Modern medical technology最新文献

{"title":"A new methodology for systemic audit of ischemic stroke in the most acute and acute periods of the disease","authors":"L. M. Smyrnova, G. A. Shifrin, K. Serikov","doi":"10.34287/mmt.4(51).2021.9","DOIUrl":"https://doi.org/10.34287/mmt.4(51).2021.9","url":null,"abstract":"Purpose of the study. Create a methodology for systemic audit of ischemic stroke (IS) in the most acute and acute periods of the disease. \u0000Materials and methods. The clinical study included 328 patients with IS (mean age 71,26 ± 0,44 years), who were in the intensive care unit of the neurology department in the most acute and acute periods of the disease. There were 147 men (mean age 69,80 ± 0,66 years), women 181 (mean age 72,45 ± 0,58 years). \u0000According to the intensity of ESST disorders, assistive technologies of personalized intensive therapy (IT) were developed, such as homeostasisprovision for eubiotic state, energy-protection for hypoergic dysfunction, energy-resuscitation for hypoergic damage, energy-correction for hypoergic insufficiency, status-protection for hyperergic dysfunction, status-resuscitation for hyperergic damage, status-correction for hyperergic insufficiency. \u0000Results. The main parameters of energystructural status (ESST), which characterize the stabilization of the general condition of patients in the most acute and acute periods of IMI, such as cardiac index (CI) in the range of 2,99–3,79 L×min-1 × m-2, oxygen delivery (DO ) at the level of 415–514 ml × min-1 × m-2; oxygen consumption (VO2) in the range of 130–160 ml × min-1 × m-2; basal metabolism (BM) in the range of 916–1134 kcal × day-1 × m-2 and specific peripheral vascular resistance (SPVR) in the range of 29–36 conditional unit. \u0000Conclusion. The conducted clinical research allowed to develop assistive technologies of personalized IT, which were used depending on the severity of energy-structural disorders in patients with IS. The use of personalized IT technologies, in accordance with the intensity of ESST recovery, has reduced mortality, the number of complications and the length of stay of patients with IS in the intensive care units of the neurology department.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130017414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic capabilities of magnetic resonance imaging in assessing the state of the large and small intestines","authors":"O. S. Sementsov, V. Ponomarenko","doi":"10.34287/mmt.3(50).2021.11","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.11","url":null,"abstract":"Purpose of the study. Purpose of the work is to show the possibilities of radiation diagnosis of the normal anatomy of the small and large intestine, as well as their pathological changes through the use of MRI (Hydro-MRI). \u0000Materials nad methods. Thirty patients were examined by the method of Hydro-MRI. All patients underwent magnetic resonance imaging on a device with a magnetic induction of 1,5 T. To carry out Hydro-MRI, we used T2-weighted sequences, such as a one-time fast spin echo signal obtained in several planes, STIR sequences in three mutually perpendicular sequences, so that edema wall edema can be estimated with additional diffusion-weighted images. \u0000Results. Twentypatientswiththemanifestations of Crohn's disease in the form of terminal ileitis, presence of interlope fistulous passages, paraproctitis (fistulous form) were detected. Colon tumors were detected in 8 patients, recurrence of gastrointestinal stromal tumor (GIST) of the small intestine in the anastomosis zone was detected in one patient, and no pathological changes were detected in one patient. \u0000Conclusion. Hydro-MRI allows visualizing the mass of the small, large intestine and determining the degree of invasion of the intestinal wall and surrounding tissues. Enterography using magnetic resonance enterography has become the most effective methods for visualizing the small intestine in patients with Crohn's disease and can visualize inflammation of the intramural or proximal small intestine in about 50% of patients with Crohn's disease who have undergone endoscopically normal studies. Hydro-MRI is indicated for Crohn's disease and for determining the degree of inflammatory activity. Recent evidence suggests that cross-section visualization may be useful in determining response to therapy, assessing bowel healing and monitoring disease progression. Also, according to researchers at the Medical Imaging Center, University College London, the quantitative motility of the small intestine is an objective biomarker of endoscopic and histopathological inflammatory activity in Crohn's disease and is comparable to previously confirmed estimates of MRI activity enhanced by gadolinium. The final ileal mobility indicator showed a good correlation with endoscopic and histopathological activity in Crohn's disease. The study is painless, no radiation load. Hydro-MRI is a method of choice, when it is impossible to conduct an X-ray examination of the intestine, the inability/ uninformativeness of an endoscopic examination of the small, large intestine. Along with video capsular endoscopy, it allows visualization of all departments of the small and large intestine.