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Drug repurposing of mito-atovaquone for cancer treatment. Mito-Atovaquone用于癌症治疗的药物再利用。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-07-01 Epub Date: 2023-10-06 DOI: 10.4155/ppa-2023-0015
Nemesio Villa-Ruano, Maricruz Anaya-Ruiz, Luis Villafaña-Diaz, Diana Barron-Villaverde, Martin Perez-Santos
{"title":"Drug repurposing of mito-atovaquone for cancer treatment.","authors":"Nemesio Villa-Ruano, Maricruz Anaya-Ruiz, Luis Villafaña-Diaz, Diana Barron-Villaverde, Martin Perez-Santos","doi":"10.4155/ppa-2023-0015","DOIUrl":"10.4155/ppa-2023-0015","url":null,"abstract":"<p><p>Repurposing of approved drugs in a new strategy to combat cancer that leads to savings in time and investment. Atovaquone is a US FDA-approved drug for treatment of <i>Pneumocystis carinii</i> pneumonia and malaria. Patent US2023017373 describe the use of mito-atovaquone for the treatment of several types of cancer. Mito-atovaquone demonstrated antiproliferative activity in cell lines of pancreatic cancer, lung cancer and brain cancer and inhibited tumor growth in syngeneic mouse models and in animals genetically prone to breast cancer. Mito-atovaquone has the potential to be used successfully in the treatment of various types of tumors.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"143-149"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent profile for the approved and in clinical trials Mpox vaccines. 已批准和正在进行临床试验的猴痘疫苗的专利简介。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-09-06 DOI: 10.4155/ppa-2023-0017
Irene von der Weid, Cristina d'Urso de Souza Mendes, Paula C Fonseca, Sandro G Viveiros Rosa
{"title":"Patent profile for the approved and in clinical trials Mpox vaccines.","authors":"Irene von der Weid, Cristina d'Urso de Souza Mendes, Paula C Fonseca, Sandro G Viveiros Rosa","doi":"10.4155/ppa-2023-0017","DOIUrl":"10.4155/ppa-2023-0017","url":null,"abstract":"<p><p>Mpox disease was reported in 110 countries since May 2022, with 88,026 cases and 148 deaths by 21 June 2023. Although some drugs were already approved for Mpox treatment, the available smallpox vaccines can provide 85% cross-prevention, but there are no scientific publications describing the patent portfolio for Mpox vaccines. This paper aims to contribute to the identification of the status of the smallpox vaccine patents now applied for Mpox. We retrieved ten vaccines, but only a few had a patent portfolio and one under patent litigation processes in three continents. Also, no specific Mpox vaccine was retrieved and, in this sense, technological monitoring studies should be performed to provide a future vision regarding Mpox prophylaxis.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"103-111"},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morita-Baylis-Hillman adducts and their derivatives: a patent-based exploration of diverse biological activities. Morita-Baylis-Hillman加合物及其衍生物：对多种生物活性的专利探索。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-09-06 DOI: 10.4155/ppa-2023-0021
Ricardo S Porto, Viviane A Porto
{"title":"Morita-Baylis-Hillman adducts and their derivatives: a patent-based exploration of diverse biological activities.","authors":"Ricardo S Porto,&nbsp;Viviane A Porto","doi":"10.4155/ppa-2023-0021","DOIUrl":"10.4155/ppa-2023-0021","url":null,"abstract":"<p><p>Morita-Baylis-Hillman adducts are polyfunctionalized compounds that result from a three-component reaction involving an electrophilic sp<sup>2</sup> carbon (aldehyde, ketone or imine) and the α-position of an activated alkene, catalyzed by a tertiary amine. These adducts exhibit a wide range of biological activities and act as valuable starting materials for developing drug candidates, pesticides, polymers, and other applications. In this regard, the present review aimed to explore the biological potential of Morita-Baylis-Hillman adducts and their derivatives as documented in patent literature. Additionally, the review delves into the synthetic methodologies employed in their preparation.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"127-141"},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights October-November 2022. 专利亮点2022年10月至11月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-07-21 DOI: 10.4155/ppa-2023-0008
Hermann Am Mucke
{"title":"Patent highlights October-November 2022.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2023-0008","DOIUrl":"10.4155/ppa-2023-0008","url":null,"abstract":"<p><p>A snapshot of recent noteworthy developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"95-102"},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9844105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent analysis of novel therapeutic approaches for treating Alzheimer's disease 2018-2023. 治疗阿尔茨海默病的新型治疗方法专利分析2018-2023。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-07-21 DOI: 10.4155/ppa-2023-0020
Faiza Saleem, Fouzia Naz, Khalid M Khan
