PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-068701
Elizabeth Ransone, Carolyn May, Evan Silverstein
{"title":"Smartphone-Detected Physiologic Photoleukocoria With Visible Optic Nerve Details.","authors":"Elizabeth Ransone, Carolyn May, Evan Silverstein","doi":"10.1542/peds.2024-068701","DOIUrl":"10.1542/peds.2024-068701","url":null,"abstract":"<p><p>A 13-month-old girl and a 3-year-old boy were referred to pediatric ophthalmology for leukocoria noticed on a smartphone photograph obtained by the family. Ophthalmologic examination revealed visual acuity appropriate for age and normal dilated fundus exams in both children without signs of retinoblastoma or other ocular abnormalities. Further review of the home photographs revealed optic nerve details in the leukocoric eyes.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-069739
Michael D Warren, Morgan F McDonald
{"title":"Now What? Making the Most of the Child Opportunity Index.","authors":"Michael D Warren, Morgan F McDonald","doi":"10.1542/peds.2024-069739","DOIUrl":"10.1542/peds.2024-069739","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-069159F
Elise D Berlan, Angela Abenaim, Kierra S Barnett, Charitha Gowda, Stacy Kramer, Sarah Saxbe, Maureen L Stapleton, Johanna Taylor, Venita Robinson
{"title":"Preventing Unintended Teenage Pregnancies With Community Engagement and Quality Improvement.","authors":"Elise D Berlan, Angela Abenaim, Kierra S Barnett, Charitha Gowda, Stacy Kramer, Sarah Saxbe, Maureen L Stapleton, Johanna Taylor, Venita Robinson","doi":"10.1542/peds.2024-069159F","DOIUrl":"https://doi.org/10.1542/peds.2024-069159F","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Nationwide Children's Hospital's (NCH) Pediatric Vital Signs (PVS) Initiative launched in May 2018 when the teenage birth rate in Franklin County was 20.9 per 1000 female adolescents in 2017. The aim of the PVS Preventing Unintended Teenage Pregnancy initiative was to leverage internal strengths and collaborations with community partners to accelerate the decline in the teenage birth rate in Franklin County using evidence-based programming, community engagement, and quality improvement science.</p><p><strong>Methods: </strong>We researched evidence-based interventions to reduce unintended teenage pregnancy and engaged community partners. NCH launched the Contraceptive Access Quality Improvement Collaborative (CAC) to increase the use of prescription contraceptives among female adolescent patients. The School Health Education Partnership focused on developing and promoting comprehensive sexual health education in community schools. Additional community collaborations and interventions activities supported the PVS aim for 5 years.</p><p><strong>Results: </strong>The teenage birth rate in Franklin County declined significantly between 2018 and 2022. The CAC achieved a statistically significant increase in the proportion of female adolescents seen at NCH who are prescribed contraceptives. Sexual health education programming has been implemented in 20 community middle schools since 2019.</p><p><strong>Conclusions: </strong>An interdisciplinary team using a quality improvement framework, in collaboration with numerous community partners, engaged in diverse evidence-based programmatic activities to reduce the teenage birth rate in Franklin County, Ohio.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"155 Suppl 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-067481
Justina Guirguis, Vignesh Ramachandran, Ruth Ann Vleugels, Steven A Greenberg, Hanna Kim, Philip J Kahn, Vikash Oza
{"title":"Monoclonal antibody targeting IFNβ for the treatment of NXP2-positive ulcerative juvenile dermatomyositis.","authors":"Justina Guirguis, Vignesh Ramachandran, Ruth Ann Vleugels, Steven A Greenberg, Hanna Kim, Philip J Kahn, Vikash Oza","doi":"10.1542/peds.2024-067481","DOIUrl":"10.1542/peds.2024-067481","url":null,"abstract":"<p><p>This report outlines the case of a 9-year-old girl with severe anti-nuclear matrix protein 2 antibody-positive juvenile dermatomyositis presenting with disease refractory to multiple traditional therapies. Treatment with an experimental monoclonal antibody inhibiting interferon beta (IFNβ) resulted in the rapid resolution of her muscle weakness and cutaneous and gastrointestinal ulcers. This case highlights the potential benefit of inhibiting IFNβ in the management of recalcitrant juvenile dermatomyositis.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-070021
Daniel J Schumacher, Benjamin Kinnear
