Pharmaceutical Chemistry Journal最新文献_第6页

Application of Response Surface Methodology for the Development of an Innovative Stability-Indicating UHPLC Method for the Simultaneous Determination of Embelin and Vilangin in Vidanga (Embelia ribes) Tablets 应用响应面方法开发一种创新型稳定性指示超高效液相色谱法，用于同时测定 Vidanga（Embelia ribes）片剂中的 Embelin 和 Vilangin 含量

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03151-9

Theja Indireddy, Ramya Kuber

{"title":"Application of Response Surface Methodology for the Development of an Innovative Stability-Indicating UHPLC Method for the Simultaneous Determination of Embelin and Vilangin in Vidanga (Embelia ribes) Tablets","authors":"Theja Indireddy, Ramya Kuber","doi":"10.1007/s11094-024-03151-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03151-9","url":null,"abstract":"The current study highlights the systematic quality by design-assisted creation of an efficient analytical technique for the estimation of embelin and vilangin in Vidanga (Embelia ribes) tablets. Response surface methodology in the design of experiments was used to identify key material attributes and critical process parameters that influence the designated critical analytical attributes. Separation was achieved on the X-Bridge (100 × 2.1 mm, 2 μm). The effects of acetonitrile content (v/v), flow rate, and column temperature on the retention times of the two drugs and their resolution, number of theoretical plates, and tailing factor were investigated and optimized. The optimal chromatographic conditions within the design space were found to be an isocratic mobile phase consisting of buffer and methanol (57.77:42.33, v/v) with a flow rate of 0.2 mL/min and a run time of 3 min. The retention times of embelin and vilangin were found to be 1.31- and 1.7-min. Different validation parameters were established, and the approach was validated in agreement with ICH and FDA requirements. Data analysis using statistical methods has revealed that the method is reliable, accurate, and robust.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"24 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptotanshinone Inhibits the Proliferation of 5-Fluorouracil-Resistant Gastric Cancer SGC-7901/5-FU Cells Via the JAK2/STAT3 Pathway 隐丹参酮通过 JAK2/STAT3 通路抑制耐 5 氟尿嘧啶的胃癌 SGC-7901/5-FU 细胞的增殖

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03133-x

Yezhi Cao, Linghu Wang, Ling Cheng, Jun Chu, Qingsheng Yu, Hui Peng, Wenkai Wu, Haiwei Liu, Fuhai Zhou, Yaqian Shu, Qi Zhang

{"title":"Cryptotanshinone Inhibits the Proliferation of 5-Fluorouracil-Resistant Gastric Cancer SGC-7901/5-FU Cells Via the JAK2/STAT3 Pathway","authors":"Yezhi Cao, Linghu Wang, Ling Cheng, Jun Chu, Qingsheng Yu, Hui Peng, Wenkai Wu, Haiwei Liu, Fuhai Zhou, Yaqian Shu, Qi Zhang","doi":"10.1007/s11094-024-03133-x","DOIUrl":"https://doi.org/10.1007/s11094-024-03133-x","url":null,"abstract":"Cryptotanshinone (CPT), which is an important active ingredient of herbs, has shown great value for research. In particular, CPT exerts antitumor effects on various types of cancer; however, there are relatively few studies of CPT on gastric cancer cells. The objectives of this study were to investigate how CPT affects apoptosis in 5-fluorouracil-resistant SGC-7901 gastric cancer cells (SGC-7901/5-FU cells) and the molecular mechanism underlying its action. In this study, SGC-7901/5-FU cells were treated with 5-fluorouracil (5-FU) and CPT and the viability of the cells was assessed by CCK8 assay. Additionally, cellular apoptosis rates were evaluated using immunofluorescence and flow cytometry. Related gene expression was evaluated using Quantitative Real-time PCR methods and Western Blot, respectively. CPT inhibited SGC-7901/5-FU cell growth. The immunofluorescence results showed that CPT caused nuclear shrinkage in the cells. Quantitative Real-time PCR and Western Blot results also showed CPT decreased the expression of Mcl-1, Bcl-xl and Bcl-2 levels, and increased the expression of Bax. We demonstrated that CPT can inhibit the growth of SGC-7901/5-FU cells, and the mechanism may be related to the inhibition of the JAK2/STAT3 pathway. Additionally, CPT increased the inhibitory effect of 5-fluorouracil on SGC-7901/5-FU cells, an effect that correlated with changes in cellular resistance.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"212 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis, Characterization and Antimicrobial Response of Silver Nanoparticles Using an Aqueous Extract of Taraxacum officinale 利用蒲公英水提取物进行银纳米粒子的生物合成、表征和抗菌反应

