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Enhancing Nanomaterial-Based Optical Spectroscopic Detection of Cancer through Machine Learning 通过机器学习提高基于纳米材料的癌症光学光谱检测能力
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-09-18 DOI: 10.1021/acsmaterialslett.4c0126710.1021/acsmaterialslett.4c01267
Célia Sahli,  and ,  Kenry*, 
{"title":"Enhancing Nanomaterial-Based Optical Spectroscopic Detection of Cancer through Machine Learning","authors":"Célia Sahli,&nbsp; and ,&nbsp; Kenry*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0126710.1021/acsmaterialslett.4c01267","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01267https://doi.org/10.1021/acsmaterialslett.4c01267","url":null,"abstract":"<p >Optical spectroscopic techniques relying on light–matter interactions, such as Raman scattering, fluorescence, and infrared absorbance spectroscopy, offer numerous advantages to complement existing cancer detection methods. By combining these spectroscopic techniques with rationally engineered nanomaterials, cancer cells and tissues can be more specifically targeted, and the readout signals can be substantially enhanced. Further integration of machine learning with its potential to identify subtle malignancy indicators may significantly improve the capability of nanomaterial-enabled optical spectroscopy to delineate cancer more precisely. As such, the synergistic integration of optical spectroscopy, nanomaterials, and machine learning may provide unique opportunities for the development of more selective, sensitive, and accurate cancer diagnostic technologies, which can be leveraged to optimize therapeutic strategies and minimize unnecessary interventions to ultimately enhance patient survival outcomes. This Perspective describes numerous strategies incorporating optical spectroscopy, nanomaterials, and machine learning to improve cancer detection and summarizes our outlook on the current landscape and potential future directions of this emerging field.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Nanomaterial-Based Optical Spectroscopic Detection of Cancer through Machine Learning 通过机器学习提高基于纳米材料的癌症光学光谱检测能力
IF 11.4 1区 化学
ACS Materials Letters Pub Date : 2024-09-18 DOI: 10.1021/acsmaterialslett.4c01267
Célia Sahli, Kenry
{"title":"Enhancing Nanomaterial-Based Optical Spectroscopic Detection of Cancer through Machine Learning","authors":"Célia Sahli, Kenry","doi":"10.1021/acsmaterialslett.4c01267","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01267","url":null,"abstract":"Optical spectroscopic techniques relying on light–matter interactions, such as Raman scattering, fluorescence, and infrared absorbance spectroscopy, offer numerous advantages to complement existing cancer detection methods. By combining these spectroscopic techniques with rationally engineered nanomaterials, cancer cells and tissues can be more specifically targeted, and the readout signals can be substantially enhanced. Further integration of machine learning with its potential to identify subtle malignancy indicators may significantly improve the capability of nanomaterial-enabled optical spectroscopy to delineate cancer more precisely. As such, the synergistic integration of optical spectroscopy, nanomaterials, and machine learning may provide unique opportunities for the development of more selective, sensitive, and accurate cancer diagnostic technologies, which can be leveraged to optimize therapeutic strategies and minimize unnecessary interventions to ultimately enhance patient survival outcomes. This Perspective describes numerous strategies incorporating optical spectroscopy, nanomaterials, and machine learning to improve cancer detection and summarizes our outlook on the current landscape and potential future directions of this emerging field.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrathin BPH Nanosheets with Exceptional Water Adsorption Properties 具有优异吸水性能的超薄 BPH 纳米片
IF 11.4 1区 化学
ACS Materials Letters Pub Date : 2024-09-16 DOI: 10.1021/acsmaterialslett.4c01625
