Pediatric Gastroenterology, Hepatology & Nutrition最新文献

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Complications of Gastrostomy and Gastrojejunostomy: The Prevalence in Children. 儿童胃造口术和胃空肠造口术的并发症发生率。
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-05-01 DOI: 10.5223/pghn.2023.26.3.156
Thomas Gestels, Bruno Hauser, Els Van de Vijver
{"title":"Complications of Gastrostomy and Gastrojejunostomy: The Prevalence in Children.","authors":"Thomas Gestels,&nbsp;Bruno Hauser,&nbsp;Els Van de Vijver","doi":"10.5223/pghn.2023.26.3.156","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.3.156","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to provide an overview of the prevalence of the complications of a gastrostomy or a gastrojejunostomy with a low-profile gastric tube in children. The study also examined the effect of presence of the gastrostomy tube on the prevalence of complications.</p><p><strong>Methods: </strong>In this cross-sectional study, parents were invited to complete an online questionnaire. Children aged 0-16 years with a low-profile gastrostomy or gastrojejunostomy tube were included in the study.</p><p><strong>Results: </strong>A total of 67 complete surveys were conducted. The mean age of the included children was seven years. The most common complications during the past week, were skin irritation (35.8%), abdominal pain (34.3%), and the formation of granulation tissue (29.9%). The most common complications during the past six months were skin irritation (47.8%), vomiting (43.4%), and abdominal pain (38.8%). Most complications occurred within the first year after gastrojejunostomy placement and gradually decreased as the duration since the placement of the gastrojejunostomy tube increased. The prevalence of severe complications was rare. Parental confidence in caring for the gastrostomy positively correlated with increases in the duration of the gastrostomy tube. Even so, parental confidence in the care of the gastrostomy tube was reduced in some parents more than a year after its placement.</p><p><strong>Conclusion: </strong>The prevalence of gastrojejunostomy complications in children is relatively high. The incidences of severe complications after the placement of a gastrojejunostomy tube were rare in this study. A lack of confidence in the care of the gastrostomy tube was noted in some parents more than a year after its placement.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 3","pages":"156-164"},"PeriodicalIF":1.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/eb/pghn-26-156.PMC10192589.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence, Risk Factors, and Pediatrician Awareness of Infant Dyschezia in Indonesia. 印度尼西亚婴儿失智症的患病率、危险因素和儿科医生的认识。
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-03-01 DOI: 10.5223/pghn.2023.26.2.116
Muzal Kadim, Ucha Merendar Putri, Hartono Gunardi, H F Wulandari, Pustika Amalia Wahidiyat, Sudung O Pardede, Wahyuni Indawati
{"title":"Prevalence, Risk Factors, and Pediatrician Awareness of Infant Dyschezia in Indonesia.","authors":"Muzal Kadim,&nbsp;Ucha Merendar Putri,&nbsp;Hartono Gunardi,&nbsp;H F Wulandari,&nbsp;Pustika Amalia Wahidiyat,&nbsp;Sudung O Pardede,&nbsp;Wahyuni Indawati","doi":"10.5223/pghn.2023.26.2.116","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.2.116","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the prevalence and risk factors of infant dyschezia as well as pediatrician awareness regarding this disease in Indonesia.</p><p><strong>Methods: </strong>This is a two-part cross-sectional study, which was divided into study A and B. Study A: Parents whose infants were under 9 months old and attended well-baby clinics were recruited at two randomly selected primary health centers. Parents also provided information on the infant's previous medical history, and socio-demographic and family details. The Rome IV criteria was translated and validated to be used for diagnosis of infant dyschezia. Study B: Randomly selected pediatricians were surveyed by using a questionnaire to evaluate their knowledge regarding infant dyschezia.</p><p><strong>Results: </strong>The prevalence of infant dyschezia based on the result of this study was 11.8%. Three risk factors had a significant relationship with infant dyschezia i.e., the number of children in the family (odds ratio [OR], 5.619; 95% confidence interval [CI], 2.194-14.390; <i>p</i><0.001), complementary food diet (OR, 4.238; 95% CI, 1.902-9.443; <i>p</i><0.001), and social-emotional disturbance (OR, 5.670; 95% CI, 2.550-12.609; <i>p</i><0.001). The percentage of pediatricians correctly diagnosed infant dyschezia was 71.5%. Most pediatricians agreed that they did not perform any diagnostic testing (79.7%) and only provided education in cases of infant dyschezia (58.5%).