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116351351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of quality of life of patients with colon cancer depending on the type of perioperative anesthetia","authors":"O. Tenkach, E. S. Palahonych","doi":"10.34287/mmt.3(50).2021.9","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.9","url":null,"abstract":"The purpose of the study. Assess the quality of life of patients with colon cancer in the perioperative period, depending on the chosen method of anesthesia. \u0000Materials and methods. In the period from January to August 2020, an analysis of the results of anesthesia in 32 patients with colon cancer was performed on the basis of the Department of Anesthesiology and Intensive Care of KNP «ZPC» ZOR. Two groups of patients were formed in a randomized manner. The difference between the groups was the difference in drug combinations and dosages of anesthesia. Subjective pain assessment studies in patients were performed using a visual analog scale (VAS) questionnaire. The EQ 5D scale (5-point pain scale) was used to assess quality of life. The Hamilton scale was used to assess the patient's psycho-emotional state. Student's mean T test was used to compare pain levels before and after surgery, and p < 0,05 was considered statistically significant. \u0000Results. There was a statistically significant difference between cortisol levels after surgery in patients of groups I and II (p = 0,0001). When comparing insulin and blood glucose, it was found that the results of biochemical parameters are lower in group II patients, indicating a lower level of pain or its absence in the first 6 hours after surgery (p = 0,0001). Patients in groups I and II had an increase in the VAS scale, but in patients who used only general anesthesia, the rates were twice as high as in the group of patients who used a combination of epidural anesthesia (p = 0,0001). \u0000Evaluating the results of the questionnaire on the EQ 5D scale, a similar picture was established as when evaluating on the VAS scale where in the second group of patients statistically significantly lower pain rates than in the first group (p = 0,0001). The level of anxiety in patients who underwent epidural anesthesia decreased slightly in the postoperative period compared with baseline (p = 0,005). \u0000Conclusions. The quality of life of patients in the second group is higher than in patients of group I according to the questionnaire scale EQ 5D (p = 0,0001). The level of anxiety in patients of group I is higher in the first 6 hours after surgery than in patients of group II where epidural anesthesia is used (p = 0,0001).","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133599055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction and energy changes of black-substance neurons in experimental parkinson's disease in rats and mothors","authors":"N. M. Buchakchyiska, I. Belenichev, V. Maramukha","doi":"10.34287/mmt.3(50).2021.5","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.5","url":null,"abstract":"Parkinson's disease is a progressive disease with moderate age of the beginning of 55 years. Over time, symptoms worsen, and although levodopa has significantly improved the quality of life of patients with PD, statistics show that these patients continue to show shorter life expectancies compared to the general population. In addition, most patients with PD suffer from significant movement disorders after 5–10 years of illness, even with qualified treatment with available symptomatic drugs.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124131554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the mechanisms of anti-inflammatory action of cryopreserved placenta extract and diclofenac sodium by their threaded administration","authors":"F. Hladkykh, M. Chyzh","doi":"10.34287/mmt.3(50).2021.8","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.8","url":null,"abstract":"Introduction. Inflammation is a complex multicomponent adaptive pathological process based on three enzymatic pathways of arachidonic acid metabolism: cyclooxygenase, lipoxygenase and epoxygenase. Nonsteroidal anti-inflammatory drugs are the most numerous and most widely used group of drugs used in the pharmacocorrection of inflammatory processes of various etiologies. \u0000Purpose of the study. The aim is to characterize the effect of cryopreserved placenta extract on the anti-inflammatory activity of diclofenac sodium with their threaded administration in a model of zymosan-induced inflammation. \u0000Materials and methods. In vivo experimental studies were performed on 28 nonlinear laboratory male rats weighing 200–220 g. Acute exudative inflammation was reproduced by subplantar administration of rat limb 0,1 ml of 2,0% zymosan suspension. The anti-exudative effect was assessed by the magnitude of limb edema, which was assessed using an aqueous plethysmometer. \u0000Results and discussion. The study showed that subplantar administration of 2,0% suspension of zymosan led to a statistically significant (p < 0,05) increase in the volume of the damaged limb after 30 minutes. by 28,1 ± 5,4% relative to baseline and was 2,01 ± 0,06 ml. The most pronounced and almost comparable anti-inflammatory activity was observed against the background of the use of cryopreserved placenta extract and the combined use of diclofenac sodium and cryopreserved placenta extract. Thus, for 60 min the antiinflammatory activity was (p < 0,05) 46,5% and 53,2%, respectively. \u0000Conclusions. It is established that one of the leading mechanisms of anti-inflammatory activity of cryopreserved placenta extract is the inhibition of the lipoxygenase pathway of arachidonic acid metabolism. This was indicated by statistically significant (p < 0,05) suppression of zymosaninduced inflammation in rats by 78,8% and 74,8% by 120 and 180 min, respectively.