Pharmaceutical Chemistry Journal最新文献_第6页

Efficacy and Safety of Montelukast Sodium Tablets Combined with Budesonide Suspension in the Treatment of Patients with Bronchial Asthma 孟鲁司特钠片联合布地奈德混悬液治疗支气管哮喘患者的疗效和安全性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-07-13 DOI: 10.1007/s11094-024-03156-4

Deyun Liu, Dawei Fei

{"title":"Efficacy and Safety of Montelukast Sodium Tablets Combined with Budesonide Suspension in the Treatment of Patients with Bronchial Asthma","authors":"Deyun Liu, Dawei Fei","doi":"10.1007/s11094-024-03156-4","DOIUrl":"https://doi.org/10.1007/s11094-024-03156-4","url":null,"abstract":"To evaluate the efficacy and safety of montelukast sodium tablets combined with budesonide suspension in the treatment of patients with bronchial asthma, ninety patients with bronchial asthma treated in The People’s Hospital of Quanjiao from January 2018 to April 2021 were randomly included in the study and then randomly divided into an observation group and a control group with 45 cases in each group. Patients in both groups were given clinical routine and symptomatic treatment. Patients in the control group were given budesonide suspension treatment on the basis of routine treatment, and patients in the observation group were treated with montelukast sodium tablets on the basis of the control group. The daytime and nighttime cough scores and asthma control scores (ACT scores) of the two groups were recorded before and after treatment. The pulmonary function indexes such as forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEFR), etc., were measured. The daytime cough score and nighttime cough score of the patients in the observation group after treatment were significantly lower than those before treatment and the control group at the same period, and the act score was significantly higher than that before treatment and the control group during the same period (P < 0.05). FEV1, FVC, PEFR and other pulmonary function indexes were significantly better than those before treatment and the control group at the same period (P < 0.05). The total clinical effective rate of the observation group was 93.33%, which was significantly higher than 71.11% of the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the other two groups (P > 0.05). Montelukast sodium tablets combined with budesonide suspension can effectively improve cough, asthma symptoms and lung function of patients with bronchial asthma.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"30 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141614471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ARE SUPRASCAPULAR NERVE BLOCKS ANEFFECTIVE FIRST-LINE MODALITY INMANAGING SHOULDER ARTHRITIS? 肩周炎的一线治疗方法--前囊静脉阻滞术是否有效？

IF 1.5 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-07-01 Epub Date: 2023-08-24 DOI: 10.1177/17585732231196802

引用次数: 0

Study of pH-Dependent Kinetics of Filgrastim Pegylation with Succinimide Derivatives of Poly(Ethylene Glycol) and Comparison of the Properties of Pegylated Forms Obtained Under Various Conditions 聚乙二醇琥珀酰亚胺衍生物与 Filgrastim Pegylation 的 pH 值相关动力学研究以及在不同条件下获得的 Pegylated 形式的特性比较

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-26 DOI: 10.1007/s11094-024-03147-5

D. V. Lonshakov, S. V. Sheremet’ev, E. M. Khursevich, I. V. Bobrysheva, O. A. Grebennikova, S. A. Korovkin

{"title":"Study of pH-Dependent Kinetics of Filgrastim Pegylation with Succinimide Derivatives of Poly(Ethylene Glycol) and Comparison of the Properties of Pegylated Forms Obtained Under Various Conditions","authors":"D. V. Lonshakov, S. V. Sheremet’ev, E. M. Khursevich, I. V. Bobrysheva, O. A. Grebennikova, S. A. Korovkin","doi":"10.1007/s11094-024-03147-5","DOIUrl":"https://doi.org/10.1007/s11094-024-03147-5","url":null,"abstract":"Filgrastim was pegylated by acylation with a linear 20-kDa pegylating agent (PEG agent) to search for conjugates characterized by biological activity comparable to or exceeding that of commercial drugs. The pegylation kinetics were studied at different pH values taking into account the contribution of the hydrolysis kinetics of the PEG agent. The optimal time for pegylation to a required protein conversion and the method of adding the PEG agent to the reaction mixture (once or fractionally) at a given pH value and ratio between the PEG agent and protein were calculated using a proposed equation based on previously obtained pegylation and hydrolysis rate constants. Various mixtures of pegylated positional isomers were obtained. Their contents in the mixtures depended on the pH value because of the different pKa values of the amino-acid residues involved in the reaction. The estimated specific biological activity of the obtained monopegylated forms of Filgrastim appeared comparable with that of the product Neulastim.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"42 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimethyl Fumarate Ameliorates the Amyotrophic Lateral Sclerosis Symptoms in Tg-SOD1G93A Mice 富马酸二甲酯可改善 Tg-SOD1G93A 小鼠的肌萎缩侧索硬化症症状

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-26 DOI: 10.1007/s11094-024-03132-y

Georgios Angelis, Anastasia S. Tsingotjidou, Nikolaos Iatridis, Georgios Pampalakis

引用次数: 0

Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids 热熔挤压技术作为提高黄酮类生物利用率的现代战略

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-24 DOI: 10.1007/s11094-024-03146-6

