Pediatrics最新文献

{"title":"Academic Achievement of Children With Neurofibromatosis Type 1.","authors":"Yang Hou, Xiaoli Zong, Xian Wu, Dan Liu, Pamela L Wolters, Jennifer Janusz, Karin S Walsh, Stephanie M Morris, Jonathan M Payne, Natalie Pride, Shruti Garg, Louise Robinson, Peter L Stavinoha","doi":"10.1542/peds.2024-067016","DOIUrl":"10.1542/peds.2024-067016","url":null,"abstract":"<p><p></p><p><strong>Background and objectives: </strong>Learning difficulties are frequently reported in children with neurofibromatosis type 1 (NF1), yet little is known about the extent and predictors of their academic functions across ages. We aimed to examine the developmental patterns of academic achievement in these children from childhood to adolescence and how these patterns differ across demographic and NF1-related disease factors.</p><p><strong>Methods: </strong>This cross-sectional study integrated data of 1512 children with NF1 (mean age, 11.2 years, SD, 3.62, range, 3-18, 46.5% female patients) from 8 institutions. Academic functioning was assessed with Woodcock-Johnson Tests of Achievement or the Wechsler Individual Achievement Test. Data were analyzed primarily using time-varying effect modeling.</p><p><strong>Results: </strong>Participants' academic achievement was significantly lower than the normative means across ages, and the gap widened from middle childhood to midadolescence. Academic age trends varied across academic domains and demographic and disease factors. Male patients demonstrated larger deviations in math at midchildhood and in reading and writing between midchildhood and midadolescence. Children with lower parental education demonstrated larger deviations in math, reading, and writing between midchildhood and midadolescence. Children with familial NF1 demonstrated larger deviations in math at midchildhood and mid-to-late-adolescence, and in reading and writing between midchildhood and midadolescence.</p><p><strong>Conclusions: </strong>Academic difficulties in children with NF1 emerge early and worsen with age. The findings also highlight the variability within this population across demographic and disease factors. The age-specific estimates of academic functions can serve as the first NF1-specific academic norms, providing useful insights for future research and practice.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Health Care Research for Children With Disability and Medical Complexity.","authors":"Carolyn Foster, Elaine Lin, James A Feinstein, Rebecca Seltzer, Robert J Graham, Cara Coleman, Erin Ward, Ryan J Coller, Sarah Sobotka, Jay G Berry","doi":"10.1542/peds.2024-067966","DOIUrl":"10.1542/peds.2024-067966","url":null,"abstract":"<p><p>Pediatric home health care represents a vital system of care for children with disability and medical complexity, encompassing services provided by family caregivers and nonfamily home health care providers and the use of durable medical equipment and supplies. Home health care is medically necessary for the physiologic health of children with disability and medical complexity and for their participation and function within home, school, and community settings. While the study of pediatric home health care in the United States has increased in the last decade, its research remains primarily methodologically limited to observational studies. Dedicated funding and research efforts are needed to transform American home health care research to address multifaceted outcomes valued by families and providers as well as payers and government programs. In this paper, we review the recent literature in pediatric home health care and then propose an actional agenda that could address its missing evidence base. We posit that pediatricians should partner with family caregiving experts and patients to advance knowledge about child and family health outcomes, home health care use, new models of care, and optimal approaches to education and training while also considering meaningful approaches to address disparities. The creation of an American pediatric home health care data-sharing consortium, patient registry, and reproducible access and quality measures is also needed. Most importantly, efforts should center on patient- and family-centered health priorities, with the goal of ensuring equitable outcomes for every child and family.