Modern medical technology最新文献

{"title":"Resonance frequency analysis – indicator of post-implantation morphology of mandibular bone tissue","authors":"A. P. Oshurko, I. Yu, C. Oliinyk A, А. П. Ошурко, І. Ю. Олійник, Н. Б. Кузняк, Л. М. Герасим","doi":"10.34287/mmt.4(59).2023.9","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.9","url":null,"abstract":"This article describes the role of resonance frequency analysis (RFA) as an indicator of the quality of primary implant stability, which is the basis of the goal and confirmed by the results of a clinical case – odontological implantation on edentulous segments of atrophied bone tissue on the right side of the mandible, taking into account the topographic features of its canal, using ultra-short (h = 5.5 mm) implants. \u0000Aim. To highlight the role of resonance frequency analysis during surgical interventions using short (ultrashort) implants in predicting their primary stability and preserving the normal morphology of the mandibular bone tissue. \u0000Materials and methods. The primary stability of 17 dental implants in seven patients was determined using the Penguin Instruments (RFA) technique in declarative units of measurement – the implant stability quotient (ISQ). Values in the range of 75 ISQ meant that the implant had adequate primary stability and could receive and distribute the immediate load on the bone tissue of the edentulous segment. \u0000Results. Following the stages of preparation, 17 ultra-short (h = 5.5 mm × b = 4.0 mm) implants were placed on the edentulous segments of the mandible without an incisional osteotomy path according to the patient rehabilitation protocol. We used the method of resonance frequency analysis to obtain a value of high primary stability of two short subcortical implants in the projection of tooth 4.7 – 92 ISQ and the projection of tooth 4.6 – 90 ISQ. On the 3rd day of the clinical stage of fixation of the supraconstruction, RFA measurements were performed, the values of which showed a significant decrease in the stability quotient of the installed implants in the projection of tooth 4.7 – 61 ISQ and in tooth 4.6 – 74 ISQ. This result made it necessary to revise the rehabilitation plan, adjust the medical prescription sheet and decide to postpone the placement of the all-milled restorative structure on the implants. \u0000Conclusions. The RFA study indicates not only the primary stability of implants but also a full-fledged stage-bystage clinical prognosis of the further functionality of a prosthetic structure based on short implants with proper preservation of the morphological functionality of bone tissue.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"15 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138591283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The behavior of the Bacillus probiotic species under conditions of co-cultivation","authors":"O. Knysh, B. A. V. Martynov A, Skliar, О. В. Книш, А. В. Мартинов, С. І. Похил, Н. І. Скляр","doi":"10.34287/mmt.4(59).2023.8","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.8","url":null,"abstract":"Combining probiotic bacteria is a promising strategy to increase the effectiveness and avoid side effects of probiotic therapy. Bacteria that find themselves in a common environment are able to both change their properties and show new ones under the influence of each other. The change of colonization and antagonistic properties, which provide bacteria with competitive advantages in the development of new spaces, deserves special attention. \u0000The aim of this research was to study the features of the mutual influence of probiotic bacilli: B. clausii, B. coagulans and B. subtilis on growth, swimming and swarming motility when co-cultivated on agar media of different solidity. \u0000Materials and methods. The study used commercial strains of bacilli from three probiotic preparations: Enterogermina, Lactovit forte and Subalin. The ability of the studied species of bacilli to influence each other’s growth was investigated by the agar block method (using 1.5 % nutrient agar) and the spot-on-lawn assay (using 0.7 % nutrient agar). The study of the mutual influence on swimming and swarming activity was carried out when bacilli were cultivated on 0.25 % and 0.70 % tryptone agar, respectively. The diameters of swimming halos and migration swarms formed by monoand mixed cultures were measured, and the areas covered by them were compared. The phenotypes of the meeting of swarms formed by cultures spotted on the swarm plates at different locations were also investigated. \u0000Results. The studied probiotic species of the bacilli did not show a strong ability to inhibit each other’s growth. The B. clausii culture had no inhibitory effect, and the B. coagulans culture demonstrated a moderate inhibitory influence on the growth of the other two species of bacilli when using