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Small-molecule inhibitor PD-1/PD-L1 interaction for colorectal cancer treatment. 用于结直肠癌治疗的小分子抑制剂 PD-1/PD-L1 相互作用。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-12-08 DOI: 10.4155/ppa-2021-0016
Maricruz Anaya-Ruiz, Martin Perez-Santos
{"title":"Small-molecule inhibitor PD-1/PD-L1 interaction for colorectal cancer treatment.","authors":"Maricruz Anaya-Ruiz, Martin Perez-Santos","doi":"10.4155/ppa-2021-0016","DOIUrl":"10.4155/ppa-2021-0016","url":null,"abstract":"<p><p>Inhibition of the PD-1/PD-L1 pathway is a target for the development of new therapies. US10710986 patent describes a small molecule that targets PDL-1/PD-1 interactions and triggers antitumor activity against colorectal cancer. However, it does not describe biological assays that allow us to suppose that this small molecule may be active in other types of cancer. So far, there are no reports of clinical trials to evaluate the safety, toxicity and efficacy, but it will be of great interest to analyze in the future if this compound surpasses the action of therapy in cancer.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39700288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights June-July 2021. 专利要点 2021 年 6 月至 7 月。
IF 1.8
Pharmaceutical patent analyst Pub Date : 2021-11-01 Epub Date: 2021-11-10 DOI: 10.4155/ppa-2021-0022
Hermann Am Mucke
{"title":"Patent highlights June-July 2021.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2021-0022","DOIUrl":"10.4155/ppa-2021-0022","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 6","pages":"237-244"},"PeriodicalIF":1.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39692971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent patents and a market overview on green or bio-based solvents for chromatographic analysis: a review. 用于色谱分析的绿色或生物基溶剂的最新专利和市场概述：综述。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-11-01 Epub Date: 2021-11-10 DOI: 10.4155/ppa-2021-0015
Abdul Muheem, Mohammed Asadullah Jahangir, Sanjula Baboota, Javed Ali
{"title":"Recent patents and a market overview on green or bio-based solvents for chromatographic analysis: a review.","authors":"Abdul Muheem, Mohammed Asadullah Jahangir, Sanjula Baboota, Javed Ali","doi":"10.4155/ppa-2021-0015","DOIUrl":"10.4155/ppa-2021-0015","url":null,"abstract":"<p><p>Green solvents (GS) in chromatography originate from green chemistry. Therefore, using GSs in liquid chromatographic analysis to separate drugs and chemicals is an emerging approach to reduce hazardous chemicals in nature. The Orbit Intelligence database was used to conduct a strategic patent search for peer-reviewed patents on GSs as a mobile phase for chromatographic analysis. This article reported numerous approaches for encouraging GSs such as ethanol, butanol, esters, polyethylene glycol, supercritical fluids and nonionic surfactants to analyze drugs or compounds. The main aim of this article is to explore the patented GSs for chromatographic analysis and forecasting of the GSs that encourage industries to shift from hazardous to GSs.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 6","pages":"227-235"},"PeriodicalIF":1.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39603806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights April-May 2021. 专利亮点2021年4-5月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-09-06 DOI: 10.4155/ppa-2021-0011
H. Mucke
{"title":"Patent highlights April-May 2021.","authors":"H. Mucke","doi":"10.4155/ppa-2021-0011","DOIUrl":"https://doi.org/10.4155/ppa-2021-0011","url":null,"abstract":"A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41578563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccines and treatments for Zika virus infection: patent status, triumphs and challenges. 寨卡病毒感染的疫苗和治疗:专利现状、胜利和挑战。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-09-01 Epub Date: 2021-09-07 DOI: 10.4155/ppa-2021-0014
Sandro G Viveiros Rosa, Wilson C Santos
{"title":"Vaccines and treatments for Zika virus infection: patent status, triumphs and challenges.","authors":"Sandro G Viveiros Rosa,&nbsp;Wilson C Santos","doi":"10.4155/ppa-2021-0014","DOIUrl":"https://doi.org/10.4155/ppa-2021-0014","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 5","pages":"209-213"},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treating Dravet syndrome: a patent landscape. 治疗Dravet综合征:专利景观。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-09-01 Epub Date: 2021-09-07 DOI: 10.4155/ppa-2021-0020
