Accounts of Chemical Research最新文献

{"title":"Zigzag-Type Molecular Belts: Synthesis, Structure, and Properties.","authors":"Tan-Hao Shi, Qing-Hui Guo, Shuo Tong, Mei-Xiang Wang","doi":"10.1021/acs.accounts.5c00328","DOIUrl":"https://doi.org/10.1021/acs.accounts.5c00328","url":null,"abstract":"<p><p>ConspectusSince Heilbronner proposed cyclacenes as hypothetical molecules in 1954, zigzag hydrocarbon belts and their heteroatom-doped analogs have captivated chemists and materials scientists with their aesthetically appealing structures, intriguing properties, and potential applications. Except for the work reported in the late 1980s and early 1990s by Stoddart, who employed iterative Diels-Alder reactions to construct such belts, the field has remained dormant for decades. This stagnation is primarily due to the lack of synthetic methods. At the beginning of this millennium, we created heteracalix[<i>n</i>]aromatics, macrocyclic hosts that have since been developed into privileged macrocyclic hosts in supramolecular chemistry due to their ease of synthesis and versatile applications. One of the salient structural features of heteracalix[<i>n</i>]aromatics and related calix[<i>n</i>]arenes and resorcin[<i>n</i>]arenes is their ability to adopt distinct conformations. Notably, these conformations can be tuned by varying the ring sizes, substituents, and synthetic conditions. We envisioned that the preorganized macrocycles with aromatic rings in close proximity could provide ideal scaffolds, and chemical bonding to stitch each fjord encompassed by adjacent aromatic rings would lead to zigzag-type molecular belts. We initiated our study with the aim of synthesizing strained belt[8]arenes. Leveraging the cone-conformational resorcin[4]arenes and facile transformations of phenolic hydroxyl groups in fjords, we successfully prepared H<sub>8</sub>-belt[8]arenes by stitching fjords through quadruple intramolecular Friedel-Crafts alkylation. Subsequent oxidative aromatization with DDQ produced a belt[8]arene-(DDQ)<sub>4</sub> adduct. Upon laser irradiation, the adduct underwent retro-Diels-Alder reactions, enabling for the first time the formation of belt[8]arene, a fully conjugated zigzag hydrocarbon belt. The fjord-stitching method has since evolved into a versatile and powerful strategy. A diversity of hydrocarbon belts having different sizes, shapes, and functional groups have been synthesized through multiple fjord-stitching reactions such as Friedel-Crafts alkylation and acylation and olefin metathesis. To bridge fjords with oxygen and nitrogen atoms through S<sub>N</sub>Ar reactions and transition-metal-mediated carbon-heteroatom bond coupling, we have achieved the construction of heteroatom-doped hydrocarbon belts. In addition, C<sub>Ar</sub>-C<sub>Ar</sub> homocoupling reactions to seal all fjords of azacalix[<i>n</i>](3,5-dibromopyridine)s furnished globally aromatic zigzag-type belts consisting of pyrrole and pyridine subunits. Depending on the combinations of constitutional hexagonal and nonhexagonal carbocyclic or heterocyclic subrings, zigzag-type belts adopt unique and appealing structures to give cavities that range from distinct prisms to truncated cones and nearly spherical frustums. Governed by the steric and electronic effects,","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":""},"PeriodicalIF":16.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral sensorineural hearing loss after opioid overdose in an adolescent male.","authors":"Kelsey Richard, Miriam R Smetak, April Peterson, James Phillips, Frank Virgin","doi":"10.1177/01455613221129932","DOIUrl":"10.1177/01455613221129932","url":null,"abstract":"<p><p>Opioid-induced hearing loss has been described as a form of sudden sensorineural hearing loss that can occur with chronic or acute opioid use. Here, we report a case of a 16-year-old patient with sudden onset hearing loss after opioid overdose requiring prolonged intubation with fentanyl sedation.