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03143-9

Fazle Rabbi, Amna Nisar, Asma Saeed

{"title":"Biosynthesis, Characterization and Antimicrobial Response of Silver Nanoparticles Using an Aqueous Extract of Taraxacum officinale","authors":"Fazle Rabbi, Amna Nisar, Asma Saeed","doi":"10.1007/s11094-024-03143-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03143-9","url":null,"abstract":"The world faces a grave threat from antimicrobial resistance. Currently, many bacterial and fungal infections cannot be treated with the majority of well-known antibiotics. Biosynthesized silver nanoparticles (AgNPs) were achieved by a novel, simple green chemistry procedure to counter microbial familiarity using Taraxacum officinale aqueous extract as a reducing agent. The current study was carried out to explore the efficacy of AgNPs by aqueous extract of Taraxacum officinale followed by physicochemical characterization including ultraviolet-visible spectrophotometry (UV-Vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FTIR). Antibacterial and antifungal activities of the aqueous extracts AgNPs were assessed using the seeding technique and the tube diluton technique respectively. The UV-Vis distinctive spectral peak was observed at 445 nm. SEM showed a particle size range of 100 nm at 30,000 × magnification whereas TEM showed the spherical shape (100 nm) of nanoparticles. XRD confirmed the crystalline structure of the AgNPs, whereas FTIR validated the phytochemicals in their capping, stabilization, and synthesis of AgNPs. Antibacterial assay of synthesized NPs showed significant action against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. Similarly, the antifungal activity of synthesized AgNPs showed significant action against Aspergillus flavus, Aspergillus niger, Alternaria alternata, and Fusarium oxysporum. These results suggest that the aqueous extract AgNPs of T. officinale could provide a safer alternative to conventional antibacterial and antifungal agents.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"3 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol, Tyrosol and Their Derivatives Inhibit Platelet Activating Factor Biosynthetic Enzymes in Homogenized U-937 Cells 白藜芦醇、酪醇及其衍生物抑制匀浆 U-937 细胞中的血小板活化因子生物合成酶

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03137-7

Filio Petsini, Maria Detopoulou, Ioannis K. Kostakis, Elizabeth Fragopoulou, Smaragdi Antonopoulou

