Pharmaciana最新文献_第4页

Comparative analysis of the stability features of human alpha-defensins as candidates for the future COVID-19 therapy through molecular dynamics 通过分子动力学对未来新冠肺炎治疗候选人α-防御素稳定性特征的比较分析

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.22616

T. M. Fakih, D. Ramadhan, A. Arfan

引用次数: 0

Fractionation of a phenolic compound from water spinach (Ipomoea aquatica) herbs as anti-dandruff against Malassezia sp. 从水菠菜(Ipomoea aquatica)草药中分离酚类化合物作为抗马拉色菌的去头皮屑。

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.21836

Meta Damaharyuningtyas, K. Kintoko, E. Darmawan

{"title":"Fractionation of a phenolic compound from water spinach (Ipomoea aquatica) herbs as anti-dandruff against Malassezia sp.","authors":"Meta Damaharyuningtyas, K. Kintoko, E. Darmawan","doi":"10.12928/pharmaciana.v12i3.21836","DOIUrl":"https://doi.org/10.12928/pharmaciana.v12i3.21836","url":null,"abstract":"Dandruff is a scalp disorder caused by a fungus ( Malassezia sp. ). Water spinach ( Ipomoea aquatica ) contains phenolic compounds which have antifungal activity. The purpose of this research is to know the active fraction of water spinach ( Ipomoea aquatica ) herbs that have an anti-dandruff activity against Malassezia sp. The study used a true experimental design for an anti-dandruff activity test. Fractionation of water spinach ( Ipomoea aquatica ) methanol extracts used column chromatography which stationary phase with silica gel 60 powder and mobile phase with chloroform: ethanol: acetyl acetate (8:2:0,1). In vitro anti-dandruff activity based on minimum inhibitory concentration (MIC) and minimum antifungal concentration (MFC) against Malassezia sp. of human dandruff isolate. The average of MIC and MFC among groups fraction of water spinach ( Ipomoea aquatica ) methanol extracts compared used Friedman test (p≤ 0,05). Fractionation produces 12 fractions, and fraction number 7 of water spinach ( Ipomoea aquatica ) herbs have the best anti-dandruff activity against Malassezia sp. with MIC 125 µg/mL and MFC 250 µg/mL identified as a phenolic compound. Based on the results, a fraction of phenolic compounds from water spinach ( Ipomoea aquatica ) herbs have anti-dandruff activity against Malassezia sp.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41940243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats Ekor Naga叶乙醇提取物对四氧嘧啶诱导的雄性大鼠的抗糖尿病和抗高血压活性

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.24484

Fathnur Sanik, Yuliasati Yuliawati, Havizur Rahman, A. Samudra

引用次数: 0

The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system 表面活性剂对kencur乙醇提取物在自纳米乳化给药体系中溶解度的影响

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.18881

Beti Pudyastuti, Triyadi Hendra Wijaya

引用次数: 0

In vitro antimicrobial activity and formulation of herbal anti-acne gel containing Rhizophora stylosa fruits extract 根茎草果实提取物抗痘凝胶的体外抑菌活性及配方研究

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.21942

Azrifitria Azrifitria, S. Purwaningsih, Annisa Rahma Fatmala

引用次数: 0

The effect of zinc oxide and Curcuma heyneana Val. combination on stability and sun protection factor (SPF) of lotion 氧化锌与姜黄复合对乳液稳定性及防晒系数的影响

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.23380

D. Ermawati, Dita Yuli Budiasih

引用次数: 0

Analysis of plasmid profiles of Escherichia coli bacteria and their resistance to several antibiotics 大肠杆菌质粒谱分析及其对几种抗生素的耐药性

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.22837

Aldise Indah Nurdevi, Mauritz Pandapotan Marpaung

引用次数: 0

Phytochemicals and toxicity of ketapang fruit flesh (Terminalia catappa. Linn) using the BSLT method ketapang果肉的植物化学成分及毒性。Linn)使用BSLT方法

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.22219

S. Widyaningsih, M. Chasani, Undri Rastuti, U. Salamah

{"title":"Phytochemicals and toxicity of ketapang fruit flesh (Terminalia catappa. Linn) using the BSLT method","authors":"S. Widyaningsih, M. Chasani, Undri Rastuti, U. Salamah","doi":"10.12928/pharmaciana.v12i3.22219","DOIUrl":"https://doi.org/10.12928/pharmaciana.v12i3.22219","url":null,"abstract":"Ketapang is widely used in traditional medicine. Parts of ketapang plant, such as roots, leaves, and bark, are known to have biological activities such as antioxidant, antimicrobial, anti-inflammatory, and anticancer. However, no biological activity has been reported on the flesh of the ketapang fruit. This research was conducted to obtain phytochemicals and toxicity information of ketapang fruit flesh as an anticancer medicine. Toxicity indicates the potential for a chemical compound to cause damage to living organisms, while phytochemicals indicate a group of compounds that have biological activity. Extraction of ketapang fruit flesh was carried out using various solvents, both polar and non-polar solvents , methanol, n-hexane, and ethyl acetate. The toxicity test used the Brine Shrimp Lethality Test (BSLT) method, while phytochemicals tests used the thin layer chromatography (TLC), in which identification of bioactive compounds of ketapang pulp extract used UV-Visible and FTIR spectroscopy. The results showed that the ketapang fruit flesh extract was toxic to Artemia salina Leach shrimp larvae. The most toxic was ethyl acetate extract, with an LC 50 value was 17,171 ppm. The phytochemicals screening showed that ethyl acetate extract of the ketapang fruit flesh contained flavonoid, alkaloid, phenolic, terpenoid, and saponin compounds. Tracing using UV-Vis shows the presence of conjugated double bonds which refer to flavonoid compounds, as well as the IR spectrum which indicates the presence of a typical functional group of flavonoid compounds.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48671052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA identification of kayu kuning (yellow-fruited moonseed) from East Kalimantan, Indonesia 印尼东加里曼丹黄果月子的DNA鉴定

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.23998

Riski Sulistiarini

引用次数: 0

Antibacterial activity of methanol extract Rhizophora mucronata leaves toward Salmonella typhi: leading the typhoid fever 木霉甲醇提取物对伤寒沙门氏菌的抗菌作用

Pharmaciana Pub Date : 2022-11-14 DOI: 10.12928/pharmaciana.v12i3.22475

R. M. Nur, Resmila Dewi, Sutriani Kaliu

引用次数: 1