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No single place for space: neuronal representation of location beyond the hippocampus 没有单一的空间空间:海马区之外的神经元表征
Pflugers Archiv Pub Date : 2022-05-07 DOI: 10.1007/s00424-022-02699-3
A. Draguhn
{"title":"No single place for space: neuronal representation of location beyond the hippocampus","authors":"A. Draguhn","doi":"10.1007/s00424-022-02699-3","DOIUrl":"https://doi.org/10.1007/s00424-022-02699-3","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"8 1","pages":"569 - 571"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88967174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flexible and multifaceted: the plasticity of renin-expressing cells 灵活和多面性:肾素表达细胞的可塑性
Pflugers Archiv Pub Date : 2022-05-05 DOI: 10.1007/s00424-022-02694-8
Katharina A. E. Broeker, Julia Schrankl, Michael Fuchs, A. Kurtz
{"title":"Flexible and multifaceted: the plasticity of renin-expressing cells","authors":"Katharina A. E. Broeker, Julia Schrankl, Michael Fuchs, A. Kurtz","doi":"10.1007/s00424-022-02694-8","DOIUrl":"https://doi.org/10.1007/s00424-022-02694-8","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"11 1","pages":"799 - 812"},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75176749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture 用线扫描多光子显微镜测量单肾元肾小球滤过率与常规显微穿刺的比较
Pflugers Archiv Pub Date : 2022-04-09 DOI: 10.1007/s00424-022-02686-8
Vincenzo Costanzo, Luciano D’Apolito, Donato Sardella, A. Iervolino, G. La Manna, G. Capasso, S. Frische, F. Trepiccione
{"title":"Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture","authors":"Vincenzo Costanzo, Luciano D’Apolito, Donato Sardella, A. Iervolino, G. La Manna, G. Capasso, S. Frische, F. Trepiccione","doi":"10.1007/s00424-022-02686-8","DOIUrl":"https://doi.org/10.1007/s00424-022-02686-8","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"146 1","pages":"733 - 741"},"PeriodicalIF":0.0,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77726990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Correction to: Nobel somatosensations and pain 更正:诺贝尔躯体感觉和疼痛
Pflugers Archiv Pub Date : 2022-04-05 DOI: 10.1007/s00424-022-02689-5
P. Reeh, M. Fischer
{"title":"Correction to: Nobel somatosensations and pain","authors":"P. Reeh, M. Fischer","doi":"10.1007/s00424-022-02689-5","DOIUrl":"https://doi.org/10.1007/s00424-022-02689-5","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"24 1","pages":"647 - 647"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84729479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Europhysiology 2022: bringing together the physiologists of Europe and the World 欧洲生理学2022:汇集欧洲和世界的生理学家
Pflugers Archiv Pub Date : 2022-03-07 DOI: 10.1007/s00424-022-02676-w
R. Brandes, S. Gründer
{"title":"Europhysiology 2022: bringing together the physiologists of Europe and the World","authors":"R. Brandes, S. Gründer","doi":"10.1007/s00424-022-02676-w","DOIUrl":"https://doi.org/10.1007/s00424-022-02676-w","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"165 1","pages":"481 - 482"},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85250912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pflügers Archiv - European journal of physiology becomes the official journal of the German Physiological Society pfl<s:1>格斯档案-欧洲生理学杂志成为德国生理学会的官方杂志
Pflugers Archiv Pub Date : 2020-11-14 DOI: 10.1007/s00424-020-02493-z
M. Hecker, A. Kurtz
{"title":"Pflügers Archiv - European journal of physiology becomes the official journal of the German Physiological Society","authors":"M. Hecker, A. Kurtz","doi":"10.1007/s00424-020-02493-z","DOIUrl":"https://doi.org/10.1007/s00424-020-02493-z","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"118 1","pages":"1657 - 1657"},"PeriodicalIF":0.0,"publicationDate":"2020-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87975336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia. WNK在正常人和镰状细胞贫血患者红细胞中KCl共转运活性调节中的作用。