</p><p><strong>Conclusion: </strong>The prevalence of infant dyschezia identified in our study was higher than that in other neighboring Asian countries, with the highest prevalence observed in infants 7-9 months old. Being an only child, receiving complementary food diet, and sociao-emotional disturbances were significant risk factors of infant dyschezia.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 2","pages":"116-126"},"PeriodicalIF":1.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/b0/pghn-26-116.PMC10025572.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pilot Study Exploring Temporal Development of Gut Microbiome/Metabolome in Breastfed Neonates during the First Week of Life. 一项探索母乳喂养的新生儿在生命第一周肠道微生物/代谢组时间发育的初步研究。
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-03-01 DOI: 10.5223/pghn.2023.26.2.99
Imad Awan, Emily Schultz, John D Sterrett, Lamya'a M Dawud, Lyanna R Kessler, Deborah Schoch, Christopher A Lowry, Lori Feldman-Winter, Sangita Phadtare
{"title":"A Pilot Study Exploring Temporal Development of Gut Microbiome/Metabolome in Breastfed Neonates during the First Week of Life.","authors":"Imad Awan,&nbsp;Emily Schultz,&nbsp;John D Sterrett,&nbsp;Lamya'a M Dawud,&nbsp;Lyanna R Kessler,&nbsp;Deborah Schoch,&nbsp;Christopher A Lowry,&nbsp;Lori Feldman-Winter,&nbsp;Sangita Phadtare","doi":"10.5223/pghn.2023.26.2.99","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.2.99","url":null,"abstract":"<p><strong>Purpose: </strong>Exclusive breastfeeding promotes gut microbial compositions associated with lower rates of metabolic and autoimmune diseases. Its cessation is implicated in increased microbiome-metabolome discordance, suggesting a vulnerability to dietary changes. Formula supplementation is common within our low-income, ethnic-minority community. We studied exclusively breastfed (EBF) neonates' early microbiome-metabolome coupling in efforts to build foundational knowledge needed to target this inequality.</p><p><strong>Methods: </strong>Maternal surveys and stool samples from seven EBF neonates at first transitional stool (0-24 hours), discharge (30-48 hours), and at first appointment (days 3-5) were collected. Survey included demographics, feeding method, medications, medical history and tobacco and alcohol use. Stool samples were processed for 16S rRNA gene sequencing and lipid analysis by gas chromatography-mass spectrometry. Alpha and beta diversity analyses and Procrustes randomization for associations were carried out.</p><p><strong>Results: </strong>Firmicutes, Proteobacteria, Bacteroidetes and Actinobacteria were the most abundant taxa. Variation in microbiome composition was greater between individuals than within (<i>p</i>=0.001). Palmitic, oleic, stearic, and linoleic acids were the most abundant lipids. Variation in lipid composition was greater between individuals than within (<i>p</i>=0.040). Multivariate composition of the metabolome, but not microbiome, correlated with time (<i>p</i>=0.030). Total lipids, saturated lipids, and unsaturated lipids concentrations increased over time (<i>p</i>=0.012, <i>p</i>=0.008, <i>p</i>=0.023). Alpha diversity did not correlate with time (<i>p</i>=0.403). Microbiome composition was not associated with each samples' metabolome (<i>p</i>=0.450).</p><p><strong>Conclusion: </strong>Neonate gut microbiomes were unique to each neonate; respective metabolome profiles demonstrated generalizable temporal developments. The overall variability suggests potential interplay between influences including maternal breastmilk composition, amount consumed and living environment.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 2","pages":"99-115"},"PeriodicalIF":1.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/5f/pghn-26-99.PMC10025571.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dyssynergic Defecation in Chronically Constipated Children in Korea. 韩国慢性便秘儿童的排便失调。
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-03-01 DOI: 10.5223/pghn.2023.26.2.127
Sun Hwan Bae
