Ping Li, Tao Li, Liang Yu, Aiping Chen, Yisha Wu, Yuzhu Wan, Li Shi
{"title":"Predictive Value of Adenoid-Nasopharyngeal Ratio in the Diagnosis of Secretory Otitis Media.","authors":"Ping Li, Tao Li, Liang Yu, Aiping Chen, Yisha Wu, Yuzhu Wan, Li Shi","doi":"10.1177/01455613221144496","DOIUrl":"10.1177/01455613221144496","url":null,"abstract":"<p><p>ObjectivesTo explore the associated factors of otitis media with effusion (OME) and analyze the diagnostic value of the adenoid-nasopharyngeal (A/N) ratio to OME.MethodsPatients with adenoid hypertrophy (AH) recently in 2 years were collected, including sex, age, duration, with/without rhinosinusitis, and examination results, including Cone Beam Computerized Tomography (CBCT) sinus imaging, tympanometry, pure tone audiometry (PTA), blood test, and allergen detection. According to Liden/Jerger's classification, the patients were divided into two groups: Type B and type C, which were defined as the tympanometry abnormal group (TAG), and the rest were classified as the tympanometry normal group (TNG).ResultsA total of 316 children were included in this study. Age and duration were significantly younger and shorter in TAG (6.0(4.0-9.0) vs.5.0(4.0-7.0)); 12.0(4.0-24.0) vs.6.0(2.0-12.0)). Compared to TNG, the allergen test results of fx5 (protein, milk, cod, wheat, peanut, and soybean) in TAG were higher (0.09(0.04-0.25) vs.0.14(0.05-0.45)), but eosinophilia in blood was lower (count: 0.21(0.13-0.35) vs. 0.18(0.12-0.27); ratio: 3.10 (1.90-4.70) vs. 2.50 (1.65-3.80)). A/N ratio and Visual obstruction ratio had a statistical difference (Z = -3.770, <i>P</i> < .01) but the two ratios didn't have too much disparity (0.82(0.74-0.88) VS 0.80(0.75-0.80)), and they had a positive correlation (r = 0.345, <i>P</i> < .01). A/N ratio of TAG was higher than TNG (0.78(0.70-0.85) vs. 0.86(0.82-0.90)) and had a positive correlation with increasing negative middle ear pressure (r = -3.777, <i>P</i> < .01). A/N ratio was an associated factor of OME (OR:1355.611, <i>P</i> = .006), the cut-off value of A/N ratio was 0.815(sensitivity: 75.3%, specificity: 64.3%, area under the curve (AUC): 0.747)ConclusionsA/N ratio indirectly reflected the abnormality of tympanometry in this study. When A/N ratio reaches 0.815, patients are at a higher risk of having OME so it could be a predictor of OME in patients with adenoid hypertrophy.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP618-NP625"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40464774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endolymphatic Sac Tumor.","authors":"Tanner P Lyons, Laura Barry, Robert T Sataloff","doi":"10.1177/01455613221139408","DOIUrl":"10.1177/01455613221139408","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"556-558"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mitsuo P Sato, Naoki Otsuki, Satoru Koike, Ryuji Yasumatsu
{"title":"Three Cases of Hematoma in the Retropharyngeal Space.","authors":"Mitsuo P Sato, Naoki Otsuki, Satoru Koike, Ryuji Yasumatsu","doi":"10.1177/01455613221141231","DOIUrl":"10.1177/01455613221141231","url":null,"abstract":"<p><p>ObjectivesHematoma in the retropharyngeal space (RPS) is a life-threatening condition that leads to rapid airway obstruction. However, the indication for airway management remains unclear. Additionally, the requirement for surgical hematoma evacuation remains undetermined. Therefore, we attempt to suggest some criteria for the management of hematoma in such cases.MethodsWe report three cases of hematoma in the RPS wherein one patient was treated without surgery and the other two underwent tracheotomy followed by hematoma evacuation.ResultsWe found that airway management should be based on whether the glottis could be visible on laryngoscopy and dyspnea severity. The degree of hematoma, swelling, subcutaneous bleeding in the anterior neck, and emotional stability should also be considered. Proper management during the acute phase may allow for conservative treatments. Hematomas extending below the tracheal bifurcation may help ease upper airway obstruction due to pressure distribution, allowing for conservative treatment. When hematomas are surgically evacuated, tracheotomy should be performed simultaneously. Our report suggests that mediastinal hematoma evacuation could be avoided.ConclusionWe should determine a therapeutic strategy for hematoma in RPS based on glottis visualization, patient's condition, and extent of hematoma growth under careful observation.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP594-NP598"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40701363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Starace, F Viviani, M A Carpanese, A Alessandrini, A Sechi, A Patrizi, T Bianchi