Edwin B. Clatworthy, Rémy Guillet-Nicolas, Philippe Boullay, Michael Badawi, Yann Foucaud, Eddy Dib, Nicolas Barrier, Arnold A. Paecklar, Maxime Debost, Sajjad Ghojavand, Jean-Pierre Gilson, Izabel Medeiros-Costa, Svetlana Mintova
{"title":"Ultrathin BPH Nanosheets with Exceptional Water Adsorption Properties","authors":"Edwin B. Clatworthy, Rémy Guillet-Nicolas, Philippe Boullay, Michael Badawi, Yann Foucaud, Eddy Dib, Nicolas Barrier, Arnold A. Paecklar, Maxime Debost, Sajjad Ghojavand, Jean-Pierre Gilson, Izabel Medeiros-Costa, Svetlana Mintova","doi":"10.1021/acsmaterialslett.4c01625","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01625","url":null,"abstract":"The synthesis of ultrathin BPH zeolite nanosheets from an aluminosilicate colloidal suspension using exclusively inorganic structure directing agents under mild conditions is reported. The improved synthesis yields nanosheets of 4–7 nm and a Si/Al ratio of 1.5; combined 3D electron diffraction and DFT calculations reveal the spatial distribution of extra-framework cations throughout the microporous structure. The ultrathin BPH nanosheets exhibit high and regular intersheet mesoporosity, and substantially improved thermal stability. The notable mesoporosity bestows exceptional water adsorption behavior typically unseen for zeolites; the as-prepared material consists of up to 49% adsorbed H<sub>2</sub>O by weight and adsorbs up to 32 wt % H<sub>2</sub>O at 90% relative humidity. <sup>2</sup>H MAS NMR spectroscopy identifies different types of O<sup>2</sup>H environments ascribed to silanol species exhibiting two motion behaviors. H<sub>2</sub>O sorption analysis demonstrates reproducible behavior over multiple cycles and low temperature regeneration, making the ultrathin BPH nanosheets attractive candidates for gas drying and membrane applications.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrathin BPH Nanosheets with Exceptional Water Adsorption Properties 具有优异吸水性能的超薄 BPH 纳米片
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-09-16 DOI: 10.1021/acsmaterialslett.4c0162510.1021/acsmaterialslett.4c01625
Edwin B. Clatworthy*, Rémy Guillet-Nicolas, Philippe Boullay, Michael Badawi, Yann Foucaud, Eddy Dib, Nicolas Barrier, Arnold A. Paecklar, Maxime Debost, Sajjad Ghojavand, Jean-Pierre Gilson, Izabel Medeiros-Costa and Svetlana Mintova*, 
{"title":"Ultrathin BPH Nanosheets with Exceptional Water Adsorption Properties","authors":"Edwin B. Clatworthy*,&nbsp;Rémy Guillet-Nicolas,&nbsp;Philippe Boullay,&nbsp;Michael Badawi,&nbsp;Yann Foucaud,&nbsp;Eddy Dib,&nbsp;Nicolas Barrier,&nbsp;Arnold A. Paecklar,&nbsp;Maxime Debost,&nbsp;Sajjad Ghojavand,&nbsp;Jean-Pierre Gilson,&nbsp;Izabel Medeiros-Costa and Svetlana Mintova*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0162510.1021/acsmaterialslett.4c01625","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01625https://doi.org/10.1021/acsmaterialslett.4c01625","url":null,"abstract":"<p >The synthesis of ultrathin BPH zeolite nanosheets from an aluminosilicate colloidal suspension using exclusively inorganic structure directing agents under mild conditions is reported. The improved synthesis yields nanosheets of 4–7 nm and a Si/Al ratio of 1.5; combined 3D electron diffraction and DFT calculations reveal the spatial distribution of extra-framework cations throughout the microporous structure. The ultrathin BPH nanosheets exhibit high and regular intersheet mesoporosity, and substantially improved thermal stability. The notable mesoporosity bestows exceptional water adsorption behavior typically unseen for zeolites; the as-prepared material consists of up to 49% adsorbed H<sub>2</sub>O by weight and adsorbs up to 32 wt % H<sub>2</sub>O at 90% relative humidity. <sup>2</sup>H MAS NMR spectroscopy identifies different types of O<sup>2</sup>H environments ascribed to silanol species exhibiting two motion behaviors. H<sub>2</sub>O sorption analysis demonstrates reproducible behavior over multiple cycles and low temperature regeneration, making the ultrathin BPH nanosheets attractive candidates for gas drying and membrane applications.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142408010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium into γ-Graphyne Multilayers: An Intercalation Compound for Anodes in Metal-Ion Batteries 钠进入γ-石墨烯多层膜:用于金属离子电池阳极的互锁化合物