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis.","authors":"Nicolaas Koen Vermeijden, Leilani de Silva, Supun Manathunga, Daphne Spoolder, Judith Korterink, Arine Vlieger, Shaman Rajindrajith, Marc Benninga","doi":"10.1542/peds.2024-067677","DOIUrl":"10.1542/peds.2024-067677","url":null,"abstract":"<p><strong>Context: </strong>Functional abdominal pain disorders (FAPDs) are debilitating disorders with unknown current prevalence.</p><p><strong>Objective: </strong>To estimate global prevalence rates of FAPDs, their entities, and variations by diagnostic criteria, geography, gender, and age.</p><p><strong>Data sources: </strong>Medline, Embase, CINAHL, PsycInfo, and Cochrane Library were searched through October 14, 2024.</p><p><strong>Study selection: </strong>Epidemiological studies of birth cohorts, school based, and from general population samples reporting FAPD prevalence in children (aged 4-18 years) using the Rome criteria.</p><p><strong>Data extraction: </strong>Two researchers independently performed screening, data extraction, and quality assessment.</p><p><strong>Results: </strong>A total of 66 studies, encompassing 201 134 participants from 29 countries, were included. The estimated global pooled prevalence of FAPDs was 11.7% (95% CI, 10.5%-13.1%). The most prevalent type was irritable bowel syndrome (5.8%; 95% CI, 4.5-7.4%), while functional abdominal pain-not otherwise specified was least prevalent (1.2%; 95% CI, 0.7%-2.1%)). Prevalence was highest using Rome III (13.2%; 95% CI, 11.3%-15.3%) and lowest under Rome IV criteria (9.0%; 95% CI, 6.7%-12.0%; P = .05). Girls had higher prevalence (14.4%; 95% CI, 12.5%-16.6%) than boys (9.4%; 95% CI, 7.8%-11.4%; P < .01). FAPDs were nonsignificantly more prevalent in Asia (13.0%; 95% CI, 10.4%-16.3%) compared to Europe (8.3%; 95% CI, 6.4%-10.7%) and North America (7.7%; 95% CI, 4.3-13.6; P = .09). No differences by age (P = .14) were recorded. Contributing factors include anxiety, depression, stress, negative life events, and poor sleep.</p><p><strong>Limitations: </strong>Language restrictions, significant interstudy heterogeneity, and underrepresentation from Africa.</p><p><strong>Conclusions and relevance: </strong>FAPDs affect over 1 in 9 children worldwide, with higher prevalence in girls and those with psychological stressors.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended Childhood and Adolescent Immunization Schedule: United States, 2025: Policy Statement.","authors":"","doi":"10.1542/peds.2024-069987","DOIUrl":"10.1542/peds.2024-069987","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instruction for Use: Developmental Milestones in Down Syndrome.","authors":"Noemi Spinazzi","doi":"10.1542/peds.2024-069954c","DOIUrl":"https://doi.org/10.1542/peds.2024-069954c","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"28 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concern About the Validity of These Norms as Representing a Population Sample.","authors":"Susan Buckley","doi":"10.1542/peds.2024-069954a","DOIUrl":"https://doi.org/10.1542/peds.2024-069954a","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"36 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response to Comments.","authors":"Nicole Baumer, Rafael DePillis, Katherine Pawlowski, Bo Zhang, Maitreyi Mazumdar","doi":"10.1542/peds.2024-069954D","DOIUrl":"https://doi.org/10.1542/peds.2024-069954D","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Self-Help vs Group Treatment for Children With Obesity: A Randomized Clinical Trial.","authors":"Kerri N Boutelle,Kyung E Rhee,David R Strong,Michael A Manzano,Rebecca S Bernard,Dawn M Eichen,Cheryl C A Anderson,Bess H Marcus,Natacha Akshoomoff,Scott J Crow","doi":"10.1542/peds.2024-066561","DOIUrl":"https://doi.org/10.1542/peds.2024-066561","url":null,"abstract":"BACKGROUND AND OBJECTIVESFamily-based behavioral treatment (FBT) for children with obesity is provided in weekly parent and child groups over 6 months. A guided self-help FBT program (gshFBT) is provided to the dyad in short meetings. Both interventions provide the same content; however, gshFBT provides this content in less time (FBT = 23 hours, gshFBT = 5.3 hours). This study aimed