{"title":"Diagnosis and Management of Intravenous Drug Users' Chronic Wounds: A Case Series Collection of a Single Center.","authors":"M Starace, F Viviani, M A Carpanese, A Alessandrini, A Sechi, A Patrizi, T Bianchi","doi":"10.1177/15347346221121465","DOIUrl":"10.1177/15347346221121465","url":null,"abstract":"<p><p><b>Background:</b> Intravenous drug users (IVDUs) represent a very small group of patients affected by chronic wounds (CWs). <b>Objectives:</b> To assess the risk factors for CWs in IVDUs, to improve their treatment. <b>Methods:</b> A retrospective review of 7 IVDUs with CWs was performed at the Dermatology of the University of Bologna. <b>Results:</b> A history of 10 years of the most frequent injection was heroin in the gaiter area. The most observed comorbidities were HIV, HCV and HBV. They were treated most with an alginate with silver dressing with an average follow-up of 2.8 years. <b>Conclusions:</b> We would like to highlight the importance of clinical history in this type of patients and that in our experience specialized skin wounds risk assessment and management could be useful, aside from traditional compression therapy.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"719-722"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33445101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Sphenoid Mucocele Causing Hypopituitarism.","authors":"Elif Gozgec, Hayri Ogul","doi":"10.1177/01455613221142123","DOIUrl":"10.1177/01455613221142123","url":null,"abstract":"<p><p>Mucocele is rarely seen in the sphenoid sinus. It may cause compression of neighboring structures due to significant destruction of the bony structure and its expansile nature. Although headache is the main symptom, it may present with different symptoms. Imaging methods play an important role in the diagnosis and differential diagnosis.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"548-549"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40707315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gary D Josephson, Joshua B Bradshaw, Cheyenne Roohani, Jobayer Hossain, Steven M Andreoli, Jason E Lang
{"title":"Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy.","authors":"Gary D Josephson, Joshua B Bradshaw, Cheyenne Roohani, Jobayer Hossain, Steven M Andreoli, Jason E Lang","doi":"10.1177/01455613221101085","DOIUrl":"10.1177/01455613221101085","url":null,"abstract":"<p><p>ObjectivesChildhood adenotonsillar hypertrophy (ATH) with sleep-disordered breathing (SDB) frequently occurs concomitant with asthma. Adenotonsillectomy and reduction in asthma severity association has been reported. We describe changes in asthma control in nonobese or normal weight and obese/overweight children undergoing adenotonsillectomy for SDB.MethodsThis prospective, nonrandomized cohort trial with 6-month follow-up at a tertiary children's hospital enrolled 41 children with persistent asthma undergoing adenotonsillectomy for SDB. Children with significant chronic medical conditions, premature birth (< 28 weeks), or recent respiratory infection were excluded. Patients were stratified by baseline BMI into nonobese or normal weight (BMI <u><</u> 85 percentile) and obese/overweight (BMI > 85%). The primary outcome was change in Childhood Asthma Control Test (cACT) scores 3 and 6 months following adenotonsillectomy. Secondary outcome examined improvement in Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) 3 and 6 months following adenotonsillectomy.ResultsBaseline characteristics were similar except for anthropometric measures and mean PACQLQ (<i>P</i> = .03). Children with nonobese or normal weight (n = 26) had statistically significant improvement in change in cACT at 3 (22.80 ± 2.33 vs. 17.86 ± 3.53, <i>P</i> < .001) and 6 (20.71±3.29 vs. 18.24 ± 4.16, <i>P</i> = .044) months compared with baseline. PACQLQ scores also improved at 3 (6.20 ± 0.87 vs. 4.56 ± 1.12, <i>P</i> < .001) and 6 (6.36 ± 0.72 vs. 4.93 ± 0.96, <i>P</i> < .001) months. Obese/overweight children (n = 10) had significant improvement in cACT scores at 6 months (20.00 ± 3.90 vs. 15.00 ± 6.90, <i>P</i> = .048). Change of cACT scores at 3 months (17.86 ± 3.53 vs. 14.86 ± 6.31, <i>P</i> = .272) was not significantly different. PACQLQ scores improved at 3 (5.47 ± 1.09 vs. 3.70 ± 0.85, <i>P</i> < .001) and 6 (5.75 ± 2.19 vs. 3.67 ± 1.04, <i>P</i> = .016) months.ConclusionNonobese or normal-weight children undergoing adenotonsillectomy demonstrated significant improvement in asthma control scores at 3 and 6 and obese/overweight children at 6 months. Using the PACQLQ, caregiver quality of life improved for all children at 3 and 6 months. Surgical management of ATH in children with comorbid SBD and asthma is a good treatment option.