ACS Materials Letters最新文献

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Macrophage Polarization-Based Biomaterials for Repairing Spinal Cord Injury 巨噬细胞极化生物材料修复脊髓损伤
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-15 DOI: 10.1021/acsmaterialslett.4c0170110.1021/acsmaterialslett.4c01701
Junchao Luo, Wei Hu, Xiang Gao, Jinyu Bai, Lei Sheng, Huilin Yang, Xiao-zhong Zhou* and Qin Shi*, 
{"title":"Macrophage Polarization-Based Biomaterials for Repairing Spinal Cord Injury","authors":"Junchao Luo,&nbsp;Wei Hu,&nbsp;Xiang Gao,&nbsp;Jinyu Bai,&nbsp;Lei Sheng,&nbsp;Huilin Yang,&nbsp;Xiao-zhong Zhou* and Qin Shi*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0170110.1021/acsmaterialslett.4c01701","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01701https://doi.org/10.1021/acsmaterialslett.4c01701","url":null,"abstract":"<p >Spinal cord injury (SCI) remains a serious problem, owing to its severe consequences and therapeutic limitations. It leads to irreversible impairment of both motor and sensory functions, posing a challenge to recovery and imposing an immense socioeconomic burden on patients. Existing treatment strategies for SCI primarily focus on secondary injury, particularly the modulation of the immune microenvironment after SCI. Infiltrating macrophages play a crucial role in regulating inflammation around the injury site. Macrophages alter their functional phenotypes in response to various stimuli. Classically activated macrophages (M1) exacerbate SCI owing to their pro-inflammatory function, whereas alternatively activated macrophages (M2) inhibit the inflammatory response. Therefore, regulating macrophage polarization represents a promising therapeutic strategy for SCI. Several biomaterial-based strategies for repairing SCI have been developed and are constantly being updated with technological advancements owing to their ability to alleviate neuroinflammation and promote neuroregeneration. In this Review, we focus on the role of macrophages in SCI and discuss the recent research progress of biomaterials targeting macrophage-mediated inflammation for repair and regeneration following SCI. Altogether, this Review provides novel insights into the treatment of SCI.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5438–5453 5438–5453"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppressing Atmospheric Degradation of Sulfide-Based Solid Electrolytes via Ultrathin Metal Oxide Layers 利用超薄金属氧化物层抑制硫化物基固体电解质的大气降解
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-12 DOI: 10.1021/acsmaterialslett.4c0192310.1021/acsmaterialslett.4c01923
Taewoo Kim, Zachary D. Hood, Aditya Sundar, Anil U. Mane, Francisco Lagunas, Khagesh Kumar, Neelam Sunariwal, Jordi Cabana, Sanja Tepavcevic, Jeffrey W. Elam, Peter Zapol and Justin G. Connell*, 
{"title":"Suppressing Atmospheric Degradation of Sulfide-Based Solid Electrolytes via Ultrathin Metal Oxide Layers","authors":"Taewoo Kim,&nbsp;Zachary D. Hood,&nbsp;Aditya Sundar,&nbsp;Anil U. Mane,&nbsp;Francisco Lagunas,&nbsp;Khagesh Kumar,&nbsp;Neelam Sunariwal,&nbsp;Jordi Cabana,&nbsp;Sanja Tepavcevic,&nbsp;Jeffrey W. Elam,&nbsp;Peter Zapol and Justin G. Connell*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0192310.1021/acsmaterialslett.4c01923","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01923https://doi.org/10.1021/acsmaterialslett.4c01923","url":null,"abstract":"<p >Sulfide-based solid-state electrolytes (SSEs) are promising materials with superior Li-ion conductivity; however, their poor atmospheric stability limits commercial manufacturing at scale. Here, we investigate the impact of ultrathin metal oxide layers deposited via atomic layer deposition (ALD) on the stability of Li<sub>6</sub>PS<sub>5</sub>Cl (LPSCl). Al<sub>2</sub>O<sub>3</sub> layers grown directly on LPSCl particles significantly stabilize the surface chemistry and Li-ion transport properties relative to uncoated material upon exposure to both an ambient atmosphere (22% relative humidity, RH) and humidified O<sub>2</sub> (100% RH). Detailed investigations indicate that coatings impede the surface and bulk degradation kinetics of exposed materials, even for coatings as thin as ∼1 Å. This suggests that stabilization is due to more than just a physical barrier. Shifts in valence band edge positions of coated LPSCl indicate that ALD coatings alter the surface electronic structure and resulting oxidation tendency of underlying LPSCl, suggesting new avenues to improving the environmental stability of sulfide SSEs.