both diffusion methods. The B. subtilis culture showed moderate or weak inhibitory activity against the B. clausii culture and weak or no inhibitory activity against the B. coagulans culture using the agar block method or spot-on-lawn assay, respectively. The B. coagulans + B. subtilis, B. clausii + B. coagulans and B. clausii + B. subtilis mixed cultures showed moderate, weak and no inhibitory activity against third cultures, respectively. The studied species of bacilli showed different swimming ability and swarming potential as well as the ability to influence each other’s motility. Swimming halos formed by the B. clausii + B. subtilis and B. clausii + B. сoagulans + B. subtilis mixed cultures covered significantly larger plate areas than the swimming halos formed by each culture separately during the same cultivation time. The highest swarming potential was observed in B. coagulans culture and B. cla usii + B. coagulans + B. subtilis mixed culture. The studied bacilli did not show the ability to merge swarms, but, on the contrary, their swarms at the point of contact formed visible “boundary” or “intermediate” lines, demonstrating the ability to identify nonself. \u0000Conclusions. The obtained results in","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"42 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of risk factors for osteopenia development in premature babies","authors":"A. Y. Tsymbal, Yu.V. Kotlova","doi":"10.34287/mmt.4(59).2023.4","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.4","url":null,"abstract":"Neonatal osteopenia (KB 61.3 (ICD-11)) – violation of mineral exchange of bone tissue (BT) of premature babies (PB). Predicting and detection of osteopenia is the key to its successful control. \u0000Aim. The aim of the article was to determine risk factors influencing the formation of neonatal osteopenia of PB and during the term of intensive care / postintensive nursing. \u0000Materials and methods. Ultrasound densitometer Sunlight Omnisense 9000 was used to measure the ultrasound speed in BT (SOS, m/s) with estimation Z-score (SD) according to gestational age of 56 PB and 20 mature babies (control group) in the early neonatal age. Verification of osteopenia was carried out under the WHO guidelines for radiation methods by Z-score indicator less than SD by -1.0. Estimation of Z-score -2.0 SD and less was attributed to ultra-low indicators. The characteristics of obstetric and gynecological, somatic anamnesis and pregnancy course of premature babies’ mothers, factors of PB postnatal development that influence the formation of BT were studied. \u0000Results. Children born at 33 weeks or earlier are 3.23 times more likely (OR = 3.23; CI 95 % [1.08; 9.70]) to develop BT demineralization by the corresponding term of birth than other PB. The chances of ultra-low SOS by Z-score are 14.22 times higher (OR = 14.22; CI 95 % [3.29; 61.57]) in PB born at 32 weeks of gestation and earlier. Extragenital diseases, clinical signs of calcium deficiency in mothers, and women’s intake of calcium and vitamin D3 during pregnancy did not have a statistically significant difference (p > 0.05) in the studied PB and control group. The mother’s preeclampsia increases the chances of insufficient BT mineralization by 5.47 times (OR = 5.47; CI 95 % [1.07; 27.93]), second parity pregnancy (and subsequent ones) – by 4.51 times (OR = 4.51, CI 95 % [1.38; 14.80]). The factors of the ratio of the duration of mechanical ventilation relative to the total time of PB treatment, the duration of parenteral feeding have an inverse correlation (moderate (r = -0.42, р < 0.05) and significant (r = -0.51, р < 0.05) respectively) with a decrease in SOS to low Z-score. \u0000Conclusions. In PB born at 32 weeks of gestation and earlier, the chances of ultra-low SOS indicators by Z-score are 14.22 times higher (OR = 14.22; CI 95 % [3.29; 61.57]). The following factors predicts insufficient mineralization of BT according to SOS indicators according to the Z-score: mother’s second parity pregnancy (and subsequent ones), preeclampsia, parenteral feeding of PB for more than 8 days (Se = 75.00 %, Sp = 71.87 %, p < 0.0001), duration of mechanical ventilation, which is more than 6.48 % of the total time of PB treatment (Se = 86.67 %, Sp = 59.38 %, p < 0.046).","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"32 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of metabolites, metabolithotropic agents and nutritional supplements in sports and sports medicine: a modern view on the problem","authors":"I. F. Bielenichev, C. A, E. E. Y. D. B, E. I. B. S. B, D. V. P. R. B, D. N. V. B. B, Ігор Федорович Бєленічев, Н. А. Горчакова, Е. Ю. Дорошенко, І. Б. Самура, В. П. Риженко, Ніна Вікторівна Бухтіярова","doi":"10.34287/mmt.4(59).2023.10","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.10","url":null,"abstract":"Aim. The purpose of this study was