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP613-NP617"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40548597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruru Tian, Haiqin Zhang, Daoyu Xie, Jinv Ding, Jianhua Jiang
{"title":"A Preliminary Study on the Characteristics and Standard Diagnosis and Treatment of Vestibular Dysfunction in Children.","authors":"Ruru Tian, Haiqin Zhang, Daoyu Xie, Jinv Ding, Jianhua Jiang","doi":"10.1177/01455613221139399","DOIUrl":"10.1177/01455613221139399","url":null,"abstract":"<p><p>ObjectiveTo understand the pathogenesis of vestibular dysfunction in children and to provide a reference for the diagnosis and treatment of vestibular dysfunction in children.MethodsA retrospective analysis was conducted on 80 children who visited our hospital from June 2011 to July 2020, aged between 4 and 17 years, with a duration of 1 day to 3 years. They were admitted to the hospital for treatment upon vestibular function-related examinations confirmed that there was peripheral vestibular function impairment.ResultsChildren aged 6-12 years old who are diagnosed are significantly more than other two age groups (4-6) and (12-17) (X<sup>2</sup> = 101.738, <i>P</i> < .001). There was a significant statistical difference (X<sup>2</sup> = 91.195, <i>P</i> < .001) in comparison of abnormal rates of vestibular function-related examinations. The Mann test had the highest abnormal rate and the lowest <i>Cervical Vestibular Evoked Myogenic Potential</i> (cVEMP) abnormality rate. Comparison of abnormal consistency rates for quantitative and qualitative examination of vestibular function, the abnormal rates (double temperature test and Mann test) were significantly better than other abnormal consistency rates, and there were statistical differences (X<sup>2</sup> = 7.485, <i>P</i> = .024 < .05). Among the children with vestibular dysfunction, the etiology was most common in 58 cases (72.50%) of benign paroxysmal vertigo, 4 cases of vestibular migraine (5.00%), 8 cases (10.00%) of vestibular neuronitis, of which 22 cases (27.50%) were combined with other diseases, and the most common was 15 cases (18.75%) of sinusitis.ConclusionA limited number of studies were conducted on vestibular dysfunction in children. The current retrospective analysis suggests that age, gender, and side of ear pain have no significant effects, while children aged 6-12 are more likely to suffer from vestibular dysfunction. On children's vestibular dysfunction, more etiology is unclear, and special attention should be paid to differential diagnosis when giving treatment and the child's medical history should be examined in detail and appropriate vestibular function tests should be selected in order to provide timely, effective, and accurate treatment for the child.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP606-NP612"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40686789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neha Nischal, Karthikeyan P Iyengar, Rajesh Botchu
{"title":"Clicking shoulder due to snapping Subacromial subdeltoid (SASD) bursitis: a case report of an unusual presentation in clinical practice with imaging features.","authors":"Neha Nischal, Karthikeyan P Iyengar, Rajesh Botchu","doi":"10.1007/s40477-022-00758-0","DOIUrl":"10.1007/s40477-022-00758-0","url":null,"abstract":"<p><p>A spectrum of pathologies can cause clicking, popping or snapping of the shoulder joint. These can lead to a patient seeking attention in clinical practice due to pain, discomfort and impact on activities of daily living. Traditionally these can originate from pathologies which involve biceps tendon, tears of the rotator cuff or the glenoid labrum, articular cartilage or due to loose bodies and scapulothoracic joint dysfunction [Guillin et al. in Br J Radiol 85:1343-1353, 2012; Vidoni et al. in Indian J Musculoskelet Radiol 4:61-69, 2022]. Subacromial subdeltoid (SASD) bursitis is a well-described entity and one of the commonest causes of shoulder pain. We present SASD bursitis as an unusual cause of clicking/snapping in the shoulder without associated pain in a healthy young male. The clinical presentation, diagnostic strategy with complementary imaging and the role of interventional radiology in its effective management is highlighted to support clinicians faced with a diagnostic dilemma.