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5409–5417 5409–5417"},"PeriodicalIF":9.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-Responsive Polymer as a New Stable Solid Electrolyte Interphase for Water-in-Salt Battery ph响应聚合物作为一种新型稳定的盐包水电池固体电解质界面
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-11 DOI: 10.1021/acsmaterialslett.4c0180710.1021/acsmaterialslett.4c01807
Rossukon Jommongkol, Nantawat Kaekratoke, Yachao Zhu, Tobias Burton, Daniel Crespy* and Olivier Fontaine*, 
{"title":"pH-Responsive Polymer as a New Stable Solid Electrolyte Interphase for Water-in-Salt Battery","authors":"Rossukon Jommongkol,&nbsp;Nantawat Kaekratoke,&nbsp;Yachao Zhu,&nbsp;Tobias Burton,&nbsp;Daniel Crespy* and Olivier Fontaine*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0180710.1021/acsmaterialslett.4c01807","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01807https://doi.org/10.1021/acsmaterialslett.4c01807","url":null,"abstract":"<p >Overcoming the cathodic limits of water-in-salt electrolyte (WiSE) and developing new active materials are crucial to producing aqueous Li-ion batteries (ALIBs) with higher voltage and energy. Stabilizing the solid-electrolyte interphase (SEI) in a WiSE is expected to improve battery performance. Here, a polymer is designed with pH-responsive properties under alkaline conditions and remains soluble in WiSE, which expands the electrochemical stability window of ALIBs. The polymer prevents water reduction and coprecipitates with the LiTFSI salt in alkaline conditions, resulting in the formation of a stable SEI layer. Moreover, this polymer promotes the crystallization of LiTFSI, leading to a change in the morphology of the SEI as observed by X-ray photoelectron spectroscopy and transmission electron microscopy. Finally, the addition of the polymer in Mo<sub>6</sub>S<sub>8</sub>//LiFePO<sub>4</sub> full cells during charge/discharge cycling tests significantly improves cycling stability, achieving 87% discharge capacity after 100 cycles at 0.5 C.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5402–5408 5402–5408"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phased-Change Materials Based Immunomodulator for Cascade-Activatable Tumor-Specific Photoimmunotherapy 基于相变材料的级联激活肿瘤特异性光免疫治疗免疫调节剂
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-09 DOI: 10.1021/acsmaterialslett.4c0130610.1021/acsmaterialslett.4c01306
Liuwei Gu, Yongxiao Xu, Xiaojie Kong, Guo Li*, Yuling Qin* and Li Wu*, 
{"title":"Phased-Change Materials Based Immunomodulator for Cascade-Activatable Tumor-Specific Photoimmunotherapy","authors":"Liuwei Gu,&nbsp;Yongxiao Xu,&nbsp;Xiaojie Kong,&nbsp;Guo Li*,&nbsp;Yuling Qin* and Li Wu*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0130610.1021/acsmaterialslett.4c01306","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01306https://doi.org/10.1021/acsmaterialslett.4c01306","url":null,"abstract":"<p >The development of activatable immunomodulators for cancer treatment in a controlled and effective manner has been extensively pursued. However, the creation of a spatiotemporally controllable and cascade-activatable tumor-specific photoimmunotherapy platform for precise immunotherapy remains a challenge. Herein, cascade-activatable tumor-specific immunomodulators (CAI) are reported for cancer photoimmunotherapy. Under 808 nm irradiation, the CAI not only mediates