Barbara Miziak, Stanislaw J Czuczwar
{"title":"Treating Dravet syndrome: a patent landscape.","authors":"Barbara Miziak,&nbsp;Stanislaw J Czuczwar","doi":"10.4155/ppa-2021-0020","DOIUrl":"https://doi.org/10.4155/ppa-2021-0020","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 5","pages":"215-217"},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier. 一种无毒离子液体组合物，用于跨越皮肤屏障递送生物大分子阴离子。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0012
Neeraj Kumar, Balraj Saini, Rajwinder Kaur
{"title":"A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier.","authors":"Neeraj Kumar,&nbsp;Balraj Saini,&nbsp;Rajwinder Kaur","doi":"10.4155/ppa-2021-0012","DOIUrl":"https://doi.org/10.4155/ppa-2021-0012","url":null,"abstract":"<p><p>The development of biocompatible ionic liquids is needed in order to explore their vastly underutilized pharmaceutical potential. US10912834 patent discloses ionic liquids comprising macromolecular biological anions and alkylated cations, which provides enhanced dermal delivery and cell internalization of the large biological anions. The studies of <i>ex vivo</i> permeation through excised pig skin indicated significantly higher skin penetration of percent dose and enhanced drug internalization was achieved using these ionic liquids. Although, the patent advances an infant field of biological macromolecule-based ionic liquids, the evaluation of these claimed ionic liquids relies only on the <i>in vivo</i> cytotoxicity data and <i>ex vivo</i> skin permeation behavior. Exhaustive studies, including dermatokinetic evaluation and long-term animal toxicity experiments, should be performed in order to unravel the potential of the aforementioned ionic liquids.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 4","pages":"191-194"},"PeriodicalIF":1.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39289974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Patentability challenges associated with emerging pharmaceutical technologies. 与新兴制药技术相关的可专利性挑战。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-07-13 DOI: 10.4155/ppa-2021-0009
Srishti Aggarwal, Amrish Chandra
{"title":"Patentability challenges associated with emerging pharmaceutical technologies.","authors":"Srishti Aggarwal,&nbsp;Amrish Chandra","doi":"10.4155/ppa-2021-0009","DOIUrl":"https://doi.org/10.4155/ppa-2021-0009","url":null,"abstract":"<p><p>According to the recent patent filing trends, it has been observed that certain pharmaceutical technologies are more popular than others and are commonly referred to as emerging technologies. The emerging technologies in the pharmaceutical sector include artificial intelligence, big data and certain advanced biological therapies such as personalized medicine and stem cell therapy. These trends have various applications in the medicine and healthcare industry. Since these technologies are relatively new and each of them is very unique in its own way, current patent laws are inadequate to deal with the complex challenges associated with them. A brief analysis of the challenges associated with these emerging technologies and their applications is discussed in this paper.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 4","pages":"195-207"},"PeriodicalIF":1.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39177129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Patent highlights February-March 2021. 2021 年 2 月至 3 月的专利要点。
IF 1.8
Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-07-07 DOI: 10.4155/ppa-2021-0010
Hermann Am Mucke
{"title":"Patent highlights February-March 2021.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2021-0010","DOIUrl":"10.4155/ppa-2021-0010","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 4","pages":"183-190"},"PeriodicalIF":1.8,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39155477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5-HT4R modulators: a patent landscape. 5-HT4R调制器:专利景观。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0017
Patrick Dallemagne, Christophe Rochais
{"title":"5-HT4R modulators: a patent landscape.","authors":"Patrick Dallemagne,&nbsp;Christophe Rochais","doi":"10.4155/ppa-2021-0017","DOIUrl":"https://doi.org/10.4155/ppa-2021-0017","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"10 4","pages":"179-181"},"PeriodicalIF":1.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39289579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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