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114621701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From secretory otitis to retraction cholesteatoma","authors":"D. M. Kokorkin, V. V. Skorobogaty, O. O. Gusakova, P. P. Shevlyuk, N. Kolyada","doi":"10.34287/mmt.3(50).2021.6","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.6","url":null,"abstract":"Based on the preliminary examination and further treatment of 980 children, the most influential consequences of secretory otitis were identified and the means of their prevention were proposed. Based on the results of long-term observation, conclusions were drawn. Chronic secretory otitis develops in 16% of children with recurrent secretory otitis, in 25% of cases the disease becomes malignant, and in 10% of cases goes into the stage of chronic purulent otitis media. In the treatment of recurrent and complicated chronic secretory otitis, it is advisable to follow the sequence of treatment, because 68% of children show existing or hidden signs of sinusitis, which requires prior surgical treatment. Among the detected forms, polyposis sinusitis with deformation of the nasal septum predominates (88,5%). \u0000The presence of retraction cholesteatoma with a predominant distribution within the tympanic cavity, limited defects of the chain of auditory ossicles and wide possibilities of their replacement, delayed cholesteatoma process with atrophy of matrix structures create conditions for organ-sparing surgery which corresponds to closed tympanoplasty. The morphological and functional effect of such operations can reach 91,5 ± 1,7% of cases in the group of children and adolescents and 88,2 ± 2,1% of observations in the group of adult patients, while the snail reserve decreased by 10,9 ± 3,3 dB in the group of children and 28,4 ± 3,3 dB in the group of adult patients.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125375480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in necrotic form of erysipelas","authors":"L. Vasylevska","doi":"10.34287/mmt.3(50).2021.4","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.4","url":null,"abstract":"Purpose of the study. To find out the mortality rate in patients with necrotic form of erysipelas and the reasons that cause it. \u0000Materials and metods. 284 case histories of patients who were hospitalized in the center of purulent-septic surgery of KNP «City Hospital \u0000№ 3» in Zaporozhye for the period 2016–2021 were analyzed. \u0000Results. It is established that in the general population of the disease, 14,1% of patients suffer from the necrotic form of erysipelas. In the complex treatment of patients with surgical forms of erysipelas, the main place belongs to antibiotic therapy (ABT) and early surgical treatment of the area of the pathological process. Determination of procalcitonin in blood serum makes it possible to assess the progression of the inflammatory process and is a sensitive test for the effectiveness of treatment. \u0000Conclusion. In 72,5% of cases, the disease was aggravated by sepsis with a mortality of 67,5%. The cause of mortality in patients with necrotic erythema is numerous irreversible changes in the internal organs.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116173897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign diseases of the breast glands on the background of hyperplastic processes of the endometry (references)","authors":"J. S. Shapoval","doi":"10.34287/mmt.3(50).2021.10","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.10","url":null,"abstract":"Purpose of the study. To highlight the most substantiated theories that reflect the dependence of benign diseases of the mammary glands in combination with hyperplastic processes of the endometrium. \u0000Materials and metods. The sources of literature related to the study of combined benign breast diseases on the background of gynecological pathology and thoroughly reflect the modern views of scientists on this pathology are analyzed. \u0000Results. Given the many unexplained patterns of hormonal diseases of the female reproductive system – the search for new options for combining these diseases continues. \u0000Conclusion. It is established that in recent years there has been an increase in the number of benign breast diseases in patients with combined gynecological pathology within 60–80%.