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Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether. 以大麻素受体 2 型配体为目标的专利：采访 Uwe Grether。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0013
Uwe Grether
{"title":"Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether.","authors":"Uwe Grether","doi":"10.4155/ppa-2021-0013","DOIUrl":"10.4155/ppa-2021-0013","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 4","pages":"175-177"},"PeriodicalIF":1.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39289970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary approaches to treat Naegleria fowleri: a patent overview. 当代治疗福氏奈格里氏杆菌的方法:专利概述。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-05-01 Epub Date: 2021-06-02 DOI: 10.4155/ppa-2020-0023
Ruqaiyyah Siddiqui, Naveed A Khan
{"title":"Contemporary approaches to treat <i>Naegleria fowleri</i>: a patent overview.","authors":"Ruqaiyyah Siddiqui,&nbsp;Naveed A Khan","doi":"10.4155/ppa-2020-0023","DOIUrl":"https://doi.org/10.4155/ppa-2020-0023","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 3","pages":"99-101"},"PeriodicalIF":1.3,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38972960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Patent highlights December 2020-January 2021. 专利要点 2020 年 12 月至 2021 年 1 月。
IF 1.8
Pharmaceutical patent analyst Pub Date : 2021-05-01 Epub Date: 2021-05-18 DOI: 10.4155/ppa-2021-0005
Hermann Am Mucke
{"title":"Patent highlights December 2020-January 2021.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2021-0005","DOIUrl":"10.4155/ppa-2021-0005","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 3","pages":"103-110"},"PeriodicalIF":1.8,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38923642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating of focal epilepsy: a patent review. 局灶性癫痫的治疗:专利回顾。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-05-01 Epub Date: 2021-06-02 DOI: 10.4155/ppa-2021-0008
Slobodan M Janković, Nenad Marković, Tanja Luković
{"title":"Treating of focal epilepsy: a patent review.","authors":"Slobodan M Janković,&nbsp;Nenad Marković,&nbsp;Tanja Luković","doi":"10.4155/ppa-2021-0008","DOIUrl":"https://doi.org/10.4155/ppa-2021-0008","url":null,"abstract":"<p><p>Focal epilepsy is one of the most frequent specific type of epilepsies, with 30% treatment-resistant patients. There are several directions researchers can follow to improve existing treatment of focal epilepsy: synthesis of new compounds with anticonvulsant activity, repurposing drugs approved for other indications, finding drugs targeted to specific genetic and biochemical defects that underlie focal epilepsy syndromes, development of viral vectors for specific gene therapy, creation of devices and methods for suppression of seizures by electrostimulation and development of methods to increase safety of epilepsy surgery. Improvement of efficacy and safety of current therapies is necessary, as well as developing targeted treatment of genetic epilepsy syndromes that will not only suppress seizures, but stop further epileptogenesis.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 3","pages":"165-173"},"PeriodicalIF":1.3,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38972959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010. 大麻素受体2型配体:2010年以来授权专利分析。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-05-01 Epub Date: 2021-06-11 DOI: 10.4155/ppa-2021-0002
Benjamin Brennecke, Thais Gazzi, Kenneth Atz, Jürgen Fingerle, Pascal Kuner, Torsten Schindler, Guy de Weck, Marc Nazaré, Uwe Grether
{"title":"Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010.","authors":"Benjamin Brennecke,&nbsp;Thais Gazzi,&nbsp;Kenneth Atz,&nbsp;Jürgen Fingerle,&nbsp;Pascal Kuner,&nbsp;Torsten Schindler,&nbsp;Guy de Weck,&nbsp;Marc Nazaré,&nbsp;Uwe Grether","doi":"10.4155/ppa-2021-0002","DOIUrl":"https://doi.org/10.4155/ppa-2021-0002","url":null,"abstract":"<p><p>The G-protein-coupled cannabinoid receptor type 2 (CB<sub>2</sub>R) is a key element of the endocannabinoid (EC) system. EC/CB<sub>2</sub>R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders, inflammation or ocular diseases. CB<sub>2</sub>R agonism exerts anti-inflammatory and tissue protective effects in preclinical animal models of cardiovascular, gastrointestinal, liver, kidney, lung and neurodegenerative disorders. Existing ligands can be subdivided into endocannabinoids, cannabinoid-like and synthetic CB<sub>2</sub>R ligands that possess various degrees of potency on and selectivity against the cannabinoid receptor type 1. This review is an account of granted CB<sub>2</sub>R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation<sup>®</sup>.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 3","pages":"111-163"},"PeriodicalIF":1.3,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39081313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Recent development of drugs for osteoporosis and anti-cancer agents: a patent analysis. 骨质疏松和抗癌药物的最新进展:专利分析。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-03-01 Epub Date: 2021-04-12 DOI: 10.4155/ppa-2021-0004
Hai-Long Zhang, Yiqian Li
{"title":"Recent development of drugs for osteoporosis and anti-cancer agents: a patent analysis.","authors":"Hai-Long Zhang,&nbsp;Yiqian Li","doi":"10.4155/ppa-2021-0004","DOIUrl":"https://doi.org/10.4155/ppa-2021-0004","url":null,"abstract":"<p><p>Osteoporosis and cancer are becoming a major public health problem. Some studies have shown that osteoporosis drugs may have anti-cancer effects. To better understand the relationship between drugs for osteoporosis and antineoplastic agents, and to better demonstrate recent developments for patents concerning drugs for osteoporosis, we conducted an analysis of US patents. The results indicated that there was a good correlation between agents for osteoporosis and antineoplastic agents, which indicated that numerous anti-osteoporosis agents displayed antineoplastic activities. Our study was the first one to provide new evidence, through comprehensive analysis, for a correlation between anti-osteoporosis agents and anticancer agents. The present study may open new avenues for developing anticancer drugs and expanding the application role of anti-osteoporosis agents.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 2","pages":"73-82"},"PeriodicalIF":1.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25581887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Patent highlights October-November 2020. 专利要点 2020 年 10 月至 11 月。