{"title":"We Need Historic Investment in Fellowship Redesign to Achieve Workforce Goals.","authors":"Daniel J Schumacher, Benjamin Kinnear","doi":"10.1542/peds.2024-070021","DOIUrl":"10.1542/peds.2024-070021","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-069926
Claudia Gaviria-Agudelo, Alexandra B Yonts, David W Kimberlin, Sean T O'Leary, Grant C Paulsen
{"title":"October 2024 ACIP Meeting Update: Influenza, COVID-19, RSV, and Other Vaccines.","authors":"Claudia Gaviria-Agudelo, Alexandra B Yonts, David W Kimberlin, Sean T O'Leary, Grant C Paulsen","doi":"10.1542/peds.2024-069926","DOIUrl":"10.1542/peds.2024-069926","url":null,"abstract":"<p><p>The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts that provides advice to the Centers for Disease Control and Prevention, normally meets 3 times per year to develop US vaccine recommendations. The ACIP met October 23 to 24, 2024, to discuss influenza vaccines, chikungunya vaccines, COVID-19 vaccines, RSV (respiratory syncytial virus) immunizations, meningococcal vaccines, human papillomavirus vaccines, pneumococcal vaccines, and adult and child/adolescent immunization schedule revisions. This update summarizes the proceedings of these meetings, with an emphasis on topics that are most relevant to the pediatric population. Major updates for pediatric clinicians include information regarding COVID-19 and influenza vaccine recommendations, meningococcal vaccination considerations, and updates regarding the implementation and effectiveness of RSV immunization in pregnant people and infants.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-068179
Craig D Newgard, Susan Malveau, Amber Lin, Patrick Carter, Jason Goldstick, Jennifer N B Cook, N Clay Mann, Xubo Song, Sean R Babcock, Nathan Kuppermann, Apoorva Salvi, Mary E Fallat, Peter C Jenkins, Ran Wei
{"title":"Geospatial Clustering of 9-1-1 Responses for Pediatric Firearm Injuries Over Time.","authors":"Craig D Newgard, Susan Malveau, Amber Lin, Patrick Carter, Jason Goldstick, Jennifer N B Cook, N Clay Mann, Xubo Song, Sean R Babcock, Nathan Kuppermann, Apoorva Salvi, Mary E Fallat, Peter C Jenkins, Ran Wei","doi":"10.1542/peds.2024-068179","DOIUrl":"10.1542/peds.2024-068179","url":null,"abstract":"<p><p></p><p><strong>Objectives: </strong>We evaluated spatial clustering of pediatric firearm injuries using national 9-1-1 emergency medical services (EMS) responses, locations where these events occurred, and geographic changes over time.</p><p><strong>Methods: </strong>This was a cross-sectional study from January 1, 2012 through December 31, 2022 using 9-1-1 EMS responses for children in 50 states from the National EMS Information Systems (NEMSIS). For 37 states with continuous data over the study period, we evaluated spatial changes over time. We included children aged 0 to 17 years with a 9-1-1 EMS response including transports, nontransports, and deaths at the scene. We stratified by child (0-10 years) and adolescent (11-17 years) age groups. The outcome was firearm injury, regardless of intent or severity.</p><p><strong>Results: </strong>There were 10 521 575 9-1-1 EMS responses from 30 393 incident zip codes, including 26 101 (0.25%) for firearm injuries (3679 [14.1%] in children and 22 422 [85.9%] in adolescents). Among 3679 children with firearm injuries, 2975 (80.9%) occurred in their home zip code and 1490 (40.5%) occurred in a cluster. Among 22 422 adolescents with firearm injuries, 15 635 (69.7%) occurred in their home zip code and 11 551 (51.5%) occurred in a cluster. Among 37 states (n = 6 103 297 events, n = 11 433 zip codes), 213 of 446 (47.8%) clustered zip codes for children were new in 2022 and 148 of 461 (32.1%) clustered zip codes for adolescents were new. Results were similar when using home zip codes.</p><p><strong>Conclusions: </strong>There was spatial clustering of pediatric firearm injuries, commonly in their home zip code. The number of zip codes included in pediatric firearm hotspots is increasing.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-067663
Emily H Ho, Berivan Ece, Zutima Tuladhar, Anne Zola, Magdalena Ewa Kupczyk, Linda Adair, Richard Gershon
