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Contact lens disinfectants against Acanthamoeba keratitis: an overview of recent patents and future needs. 抗棘阿米巴角膜炎的隐形眼镜消毒剂：近期专利和未来需求综述。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-05-01 Epub Date: 2023-08-31 DOI: 10.4155/ppa-2023-0012
Ruqaiyyah Siddiqui, Naveed A Khan
{"title":"Contact lens disinfectants against <i>Acanthamoeba</i> keratitis: an overview of recent patents and future needs.","authors":"Ruqaiyyah Siddiqui,&nbsp;Naveed A Khan","doi":"10.4155/ppa-2023-0012","DOIUrl":"10.4155/ppa-2023-0012","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10113080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent highlights August-September 2022. 专利亮点2022年8月至9月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 DOI: 10.4155/ppa-2022-0049
Hermann Am Mucke
{"title":"Patent highlights August-September 2022.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2022-0049","DOIUrl":"https://doi.org/10.4155/ppa-2022-0049","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9590079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Riluzole and its prodrugs for the treatment of Alzheimer's disease. 用于治疗阿尔茨海默病的利鲁唑及其原药。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 Epub Date: 2023-05-04 DOI: 10.4155/ppa-2023-0001
Rami A Al-Horani
{"title":"Riluzole and its prodrugs for the treatment of Alzheimer's disease.","authors":"Rami A Al-Horani","doi":"10.4155/ppa-2023-0001","DOIUrl":"10.4155/ppa-2023-0001","url":null,"abstract":"<p><p>Current medications for Alzheimer's disease help manage symptoms and behavioral problems. Nevertheless, they do not slow the progression of cognitive decline or dementia. A potential approach for treating Alzheimer's disease is to target neurons that are sensitive to disease pathobiology such as glutamatergic neurons. Several patents disclosed methods for treating Alzheimer's disease by administering riluzole or its prodrugs. Clinical trials revealed that 6 months treatment using riluzole or troriluzole is associated with a slower decline in the tomographic measures of the positron emissions of cerebral glucose metabolism in Alzheimer's patients. The proposed strategy claims to prevent and/or slow the cognitive decline of Alzheimer's patients and to enhance global functioning. These claims may also pave the way for other glutamate modulators to be used for Alzheimer's disease.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9756399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patents, pharmaceutical industry and healthcare. 专利，制药工业和医疗保健。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 DOI: 10.4155/ppa-2023-0009
Ruqaiyyah Siddiqui, Naveed A Khan
{"title":"Patents, pharmaceutical industry and healthcare.","authors":"Ruqaiyyah Siddiqui,&nbsp;Naveed A Khan","doi":"10.4155/ppa-2023-0009","DOIUrl":"https://doi.org/10.4155/ppa-2023-0009","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9684984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent landscape highlighting double-edged scaffold of a WNT5A-agonizing peptide, Foxy5. 专利景观突出wnt5a痛苦肽Foxy5的双刃支架。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 DOI: 10.4155/ppa-2022-0037
Vikas Yadav, Rubina Islam, Hardeep Singh Tuli
{"title":"Patent landscape highlighting double-edged scaffold of a WNT5A-agonizing peptide, Foxy5.","authors":"Vikas Yadav,&nbsp;Rubina Islam,&nbsp;Hardeep Singh Tuli","doi":"10.4155/ppa-2022-0037","DOIUrl":"https://doi.org/10.4155/ppa-2022-0037","url":null,"abstract":"<p><p>Aberrant expression of the WNT signaling pathway has been associated with cancer progression and recurrence. Research over the decades has led to development of WNT-targetable small molecules, but has faced challenges in translating to clinics. Unlike WNT/β-catenin inhibitors, WNT5A-mimicking peptide, Foxy5 has shown encouraging efficacy in impairing metastasis of cancers with low or absent WNT5A expression. Recent patent application US20210008149 advocates the implication of Foxy5 for treatment and prevention of cancer relapse. The inventors have demonstrated the anti-stemness activity of Foxy5 in mice xenograft model via suppressing the expression of colonic cancer stem cell markers. Foxy5 also exhibits non-toxic nature when administered alone or in synergy with standard chemotherapy thus strengthening its candidature in the field of cancer therapeutics.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of EPO Board of Appeal antibody decisions in 2022. 2022年对欧洲专利局上诉委员会抗体决定的复审。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-03-01 DOI: 10.4155/ppa-2023-0014