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP457-NP459"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33478253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival analysis in head and neck melanoma after negative sentinel lymph node biopsy: A seer-based population study.","authors":"Shulian Li, Jun Tang, Lanlan Wang, Juxiang Gou, Wei You, Qiang Ji","doi":"10.1177/01455613221126327","DOIUrl":"10.1177/01455613221126327","url":null,"abstract":"<p><p>BackgroundCutaneous malignant melanoma (CMM) is one of the most aggressive skin tumors. Sentinel lymph node biopsy (SLNB) is an important test before thorough treatment of melanoma. The aim of this study was to investigate cancer-specific survival (CSS) in patients with head and neck CMM after negative SLNB and to analyze predictors of decreased survival.MethodsBased on the Surveillance, Epidemiology and End Results (SEER) database, a study was conducted using data from patients with head and neck CMM after negative SLNB. The demographic, clinical, and pathological characteristics of the case population were analyzed. Cox univariate, Kaplan-Meier analysis, and multivariate Cox regression models were used to explore predictors of decreased survival; propensity score matching (PSM) analysis was used to reduce confounding bias, and outcomes were compared between the wide margin excision and narrow margin excision groups.ResultsA total of 1597 confirmed head and neck CMM patients with SLNB-negative were found. A Breslow>4.0 mm was the highest independent risk predictor for patients (HR 3.82, 95% CI 2.04-7.16, <i>P</i> < .001), and significant risk independent predictors also included a high mitotic rate >4 (HR 1.54, 95% CI 1.06-2.25, <i>P</i> = .023). Age< 60 years old was a significant survival predictor (HR 0.56, 95% CI .37-.85, <i>P</i> = .007), and not scalp and neck CMM were also important factors for longer survival (auricle skin: HR .51, 95% CI .29-.90, <i>P</i> = .02; unspecified parts of face: HR .59, 95% CI .40-.87, <i>P</i> = .007). After harmonizing baseline data by PSM, it was found that the extent of surgical resection did not affect patient survival.ConclusionThis study analyzed the risk factors affecting CSS in patients with CMM of the head and neck region with SLNB-negative and observed a statistically significant difference in the prognosis of patients with CMM in different aesthetic subunits of the head and neck region. Close clinical follow-up for this population is necessary, and periodic medical examinations should be carried out.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP441-NP449"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40368927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Respiratory Events After Pediatric Endoscopic Airway Surgeries.","authors":"Waleed A Alshareef, Bshair A Aldriweesh, Nasser K Almutairi, Albaraa Y Alsini, Abdulmajeed S Zakzouk, Abdullah I Aljasser, Ahmed Y Alammar","doi":"10.1177/01455613221128111","DOIUrl":"10.1177/01455613221128111","url":null,"abstract":"<p><p>ObjectivePerioperative risk stratification of pediatric patients undergoing airway intervention remains crucial in identifying those at a higher risk of requiring postoperative intensive care unit (ICU) care. Here we determined the likelihood of and possible risk factors for developing perioperative adverse respiratory events (PAREs) requiring ICU care after various pediatric endoscopic airway surgeries (EASs).MethodsWe conducted a retrospective chart review of pediatric patients who were aged <18 years and underwent EAS between 2015 and 2021. Early postoperative adverse events within 24 h of surgery were recorded and analyzed.ResultsOverall, 99 patients who underwent EAS were included. The age at the time of the intervention ranged from 8 months to 18 years. Fifty-eight patients, median age was 4.83 years, underwent papilloma debulking with no high likelihood of PARE in this patient subgroup (OR = 0.48; 0.16-1.44). Twenty-five patients, median age was 9.72 years, underwent balloon dilation of laryngotracheal stenosis with no increase in the likelihood of PARE in this patient population (OR = 2.02; 0.65-6.28). Early postoperative respiratory events occurred in 16 patients (16.2%). Most of these events (75%) manifested within 4 h after surgery. In a univariate analysis, intervention at the level of the subglottis or 2 or more laryngeal subsites increased the risk of PARE (OR = 6.57; 1.11-12.52 and OR = 3.73; 1.93-22.34, respectively). In a multivariate analysis, only intervention in the subglottic area maintained its effect (OR = 6.84; 1.82-25.65).ConclusionRespiratory adverse events following pediatric EAS are not uncommon, and the majority are encountered shortly after surgery. Intervention in the subglottic area was an independent predictor of PARE.