phototherapy effect to achieve tumor eradication and immunogenic cell death but also triggers in situ release of caged toll-like receptor 7/8 R848-QPA. Additionally, the intracellular NQO1 activates R848-QPA, leading to the cleavage of trimethyl lock and release of active R848 agonist, enhancing the antitumor immune response. Such a cascade-activatable nanoimmunomodulator can effectively inhibit bilateral tumor growth and enhances systemic immune activation, resulting in improved infiltration of cytotoxic T lymphocytes and helper T cell. Therefore, this modular-designed engineered paradigm provides a generic strategy for developing immunomodulators for precise cascade-activatable immunotherapy.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5392–5401 5392–5401"},"PeriodicalIF":9.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choosing Impactful Perspectives for Energy Research: A Case Study of CO2 Electroreduction 为能源研究选择有影响力的视角:二氧化碳电还原案例研究
IF 19.3 1区 化学
ACS Materials Letters Pub Date : 2024-11-08 DOI: 10.1021/acsenergylett.4c0290710.1021/acsenergylett.4c02907
Phillip Christopher*, 
{"title":"Choosing Impactful Perspectives for Energy Research: A Case Study of CO2 Electroreduction","authors":"Phillip Christopher*,&nbsp;","doi":"10.1021/acsenergylett.4c0290710.1021/acsenergylett.4c02907","DOIUrl":"https://doi.org/10.1021/acsenergylett.4c02907https://doi.org/10.1021/acsenergylett.4c02907","url":null,"abstract":"","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"9 11","pages":"5539–5540 5539–5540"},"PeriodicalIF":19.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Achieving Ultralong Room-Temperature Phosphorescence Via Single-Bond Locking Planarization Strategy 通过单键锁定平面化策略实现超长室温磷光
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-08 DOI: 10.1021/acsmaterialslett.4c0211610.1021/acsmaterialslett.4c02116
Lei Zhou, Shunxing Mu, Liangwei Ma*, Ping Jiang, Zhenyi He, Jinming Song and Xiang Ma*, 
{"title":"Achieving Ultralong Room-Temperature Phosphorescence Via Single-Bond Locking Planarization Strategy","authors":"Lei Zhou,&nbsp;Shunxing Mu,&nbsp;Liangwei Ma*,&nbsp;Ping Jiang,&nbsp;Zhenyi He,&nbsp;Jinming Song and Xiang Ma*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0211610.1021/acsmaterialslett.4c02116","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c02116https://doi.org/10.1021/acsmaterialslett.4c02116","url":null,"abstract":"<p >Ultralong room-temperature phosphorescence (URTP) materials have been widely studied due to their broad applications. However, achieving phosphorescent materials with ultralong lifetimes is engaging and challenging. In this work, the indolo[3,2,1-j,k]carbazole (ICZ) with excellent planarity is obtained through twice single-bond locking on triphenylamine (TPA). Doping ICZ into a rigid matrix, URTP materials with a lifetime of 3.24 s and a photoluminescence quantum yield of 37.37% is successfully prepared.. The analysis of single-crystal, temperature-dependent photophysical characterization, Huang–Rhys factor, and theoretical calculations demonstrates that it is possible to make the molecules more planar and rigid by single-bond locking, which can inhibit the structural relaxation of the excited state and thus reduce the nonradiative transition to generate URTP. In addition, we achieve full-color afterglow by energy transfer. The potential applications of anticounterfeiting and optoelectronic information display of these URTP materials have been conducted. This work is an important reference for the construction of URTP materials.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5384–5391 5384–5391"},"PeriodicalIF":9.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in Carbon Cathodic Host Matrices for Lithium–Sulfur Cells: A Meta Analysis 锂硫电池用碳阴极基质研究进展:Meta分析
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-07 DOI: 10.1021/acsmaterialslett.4c0164610.1021/acsmaterialslett.4c01646
Liam R. Bird, James B. Robinson and Paul R. Shearing*, 