{"title":"Resveratrol, Tyrosol and Their Derivatives Inhibit Platelet Activating Factor Biosynthetic Enzymes in Homogenized U-937 Cells","authors":"Filio Petsini, Maria Detopoulou, Ioannis K. Kostakis, Elizabeth Fragopoulou, Smaragdi Antonopoulou","doi":"10.1007/s11094-024-03137-7","DOIUrl":"https://doi.org/10.1007/s11094-024-03137-7","url":null,"abstract":"Platelet activating factor (PAF) is a potent lipid mediator involved in inflammation, among other pathophysiological conditions. Bioactive compounds from foods have been suggested to suppress inflammation as well as regulate PAF biosynthesis. Phenolics, such as resveratrol and tyrosol, and their acetylated derivatives, inhibited PAF biosynthetic enzymes’ activity, namely acetyl-coenzyme A: lyso–platelet-activating factor acetyltransferases (lysoPAF-AT), and 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT) under inflammatory stimuli. This study investigates whether resveratrol and tyrosol lipophilic derivatives are capable of affecting the activity of the two isoforms of lysoPAF-AT along with the activity of PAF-CPT compared with the initial compounds under basal conditions. The derivatives were chemically synthesized and the experiments were conducted either with or without pre-incubation of homogenized U-937 cells and the phenolics and the enzyme activities were determined. Pre-incubation experiments resulted in lower half inhibitory concentration (IC50) than those without pre-incubation, reaching a 5-fold difference between them. Moreover, there were differences among parent compounds and their derivatives, suggesting a dependence on the differently substituted groups of the phenolics. PAF-CPT tends to be less phenolic structure dependent than lysoPAF-ATC, whereas the other isoform, lysoPAF-ATE, was less sensitive in general. Resveratrol and its derivatives were more potent than the tyrosolic compounds, regardless of the enzyme test or the conditions of the experiment. The use of phenolic lipophilic derivatives in pharmaceuticals and in food preparation may overcome the limitations of natural phenolics with regard to their weak solubility and stability in a lipophilic environment.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"31 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Compositions and Pharmacological Activities of Iberis amara L. (A Review) Iberis amara L.的化学成分和药理活性（综述）

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03145-7

Xingyu Liu, Xiaohan Wang, Hans Gregersen, Jing Zuo

引用次数: 0

Toxicity and Antihypoxic Activity of a Preparation Containing a Complex Compound of 5-Hydroxy-6-Methyluracil with N-Acetyl Cysteine 含有 5-羟基-6-甲基尿嘧啶与 N-乙酰半胱氨酸复合物的制剂的毒性和抗缺氧活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03131-z

G. G. Kutlugildina, Yu. S. Zimin, A. R. Gimadieva, E. F. Repina, E. R. Kudoyarov

引用次数: 0

Synthesis and Biological Evaluation of Arctigenin-Dipeptide Derivatives as Potential Anti-Fatigue Agents 作为潜在抗疲劳剂的 Arctigenin-二肽衍生物的合成与生物学评价

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-22 DOI: 10.1007/s11094-024-03140-y

Wanbo Zeng, Siyuan Li, Weiguo Shi, Junjie Tan, Xiang Li, Liang Xu

{"title":"Synthesis and Biological Evaluation of Arctigenin-Dipeptide Derivatives as Potential Anti-Fatigue Agents","authors":"Wanbo Zeng, Siyuan Li, Weiguo Shi, Junjie Tan, Xiang Li, Liang Xu","doi":"10.1007/s11094-024-03140-y","DOIUrl":"https://doi.org/10.1007/s11094-024-03140-y","url":null,"abstract":"Fatigue is a physiological phenomenon experienced by the human body when it undergoes prolonged physical and mental exertion, which can have detrimental effects on both health and work productivity. Previous research has demonstrated that arctigenin (ArcG) has the ability to enhance the physical performance of mice during exercise. In this study, five ArcG derivatives containing different dipeptides coupled via an ethoxy linker were synthesized and tested for their activities to improve exercise performance in mice. All of the derivatives extended the exhaustion distance of mice in the running wheel test. Derivative Z-B-4 exhibited the highest activity, showing that the mice ran a distance 1.3-fold greater than that of the ArcG group and 3.4-fold greater than that of the sport control group. Furthermore, Z-B-4 was found to increase the concentrations of superoxide dismutase (SOD) and catalase (CAT), while simultaneously decreasing levels of lactic acid (LA) and blood urea nitrogen (BUN) during exercise. This study provides new references and promising lead compounds for the development of antifatigue agents.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"14 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Stability of Ibuprofen Upon Co-Milling with Caffeine and Polyvinylpyrrolidone at Room Temperature 布洛芬在室温下与咖啡因和聚乙烯吡咯烷酮共研磨时的物理稳定性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-21 DOI: 10.1007/s11094-024-03148-4