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130097364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopersonal characteristics of women with varying degrees of menopausal disorders","authors":"N. Lutsenko, O. D. Mazur, O. Shapoval, L. I. Zvarich, N. Efimenko","doi":"10.34287/mmt.3(50).2021.3","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.3","url":null,"abstract":"The perimenopausal period is the age of the highest spiritual and intellectual development of a woman; therefore, neurovegetative and psycho-emotional disorders of this period acquire a pecial medical and social value and require an interdisciplinary approach. \u0000Purpose of the study. To identify the psychological characteristics of women with mild and moderate menopausal disorders in the perimenopausal period. \u0000Materials and methods. A total of 51 women were examined in the perimenopausal period: I main group – 20 patients with a low degree of CS, II main group – 16 women with menopausal disorders of moderate severity; the control group consisted of 15 healthy women. The severity of menopausal syndrome was determined using a modified menopausal Cooperman's index. All patients underwent psychodiagnostic examination using reactive and personal anxiety scales according to Ch.D. Spielberg and J.L. Hanina, G. Eisenko's test questionnaire, the Women's Sexual Function Index (FSFI) questionnaire, used the SF-36 (Medical Outcomes Study Short Form) general questionnaire to assess quality of life. \u0000Results. In women of the main groups, neurovegetative (14,5 ± 2,6 and 26,6 ± 4,2 points in the first and second groups of observation) and psycho-emotional disorders (4,9 ± 1,3 and 11,2 ± 1,6 points) prevailed. respectively). Hormone levels (FSH, E2, PRL) corresponded to perimenopausal values, but were significantly different from those of the control group. Identified individual-personal properties of women with the CS, in particular introversion and emotional instability. A comparative analysis on the SpielbergKhanin scales showed that more than half (55,0%) in the first main group and the majority (81,25%) of women in the second main group versus 33,35% in the control group (p ˂ 0,05), a high level of personal anxiety was diagnosed; the average level of situational anxiety was highest among women in group II – 54,83 ± 6,0 points versus 43,2 ± 5,3 points in the first group and 36,3 ± 4,8 points in patients without menopausal disorders (p ˂ 0,05). In 24 (77,42%) women of the main group, sexual dysfunction was detected, while its degree was greatest with moderately severe climacteric disorders. Menopausal disorders of varying severity, increased anxiety and neuroticism, sexual dysfunction affected the quality of life of patients. \u0000Conclusion. Formed psychopersonal characteristics of women with varying degrees of menopausal disorders in the perimenopausal period.","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128821254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological landscape of pyogenic liver abscesses","authors":"V. Novak, V. Yareshko, S. D. Shapoval","doi":"10.34287/mmt.3(50).2021.2","DOIUrl":"https://doi.org/10.34287/mmt.3(50).2021.2","url":null,"abstract":"Purpose of the study. To study the features of the microbial landscape of AP at different stages of their formation. \u0000Materials and methods. The results of examination and treatment of 80 patients with pyogenic liver abscesses for the period 2019–2020 were analyzed. The average age of patients was 48,4 ± 4,7 years. The duration of the disease at the time of hospitalization averaged 10,2 ± 3,4 days. The condition of all patients was assessed as moderate and severe, hospitalization was carried out on urgent indications. The inclusion criterion was the presence of pyogenic liver abscesses, the exclusion criteria were cholangiogenic and specific abscesses. Microbiological studies of the species composition of pathogens and their sensitivity to antibiotics were performed in all patients during surgery and in the dynamics of the postoperative period. \u0000Results. The microbial landscape of pyogenic abscesses in their different stages of formation differed both in quantitative and qualitative ratio. Seeding of aerobic monoinfection from purulent foci in stage I was predominant (P <0,05) and amounted to 69,4%. In this case, the aerobic gramnegative (gram (-)) flora of the foci of infection prevailed over the gram-positive (gram (+)). In stage III, the number of microbial associations sown from the purulent cell increased from 26,6 to 36,6% (P < 0,05). The increase was due to the sowing of aerobic associations. The main share among gram (-) aerobes was E. coli and Klebsiella pneumoniae, and the main representative of the mixed aerobic infection was St. auerus (including MRSA strains). In stage IV formation of pyogenic liver abscesses, the number of microbial associations sown from the purulent cell did not differ from the sowing of monoinfection (P > 0,05). There have been cases of seeding of facultative anaerobes of the genus Peptostreptococcacea and facultative anaerobic bacteria of the genus Clostridium. \u0000Conclusion. Carrying out of adequate combined ABT to patients with AP according to the developed algorithms, allowed to reduce terms of recovery of patients: for 3–4 days normalization of body temperature (t = 5,66176; P <0,000001) and a leukocyte formula (t = 8,56860; P < 0,000001) in patients of the main group compared with control patients. In turn, this contributed to a probable reduction in the length of stay of patients in the hospital for 3 days (t = 3,95561; P = 0,000116).","PeriodicalId":199868,"journal":{"name":"Modern medical technology","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122939570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}