{"title":"Progress in Carbon Cathodic Host Matrices for Lithium–Sulfur Cells: A Meta Analysis","authors":"Liam R. Bird,&nbsp;James B. Robinson and Paul R. Shearing*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0164610.1021/acsmaterialslett.4c01646","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01646https://doi.org/10.1021/acsmaterialslett.4c01646","url":null,"abstract":"<p >The development of cathodes for lithium–sulfur (Li–S) batteries requires optimizing a variety of interacting and competing variables, with the early technology readiness level (TRL) of Li–S relative to Li-ion batteries presenting researchers with a wide parameter space. Given the interactions between the positive electrode design and the electrolyte, the development of Li–S electrodes requires comprehensive reporting of parameters to enable a comparison of developments. By developing a tool to aggregate synthesis parameters with cell performance, we summarize the frequency with which different components and electrochemical testing conditions are used, including data from 100 articles. Grouping reported capacity data by composite carbon type, C rate, and sulfur content revealed widespread variation in the maximum capacity and rate of degradation. We hope that the tool developed here will provide a facile workflow and promote consistent reporting across the literature, while also pointing toward routes to improve the design of Li–S positive electrodes.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5363–5374 5363–5374"},"PeriodicalIF":9.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialslett.4c01646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Situ Oxygen-Vacancy Engineering for Enhancing CO2 Reduction Activity 提高CO2还原活性的原位氧空位工程
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-07 DOI: 10.1021/acsmaterialslett.4c0177610.1021/acsmaterialslett.4c01776
Jianing Mao, Bingbao Mei*, Shuai Yang, Jianrong Zeng, Fanfei Sun, Wei Chen, Fei Song* and Zheng Jiang*, 
{"title":"In Situ Oxygen-Vacancy Engineering for Enhancing CO2 Reduction Activity","authors":"Jianing Mao,&nbsp;Bingbao Mei*,&nbsp;Shuai Yang,&nbsp;Jianrong Zeng,&nbsp;Fanfei Sun,&nbsp;Wei Chen,&nbsp;Fei Song* and Zheng Jiang*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0177610.1021/acsmaterialslett.4c01776","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01776https://doi.org/10.1021/acsmaterialslett.4c01776","url":null,"abstract":"<p >Bulk metallic oxides with abundant surface oxygen vacancies are promising for the electrocatalytic carbon dioxide reduction reaction (CO<sub>2</sub>RR). However, the obscure quantification of oxygen-release behavior has hindered the development of highly active and robust electrocatalysts. Herein, based on theoretical guidance, graphene confined SnO<sub><i>x</i></sub> nanodots (rGO@SnO<sub><i>x</i></sub> ND) holding the capacity for <i>in situ</i> formation of reaction-induced oxygen vacancies were prepared and taken as the model catalyst. <i>Operando</i> X-ray absorption fine structure (XAFS) quantitatively analyzed the reversible oxygen-released behavior, promoting the SnO<sub><i>x</i></sub> lattice modulation of the adsorption of *OCHO intermediate. These structure changes further facilitate the exceptional performance, yielding a peak <i>j</i><sub>formate</sub> of 567 mA cm<sup>–2</sup>, a selectivity of 92.5% and a 50 h long-term stability of rGO@SnO<sub><i>x</i></sub> ND. The findings significantly advance the comprehensive understanding of the quantitative relationship between controllable oxygen vacancies and reaction activity, highlighting the capabilities of <i>operando</i> spectroscopy toward much wider metallic oxide-based electrochemical systems.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5375–5383 5375–5383"},"PeriodicalIF":9.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanozyme Microgels: Multifunctional Tools for Dilute Carbon Dioxide Detection and Environmental Remediation 纳米酶微凝胶:用于稀释二氧化碳检测和环境修复的多功能工具
