发布求助
文献互助 智能选刊 最新文献

Physiological chemistry and physics最新文献

筛选
英文 中文
Comments on Kernan's misrepresentation of the association-induction hypothesis in his book Cell Potassium. 评论Kernan在其著作《细胞钾》中对联想-诱导假说的错误表述。
Physiological chemistry and physics Pub Date : 1982-01-01
L Edelmann
{"title":"Comments on Kernan's misrepresentation of the association-induction hypothesis in his book Cell Potassium.","authors":"L Edelmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"14 3","pages":"215-8"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18200708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial disease in man. Report of a probable case with successful therapy. 人类线粒体疾病报告一例成功治疗的可能病例。
Physiological chemistry and physics Pub Date : 1981-01-01
F W Cope
{"title":"Mitochondrial disease in man. Report of a probable case with successful therapy.","authors":"F W Cope","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Probable mitochondrial damage in brain and possibly in other tissues of an elderly woman after open heart surgery was treated by therapy aimed at providing the cell with materials necessary to synthesize new mitochondria to replace those damaged by imperfect perfusion of body tissues with blood by the artificial heart-lung machine. Large quantities of B-complex vitamins for Krebs cycle enzyme cofactors, vitamin C for protein synthesis, and ribonucleic acid for templates for protein synthesis were provided. With this therapy started 5 days post-operatively, marked acceleration of clinical recovery from a previously static state of presumed mitochondrial damage occurred. On the basis of animal experiments, a diagnosis of mitochondrial damage is suggested to be reasonable in appropriate human patients. On the basis of the successful result reported here, specific mitochondrial therapy is suggested as feasible and probably beneficial for patients with a diagnosis of mitochondrial damage.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 3","pages":"275-9"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18315158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical studies on tricyclic antidepressants: III. Analysis of stereospecificity. 三环类抗抑郁药的理论研究:立体特异性分析。
Physiological chemistry and physics Pub Date : 1981-01-01
K Sundaram, S Mahajan
{"title":"Theoretical studies on tricyclic antidepressants: III. Analysis of stereospecificity.","authors":"K Sundaram,&nbsp;S Mahajan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By dynamic simulation of molecular structures in a digital computer, search was made for all possible ways of superposing a phenyl ring of a tricyclic antidepressant on the phenyl ring of norepinephrine. Using all available structure activity data and deductive reasoning, attempt was then made to reject all but one superposition. A significant outcome was information regarding 2-hydroxydesipramine. Although manifestly inactive when administered, this drug is likely to be potent if delivered at the neuronal site of action. From the chosen superposition a dihydroxy derivative is predicted to be even more potent if it can be endogenously generated or suitably modified to enable delivery at the site of action. Among the various superpositions obtained, it was indirectly possible to make a Monte Carlo type of conformational analysis on the side chain of norepinephrine. Previous conformational studies on norepinephrine are reviewed in this context.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 5","pages":"387-406"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunologic reactions carried out at high altitude at a liquid-solid interface. 在高海拔的液-固界面上进行的免疫反应。
Physiological chemistry and physics Pub Date : 1981-01-01
A Rothen, A Baer
{"title":"Immunologic reactions carried out at high altitude at a liquid-solid interface.","authors":"A Rothen,&nbsp;A Baer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 1","pages":"25-7"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18282449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An approach to chemical characterization of human placental extracts: proteins, peptides, and amino acids analyses. 人胎盘提取物的化学表征方法:蛋白质、多肽和氨基酸分析。
Physiological chemistry and physics Pub Date : 1981-01-01
D Carotti, E Allegra
{"title":"An approach to chemical characterization of human placental extracts: proteins, peptides, and amino acids analyses.","authors":"D Carotti,&nbsp;E Allegra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A procedure is described for characterization of the proteinic, peptidic, and amino-acidic components of human placental extracts. Four different preparations were analyzed. The first was an extract prepared in our laboratory from fresh on-term placenta. The other three were commercial products obtained by different procedures including autolysis and sterilization. The patterns given by each type of preparation are reproducible and characteristic.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 2","pages":"129-36"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18291497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The logistic curve for the fitting of sigmoidal data. 拟合s型数据的logistic曲线。
Physiological chemistry and physics Pub Date : 1981-01-01
L C Cerny, D M Stasiw, W Zuk
{"title":"The logistic curve for the fitting of sigmoidal data.","authors":"L C Cerny,&nbsp;D M Stasiw,&nbsp;W Zuk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 1838 a differential equation was developed by Verhulst to explain what is currently termed the S-shaped curve. Reviewed here are his application of the equation to population data and significant later applications by various workers to problems in physics, chemistry, and biology. The usefulness, versatility, and convenience of this integrated equation are illustrated by examples from our own work, including superimposition of data by use of reduced variables.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 3","pages":"221-30"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18315154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactivity of sarcoplasmic reticulum from rabbit cardiac muscle with 1-fluoro- and 1,5-difluoro- 2,4-dinitrobenzene. 兔心肌肌浆网与1-氟和1,5-二氟- 2,4-二硝基苯的反应性。