IF 1.8
Pharmaceutical patent analyst Pub Date : 2021-03-01 Epub Date: 2021-02-17 DOI: 10.4155/ppa-2021-0003
Hermann Am Mucke
{"title":"Patent highlights October-November 2020.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2021-0003","DOIUrl":"10.4155/ppa-2021-0003","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 2","pages":"51-58"},"PeriodicalIF":1.8,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25375469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bispecific anti-OX40/5T4 antibodies for cancer treatment. 用于癌症治疗的双特异性抗ox40 / 5t4抗体。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-03-01 Epub Date: 2021-03-12 DOI: 10.4155/ppa-2020-0030
Martin Perez-Santos
{"title":"Bispecific anti-OX40/5T4 antibodies for cancer treatment.","authors":"Martin Perez-Santos","doi":"10.4155/ppa-2020-0030","DOIUrl":"https://doi.org/10.4155/ppa-2020-0030","url":null,"abstract":"<p><p>OX40 and 5T4 are molecules that play a role in T-cell expansion and cytoskeleton's disruption in cancer, respectively. US2019161555 patent describes a bispecific antibody that targets OX40/5T4 with the potential application of cancer treatment. The method of analysis of the US201916155 patent consisted of claim's analysis, as well as the chemical/biological information's analysis of the bispecific antibody. The patent includes independent claims related to bispecific antibodies that bind to OX40/5T4, DNA encoding the antibodies, a vector that harbors the DNA, a host cell that contains the vector, a pharmaceutical composition containing a pharmaceutically effective amount of the antibodies, medical use of the antibodies, use of the antibodies in the treatment or prevention of neoplastic disorders and a method of treating neoplastic disorders. Bispecific antibodies that target OX40/5T4 can activate IL-2 secretion in CD4<sup>+</sup> T cells.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 2","pages":"59-66"},"PeriodicalIF":1.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25468368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment of solid tumors using bispecific anti-PDL-1/ICOS antibody. 双特异性抗pdl -1/ICOS抗体治疗实体瘤。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-03-01 Epub Date: 2021-04-08 DOI: 10.4155/ppa-2020-0035
Martin Perez-Santos, Maricruz Anaya-Ruiz, Gabriela Sanchez-Esgua, Luis Villafaña-Diaz, Diana Barron-Villaverde
{"title":"Treatment of solid tumors using bispecific anti-PDL-1/ICOS antibody.","authors":"Martin Perez-Santos,&nbsp;Maricruz Anaya-Ruiz,&nbsp;Gabriela Sanchez-Esgua,&nbsp;Luis Villafaña-Diaz,&nbsp;Diana Barron-Villaverde","doi":"10.4155/ppa-2020-0035","DOIUrl":"https://doi.org/10.4155/ppa-2020-0035","url":null,"abstract":"<p><p>PD-L1 and ICOS are immune control points in cancer and their presence in cancer tends to have a poor prognosis. WO2019122882 patent describes a bispecific antibody that targets PDL-1/ICOS with the potential application of cancer treatment. WO2019122882 patent describes a bispecific antibody with antitumor efficacy in CT26 model through of the depletion of T<sub>Reg</sub> cells and improved ratio of CD8<sup>+</sup> T cells: T<sub>Reg</sub> in tumor microenvironment. The anti-PDL-1/ICOS antibody is new; however, only preclinical assays are shown using colon carcinoma model. So far, there are no reports of clinical trials to evaluate the safety, toxicity and efficacy, but it will be of great interest to analyze in the future if this antibody surpasses the action of the combinatorial therapy in cancer.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 2","pages":"67-72"},"PeriodicalIF":1.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25586617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccines against antimicrobial resistance: a promising escape route for multidrug resistance. 抗微生物药物耐药性疫苗:一种有希望的多药耐药性逃避途径。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-03-01 Epub Date: 2021-04-08 DOI: 10.4155/ppa-2020-0022
Absar Talat, Asad U Khan
{"title":"Vaccines against antimicrobial resistance: a promising escape route for multidrug resistance.","authors":"Absar Talat,&nbsp;Asad U Khan","doi":"10.4155/ppa-2020-0022","DOIUrl":"https://doi.org/10.4155/ppa-2020-0022","url":null,"abstract":"<p><p>Antibiotic resistance has become a global health problem requiring urgent intervention. The pace of development and frequency of transmission of antimicrobial resistance have tremendously surpassed the number of antibiotics developed in the past few decades. Emergence and transmission of multidrug-resistant genes, for example, <i>mcr-1</i> and <i>mcr-5.3</i>, against the last resort of antibiotics has challenged the treatment options. Vaccination is a promising approach with no instance of antimicrobial resistance generation or transmission reported so far. The time required for developing a vaccine, extensive pre- and post-licensure studies and the financial constraints for the R&D has hampered vaccine development over the past few decades. Vaccine can prove to be an effective future strategy for combating antimicrobial resistance.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 2","pages":"83-98"},"PeriodicalIF":1.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25570550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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