to conduct an up-to-date semantic analysis of the results of our own research and literature data on the medical and pharmacological characteristics of metabolites, metabolitotropic agents and nutritional supplements, the peculiarities of their use in sports practice and sports medicine. \u0000Materials and methods. This study used bibliosemantic, analytical, logical, and generalization methods. The life sciences and biomedical information bibliographic databases MEDLINE, EMBASE, Medline (PubMed), Web of Science, and Cochrane Central were searched to find publications in English that matched the research keywords. The authors carried out an independent search and selection of articles, assessment of the quality of the data, compliance of the presentation and interpretation with the main idea of the study, with the formation of the final list of references. \u0000Results. Based on the analysis of modern literature data and the results of our own studies, a generalized medical and pharmacological characteristic of metabolite agents, metabolitotropic drugs and nutritional supplements that can influence the main and compensatory mechanisms of macroergic phosphates production under the influence of physical activity is presented. The mechanisms of action, indications for use and main side effects of drugs and food additives based on ATP, malate, succinate, citrate, pyruvate, carnitine, carnosine, etc. are presented. \u0000Conclusions. Semantic analysis data indicate that an urgent problem for sports medicine physicians and pharmacologists is the development and use of metabolites, metabolitotropic agents and nutritional supplements, as well as approaches to their rational combination to improve energy metabolism, replenish ATP reserves in the body that will help ensure the intensity muscular activity and simultaneously protect target organs.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"119 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetrical and perinatal consequences of childbirth in women with antenatally undiagnosed fetal growth restriction","authors":"V. A. Puchkov, M. Pavliuchenko, O. A. Bohomolova","doi":"10.34287/mmt.4(59).2023.3","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.3","url":null,"abstract":"Fetal growth restriction (FGR) is one of the most studied topics in the medicine of the mother and fetus. However, not identified antenatally FGR can have an increased risk of both perinatal morbidity and mortality, as well as adverse long-term consequences. The identification of FGR during pregnancy will contribute to the reduction of both perinatal morbidity and perinatal mortality. \u0000Aim. Based on a retrospective analysis, assess the obstetric and perinatal consequences of childbirth in women with antenatally undiagnosed fetal growth restriction. \u0000Materials and methods. An analysis of 488 cases of childbirth in women with singleton pregnancy, who gave birth to a live child, was conducted. In all cases, the gestational age was ≥22 weeks with a fetal weight less than the 10th percentile for the corresponding gestational age. Depending on the antenatally established diagnosis of FGR, two study groups were formed: group I consisted of 204 (41.8 %) cases with antenatally diagnosed FGR, group II – 284 (58.2 %) cases in which signs of FGR were identified after the birth of the child. Maternal characteristics, neonatal outcomes, and evaluation of short-term infant outcomes were analyzed. \u0000Results. Both groups were dominated by women with first births, the number of which was almost the same. Somatic pathology was almost 2 times more common in women of group I, 17.2 %, compared to 9.2 % of women in group II (p < 0.01), this indicates that the majority of women who were not diagnosed with FGR during pregnancy belong to the low-risk group. Fetuses with impaired blood flow in the umbilical cord arteries were twice as common in group I, 49.5 % versus 23.9 % in group II (p < 0.0001), and the frequency of absent/reversible end flow in the umbilical arteries in group I compared to group II, prevailed 3 times (p < 0.0001), indicating more serious lesions of the placenta and, as a result, early manifestation of the fetal condition disorder. The frequency of premature abdominal delivery was 3.75 times higher in group I compared to group II. The most frequent indication for cesarean delivery in both groups was signs of fetal distress syndrome. Analysis of neonatal outcomes showed that the average birth weight was significantly lower in group I and was 2180 ± 55 g against 2420 ± 61 g in group II (p < 0.0001). The need for hospitalization of newborns in the intensive care unit had no statistical difference between the groups (p > 0.05). However, the complications of the early neonatal period and the total length of stay in the hospital were greater in children of the I group, compared to the II group (p < 