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-09-12 DOI: 10.1021/acsmaterialslett.4c0111910.1021/acsmaterialslett.4c01119
Massimiliano Bartolomei*,  and , Giacomo Giorgi*, 
{"title":"Sodium into γ-Graphyne Multilayers: An Intercalation Compound for Anodes in Metal-Ion Batteries","authors":"Massimiliano Bartolomei*,&nbsp; and ,&nbsp;Giacomo Giorgi*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0111910.1021/acsmaterialslett.4c01119","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01119https://doi.org/10.1021/acsmaterialslett.4c01119","url":null,"abstract":"<p >The bulk synthesis of γ-graphyne has been recently achieved and evidenced a multilayered structure, which suggests its potential exploitation as a substitute of graphite-based anode materials for metals heavier than lithium (Li). In fact, each of its regular pores of sub-nanometric size features an optimal environment for hosting a single sodium (Na) ion, as reported here by means of accurate electronic structure calculations. We show that the graphyne<i>/</i>Na ion coupling mimics that found on the graphene<i>/</i>Li ion in terms of metal-single layer interaction and equilibrium distance. More importantly, in contrast to what is found for graphite, we demonstrate that graphyne intercalation compounds with Na are thermodynamically stable and feature an optimal storage capacity of 372 mAh·g<sup>–1</sup>. These findings, together with a limited crystal structure expansion upon Na intercalation, a low metal diffusion barrier as well as high electrical conductivity, pave the way to the development of novel graphyne-based anodes for efficient Na-ion batteries.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialslett.4c01119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium into γ-Graphyne Multilayers: An Intercalation Compound for Anodes in Metal-Ion Batteries 钠进入γ-石墨烯多层膜:用于金属离子电池阳极的互锁化合物
IF 11.4 1区 化学
ACS Materials Letters Pub Date : 2024-09-12 DOI: 10.1021/acsmaterialslett.4c01119
Massimiliano Bartolomei, Giacomo Giorgi
{"title":"Sodium into γ-Graphyne Multilayers: An Intercalation Compound for Anodes in Metal-Ion Batteries","authors":"Massimiliano Bartolomei, Giacomo Giorgi","doi":"10.1021/acsmaterialslett.4c01119","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01119","url":null,"abstract":"The bulk synthesis of γ-graphyne has been recently achieved and evidenced a multilayered structure, which suggests its potential exploitation as a substitute of graphite-based anode materials for metals heavier than lithium (Li). In fact, each of its regular pores of sub-nanometric size features an optimal environment for hosting a single sodium (Na) ion, as reported here by means of accurate electronic structure calculations. We show that the graphyne<i>/</i>Na ion coupling mimics that found on the graphene<i>/</i>Li ion in terms of metal-single layer interaction and equilibrium distance. More importantly, in contrast to what is found for graphite, we demonstrate that graphyne intercalation compounds with Na are thermodynamically stable and feature an optimal storage capacity of 372 mAh·g<sup>–1</sup>. These findings, together with a limited crystal structure expansion upon Na intercalation, a low metal diffusion barrier as well as high electrical conductivity, pave the way to the development of novel graphyne-based anodes for efficient Na-ion batteries.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic Photodynamic and Chemodynamic Therapy for Tumor Treatment Using a Glutathione-Activated Photosensitizer with Near-Infrared (NIR) Imaging 利用谷胱甘肽激活的光敏剂和近红外成像技术协同光动力疗法和化学动力疗法治疗肿瘤