to evaluate whether gshFBT is noninferior to FBT on child weight loss and cost-effectiveness.METHODS150 children aged between 7.0 and 12.9 years with a BMI between the 85th and 99.9th percentile and their parent were recruited and randomized to a 6-month program of gshFBT (n = 75) or FBT (n = 75) and were followed 12 months post-treatment.RESULTSA total of 150 children (mean age = 10.1 years, 49% female, mean BMIz = 2.09) and their parent (mean age = 41.5 years, 87% female, 45% Hispanic, 37% White non-Hispanic, 9.7% Asian, 4.8% Black, 7.3% other) were recruited from the San Diego Metropolitan area. Joint LME models showed that gshFBT was noninferior to FBT on child weight loss (ΔBMIz = -0.02 [90% credible interval [CI] -0.08-0.05, P = .65]; ΔBMIp95% = -1.57 [90% CI -4.46-1.31, P = .28]) and cost less (cost/dyad gshFBT = $1498; FBT = $2775).CONCLUSIONThe gshFBT program provided similar weight losses for children with less contact hours and with lower cost than FBT. The reduced time and ease of scheduling for the family in gshFBT will allow for an increased reach of treatment to a greater proportion of families in need.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"48 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy Lifestyle in the First 1000 Days and Overweight and Obesity Throughout Childhood.","authors":"Adrien M Aubert,Marion Lecorguillé,Mireille C Schipper,Alexander Douglass,Cecily C Kelleher,Sandrine Lioret,Barbara Heude,Romy Gaillard,Catherine M Phillips","doi":"10.1542/peds.2024-066406","DOIUrl":"https://doi.org/10.1542/peds.2024-066406","url":null,"abstract":"OBJECTIVESInvestigate associations of different family healthy lifestyle scores (HLS) during the first 1000 days with childhood overweight and obesity (OWOB).METHODSCohort-specific analyses were conducted on participants (n = 25 006) from 4 European birth cohorts (The study on the pre- and early postnatal determinants of child health and development [EDEN], Elfe, France; Generation R, the Netherlands; and Lifeways, Ireland). Three composite HLSs were calculated: a maternal pregnancy HLS based on prepregnancy body mass index (BMI) and diet quality, physical activity, smoking status, and alcohol consumption during pregnancy; a parental pregnancy HLS additionally considering paternal BMI and smoking status; and an infancy HLS based on breastfeeding duration, age of solid food introduction, and exposure to passive smoking. Associations with child BMI (primary outcome) and waist-to-height ratio (WHtR, available in 2 cohorts) in early (5-5.5 years), middle (7-8 years), and late childhood (9-12 years) were assessed using linear (BMI and WHtR z-scores) and robust Poisson (International Obesity Task Force [IOTF] categories) regression analyses adjusted for sociodemographic confounders.RESULTSOnly a small proportion of families had favorable lifestyle factors during pregnancy and early infancy, with 3.4% to 10.0%, 1.9% to 3.7%, and 12.2% to 23.6% scoring maximum for maternal, parental, and infancy HLS, respectively. Associations between higher HLSs and a lower risk of OWOB when measured by BMI z-scores or IOTF categories were found for maternal HLS and early (3/4 cohorts with available data), middle (1/2), and late childhood (2/4); parental HLS and early (3/4), middle (2/2), and late childhood (4/4). Associations between infancy HLS and childhood OWOB were less consistent and did not remain significant after additional adjustment for parental HLS. Associations with WHtR were solely significant in EDEN at 5.5 years.CONCLUSIONSGreater maternal and parental adherence to healthy lifestyle behaviors during pregnancy was associated with a lower risk of offspring OWOB throughout childhood, illustrating the importance of promoting healthy lifestyle behaviors at the family level during pregnancy.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"28 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Traditional Milestones: Questioning Developmental Framework for Children With Down Syndrome.","authors":"Julija Atanasova,Jennifer Saenz,Peter Rosenbaum","doi":"10.1542/peds.2024-069954b","DOIUrl":"https://doi.org/10.1542/peds.2024-069954b","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"130 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}