{"title":"Patent analysis of novel therapeutic approaches for treating Alzheimer's disease 2018-2023.","authors":"Faiza Saleem,&nbsp;Fouzia Naz,&nbsp;Khalid M Khan","doi":"10.4155/ppa-2023-0020","DOIUrl":"10.4155/ppa-2023-0020","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"91-94"},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9844106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contact lens disinfectants against Acanthamoeba keratitis: an overview of recent patents and future needs. 抗棘阿米巴角膜炎的隐形眼镜消毒剂：近期专利和未来需求综述。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-08-31 DOI: 10.4155/ppa-2023-0012
Ruqaiyyah Siddiqui, Naveed A Khan
{"title":"Contact lens disinfectants against <i>Acanthamoeba</i> keratitis: an overview of recent patents and future needs.","authors":"Ruqaiyyah Siddiqui,&nbsp;Naveed A Khan","doi":"10.4155/ppa-2023-0012","DOIUrl":"10.4155/ppa-2023-0012","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"87-89"},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10113080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current landscape and future prospects of RET and ROS1 targets. RET和ROS1目标的现状和未来前景。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-09-06 DOI: 10.4155/ppa-2023-0011
Hai-Long Zhang, Qian Kong
{"title":"Current landscape and future prospects of RET and ROS1 targets.","authors":"Hai-Long Zhang,&nbsp;Qian Kong","doi":"10.4155/ppa-2023-0011","DOIUrl":"10.4155/ppa-2023-0011","url":null,"abstract":"<p><p>RET and ROS1 are becoming key targets for targeted therapy. To show current landscape of ROS1 and RET targets, a patent analysis was performed. The present results indicated that inhibitor structures of ROS1 target demonstrated unique elements compared with inhibitor structures of RET or BRAF targets. Our study was the first time to uncover that a number of inhibitor structures of ROS1 target contained sulfur and boron elements. The inhibitors of RET target could be developed for treatment of various cancers, including lung cancer, thyroid cancer, and other solid tumor, while the inhibitors of ROS1 target are virtually developed for treatment of lung cancer. Our findings provide a new insight for drug discovery of ROS1 and RET target.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":" ","pages":"113-126"},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10163336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights August-September 2022. 专利亮点2022年8月至9月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 DOI: 10.4155/ppa-2022-0049
Hermann Am Mucke
{"title":"Patent highlights August-September 2022.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2022-0049","DOIUrl":"https://doi.org/10.4155/ppa-2022-0049","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"12 2","pages":"61-68"},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9590079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Riluzole and its prodrugs for the treatment of Alzheimer's disease. 用于治疗阿尔茨海默病的利鲁唑及其原药。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 Epub Date: 2023-05-04 DOI: 10.4155/ppa-2023-0001
Rami A Al-Horani
{"title":"Riluzole and its prodrugs for the treatment of Alzheimer's disease.","authors":"Rami A Al-Horani","doi":"10.4155/ppa-2023-0001","DOIUrl":"10.4155/ppa-2023-0001","url":null,"abstract":"<p><p>Current medications for Alzheimer's disease help manage symptoms and behavioral problems. Nevertheless, they do not slow the progression of cognitive decline or dementia. A potential approach for treating Alzheimer's disease is to target neurons that are sensitive to disease pathobiology such as glutamatergic neurons. Several patents disclosed methods for treating Alzheimer's disease by administering riluzole or its prodrugs. Clinical trials revealed that 6 months treatment using riluzole or troriluzole is associated with a slower decline in the tomographic measures of the positron emissions of cerebral glucose metabolism in Alzheimer's patients. The proposed strategy claims to prevent and/or slow the cognitive decline of Alzheimer's patients and to enhance global functioning. These claims may also pave the way for other glutamate modulators to be used for Alzheimer's disease.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"12 2","pages":"79-85"},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9756399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patents, pharmaceutical industry and healthcare. 专利，制药工业和医疗保健。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 DOI: 10.4155/ppa-2023-0009
Ruqaiyyah Siddiqui, Naveed A Khan
{"title":"Patents, pharmaceutical industry and healthcare.","authors":"Ruqaiyyah Siddiqui,&nbsp;Naveed A Khan","doi":"10.4155/ppa-2023-0009","DOIUrl":"https://doi.org/10.4155/ppa-2023-0009","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":"12 2","pages":"57-60"},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9684984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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