Physiological chemistry and physics Pub Date : 1981-01-01
G Bailin
{"title":"Reactivity of sarcoplasmic reticulum from rabbit cardiac muscle with 1-fluoro- and 1,5-difluoro- 2,4-dinitrobenzene.","authors":"G Bailin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sarcoplasmic reticulum preparations from rabbit cardiac and fast skeletal muscle react differentially with low concentrations of 1-fluoro- and 1,5-difluoro-2,4-dinitrobenzene. Dinitrophenylation of cardiac sarcoplasmic reticulum by 1-fluoro-2,4-dinitrobenzene is not affected by Ca2+ and is limited to the lipoprotein-lipid region. This contrasts sharply with the predominant Ca2+-dependent dinitrophenylation of the ATPase protein of rabbit skeletal sarcoplasmic reticulum by this reagent. Formation of non-serial high mol. wt. oligomers by 1,5-difluoro-2,4-dinitrobenzene is significantly greater in cardiac than in skeletal vesicles. Substrate MgATP2- does not protect rabbit cardiac sarcoplasmic reticulum ATPase activity or Ca2+ uptake from dinitrophenylation when monofunctional and bifunctional reagents are used. Chemical differences in the overall structure of the two kinds of membrane preparations can be ascertained from a comparison of the effects of Ca2+ and MgATP2- on the reactivity of these reagents.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 2","pages":"121-7"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17514897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of protein synthesis in cell cultures by vanadate and in brain homogenates of rats fed vanadate. 钒酸盐对细胞培养和饲喂钒酸盐的大鼠脑匀浆中蛋白质合成的抑制作用。
Physiological chemistry and physics Pub Date : 1981-01-01
M R Montero, C Guerri, M Ribelles, S Grisolía
{"title":"Inhibition of protein synthesis in cell cultures by vanadate and in brain homogenates of rats fed vanadate.","authors":"M R Montero,&nbsp;C Guerri,&nbsp;M Ribelles,&nbsp;S Grisolía","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Following the observation of polysome disaggregation by vanadate, when Neuro-2a cells were incubated with vanadate, incorporation of 3H-leucine into protein was markedly inhibited. The inhibition of protein synthesis was dependent on vanadate concentration and on time of incubation. Inhibition of cell growth was also observed. Simultaneous measurements on vanadate-treated cells showed decreased Na,K-ATPase activity. Rats given sodium vanadate as their sole drinking fluid also showed an inhibition of brain protein synthesis (18 and 20% after 30 and 60 days, respectively, of treatment). Possible implications of the inhibition of Na,K-ATPase and of protein synthesis by vanadate are discussed.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 3","pages":"281-7"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17334660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascorbic acid as a thiolprive: ability to induce immunity against some cancers in mice. 抗坏血酸作为硫醚:诱导小鼠免疫某些癌症的能力。
Physiological chemistry and physics Pub Date : 1981-01-01
F E Knock, P R Gascoyne, R Sylvester, R Wibel
{"title":"Ascorbic acid as a thiolprive: ability to induce immunity against some cancers in mice.","authors":"F E Knock,&nbsp;P R Gascoyne,&nbsp;R Sylvester,&nbsp;R Wibel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunological studies are reported showing that ascorbic acid, like selected sulfhydryl inhibitors, can induce immunity against some cancers in mice. Accompanying this immunizing action are changes in the surface structure of the cancer cells, as revealed by scanning electron microscopy. Electron spin resonance measurements show that the ascorbate anion free radical is readily produced in oxygenated cancer tissue and that this radical can react with sulfhydryl groups which are free radical scavengers. It is proposed that ascorbate acts as an effective thiolprive in oxygenated cancer tissues. This action is thought to lead to the observed changes in the cancer cell surface structure and to the concomitant immunological response.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 4","pages":"325-33"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17339624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buffer-induced rat liver mitochondrial aggregation during differential centrifugation. 差动离心时缓冲诱导的大鼠肝脏线粒体聚集。
Physiological chemistry and physics Pub Date : 1981-01-01
M Petersons, J B Allred
{"title":"Buffer-induced rat liver mitochondrial aggregation during differential centrifugation.","authors":"M Petersons,&nbsp;J B Allred","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Use of buffers in homogenization media can result in loss of considerable particulate enzyme activity even with low-speed centrifugation. Addition of tris chloride buffer to 0.25 M sucrose homogenization media resulted in precipitation of 80 to 95% of the activity of two mitochondrial marker enzymes (3-hydroxy-3-methylglutaryl CoA lyase and citrate synthase) with the nuclear fraction during differential centrifugation. Lactate dehydrogenase, a cytoplasmic marker, was not precipitated under the same conditions, indicating that the precipitated enzymes were not associated with intact cells. Photomicrographs showed that tris chloride buffers resulted in mitochondrial aggregation. Isolated mitochondria resuspended in tris chloride or potassium phosphate buffer also aggregated, which resulted in a marked decrease in assayable mitochondrial enzyme activity.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":"13 5","pages":"473-80"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17189416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信