{"title":"Dyssynergic Defecation in Chronically Constipated Children in Korea.","authors":"Sun Hwan Bae","doi":"10.5223/pghn.2023.26.2.127","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.2.127","url":null,"abstract":"<p><strong>Purpose: </strong>Dyssynergic defecation (DSD) is one of the important causes of chronic constipation in children. We aimed to analyze the clinical features, diagnostic test results, and treatments for DSD in children.</p><p><strong>Methods: </strong>Children diagnosed with DSD using fluoroscopic defecography were enrolled in this study. Clinical data, including the results of colon transit time (CTT) test and biofeedback (BF) therapy, were collected from medical records retrospectively.</p><p><strong>Results: </strong>Nineteen children were enrolled. The median age was 9 years (6-18 years), the median frequency of bowel movement was 1/7 days (1-10 days), the median duration of constipation was 7.0 years (2-18 years), the median age of onset of constipation was 2.5 years (1-11 years). In the CTT test, outlet obstruction type was noted in 10/18 (55.6%), slow transit type in 5/18 (27.8%), and normal transit in 1/18 (5.6%). The median CTT was 52 hours (40-142 hours). Initial medical therapy was performed with the polyethylene glycol 4000, and the response was good in 9/19 (47.4%), fair in 9/19 (47.4%), and poor in 1/19 (5.0%). BF was performed in 8/19, with good results in 6/8 (75.0%) children and failure in 2/8 (25.0%) children. After long-term medical therapy (11/19), 3/5 showed good response with medication alone, 6/8 showed good response with BF and medication combined.</p><p><strong>Conclusion: </strong>DSD should be considered as a cause of chronic constipation in children, especially in those with abnormal CTT test results. BF combined with medical therapy is effective even with age-limited cooperation.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 2","pages":"127-133"},"PeriodicalIF":1.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/ab/pghn-26-127.PMC10025570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Agreement Level of Inflammatory Bowel Disease Symptom Reports between Children and Their Parents. 儿童与父母炎症性肠病症状报告的一致性水平
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-03-01 Epub Date: 2023-03-07 DOI: 10.5223/pghn.2023.26.2.88
Angharad Vernon-Roberts, Emma Rouse, Nerissa L Bowcock, Daniel A Lemberg, Andrew S Day
{"title":"Agreement Level of Inflammatory Bowel Disease Symptom Reports between Children and Their Parents.","authors":"Angharad Vernon-Roberts,&nbsp;Emma Rouse,&nbsp;Nerissa L Bowcock,&nbsp;Daniel A Lemberg,&nbsp;Andrew S Day","doi":"10.5223/pghn.2023.26.2.88","DOIUrl":"10.5223/pghn.2023.26.2.88","url":null,"abstract":"<p><strong>Purpose: </strong>Children with inflammatory bowel disease (IBD) frequently undergo clinical assessments, involving triadic communication between clinician, parent, and child. During such encounters parents are traditionally the main communicator of information on their child's IBD, including subjective symptom reports. The level of agreement between children and their parents for IBD symptoms is poorly understood, and this study aimed to examine this factor.</p><p><strong>Methods: </strong>This was a cross-sectional study among children with IBD, and one parent. A validated paediatric IBD symptom report tool (IBDnow) enabled children and their parent to rate seven pain, well-being, and stool metrics, with dyads completing the tool concurrently. Results were assessed using: Individual agreement: proportion of identical symptom reports by each dyad (ideal score >0.7); Category agreement: percentage of identical reports for IBDnow metrics for the cohort; Inter-rater reliability: Gwet's AC1 coefficient with higher scores indicating better reliability (maximum=1).</p><p><strong>Results: </strong>Seventy-four parent/child dyads participated; child's mean age 12.2 years (standard deviation [SD] 2.9, range 6-16), mean time since diagnosis 2.8 years (SD 3), 54% female, 73% had Crohn's Disease. Mean individual agreement level was 0.6, with 27% of dyads agreeing on ≥6/7 IBDnow metrics. Category agreement was reported by 61% of dyads, 20% of parents overestimated, and 19% underestimated, their child's symptoms. Inter-rater reliability ranged from fair to good.</p><p><strong>Conclusion: </strong>These results should improve clinician awareness of how IBD symptom reports from parents may introduce bias. Children should be considered the most important source of symptom reports, and tools such as IBDnow utilised to enhance communication.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 2","pages":"88-98"},"PeriodicalIF":1.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/3c/pghn-26-88.PMC10025573.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Nationwide Survey on Gastrointestinal Endoscopy Practice Patterns among Pediatric Endoscopists in South Korea. 韩国儿科内镜医师胃肠内镜检查实践模式的全国性调查。