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-06 DOI: 10.1021/acsmaterialslett.4c0190610.1021/acsmaterialslett.4c01906
Haojie Zhang, Ting Zhao, Yanying Ye, Chao Ma, Jie Xu, Jianda Xie, Jing Shen and Weitai Wu*, 
{"title":"Nanozyme Microgels: Multifunctional Tools for Dilute Carbon Dioxide Detection and Environmental Remediation","authors":"Haojie Zhang,&nbsp;Ting Zhao,&nbsp;Yanying Ye,&nbsp;Chao Ma,&nbsp;Jie Xu,&nbsp;Jianda Xie,&nbsp;Jing Shen and Weitai Wu*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0190610.1021/acsmaterialslett.4c01906","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01906https://doi.org/10.1021/acsmaterialslett.4c01906","url":null,"abstract":"<p >Inspired by the diversity of natural metalloenzymes, we designed microgels incorporating metal centers that mimic carbonic anhydrase for efficient CO<sub>2</sub> capture and detection, even in aqueous environments. These microgels demonstrate high sensitivity, detecting CO<sub>2</sub> at concentrations as low as 300 ppm, surpassing conventional methods. The metal centers in the microgels can be constructed by coordinating with metal ions such as Mn<sup>2+</sup>, Cr<sup>3+</sup>, Ni<sup>2+</sup>, Cu<sup>2+</sup>, and Zn<sup>2+</sup>. Upon absorption of CO<sub>2</sub>, the system becomes weakly acidic, enabling multifunctional applications. Notably, Cu<sup>2+</sup>-based microgels display catalytic versatility, acting as carbonic anhydrase in neutral to alkaline conditions and as laccase or peroxidase in neutral to acidic environments. This versatility highlights their potential for transforming water pollutants across a broad pH range, offering significant promise for environmental remediation.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5340–5347 5340–5347"},"PeriodicalIF":9.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia 有效治疗雄激素性脱发的多阶段经皮一氧化氮输送系统
IF 9.6 1区 化学
ACS Materials Letters Pub Date : 2024-11-06 DOI: 10.1021/acsmaterialslett.4c0189110.1021/acsmaterialslett.4c01891
Hui Xing, Xinlin Jiang, Ziyi Zhao, Yuhui Yang, Zhen Wang, Yang Yi, Guodong Sun, Shixin Liu* and Dong Ma*, 
{"title":"Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia","authors":"Hui Xing,&nbsp;Xinlin Jiang,&nbsp;Ziyi Zhao,&nbsp;Yuhui Yang,&nbsp;Zhen Wang,&nbsp;Yang Yi,&nbsp;Guodong Sun,&nbsp;Shixin Liu* and Dong Ma*,&nbsp;","doi":"10.1021/acsmaterialslett.4c0189110.1021/acsmaterialslett.4c01891","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.4c01891https://doi.org/10.1021/acsmaterialslett.4c01891","url":null,"abstract":"<p >Androgenic alopecia (AGA) is a prevalent progressive hair loss condition. The main therapeutic drug, minoxidil, is limited by its poor efficacy and side effects such as contact dermatitis and hypertrichosis. Nitric oxide (NO), an endothelial-derived relaxing factor, promotes angiogenesis and accelerates blood flow, enhancing nutrient supply similar to minoxidil. Accordingly, we utilized a poly(vinyl alcohol) film (PVA) loaded with hyaluronic acid (HA) liposomes to construct a multistage transdermal NO delivery system (PVA@HL/NONOate) for the treatment of AGA. The HA liposomes provided efficient NO loading and extended release, while the PVA film improved skin penetration and sustained NO release, increasing NO bioavailability. Low-concentration NO effectively enhanced hair follicle vitality and repaired blood vessels. Mechanistically, low-concentration NO could treat AGA mainly by regulating the HIF-1 signaling pathway to promote angiogenesis, reducing inflammation by downregulating the expression of TNFRSF9 and IL-6, repairing hair follicles by downregulating the expression of genes in the CXCL5-IL-17 inflammatory axis.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 12","pages":"5354–5362 5354–5362"},"PeriodicalIF":9.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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