0.0001). \u0000Conclusions. The results of the conducted research indicate a low level of prenatal diagnosis of fetal growth restriction. Most pregnant women with antenatally undiagnosed fetal growth restriction belong to the group of low perinatal risk. The most frequent indication for cesarean section operation, regardless of the date of delivery, in both groups were ","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"57 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138592975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of organism stimulation with bacterial lipopolysaccharide on nitric oxide production and metabolism in rat heart on the background of metabolic syndrome","authors":"O. Ye, Akimov, A. Mykytenko, C. V. O. Kostenko A, О. Є. Акімов, Андрей Олегович Микитенко, В. О. Костенко","doi":"10.34287/mmt.4(59).2023.6","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.6","url":null,"abstract":"Aim. The aim of the study was to establish the changes in nitric oxide production and metabolism in rat heart during combined influence of organism stimulation with bacterial lipopolysaccharide (LPS) and modeling of metabolic syndrome (MetS). \u0000Materials and methods. The study was conducted on 24 mature male Wistar rats weighing 200–260 g. Experiment lasted 60 days. The animals were divided into 4 groups of 6 animals each: control group, MetS group, LPS stimulation group, LPS + MetS group. MetS was reproduced by using a 20 % fructose solution as the only source of drinking water. LPS of Salmonella typhi was administered at a dose of 0.4 μg/kg intraperitoneally. Animals from LPS + MetS group received a 20 % fructose solution as the only source of drinking water and were administered LPS. In 10 % tissue homogenate of rat heart we studied: total activity of NO-synthases (NOS), activity of constitutive (cNOS) and inducible (iNOS) isoforms, activity of nitrate (NaR) and nitrite (NiR) reductases, concentration of peroxynitrites (ONOO-), nitrites, nitrosothiols and hydrogen sulfide. \u0000Results. Combination of MetS and stimulation of organism with LPS led to increase in total NOS activity by 32.72 % compared to control group. Activity of cNOS did not change compared to control group. Activity of iNOS increased by 33.76 %. Arginase activity decreased by 23.53 %. NaR activity and NiR activity were increased by 86.67 % and by 149.29 %, respectively. Combination of MetS and stimulation of organism with LPS led to decrease in nitrite and nitrosothiols concentration by 38.73 % and by 54.79 %, respectively. Under these conditions concentration of ONOOelevated by 398.0 % compared to control group. Concentration of H S decreased by 27.56 %. \u0000Conclusions. Combination of metabolic syndrome and stimulation of organism with bacterial lipopolysaccharide leads to prevalence of peroxynitrite formation during increased nitric oxide production NO-synthase-dependent and nitrate-nitrite-NO pathways in rat heart.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"31 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex use of cycleand power-ergometry in determining the physical working capacity of young athletes","authors":"M. F. Khoroshukha, M. M. Filippov, A. Bosenko, Ye. L. Mykhaliuk, O. Y. Buriak","doi":"10.34287/mmt.4(59).2023.5","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.5","url":null,"abstract":"The aim of this study is to scientifically substantiate the possibilities of complex use of cycle- and power-ergometry in determining aerobic and anaerobic-aerobic performance of power nature. \u0000Materials and methods. Young athletes (boys) aged 15–16 (n = 91) of the Brovary Higher School of Physical Education (Kyiv region) (experimental group), who participated in the study, were divided into two groups. Group А (n = 47) – speed-power sports (boxing, freestyle wrestling); group B (n = 44) – endurance sports (track and field athletics: 800, 1500, 3000 and 5000-meters race, bicycle racing 50 and 75 km). Sports experience was 3–5 years and more. The control group (group К) consisted of students aged 15–16, who did not play sports (n = 25). Physical working capacity was determined using two methods: submaximal cycle ergometric test PWC170 and submaximal power ergometric test PWC170. Method of power ergometry (patent of Ukraine No 49417) has no analogues in countries of near and far abroad. \u0000Results. The fact of the specific influence of different kinds of dosed physical exercises (strength and power exercises) on PWC170 indicators was established. Thus, no probable differences in aerobic performance indicators were found in wrestlers and boxers during the cycle ergometric test. And conversely, under the conditions of power ergometric testing, we find a significant increase in their PWC170 indicators in relation to athletes of endurance sports. The opposite character of changes was observed when testing the track and