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-03-01 DOI: 10.5223/pghn.2023.26.2.79
Yoo Min Lee, Yoon Lee, So Yoon Choi, Hyun Jin Kim, Suk Jin Hong, Yunkoo Kang, Eun Hye Lee, Kyung Jae Lee, Youjin Choi, Dae Yong Yi, Seung Kim, Ben Kang
{"title":"A Nationwide Survey on Gastrointestinal Endoscopy Practice Patterns among Pediatric Endoscopists in South Korea.","authors":"Yoo Min Lee,&nbsp;Yoon Lee,&nbsp;So Yoon Choi,&nbsp;Hyun Jin Kim,&nbsp;Suk Jin Hong,&nbsp;Yunkoo Kang,&nbsp;Eun Hye Lee,&nbsp;Kyung Jae Lee,&nbsp;Youjin Choi,&nbsp;Dae Yong Yi,&nbsp;Seung Kim,&nbsp;Ben Kang","doi":"10.5223/pghn.2023.26.2.79","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.2.79","url":null,"abstract":"<p><strong>Purpose: </strong>Gastrointestinal (GI) endoscopy is an important tool for diagnosing and treating GI diseases in children. This study aimed to analyze the current GI endoscopy practice patterns among South Korean pediatric endoscopists.</p><p><strong>Methods: </strong>Twelve members of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition developed a questionnaire. The questionnaire was emailed to pediatric gastroenterologists attending general and tertiary hospitals in South Korea.</p><p><strong>Results: </strong>The response rate was 86.7% (52/60), and 49 of the respondents (94.2%) were currently performing endoscopy. All respondents were performing esophagogastroduodenoscopy, and 43 (87.8%) were performing colonoscopy. Relatively rare procedures for children, such as double-balloon enteroscopy (DBE) (4.1%), endoscopic retrograde cholangiopancreatography (ERCP) (2.0%), and endoscopic ultrasound (EUS) (2.0%), were only performed by pediatric gastroenterologists at very few centers, but were performed by adult endoscopists in most of the centers; of all the respondents, 83.7% (41/49) performed emergency endoscopy. In most centers, the majority of the endoscopies were performed under sedation, with midazolam (100.0%) and ketamine (67.3%) as the most frequently used sedatives.</p><p><strong>Conclusion: </strong>While most pediatric GI endoscopists perform common GI endoscopic procedures, rare procedures, such as DBE, ERCP, and EUS, are only performed by pediatric gastroenterologists at very few centers, and by adult GI endoscopists at most of the centers. For such rare procedures, close communication and cooperation with adult GI endoscopists are required.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 2","pages":"79-87"},"PeriodicalIF":1.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/ec/pghn-26-79.PMC10025574.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Symptomatic Focal Hepatic Hemangioma with Propranolol in Neonates: Is It Efficient? 心得安治疗新生儿症状性局灶性肝血管瘤是否有效?
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-01-01 DOI: 10.5223/pghn.2023.26.1.70
Jana Lozar Krivec, Nina Lah, Mojca Glušič, Orjana Velikonja, Darja Paro-Panjan
{"title":"Treatment of Symptomatic Focal Hepatic Hemangioma with Propranolol in Neonates: Is It Efficient?","authors":"Jana Lozar Krivec,&nbsp;Nina Lah,&nbsp;Mojca Glušič,&nbsp;Orjana Velikonja,&nbsp;Darja Paro-Panjan","doi":"10.5223/pghn.2023.26.1.70","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.1.70","url":null,"abstract":"<p><p>Hepatic hemangiomas (HH) - classified into congenital hepatic hemangiomas (CHH) or infantile hepatic hemangiomas (IHH) - are benign vascular tumors that are mainly asymptomatic, but may cause clinical problems that require treatment. While focal, multifocal, and diffuse IHH are responsive to propranolol treatment, CHH is mainly focal and thought to be resistant to treatment with propranolol. The clinical and imaging distinctions between CHH and IHH in cases of focal lesions can be challenging, while histopathological distinction is mostly lacking in the clinical setting. We report 4 neonatal symptomatic cases of focal HH treated with propranolol, with partial or complete resolution of the tumor, and the positive hemodynamic effect of propranolol in one case. We believe that although clear differentiation cannot be achieved between CHH and IHH without histopathological examination in cases of focal HH in neonates, propranolol treatment should be attempted in symptomatic cases since its benefits outweigh the possible small risk of side effects of propranolol.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 1","pages":"70-77"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/f9/pghn-26-70.PMC9911173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9314487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fecal Calprotectin and Cow's Milk-Related-Symptoms Score in Children with Cow's Milk Protein Allergy. 牛奶蛋白过敏儿童粪便钙保护蛋白与牛奶相关症状评分
