金刚乙胺治疗癌症的药物再利用。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Pharmaceutical patent analyst Pub Date : 2023-09-01 Epub Date: 2023-11-20 DOI:10.4155/ppa-2023-0019
Nemesio Villa-Ruano, Vianey Marin-Cevada, Gabriela Sanchez-Esgua, Luis Villafaña-Diaz, Martin Perez-Santos
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引用次数: 0

摘要

重新利用已批准的药物可以大大节省时间和投资。金刚乙胺是fda批准的预防和治疗甲型流感感染的药物。专利US2021330605描述了金刚烷衍生物金刚乙胺用于治疗黑色素瘤、乳腺癌和头颈部鳞状细胞癌的用途。金刚乙胺抑制黑色素瘤、乳腺癌和头颈部鳞状细胞癌细胞系的增殖,增加注射癌细胞的小鼠的存活率,恢复MHC i类的表达。金刚乙胺有可能成功用于头颈部鳞状细胞癌的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Drug repurposing of rimantadine for treatment of cancer.

Repurposing of approved drugs allows strong savings in time and investment. Rimantadine is an FDA-approved drug for prevention and treatment of influenza A infection. Patent US2021330605 describes the use of rimantadine, an adamantane derivative, for the treatment of melanoma, breast cancer and head and neck squamous cell carcinoma. Rimantadine inhibited proliferation of cell lines of melanoma, breast cancer, and head and neck squamous cell carcinoma, increased the survival of mice injected with cancer cell lines and restores the expression of MHC class I. Rimantadine has the potential to be used successfully in the treatment of head and neck squamous cell carcinoma.

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Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
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22
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