field athletes and bike riders. According to the results of the conducted cycle ergometry, these athletes had a significant increase in aerobic performance indicators in comparison with the athletes of speed-power sports. However, the changes of anaerobic-aerobic performance were not significant. It was observed that the adolescents, who did not play sports, had statistically insignificant changes in PWC170 indicators both in the conditions of cycle ergometric and power ergometric testing. \u0000Conclusions. The fact of specific influence of different types of training exercises on the body functions of adolescents was confirmed. The possibility of introducing the methods of complex use of aerobic (cycle ergometry) and anaerobic-aerobic loads (power-ergometry) into the practice of medico-biological control of young athletes is shown. Diagnostics of various types of physical working capacity (PWC170) will provide the coach with operational information about the functional state of the athletes’ body, which will allow to effectively manage a training process.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"60 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary comprehensive approaches to assessing the effectiveness of experimental model of neurodegenerative disorders with cognitive status changes","authors":"M. Danukalo, Y. Kolesnyk, O. Hancheva","doi":"10.34287/mmt.4(59).2023.7","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.7","url":null,"abstract":"Aim of the study was to characterize the locomotor and cognitive aspects of the behavior of experimental rats under intracerebroventricular colchicine administration in the open field test and the 8-arm radial maze, as well as identify a set of behavioral features of experimental animals that emerged during the study. \u0000Materials and methods. The study was conducted in two stages on 20 male Wistar rats aged 10–11 months. The first stage involved assessment of initial locomotor activity and cognitive functions in all intact rats. At the next stage, the rats were divided into two experimental groups (n = 10): the first group with intracerebroventricular injection of physiological NaCl solution, and the second group with intracerebroventricular injection of colchicine. In 14 days after the surgery, repeated recording of locomotive and cognitive activity indicators was performed. \u0000Results. The locomotor activity characteristics did not statistically differ between the animals before the surgical procedures and the rats of the first group. However, in the second group, the activity indicators were significantly higher than in the respective pre-surgery rats. In the intergroup comparison of the rats that entered the second stage of the experiment, it was found that among all the investigated parameters, only the indicator of high activity duration was significantly higher in the second group compared to the first group. At the same time, the animals in the second group showed significant cognitive impairments compared to the first group, as indicated by significantly lower memory index values, the number of correct entries into the maze arms, and a significantly longer time to make the first correct entry into the maze arm. \u0000Conclusions. Intracerebroventricular administration of colchicine to experimental rats is accompanied by increased locomotor activity and impairment of cognitive functions. The administration of a physiological solution is not accompanied by a statistically significant increase in locomotor activity, but it demonstrates a clear tendency to increase, which may indicate a certain influence of the procedure itself. The applied pharmacological model of neurodegeneration with subsequent comprehensive assessment of animal behavior in an open field and an 8-arm radial maze is legitimate and can be used to study the early development of neuroinflammation, neuroapoptosis, and synaptogenesis disorders in the experiment.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"58 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A differentiated approach to complex treatment of radioiodine-induced salivary gland lesions","authors":"A. V. Kopchak, V. Makarenko","doi":"10.34287/mmt.4(59).2023.2","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.2","url":null,"abstract":"The number of patients treated with radioactive iodine for highly differentiated thyroid carcinomas who develop chronic radiation-induced salivary gland lesions is constantly rising, that necessitates the search for new pathogenetically focused approaches and methods of treatment considering the stage of the process and pre-existing risk factors. \u0000Aim. The aim of the study was to determine the clinical effectiveness of a new pathogenetic therapy based on a differentiated and personalized approach compared to standard approaches for radioactive iodine-induced salivary glands