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-01-01 DOI: 10.5223/pghn.2023.26.1.43
Sahar Zain-Alabedeen, Noha Kamel, Mona Amin, Angharad Vernon-Roberts, Andrew S Day, Abdelmoneim Khashana
{"title":"Fecal Calprotectin and Cow's Milk-Related-Symptoms Score in Children with Cow's Milk Protein Allergy.","authors":"Sahar Zain-Alabedeen,&nbsp;Noha Kamel,&nbsp;Mona Amin,&nbsp;Angharad Vernon-Roberts,&nbsp;Andrew S Day,&nbsp;Abdelmoneim Khashana","doi":"10.5223/pghn.2023.26.1.43","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.1.43","url":null,"abstract":"<p><strong>Purpose: </strong>The cow's milk-related-symptom-score (CoMiSS) tool was developed as an awareness tool for the assessment of cow's milk-related symptoms in infants or children. Fecal calprotectin (FC) is a noninvasive biomarker of gut inflammation that can be measured in serum and stool. This study aimed to investigate the relationship between FC levels and CoMiSS scores in infants with cow's milk protein allergy.</p><p><strong>Methods: </strong>Infants (aged 6-12 months) who were allergic to cow's milk protein were enrolled prospectively. Following completion of the CoMiSS scoring, the infants were divided into group 1 (positive CoMiSS scores ≥12) and group 2 (negative CoMiSS scores <12). FC was measured using immunoassay.</p><p><strong>Results: </strong>Of the 120 infants enrolled in this study, 60 (50.0%) had positive CoMiSS scores (group 1), while 60 (50.0%) had negative scores (group 2). The mean FC level was higher in the infants in group 1 than those in group 2 (2,934.57 µg/g vs. 955.13 µg/g; <i>p</i><0.001). In addition, there was a positive correlation between FC and CoMiSS scores (R=0.168, <i>p</i><0.0001). A FC level of 1,700 µg/g provided a sensitivity of 98.3%, specificity of 93.3%, and accuracy of 95.8% for the diagnosis of cow's milk protein allergy (CMPA).</p><p><strong>Conclusion: </strong>FC measurement may have a role in the assessing infants with CMPA.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 1","pages":"43-49"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/21/pghn-26-43.PMC9911171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9314492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Management of Gastrointestinal Foreign Bodies with Brief Review of the Guidelines. 胃肠道异物的处理与指南的简要回顾。
IF 1.9
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-01-01 DOI: 10.5223/pghn.2023.26.1.1
Kaan Demiroren
{"title":"Management of Gastrointestinal Foreign Bodies with Brief Review of the Guidelines.","authors":"Kaan Demiroren","doi":"10.5223/pghn.2023.26.1.1","DOIUrl":"https://doi.org/10.5223/pghn.2023.26.1.1","url":null,"abstract":"<p><p>Foreign body (FB) ingestion is a common health problem that affects children more than adults. According to gastroenterologists' guidelines, the management of FB ingestion differs slightly between adult and children. This review aimed to compile adult and children guidelines and establish an understandable association to reveal the requirements and timing of the endoscopic procedure, which is the most effective and least complicated technique for gastrointestinal FBs. Coins, pins, and chicken and fish bones have been the most commonly ingested FBs. However, with their increasing use in recent years, large batteries with lithium-ion conversion, stronger magnets composed of rare earth metals, such as neodymium, and superabsorbent objects have become the most morbid and mortal, necessitating new management strategies. Although the approach to gastrointestinal FBs is controversial, with different treatment options available in different disciplines, many studies have demonstrated the efficacy and safety of endoscopic procedures. Many factors influence the timing of endoscopy, including the nature, size, and location of the ingested object and the patient's clinical condition.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"26 1","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/6f/pghn-26-1.PMC9911172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9328829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
APPSPGHAN 2023 APPSPGHAN 2023
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-01-01 DOI: 10.5223/appspghan2023
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