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"723-726"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35346624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Palpable Distal Pulses Ensure Optimal Wound Healing of Large Ulcer Areas by Secondary Intention.","authors":"Konstantinos Dimitriadis, Kalliopi-Maria Tasopoulou, Efstratios Georgakarakos","doi":"10.1177/15347346221139351","DOIUrl":"10.1177/15347346221139351","url":null,"abstract":"","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"733-735"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiao-Fei Xu, Ruo-Tong Wu, La-Sheng Long* and Lan-Sun Zheng,
{"title":"Ultralow-Temperature Magnetic Refrigeration Inorganic Materials: From Designed Synthesis to Adiabatic Demagnetization Refrigeration","authors":"Qiao-Fei Xu, Ruo-Tong Wu, La-Sheng Long* and Lan-Sun Zheng, ","doi":"10.1021/acs.accounts.5c00502","DOIUrl":"10.1021/acs.accounts.5c00502","url":null,"abstract":"<p >Adiabatic demagnetization refrigeration (ADR), which exploits the magnetocaloric effect (MCE), remains the only helium-free refrigeration technology capable of reaching temperatures below 1 K. With the rapid growth of quantum computing and astronomical observation, there is a pressing need for large-capacity ADR systems─underscoring the critical demand for magnetic refrigerants capable of generating substantial magnetic entropy changes (−Δ<i>S</i><sub>m</sub>) at millikelvin temperatures. However, a long-standing challenge persists: achieving both large −Δ<i>S</i><sub>m</sub> values and low magnetic ordering temperatures (<i>T</i><sub>0</sub>). This trade-off has limited the performance of existing refrigerants in the sub-Kelvin regime, thereby hindering ADR advancement. To address this, our work focuses on the rational design of next-generation refrigerants. Rather than relying on readily available materials, we emphasize the importance of tuning key magnetic parameters, <i>T</i><sub>0</sub>, exchange and dipolar interactions. This approach began with the discovery that incorporating fluoride (F<sup>–</sup>) bridges into antiferromagnetic frameworks transforms their magnetic behavior, shifting it from antiferromagnetic to weak ferromagnetic and lowering <i>T</i><sub>0</sub> from 1.4 K to 1.0 K while yielding large −Δ<i>S</i><sub>m</sub> values. Building on this concept, we extended the strategy to the Gd(OH)<sub>3–<i>x</i></sub>F<sub><i>x</i></sub>. In particular, Gd(OH)F<sub>2</sub> combines weak magnetic interactions with high magnetic density, achieving record −Δ<i>S</i><sub>m</sub> values and demonstrating a robust route to simultaneously enhance −Δ<i>S</i><sub>m</sub> and suppress <i>T</i><sub>0</sub>. By integrating the mean-field approximation with quantum Monte Carlo (QMC) simulations, we accurately predicted <i>T</i><sub>0</sub> values in systems with weak exchange and low anisotropy, such as GdCO<sub>3</sub>F, Gd(HCOO)F<sub>2</sub>, Gd<sub>2</sub>(SO<sub>4</sub>)<sub>3</sub>·8H<sub>2</sub>O, GdF<sub>3</sub> and Gd(HCOO)<sub>3</sub>, revealing the dominant role of dipolar interactions in determining <i>T</i><sub>0</sub>. Expanding this framework, we introduced Gd<sup>3+</sup> into Yb-based compounds characterized by intrinsically weak exchange and dipolar interactions. This doping strategy enabled the realization of low <i>T</i><sub>0</sub> and large −Δ<i>S</i><sub>m</sub> values at ultralow temperatures, demonstrating that a balance between competing magnetic interactions and chemical disorder can achieve the coexistence of high −Δ<i>S</i><sub>m</sub> and low <i>T</i><sub>0</sub>. To translate these insights into practical ADR systems, we synthesized LiGd<sub>0.1</sub>Yb<sub>0.9</sub>F<sub>4</sub> and investigated its performance in an ADR setup. Notably, LiGd<sub>0.1</sub>Yb<sub>0.9</sub>F<sub>4</sub> cooled a test sample to 160 mK and delivered a specific cooling capacity more than twice that of the commercial refrigerant CrK(SO<","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"58 18","pages":"2898–2909"},"PeriodicalIF":17.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}