Pflugers Archiv Pub Date : 2019-12-01 Epub Date: 2019-11-15 DOI: 10.1007/s00424-019-02327-7
David C-Y Lu, Anke Hannemann, Rasiqh Wadud, David C Rees, John N Brewin, Philip S Low, John S Gibson
{"title":"The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia.","authors":"David C-Y Lu, Anke Hannemann, Rasiqh Wadud, David C Rees, John N Brewin, Philip S Low, John S Gibson","doi":"10.1007/s00424-019-02327-7","DOIUrl":"10.1007/s00424-019-02327-7","url":null,"abstract":"<p><p>Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to various stimuli including pH, volume, urea, and oxygen tension, and regulation involves protein phosphorylation. The main aim of this study was to investigate the role of the WNK/SPAK/OSR1 pathway in sickle cells. The pan WNK inhibitor WNK463 stimulated KCC with an EC<sub>50</sub> of 10.9 ± 1.1 nM and 7.9 ± 1.2 nM in sickle and normal red cells, respectively. SPAK/OSR1 inhibitors had little effect. The action of WNK463 was not additive with other kinase inhibitors (staurosporine and N-ethylmaleimide). Its effects were largely abrogated by pre-treatment with the phosphatase inhibitor calyculin A. WNK463 also reduced the effects of physiological KCC stimuli (pH, volume, urea) and abolished any response of KCC to changes in oxygen tension. Finally, although protein kinases have been implicated in regulation of phosphatidylserine exposure, WNK463 had no effect. Findings indicate a predominant role for WNKs in control of KCC in sickle cells but an apparent absence of downstream involvement of SPAK/OSR1. A more complete understanding of the mechanisms will inform pathogenesis whilst manipulation of WNK activity represents a potential therapeutic approach.</p>","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"22 1","pages":"1539-1549"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72756635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors 丁酸是一种肠道细菌代谢物，通过结肠-迷走神经信号和GPR41/43受体降低动脉血压
Pflugers Archiv Pub Date : 2019-11-15 DOI: 10.1007/s00424-019-02322-y
Maksymilian Onyszkiewicz, M. Gawryś-Kopczyńska, P. Konopelski, M. Aleksandrowicz, Aneta Sawicka, E. Kozniewska, E. Samborowska, M. Ufnal
{"title":"Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors","authors":"Maksymilian Onyszkiewicz, M. Gawryś-Kopczyńska, P. Konopelski, M. Aleksandrowicz, Aneta Sawicka, E. Kozniewska, E. Samborowska, M. Ufnal","doi":"10.1007/s00424-019-02322-y","DOIUrl":"https://doi.org/10.1007/s00424-019-02322-y","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"123 1","pages":"1441 - 1453"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72827949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 71
The cytokine alterations/abnormalities and oxidative damage in the pancreas during hypertension development 高血压发展过程中胰腺细胞因子改变/异常和氧化损伤
Pflugers Archiv Pub Date : 2019-10-01 DOI: 10.1007/s00424-019-02312-0
A. Kozłowska, P. Wojtacha, M. Majewski, M. Równiak
{"title":"The cytokine alterations/abnormalities and oxidative damage in the pancreas during hypertension development","authors":"A. Kozłowska, P. Wojtacha, M. Majewski, M. Równiak","doi":"10.1007/s00424-019-02312-0","DOIUrl":"https://doi.org/10.1007/s00424-019-02312-0","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"4 1","pages":"1331 - 1340"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87583424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms 异丙肾上腺素通过不同的机制增强小鼠糖酵解和氧化肌肉的产力
Pflugers Archiv Pub Date : 2019-08-21 DOI: 10.1007/s00424-019-02304-0
S. Blackwood, A. Katz
{"title":"Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms","authors":"S. Blackwood, A. Katz","doi":"10.1007/s00424-019-02304-0","DOIUrl":"https://doi.org/10.1007/s00424-019-02304-0","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"516 1","pages":"1305 - 1316"},"PeriodicalIF":0.0,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77109998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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