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-09-10 DOI: 10.1021/acsmaterialslett.4c0140010.1021/acsmaterialslett.4c01400
Fan Zheng, Duoyang Fan, Heying Yao, Jipeng Ding, Shuai Huang, Yanpeng Fang, Jie Dong, Fei Chen and Wenbin Zeng*, 
{"title":"Synergistic Photodynamic and Chemodynamic Therapy for Tumor Treatment Using a Glutathione-Activated Photosensitizer with Near-Infrared (NIR) Imaging","authors":"Fan Zheng,&nbsp;Duoyang Fan,&nbsp;Heying Yao,&nbsp;Jipeng Ding,&nbsp;Shuai Huang,&nbsp;Yanpeng Fang,&nbsp;Jie Dong,&nbsp;Fei Chen and Wenbin Zeng*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0140010.1021/acsmaterialslett.4c01400","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01400https://doi.org/10.1021/acsmaterialslett.4c01400","url":null,"abstract":"<p >Photodynamic therapy (PDT) utilizes photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) upon irradiation, leading to cell death. However, conventional PSs can cause unwanted side effects. Activatable photosensitizers (aPSs) offer a solution by remaining inactive until triggered within tumor microenvironment. Here, we present <b>HFP-SS-Fc</b>, a novel glutathione (GSH) aPS that leverages the high GSH concentration in tumors. <b>HFP-SS-Fc</b> exhibits potent near-infrared (NIR) fluorescence and a robust photodynamic effect upon exposure to tumor-specific GSH levels. A disulfide bond links ferrocene to <b>HFP-SS-Fc</b>, quenching NIR emission and hindering ROS generation. This ferrocene moiety also facilitates •OH production and O<sub>2</sub> release through a Fenton-like reaction, maintaining efficacy in hypoxic tumors. Inspired by its theranostic potential in vitro, <b>HFP-SS-Fc</b> successfully achieves real-time tumor imaging and significant tumor growth inhibition in vivo. This study has presented <b>HFP-SS-Fc</b> as a promising tool for synergistic PDT and CDT with minimized side effects, guided by NIR fluorescence.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142403136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Immobilization for Enhancing Environmental Sustainability of Perovskite Photovoltaics 利用微生物固定技术提高过氧化物光伏技术的环境可持续性
IF 11.4 1区 化学
ACS Materials Letters Pub Date : 2024-09-10 DOI: 10.1021/acsmaterialslett.4c01360
Jianhua Yuan, Tianxiao Sun, Guixiang Li, Markus Weigand, Fei Yu, Zhe Li, Jianglin Cao, Jiayuan Yu, Meng Li, Weijia Zhou, Antonio Abate, Jie Ma
{"title":"Microbial Immobilization for Enhancing Environmental Sustainability of Perovskite Photovoltaics","authors":"Jianhua Yuan, Tianxiao Sun, Guixiang Li, Markus Weigand, Fei Yu, Zhe Li, Jianglin Cao, Jiayuan Yu, Meng Li, Weijia Zhou, Antonio Abate, Jie Ma","doi":"10.1021/acsmaterialslett.4c01360","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01360","url":null,"abstract":"Metal halide perovskite solar cells (PSCs) demonstrate growing commercialization potential among emerging photovoltaic technologies. However, the potential leakage of heavy metal ions such as Pb(II) and Sn(II) from PSCs poses significant environmental and health threats, yet the environment’s capacity to respond remains unknown. This work pioneeringly reports the environment’s natural remediation potential in addressing the risks of perovskite leakage. We find that environmental waste yeasts can efficiently capture leaked Pb(II) and Sn(II) through a combination of physical and chemical adsorption mechanisms. These perovskite heavy metals are further biotransformed and immobilized. Additionally, our study shows a higher removal rate for Sn ions, revealing enhanced environmental sustainability by applying lead-free perovskite photovoltaics. This work conveys a microbial cleanup strategy for removing perovskite heavy metals from the environment, contributing to the advancing practical implementation of perovskite photovoltaics.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Immobilization for Enhancing Environmental Sustainability of Perovskite Photovoltaics 利用微生物固定技术提高过氧化物光伏技术的环境可持续性