lesions. \u0000Materials and methods. The prospective study included 60 patients (5 men and 55 women, aged 45.0 ± 0.5 years) with chronic radioactive iodine-induced salivary gland lesions following radiation treatment. The patients were divided into 2 groups depending on the type of therapy they received. The clinical effectiveness of the developed methods was evaluated with the use of objective clinical criteria within a year after radioiodine therapy. \u0000Results. Our approach demonstrated reliably improved treatment outcomes compared to standard techniques. Thus, the treatment we offered, which included long-acting glucocorticoids, proteolysis inhibitors, and sialendoscopic techniques, completely resolved or minimized the clinical manifestations of the disease in 73.3 % of patients (33.3 % in the control group) one year after the start of treatment. The therapeutic effect was not found only in 6.7 % of patients compared to 20.0 % in the control group. \u0000The developed approach effectively eliminated saliva outflow disorders and inflammatory symptoms, with significantly better results of the treatment group compared to the control group (χ2 = 6.20; p < 0.05 and χ2 = 6.67; p < 0.05). The disorders of secretory function were more difficult to correct, especially in the later stages of the disease, associated with severe xerostomia development. \u0000Conclusions. The differentiated use of the developed pathogenetically oriented complex treatment enabled us to significantly improve the condition of patients with chronic radiation-induced sialoadenitis during the observation period of up to 1 year. This treatment also outperformed traditional symptomatic correction in solving the problem of saliva retention (χ2 = 6.67; p < 0.05) and inflammation manifestations (χ2 = 6.20; p < 0.05). Clinical symptoms of the disease were fully resolved or reduced in 73.3 % of patients versus 33.3 % in control group and partially improved in 20.0 % versus 46.0 % of control group within 12 months after radiation exposure. Longterm treatment and strict adherence to lifestyle and oral hygiene recommendations were required to achieve the desired clinical result and stable remission of clinical symptoms in patients with chronic radiation sialoadenitis.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"22 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelets characteristics in patients with coronary artery disease and atrial fibrillation","authors":"I. Melnychuk","doi":"10.34287/mmt.4(59).2023.1","DOIUrl":"https://doi.org/10.34287/mmt.4(59).2023.1","url":null,"abstract":"The aim. To estimate the connections between platelet morphological characteristics and amino acids (AA) profile in patients with coronary artery disease (CAD) and atrial fibrillation (AF). \u0000Materials and methods. 300 patients were included in the study. They were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias, second (CAD+AF) – 124 patients with CAD and AF paroxysm and control group – 27 patients without CAD and arrhythmias. Platelets AA level was detected by method of ion exchange liquid column chromatography. Total platelet count (PC), mean platelet volume (MPV), platelets distribution width (PDW), platelet-to-leukocyte (PLR) were obtained from common blood count. \u0000Results. Significant decline of PC and rise of MPV and PLR ratio was found in CAD patients and AF paroxysm in comparison with group with CAD without arrhythmia, p < 0.05. Significant increase of isoleucine, leucine and decrease of threonine, serine, glycine, valine levels was found, changes in branched chain amino acids (rise of Isoleucine + Leucine / Valine ratio) and Glycine + Serine (decline Glycine + Serine sum) metabolism were revealed in CAD patients and AF paroxysm in comparison with group with CAD without arrhythmia, p < 0.05. Phenylalanine / Tyrosine ratio was significantly elevated in CAD patients with and without AF, p < 0.05. \u0000Taurine, serine, and glycine correlated with platelets morphological characteristics: PC (r = 0.714, r = 0.732 and r = 0.340 consequently), MPV (r = -0.724, r = -0.390 and r = -0.571 consequently), PDW (r = -0.666 and r = -0.364 consequently) and PLR (r = 0.586 and r = 0.648 consequently), p < 0.05. Platelets glycine (AUC = 0.8760), valine (AUC = 0.8707), leucine (AUC = 0.8267) and threonine (AUC = 0.8213) levels are closely connected with AF paroxysm in CAD patients by ROC-analysis results, p < 0.05. \u0000Platelets amino acids combinations: Glycine + 0.6 × Valine (AUC = 0.9987), Threonine – 3.6 × Leucine (AUC = 0.9040) were found in prediction AF paroxysm for CAD patients by ROC-analysis results, p < 0.05. \u0000Conclusions. Connections between platelets morphology and AA profile violations in patients with CAD and AF paroxysm were found in our study.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"104 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}