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"444-449"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40361506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Siqiang Fang,&nbsp;Zanjiao Liu,&nbsp;Fan Wang and Tianli Wang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Mian Chen,&nbsp; and ,&nbsp;Jinyao Liu*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 13","pages":"962–968 XXX-XXX"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.5c00271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interprofessional model of care for oral health during pregnancy.","authors":"A Adeniyi, L Donnelly, P Janssen, C Jevitt, Hc Von Bergmann, M Brondani","doi":"10.1080/13561820.2021.2017417","DOIUrl":"10.1080/13561820.2021.2017417","url":null,"abstract":"<p><p>The study aim was to appraise the relevance and appropriateness of an interprofessional prenatal oral care model among pregnant women and healthcare providers in British Columbia (BC), Canada. Audio-recorded semi-structured interviews with 39 purposefully selected participants (13 pregnant women and 26 healthcare professionals) were used qualitatively to appraise relevance of an existing model. The existing model emphasizes communication and collaboration among multiple health providers for the delivery of integrated prenatal oral care. All interviews were transcribed verbatim and analyzed using an inductive thematic approach and N-Vivo® software. During the first round of interviews, most participants considered the existing model as simple and well-defined but not fully relevant to the BC context. The participants suggested revisions to Steven's model to incorporate facilitators of integrated care, including interprofessional education, oral health funding, and advocacy for oral healthcare. Participants suggested a different graphical portrayal for the revised model; an implementation guide was also suggested. A revised model based on participants' feedback, was shared with 14 of the initial participants during secondary interviews. Further evaluation of the appropriateness of the revised model is warranted.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"627-635"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/10790268.2022.2123656","DOIUrl":"10.1080/10790268.2022.2123656","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"758-759"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33481620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Extremely Rare Case of Carcinosarcoma Ex Pleomorphic Adenoma.","authors":"Elif Gozgec, Hayri Ogul, Onur Ceylan","doi":"10.1177/01455613221130888","DOIUrl":"10.1177/01455613221130888","url":null,"abstract":"<p><p>Carcinosarcoma ex pleomorphic adenoma (CCPA), also known as true mixed malignant tumor, is an extremely rare high-grade aggressive tumor. The histopathologic examination is the gold standard for diagnosis and radiologic imaging also plays an important role. CCPA should be considered in the differential diagnosis of salivary gland tumors when there are findings suggestive of malignancy such as necrosis and diffusion limitation on imaging.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP465-NP468"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40380318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Gland Flap for Prevention of Pharyngocutaneous Fistula After Total Laryngectomy.","authors":"Bokhyun Song, Ye-Jin Suh, Tae Hwan Kim, Young-Ik Son, Nayeon Choi","doi":"10.1177/01455613221124774","DOIUrl":"10.1177/01455613221124774","url":null,"abstract":"<p><p>ObjectivesPharyngocutaneous fistula (PCF) is the one of the major complications after total laryngectomy (TL), which can result in saliva leakage, rupture of major vessels, and increased hospitalization. Several flaps have been tried to prevent PCF during TL, and they are usually associated with donor site morbidity and uncertain viability in case of previously irradiated patients. This study aimed to report a novel bilateral pedicled thyroid gland flap (TGF) technique for delicate and effective reinforcement of neopharynx suture line after TL.MethodsBilateral pedicled TGF was performed for the reinforcement of neopharynx T-shape suture sites after TL in this case series.ResultsA total of five cases of the TGF were performed during TL, with four of them being salvage setting following previous chemoradiation therapy (CRT). The well-adapted and viable TGF status was confirmed by post-operative computed tomography scan and normally preserved thyroid hormone levels in all patients. No post-operative infections, hemorrhage, hypothyroidism, hypoparathyroidism, or PCF were reported.ConclusionThe TGF is an effective and reliable flap in TL patents and should be considered as a method in neopharynx reconstruction, even in salvage TL following prior CRT.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"405-410"},"PeriodicalIF":16.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40337819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}