M. Bejaoui, R. Djemi, S. Kouass, H. Galai

{"title":"Physical Stability of Ibuprofen Upon Co-Milling with Caffeine and Polyvinylpyrrolidone at Room Temperature","authors":"M. Bejaoui, R. Djemi, S. Kouass, H. Galai","doi":"10.1007/s11094-024-03148-4","DOIUrl":"https://doi.org/10.1007/s11094-024-03148-4","url":null,"abstract":"The purpose of this work is to investigate the physical stability of a ternary amorphous system (Ibuprofen, Caffeine, Polyvinylpyrrolidone (PVP K30)) generated by co-milling technique at room temperature, as well as the intermolecular interactions that could contribute to physical stabilization of amorphous ibuprofen (a poorly water-soluble drug). The milled mixtures were characterized by x-ray diffraction (XRD), infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electronic microscopy (SEM). As shown by XRD results, amorphous Ibuprofen maintains its physical stability even after exposure to high humidity levels (RH = 75%, T = 40°C) for 6 months. FTIR results highlighted the establishment of hydrogen bonds in the binary and ternary systems involving the carboxylic group of Ibuprofen. At higher amounts (more than 75%), the polyvinylpyrrolidone has totally amorphized drug/caffeine mixtures and inhibited polymorphic transition of Caffeine (Form II ≥ Form I) which occurred at higher temperatures. Thus, this polymer has shown an ability to stabilize amorphous solid dispersion (Ibuprofen: Caffeine) and preserve the chemical structure of each molecule.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"59 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of the Modern Market of Reagents for the Detection of Bacterial Endotoxins in Drugs 检测药物中细菌内毒素的现代试剂市场回顾

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-21 DOI: 10.1007/s11094-024-03149-3

O. V. Shapovalova, A. O. Tutnova, N. P. Neugodova, G. A. Sapozhnikova

引用次数: 0

E1231 Alleviates Diabetic Cardiomyopathy by Regulating the Silent Information Regulator 1/Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α/Nuclear Factor Erythroid 2-Related Factor 2 Pathway E1231 通过调节沉默信息调节器 1/Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α/Nuclear Factor Erythroid 2-Related Factor 2 通路减轻糖尿病心肌病的病情

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-06-21 DOI: 10.1007/s11094-024-03138-6

Yunxia Cui, Hongjun Lou, Qi Guo, Guiyun Qi, Xi Gao

{"title":"E1231 Alleviates Diabetic Cardiomyopathy by Regulating the Silent Information Regulator 1/Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α/Nuclear Factor Erythroid 2-Related Factor 2 Pathway","authors":"Yunxia Cui, Hongjun Lou, Qi Guo, Guiyun Qi, Xi Gao","doi":"10.1007/s11094-024-03138-6","DOIUrl":"https://doi.org/10.1007/s11094-024-03138-6","url":null,"abstract":"We aimed to investigate the underlying function and mechanism of E1231 against diabetic cardiomyopathy (DCM). H9c2 cells were exposed to either 33 mmol/L mannitol or an identical concentration of glucose (high glucose, HG) in vitro. In vivo, diabetes mellitus (DM) mice were induced by injection of 60 mg/kg streptozotocin intraperitoneally. E1231 was used to treat cells (5 mmol/L) or animals (40 mg/kg), and subsequent assays were conducted to determine its effect on DCM-associated manifestations. Western blot was employed to evaluate protein expressions of the silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and nuclear factor erythroid 2-related factor 2 (Nrf2). In vitro, treatment with E1231 significantly reduced oxidative stress and apoptosis induced by HG via activating the SIRT1-PGC-1α/Nrf2 pathway in H9c2 cells, compared to cardiomyocytes under HG conditions. In vivo, DM mice showed up-regulated SIRT1, PGC-1α, and Nrf2 expression, with protection against cardiac fibrosis, dysfunction, and oxidative stress impairment. The study demonstrated that E1231 alleviates cardiac dysfunction via activating the SIRT1-PGC-1α signaling pathway in DCM, leading to the activation of Nrf2. Therefore, E1231 has the potential to facilitate the treatment of DCM.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"4 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0