A. A. Danilova, K. A. Gusev, D. N. Maimistov, E. V. Flisyuk

引用次数: 0

Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review 含吡唑化合物的治疗潜力：最新综述

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-24 DOI: 10.1007/s11094-024-03141-x

Anandi Kapri, Nitin Gupta, Sumitra Nain

{"title":"Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review","authors":"Anandi Kapri, Nitin Gupta, Sumitra Nain","doi":"10.1007/s11094-024-03141-x","DOIUrl":"https://doi.org/10.1007/s11094-024-03141-x","url":null,"abstract":"Among a large number of nitrogen-containing heterocyclic compounds, pyrazole is a privileged scaffold with the molecular formula C3H3N2H. It consists of a five-membered ring with 3-carbon atoms and 2-nitrogen atoms which are present in adjacent positions. The nucleus has attracted synthetic interest due to numerous pharmacological activities. This molecule is used as one of the basic moieties for leads in the area of drug discovery and development and thereby plays a vital role in the field of medicinal chemistry. The present review article highlights the SAR studies of potent compounds of pyrazole and its derivatives (2015–2022) reported as anti-inflammatory, anticancer, antidiabetic, anticonvulsant, antimicrobial, antimycobacterial, antineurodegenerative and antioxidant. Furthermore, a patent application published in this period is also discussed. Google, PubMed, Cochrane, Scopus, ResearchGate, Google Scholar, and Science Direct were primarily used for article search, whereas the databases used for the pyrazole patent were Espacenet, Google Patent, and SciFinder. More than one hundred thirty papers were screened after which inclusion and exclusion criteria were applied to make this review article. We hope the current review article can pave the way for the future drug design and development of pyrazole derivatives as a potential drug candidate.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"59 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Lycium barbarum (Goji Berry) in Apoptosis and Autophagy in the Experimental Ulcerative Colitis Model 枸杞在实验性溃疡性结肠炎模型的细胞凋亡和自噬中的作用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-24 DOI: 10.1007/s11094-024-03144-8

Büþra Çimen, Abdullah Aslan, Seda Beyaz, Ozlem Gok, Serpil Baspinar, Fatih Tan, Ibrahim Hanifi Ozercan

{"title":"The Role of Lycium barbarum (Goji Berry) in Apoptosis and Autophagy in the Experimental Ulcerative Colitis Model","authors":"Büþra Çimen, Abdullah Aslan, Seda Beyaz, Ozlem Gok, Serpil Baspinar, Fatih Tan, Ibrahim Hanifi Ozercan","doi":"10.1007/s11094-024-03144-8","DOIUrl":"https://doi.org/10.1007/s11094-024-03144-8","url":null,"abstract":"Ulcerative colitis is one of the most common intestinal diseases in the world. Lycium barbarum (Goji Berry) is a type of fruit that is frequently used in alternative medicine, with antioxidant, antimicrobial, anti-aging, and anti-inflammatory effects. Although the effect of Lycium barbarum (LB) on intestinal diseases has been extensively studied, the mechanism of action on apoptosis and autophagic pathways in the ulcerative colitis model has not yet been fully elucidated. In this study, the effect of LB on the apoptosis and autophagy pathways in the ulcerative colitis model was investigated. Wistar albino male rats were used in the study. DSS chemical was used to create an ulcerative colitis model and LB was used to prevent colitis formation. In our study, in the LB+DSS group compared to the DSS group, wherein it was determined that p53 and Beclin 1 protein levels increased, TIGAR protein level decreased, MDA levels decreased, GSH level and catalase activity increased. Also, in the histopathological results, ulcerative colitis did not occur in the LB+DSS group. In general, our findings show that LB prevents the formation of ulcerative colitis, reduces damage, and activates the defense and apoptosis/autophagy mechanisms. When the results of our study are evaluated as a whole, we can say that LB has a promising potential to prevent ulcerative colitis.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"58 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Response Surface Methodology for the Development of an Innovative Stability-Indicating UHPLC Method for the Simultaneous Determination of Embelin and Vilangin in Vidanga (Embelia ribes) Tablets 应用响应面方法开发一种创新型稳定性指示超高效液相色谱法，用于同时测定 Vidanga（Embelia ribes）片剂中的 Embelin 和 Vilangin 含量

