Pflugers Archiv最新文献

{"title":"Immediate post-breakfast physical activity improves interstitial postprandial glycemia: a comparison of different activity-meal timings","authors":"T. P. Solomon, Eloise Tarry, C. Hudson, Alice I. Fitt, M. Laye","doi":"10.1007/s00424-019-02300-4","DOIUrl":"https://doi.org/10.1007/s00424-019-02300-4","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"334 1","pages":"271 - 280"},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76564892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac inotropy, lusitropy, and Ca2+ handling with major metabolic substrates in rat heart","authors":"Z. Zhao, J. Youm, Y. Wang, J. Lee, J. Sung, Joon-Chul Kim, S. Woo, C. Leem, Sung Joon Kim, Lan Cui, Yin Hua Zhang","doi":"10.1007/s00424-016-1892-8","DOIUrl":"https://doi.org/10.1007/s00424-016-1892-8","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"231 1","pages":"1995 - 2006"},"PeriodicalIF":0.0,"publicationDate":"2016-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73624240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiarrhythmic effect of the Ca2+-activated K+ (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation","authors":"J. Kirchhoff, J. G. Diness, L. Abildgaard, M. Sheykhzade, M. Grunnet, T. Jespersen","doi":"10.1007/s00424-016-1883-9","DOIUrl":"https://doi.org/10.1007/s00424-016-1883-9","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"12 1","pages":"1853 - 1863"},"PeriodicalIF":0.0,"publicationDate":"2016-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72564721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles.","authors":"Feifei Ning, Ling Luo, Shiraz Ahmad, Haseeb Valli, Kamalan Jeevaratnam, Tingzhong Wang, Laila Guzadhur, Dandan Yang, James A Fraser, Christopher L-H Huang, Aiqun Ma, Samantha C Salvage","doi":"10.1007/s00424-015-1750-0","DOIUrl":"10.1007/s00424-015-1750-0","url":null,"abstract":"<p><p>Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to ventricular arrhythmia due to altered Ca(2+) homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established that homozygotic murine RyR2-P2328S (RyR2 (S/S)) hearts show an atrial arrhythmic phenotype associated with reduced action potential (AP) conduction velocity and sodium channel (Nav1.5) expression. We now relate ventricular arrhythmogenicity and slowed AP conduction in RyR2 (S/S) hearts to connexin-43 (Cx43) and Nav1.5 expression and Na(+) current (I Na). Stimulation protocols applying extrasystolic S2 stimulation following 8 Hz S1 pacing at progressively decremented S1S2 intervals confirmed an arrhythmic tendency despite unchanged ventricular effective refractory periods (VERPs) in Langendorff-perfused RyR2 (S/S) hearts. Dynamic pacing imposing S1 stimuli then demonstrated that progressive reductions of basic cycle lengths (BCLs) produced greater reductions in conduction velocity at equivalent BCLs and diastolic intervals in RyR2 (S/S) than WT, but comparable changes in AP durations (APD90) and their alternans. Western blot analyses demonstrated that Cx43 protein expression in whole ventricles was similar, but Nav1.5 expression in both whole tissue and membrane fractions were significantly reduced in RyR2 (S/S) compared to wild-type (WT). Loose patch-clamp studies similarly demonstrated reduced I Na in RyR2 (S/S) ventricles. We thus attribute arrhythmogenesis in RyR2 (S/S) ventricles resulting from arrhythmic substrate produced by reduced conduction velocity to downregulated Nav1.5 reducing I Na, despite normal determinants of repolarization and passive conduction. The measured changes were quantitatively compatible with earlier predictions of linear relationships between conduction velocity and the peak I Na of the AP but nonlinear relationships between peak I Na and maximum Na(+) permeability.</p>","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"37 1","pages":"655-65"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81906183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis","authors":"M. Széll, J. Danis, Z. Bata-Csörgő, L. Kemény","doi":"10.1007/s00424-016-1803-z","DOIUrl":"https://doi.org/10.1007/s00424-016-1803-z","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"45 1","pages":"935 - 943"},"PeriodicalIF":0.0,"publicationDate":"2016-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81290016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of chronic intermittent hypoxia on hematopoiesis and the bone marrow microenvironment","authors":"Inês Alvarez-Martins, Leonor Remédio, Inês Matias, L. Diogo, E. Monteiro, S. Dias","doi":"10.1007/s00424-016-1797-6","DOIUrl":"https://doi.org/10.1007/s00424-016-1797-6","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"18 1","pages":"919 - 932"},"PeriodicalIF":0.0,"publicationDate":"2016-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91086184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular functions of TMEM16/anoctamin","authors":"U. Oh, Jooyoung Jung","doi":"10.1007/s00424-016-1790-0","DOIUrl":"https://doi.org/10.1007/s00424-016-1790-0","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"13 1","pages":"443 - 453"},"PeriodicalIF":0.0,"publicationDate":"2016-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82222681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term repeated corticosterone administration enhances glutamatergic but not GABAergic transmission in the rat motor cortex","authors":"Joanna Kula, A. Błasiak, Anna Czerw, G. Tylko, J. Sowa, Grzegorz Hess","doi":"10.1007/s00424-015-1773-6","DOIUrl":"https://doi.org/10.1007/s00424-015-1773-6","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"16 1","pages":"679 - 691"},"PeriodicalIF":0.0,"publicationDate":"2015-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82654856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons","authors":"Aurélie Menigoz, T. Ahmed, V. Sabanov, Koenraad Philippaert, Shirly Pinto, Sara Kerselaers, A. Segal, M. Freichel, T. Voets, Bernd Nilius, R. Vennekens, D. Balschun","doi":"10.1007/s00424-015-1764-7","DOIUrl":"https://doi.org/10.1007/s00424-015-1764-7","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"6 1","pages":"593 - 607"},"PeriodicalIF":0.0,"publicationDate":"2015-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76469766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells","authors":"R. Crutzen, Myrna Virreira, Nicolas Markadieu, V. Shlyonsky, A. Sener, W. Malaisse, R. Beauwens, A. Boom, P. Golstein","doi":"10.1007/s00424-015-1758-5","DOIUrl":"https://doi.org/10.1007/s00424-015-1758-5","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"15 1","pages":"573 - 591"},"PeriodicalIF":0.0,"publicationDate":"2015-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83738667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}