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-09-10 DOI: 10.1021/acsmaterialslett.4c0136010.1021/acsmaterialslett.4c01360
Jianhua Yuan, Tianxiao Sun, Guixiang Li*, Markus Weigand, Fei Yu, Zhe Li, Jianglin Cao, Jiayuan Yu, Meng Li, Weijia Zhou*, Antonio Abate and Jie Ma*, 
{"title":"Microbial Immobilization for Enhancing Environmental Sustainability of Perovskite Photovoltaics","authors":"Jianhua Yuan,&nbsp;Tianxiao Sun,&nbsp;Guixiang Li*,&nbsp;Markus Weigand,&nbsp;Fei Yu,&nbsp;Zhe Li,&nbsp;Jianglin Cao,&nbsp;Jiayuan Yu,&nbsp;Meng Li,&nbsp;Weijia Zhou*,&nbsp;Antonio Abate and Jie Ma*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0136010.1021/acsmaterialslett.4c01360","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01360https://doi.org/10.1021/acsmaterialslett.4c01360","url":null,"abstract":"<p >Metal halide perovskite solar cells (PSCs) demonstrate growing commercialization potential among emerging photovoltaic technologies. However, the potential leakage of heavy metal ions such as Pb(II) and Sn(II) from PSCs poses significant environmental and health threats, yet the environment’s capacity to respond remains unknown. This work pioneeringly reports the environment’s natural remediation potential in addressing the risks of perovskite leakage. We find that environmental waste yeasts can efficiently capture leaked Pb(II) and Sn(II) through a combination of physical and chemical adsorption mechanisms. These perovskite heavy metals are further biotransformed and immobilized. Additionally, our study shows a higher removal rate for Sn ions, revealing enhanced environmental sustainability by applying lead-free perovskite photovoltaics. This work conveys a microbial cleanup strategy for removing perovskite heavy metals from the environment, contributing to the advancing practical implementation of perovskite photovoltaics.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142403135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic Photodynamic and Chemodynamic Therapy for Tumor Treatment Using a Glutathione-Activated Photosensitizer with Near-Infrared (NIR) Imaging 利用谷胱甘肽激活的光敏剂和近红外成像技术协同光动力疗法和化学动力疗法治疗肿瘤
IF 11.4 1区 化学
ACS Materials Letters Pub Date : 2024-09-10 DOI: 10.1021/acsmaterialslett.4c01400
Fan Zheng, Duoyang Fan, Heying Yao, Jipeng Ding, Shuai Huang, Yanpeng Fang, Jie Dong, Fei Chen, Wenbin Zeng
{"title":"Synergistic Photodynamic and Chemodynamic Therapy for Tumor Treatment Using a Glutathione-Activated Photosensitizer with Near-Infrared (NIR) Imaging","authors":"Fan Zheng, Duoyang Fan, Heying Yao, Jipeng Ding, Shuai Huang, Yanpeng Fang, Jie Dong, Fei Chen, Wenbin Zeng","doi":"10.1021/acsmaterialslett.4c01400","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01400","url":null,"abstract":"Photodynamic therapy (PDT) utilizes photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) upon irradiation, leading to cell death. However, conventional PSs can cause unwanted side effects. Activatable photosensitizers (aPSs) offer a solution by remaining inactive until triggered within tumor microenvironment. Here, we present <b>HFP-SS-Fc</b>, a novel glutathione (GSH) aPS that leverages the high GSH concentration in tumors. <b>HFP-SS-Fc</b> exhibits potent near-infrared (NIR) fluorescence and a robust photodynamic effect upon exposure to tumor-specific GSH levels. A disulfide bond links ferrocene to <b>HFP-SS-Fc</b>, quenching NIR emission and hindering ROS generation. This ferrocene moiety also facilitates •OH production and O<sub>2</sub> release through a Fenton-like reaction, maintaining efficacy in hypoxic tumors. Inspired by its theranostic potential in vitro, <b>HFP-SS-Fc</b> successfully achieves real-time tumor imaging and significant tumor growth inhibition in vivo. This study has presented <b>HFP-SS-Fc</b> as a promising tool for synergistic PDT and CDT with minimized side effects, guided by NIR fluorescence.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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