Daniel Hilton, Vicki Allen, Graham Lewis
{"title":"Review of EPO Board of Appeal antibody decisions in 2022.","authors":"Daniel Hilton,&nbsp;Vicki Allen,&nbsp;Graham Lewis","doi":"10.4155/ppa-2023-0014","DOIUrl":"https://doi.org/10.4155/ppa-2023-0014","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
4-(Imidazo[1,2-a]pyridin-3-yl): pyrimidine derivatives as anticancer agents. 4-(咪唑并[1,2-a]吡啶-3-基)：作为抗癌剂的嘧啶衍生物。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-01-01 Epub Date: 2022-11-10 DOI: 10.4155/ppa-2022-0033
Rami A Al-Horani
{"title":"4-(Imidazo[1,2-a]pyridin-3-yl): pyrimidine derivatives as anticancer agents.","authors":"Rami A Al-Horani","doi":"10.4155/ppa-2022-0033","DOIUrl":"10.4155/ppa-2022-0033","url":null,"abstract":"<p><p>A series of 4-(imidazo[1,2-a]pyridin-3-yl)-pyrimidine derivatives are claimed as inhibitors of c-KIT and as potential treatments for cancer. Their chemical preparation and biological evaluation against imatinib-resistant tumor cells have been described. Several claimed molecules have excellent IC<sub>50</sub> values in the nanomolar range. Several molecules were also selective against a wide panel of kinases. Few specific inhibitors have been found to have promising oral bioavailability and acceptable to excellent values regarding the inhibition of hERG channel. This class represents a new platform for developing new anticancer treatment against a wide range of c-KIT mutations and secondary mutations that may arise in gastrointestinal stromal tumor patients.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9320448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patent developments via Schiff bases in medicinal chemistry. 药物化学中希夫碱基的专利开发。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-01-01 DOI: 10.4155/ppa-2022-0045
Maham Haider, Khalid Mohammed Khan
{"title":"Patent developments <i>via</i> Schiff bases in medicinal chemistry.","authors":"Maham Haider,&nbsp;Khalid Mohammed Khan","doi":"10.4155/ppa-2022-0045","DOIUrl":"https://doi.org/10.4155/ppa-2022-0045","url":null,"abstract":"","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9290506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoresponsive liposomes: an alternative of ELISA for the detection of low quantities of target substances. 光反应性脂质体:用于检测少量目标物质的ELISA替代方法。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-01-01 DOI: 10.4155/ppa-2022-0046
Ramesh Joga, Hitesh Kumar Behera, Chetan Dushant Sabanis, Simran, Sandeep Kumar, Neeraj Kumar
{"title":"Photoresponsive liposomes: an alternative of ELISA for the detection of low quantities of target substances.","authors":"Ramesh Joga,&nbsp;Hitesh Kumar Behera,&nbsp;Chetan Dushant Sabanis,&nbsp;Simran,&nbsp;Sandeep Kumar,&nbsp;Neeraj Kumar","doi":"10.4155/ppa-2022-0046","DOIUrl":"https://doi.org/10.4155/ppa-2022-0046","url":null,"abstract":"<p><p>Photoresponsive liposome development is needed to serve as a facile alternative to ELISA which is ineffective for detecting small levels of biomarkers due to low detection sensitivity. The US20210396744 patent application outlines novel photoresponsive liposomes for the detection of target substances with the aid of light. Although versatile, there may be possible stability issues that can be avoided with the appropriate selection of liposome components. Furthermore, the clinical success of this technology depends on many parameters like plasma stability, efficient loading of photosensitive components in the membrane and immobilization of molecular recognition elements to the membrane. Despite several challenges, they possess enormous potential to become a non-invasive tool for the detection of target substances.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9579358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Patent Highlights June-July 2022. 专利亮点2022年6月至7月。
IF 1.3
Pharmaceutical patent analyst Pub Date : 2023-01-01 DOI: 10.4155/ppa-2022-0043
Hermann Am Mucke
{"title":"Patent Highlights June-July 2022.","authors":"Hermann Am Mucke","doi":"10.4155/ppa-2022-0043","DOIUrl":"https://doi.org/10.4155/ppa-2022-0043","url":null,"abstract":"<p><p>A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.</p>","PeriodicalId":20011,"journal":{"name":"Pharmaceutical patent analyst","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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