{"title":"Remote Assessment of Pediatric Anthropometrics.","authors":"Emily H Ho, Berivan Ece, Zutima Tuladhar, Anne Zola, Magdalena Ewa Kupczyk, Linda Adair, Richard Gershon","doi":"10.1542/peds.2024-067663","DOIUrl":"10.1542/peds.2024-067663","url":null,"abstract":"<p><strong>Objective: </strong>To assess the reliability and fidelity of caregiver- and examiner-administered anthropometric measurements in English- and Spanish-speaking children aged 0-17 years.</p><p><strong>Methods: </strong>Participants (N = 199; median age, 4.69 years; interquartile range, 1.58-10.37; 46.7% male) were recruited in 6 sites across the United States in May-August 2023. Examiners were trained by a pediatric nurse; caregivers received well-developed administration materials. The key anthropometric outcomes assessed were infant length/child height, weight, percent body fat (PBF), head size, and waist circumference. Concordance between caregiver/examiner measurements was assessed using interrater reliability estimates, technical error of measurement (TEM), and mean absolute difference (MAD). Secondary outcomes included reported ease of use and language used.</p><p><strong>Results: </strong>High concordance was observed between caregivers and examiners, with reliability coefficients ranging from 0.91 to >0.99 and intraclass correlation coefficient values from 0.92 to >0.99 across all assessments and age groups. The TEM was low (height = 2.10 cm, weight = 0.39 kg, PBF = 2.33%; head circumference = 0.73 cm, waist circumference = 3.65 cm) as were MAD estimates (height = 2.12 cm, 95% confidence interval [CI], 1.82-2.42; weight = 0.35 kg, 95% CI, 0.29-0.41; PBF = 2.39%, 95% CI, 1.89-2.88; head size = 0.71 cm, 95% CI, 0.54-0.89; waist circumference = 3.15 cm, 95% CI, 2.41-3.88).</p><p><strong>Conclusions: </strong>Across multiple metrics, there was high concordance between caregiver- and examiner-administered measurements, providing evidence of interchangeability between remote and in-person assessments of anthropometric outcomes. Remote anthropometric assessment appears feasible and low burden and has comparably high validity and reliability to in-person methods.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-068774
Rebekah Levine Coley, Jane Leer, Lindsay Lanteri
{"title":"Trends in Mental and Behavioral Health Risks in Adolescents: 1999-2021.","authors":"Rebekah Levine Coley, Jane Leer, Lindsay Lanteri","doi":"10.1542/peds.2024-068774","DOIUrl":"10.1542/peds.2024-068774","url":null,"abstract":"<p><p></p><p><strong>Objectives: </strong>To identify distinct profiles of adolescent mental and behavioral health risks and variation over cohorts and demographic strata from 1999 through 2021. We expected increased mental health risks and decreased behavioral health risks.</p><p><strong>Methods: </strong>We analyzed repeated, cross-sectional, nationally representative samples of high school students from the 1991-2021 national Youth Risk Behavior Survey (N = 178 658) using latent class analysis. Adolescents self-reported mental and behavioral health risk behaviors, including internalizing (depressive symptoms, suicidality), substance use (alcohol, marijuana use), sexual risk behaviors (number of sexual partners, effective birth control), and violence (weapons carriage, fighting).</p><p><strong>Results: </strong>We identified 5 distinct profiles. The largest group, Low Everything (48% of adolescents), grew notably in prevalence from 1999 to 2021. The smallest, High Internalizing (9% of adolescents), also grew. High Sex (20%), High Everything (13%), and High Substance Use (10%) all decreased, with all trajectories strengthening between 2019 and 2021 during the COVID-19 pandemic. Younger adolescents predominated in the Low Everything and High Internalizing profiles, and older adolescents predominated in the High Sex and High Everything profiles. Females were more prevalent in the High Internalizing and High Sex profiles, and males were more prevalent in the High Everything and High Substance Use profiles. White adolescents were overrepresented in the High Substance Use profile, and youth of color were overrepresented in the other profiles.</p><p><strong>Conclusions: </strong>Results showing decreasing proportions of adolescents reporting comorbid mental and behavioral health risks or behavioral health risks only, but increases in mental health problems only, help to identify and target key populations for prevention and treatment efforts.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PediatricsPub Date : 2025-04-01DOI: 10.1542/peds.2024-069507
Adiel Marom, Alexandra Yannopoulos, Kelley-Anne Dionne, Brett Burstein
{"title":"Procalcitonin and Other Inflammatory Markers in Febrile Infants Aged 60 Days or Younger.","authors":"Adiel Marom, Alexandra Yannopoulos, Kelley-Anne Dionne, Brett Burstein","doi":"10.1542/peds.2024-069507","DOIUrl":"10.1542/peds.2024-069507","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}