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Patent highlights August-September 2021. 专利亮点2021年8月至9月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2022-01-01 Epub Date: 2022-02-03 DOI: 10.4155/ppa-2021-0025
Hermann Am Mucke
{"title":"Patent highlights August-September 2021.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2021-0025","DOIUrl":"https://doi.org/10.4155/ppa-2021-0025","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"11 1","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39758418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug repurposing of adapalene for melanoma treatment. 阿达帕林用于黑色素瘤治疗的药物再利用。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2022-01-01 Epub Date: 2022-02-16 DOI: 10.4155/ppa-2021-0021
Maricruz Anaya-Ruiz, Martin Perez-Santos
{"title":"Drug repurposing of adapalene for melanoma treatment.","authors":"Maricruz Anaya-Ruiz,&nbsp;Martin Perez-Santos","doi":"10.4155/ppa-2021-0021","DOIUrl":"https://doi.org/10.4155/ppa-2021-0021","url":null,"abstract":"<p><p>Cancer drug repurposing is an attractive approach that leads to savings in time and investment. Adapalene, the first medical application of which was for the treatment of acne, has been described as a repurposing drug for the treatment of various types of cancer. Patent application CN111329851 describes the use of adapalene for the treatment of melanoma, by assays carried out on melanoma cell lines. Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51. Even though no evidence on efficacy and efficiency is shown in preclinical and clinical studies, CN111329851 patent shows that adapalene may be a repurposing drug for the treatment of melanoma.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"11 1","pages":"9-14"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39633611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Multicomponent crystal compromising dasatinib and selected co-crystals formers: a patent evaluation of EP2861589B1. 多组分晶体损害达沙替尼和选择的共晶体形成:EP2861589B1的专利评估。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2022-01-01 Epub Date: 2022-02-17 DOI: 10.4155/ppa-2021-0024
Ritu Rathi, Inderbir Singh
{"title":"Multicomponent crystal compromising dasatinib and selected co-crystals formers: a patent evaluation of EP2861589B1.","authors":"Ritu Rathi,&nbsp;Inderbir Singh","doi":"10.4155/ppa-2021-0024","DOIUrl":"https://doi.org/10.4155/ppa-2021-0024","url":null,"abstract":"<p><p>Cocrystallization has gained significant prominence in pharmaceutical product development because of the enhancement of physical, chemical and pharmacological properties of active pharmaceutical ingredients, such as stability, solubility, dissolution rate, taste, hygroscopicity, mechanical property, bioavailability, permeability and therapeutic activity. Traditionally, co-crystals can be prepared by a grinding, solvent evaporation and slurry method. However, sophisticated methods such as spa drying, hot-melt extrusion, supercritical fluid and laser irradiation are also reported to be used for producing co-crystals. The selected patent describes the development of multicomponent crystals of dasatinib, with an aim to enhance the aqueous solubility of a selected drug. However issues surrounding the toxicity, stability, large scale manufacture, <i>in vivo</i> performance in human beings and regulations require adequate addressal prior to exploring the commercial viability of pharmaceutical co-crystals.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"11 1","pages":"15-21"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39790790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Small-molecule inhibitor PD-1/PD-L1 interaction for colorectal cancer treatment. 用于结直肠癌治疗的小分子抑制剂 PD-1/PD-L1 相互作用。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-12-08 DOI: 10.4155/ppa-2021-0016
Maricruz Anaya-Ruiz, Martin Perez-Santos
{"title":"Small-molecule inhibitor PD-1/PD-L1 interaction for colorectal cancer treatment.","authors":"Maricruz Anaya-Ruiz, Martin Perez-Santos","doi":"10.4155/ppa-2021-0016","DOIUrl":"10.4155/ppa-2021-0016","url":null,"abstract":"<p><p>Inhibition of the PD-1/PD-L1 pathway is a target for the development of new therapies. US10710986 patent describes a small molecule that targets PDL-1/PD-1 interactions and triggers antitumor activity against colorectal cancer. However, it does not describe biological assays that allow us to suppose that this small molecule may be active in other types of cancer. So far, there are no reports of clinical trials to evaluate the safety, toxicity and efficacy, but it will be of great interest to analyze in the future if this compound surpasses the action of therapy in cancer.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39700288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights June-July 2021. 专利要点 2021 年 6 月至 7 月。
IF 1.8
Pharmaceutical patent analyst Pub Date : 2021-11-01 Epub Date: 2021-11-10 DOI: 10.4155/ppa-2021-0022
Hermann Am Mucke
