </strong>The authors defined novel tissue metrics-TDF and EV-relative to HA treatments, with greatest volume maintenance in the midface and greatest loss around the mimetic areas through 12 weeks. Significantly improved PROs were observed for patients undergoing large-volume HA filler injections.</p><p><strong>Clinical question/level of evidence: </strong>Therapeutic, IV.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"550-559"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}