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03151-9

Theja Indireddy, Ramya Kuber

{"title":"Application of Response Surface Methodology for the Development of an Innovative Stability-Indicating UHPLC Method for the Simultaneous Determination of Embelin and Vilangin in Vidanga (Embelia ribes) Tablets","authors":"Theja Indireddy, Ramya Kuber","doi":"10.1007/s11094-024-03151-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03151-9","url":null,"abstract":"The current study highlights the systematic quality by design-assisted creation of an efficient analytical technique for the estimation of embelin and vilangin in Vidanga (Embelia ribes) tablets. Response surface methodology in the design of experiments was used to identify key material attributes and critical process parameters that influence the designated critical analytical attributes. Separation was achieved on the X-Bridge (100 × 2.1 mm, 2 μm). The effects of acetonitrile content (v/v), flow rate, and column temperature on the retention times of the two drugs and their resolution, number of theoretical plates, and tailing factor were investigated and optimized. The optimal chromatographic conditions within the design space were found to be an isocratic mobile phase consisting of buffer and methanol (57.77:42.33, v/v) with a flow rate of 0.2 mL/min and a run time of 3 min. The retention times of embelin and vilangin were found to be 1.31- and 1.7-min. Different validation parameters were established, and the approach was validated in agreement with ICH and FDA requirements. Data analysis using statistical methods has revealed that the method is reliable, accurate, and robust.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"24 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptotanshinone Inhibits the Proliferation of 5-Fluorouracil-Resistant Gastric Cancer SGC-7901/5-FU Cells Via the JAK2/STAT3 Pathway 隐丹参酮通过 JAK2/STAT3 通路抑制耐 5 氟尿嘧啶的胃癌 SGC-7901/5-FU 细胞的增殖

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03133-x

Yezhi Cao, Linghu Wang, Ling Cheng, Jun Chu, Qingsheng Yu, Hui Peng, Wenkai Wu, Haiwei Liu, Fuhai Zhou, Yaqian Shu, Qi Zhang

{"title":"Cryptotanshinone Inhibits the Proliferation of 5-Fluorouracil-Resistant Gastric Cancer SGC-7901/5-FU Cells Via the JAK2/STAT3 Pathway","authors":"Yezhi Cao, Linghu Wang, Ling Cheng, Jun Chu, Qingsheng Yu, Hui Peng, Wenkai Wu, Haiwei Liu, Fuhai Zhou, Yaqian Shu, Qi Zhang","doi":"10.1007/s11094-024-03133-x","DOIUrl":"https://doi.org/10.1007/s11094-024-03133-x","url":null,"abstract":"Cryptotanshinone (CPT), which is an important active ingredient of herbs, has shown great value for research. In particular, CPT exerts antitumor effects on various types of cancer; however, there are relatively few studies of CPT on gastric cancer cells. The objectives of this study were to investigate how CPT affects apoptosis in 5-fluorouracil-resistant SGC-7901 gastric cancer cells (SGC-7901/5-FU cells) and the molecular mechanism underlying its action. In this study, SGC-7901/5-FU cells were treated with 5-fluorouracil (5-FU) and CPT and the viability of the cells was assessed by CCK8 assay. Additionally, cellular apoptosis rates were evaluated using immunofluorescence and flow cytometry. Related gene expression was evaluated using Quantitative Real-time PCR methods and Western Blot, respectively. CPT inhibited SGC-7901/5-FU cell growth. The immunofluorescence results showed that CPT caused nuclear shrinkage in the cells. Quantitative Real-time PCR and Western Blot results also showed CPT decreased the expression of Mcl-1, Bcl-xl and Bcl-2 levels, and increased the expression of Bax. We demonstrated that CPT can inhibit the growth of SGC-7901/5-FU cells, and the mechanism may be related to the inhibition of the JAK2/STAT3 pathway. Additionally, CPT increased the inhibitory effect of 5-fluorouracil on SGC-7901/5-FU cells, an effect that correlated with changes in cellular resistance.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"212 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis, Characterization and Antimicrobial Response of Silver Nanoparticles Using an Aqueous Extract of Taraxacum officinale 利用蒲公英水提取物进行银纳米粒子的生物合成、表征和抗菌反应

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03143-9

Fazle Rabbi, Amna Nisar, Asma Saeed

{"title":"Biosynthesis, Characterization and Antimicrobial Response of Silver Nanoparticles Using an Aqueous Extract of Taraxacum officinale","authors":"Fazle Rabbi, Amna Nisar, Asma Saeed","doi":"10.1007/s11094-024-03143-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03143-9","url":null,"abstract":"The world faces a grave threat from antimicrobial resistance. Currently, many bacterial and fungal infections cannot be treated with the majority of well-known antibiotics. Biosynthesized silver nanoparticles (AgNPs) were achieved by a novel, simple green chemistry procedure to counter microbial familiarity using Taraxacum officinale aqueous extract as a reducing agent. The current study was carried out to explore the efficacy of AgNPs by aqueous extract of Taraxacum officinale followed by physicochemical characterization including ultraviolet-visible spectrophotometry (UV-Vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FTIR). Antibacterial and antifungal activities of the aqueous extracts AgNPs were assessed using the seeding technique and the tube diluton technique respectively. The UV-Vis distinctive spectral peak was observed at 445 nm. SEM showed a particle size range of 100 nm at 30,000 × magnification whereas TEM showed the spherical shape (100 nm) of nanoparticles. XRD confirmed the crystalline structure of the AgNPs, whereas FTIR validated the phytochemicals in their capping, stabilization, and synthesis of AgNPs. Antibacterial assay of synthesized NPs showed significant action against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. Similarly, the antifungal activity of synthesized AgNPs showed significant action against Aspergillus flavus, Aspergillus niger, Alternaria alternata, and Fusarium oxysporum. These results suggest that the aqueous extract AgNPs of T. officinale could provide a safer alternative to conventional antibacterial and antifungal agents.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"3 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0