{"title":"Patent highlights June-July 2021.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2021-0022","DOIUrl":"10.4155/ppa-2021-0022","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 6","pages":"237-244"},"PeriodicalIF":1.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39692971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent patents and a market overview on green or bio-based solvents for chromatographic analysis: a review. 用于色谱分析的绿色或生物基溶剂的最新专利和市场概述：综述。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-11-01 Epub Date: 2021-11-10 DOI: 10.4155/ppa-2021-0015
Abdul Muheem, Mohammed Asadullah Jahangir, Sanjula Baboota, Javed Ali
{"title":"Recent patents and a market overview on green or bio-based solvents for chromatographic analysis: a review.","authors":"Abdul Muheem, Mohammed Asadullah Jahangir, Sanjula Baboota, Javed Ali","doi":"10.4155/ppa-2021-0015","DOIUrl":"10.4155/ppa-2021-0015","url":null,"abstract":"<p><p>Green solvents (GS) in chromatography originate from green chemistry. Therefore, using GSs in liquid chromatographic analysis to separate drugs and chemicals is an emerging approach to reduce hazardous chemicals in nature. The Orbit Intelligence database was used to conduct a strategic patent search for peer-reviewed patents on GSs as a mobile phase for chromatographic analysis. This article reported numerous approaches for encouraging GSs such as ethanol, butanol, esters, polyethylene glycol, supercritical fluids and nonionic surfactants to analyze drugs or compounds. The main aim of this article is to explore the patented GSs for chromatographic analysis and forecasting of the GSs that encourage industries to shift from hazardous to GSs.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 6","pages":"227-235"},"PeriodicalIF":1.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39603806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights April-May 2021. 专利亮点2021年4-5月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-09-06 DOI: 10.4155/ppa-2021-0011
H. Mucke
{"title":"Patent highlights April-May 2021.","authors":"H. Mucke","doi":"10.4155/ppa-2021-0011","DOIUrl":"https://doi.org/10.4155/ppa-2021-0011","url":null,"abstract":"A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41578563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccines and treatments for Zika virus infection: patent status, triumphs and challenges. 寨卡病毒感染的疫苗和治疗:专利现状、胜利和挑战。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-09-01 Epub Date: 2021-09-07 DOI: 10.4155/ppa-2021-0014
Sandro G Viveiros Rosa, Wilson C Santos
{"title":"Vaccines and treatments for Zika virus infection: patent status, triumphs and challenges.","authors":"Sandro G Viveiros Rosa,&nbsp;Wilson C Santos","doi":"10.4155/ppa-2021-0014","DOIUrl":"https://doi.org/10.4155/ppa-2021-0014","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 5","pages":"209-213"},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treating Dravet syndrome: a patent landscape. 治疗Dravet综合征:专利景观。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-09-01 Epub Date: 2021-09-07 DOI: 10.4155/ppa-2021-0020
Barbara Miziak, Stanislaw J Czuczwar
{"title":"Treating Dravet syndrome: a patent landscape.","authors":"Barbara Miziak,&nbsp;Stanislaw J Czuczwar","doi":"10.4155/ppa-2021-0020","DOIUrl":"https://doi.org/10.4155/ppa-2021-0020","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 5","pages":"215-217"},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier. 一种无毒离子液体组合物，用于跨越皮肤屏障递送生物大分子阴离子。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0012
Neeraj Kumar, Balraj Saini, Rajwinder Kaur
{"title":"A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier.","authors":"Neeraj Kumar,&nbsp;Balraj Saini,&nbsp;Rajwinder Kaur","doi":"10.4155/ppa-2021-0012","DOIUrl":"https://doi.org/10.4155/ppa-2021-0012","url":null,"abstract":"<p><p>The development of biocompatible ionic liquids is needed in order to explore their vastly underutilized pharmaceutical potential. US10912834 patent discloses ionic liquids comprising macromolecular biological anions and alkylated cations, which provides enhanced dermal delivery and cell internalization of the large biological anions. The studies of <i>ex vivo</i> permeation through excised pig skin indicated significantly higher skin penetration of percent dose and enhanced drug internalization was achieved using these ionic liquids. Although, the patent advances an infant field of biological macromolecule-based ionic liquids, the evaluation of these claimed ionic liquids relies only on the <i>in vivo</i> cytotoxicity data and <i>ex vivo</i> skin permeation behavior. Exhaustive studies, including dermatokinetic evaluation and long-term animal toxicity experiments, should be performed in order to unravel the potential of the aforementioned ionic liquids.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 4","pages":"191-194"},"PeriodicalIF":1.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39289974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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