Planta Medica International Open最新文献_第4页

Clinical and Microbiological Outcomes of Topical Aloe Vera Gel vs. Photochemotherapy as an Adjunct to Non-surgical Periodontal Treatment in Periodontitis 局部芦荟凝胶与光化学疗法作为牙周炎非手术治疗辅助的临床和微生物学结果

Planta Medica International Open Pub Date : 2020-06-05 DOI: 10.1055/a-1159-0738

M. Elsadek, B. M. Ahmed, Rayan M. Eskandrani, Tasneem Sobhy Fahmy

{"title":"Clinical and Microbiological Outcomes of Topical Aloe Vera Gel vs. Photochemotherapy as an Adjunct to Non-surgical Periodontal Treatment in Periodontitis","authors":"M. Elsadek, B. M. Ahmed, Rayan M. Eskandrani, Tasneem Sobhy Fahmy","doi":"10.1055/a-1159-0738","DOIUrl":"https://doi.org/10.1055/a-1159-0738","url":null,"abstract":"The present clinical trial aimed to assess the effectiveness of antimicrobial\u0000 photodynamic therapy versus Aloe vera gel as an adjunct to scaling and\u0000 root planing on periodontal and microbial outcomes in patients with\u0000 periodontitis. Eligible patients undergoing nonsurgical periodontal treatment\u0000 were divided into 3 groups: group 1: antimicrobial photodynamic therapy; group\u0000 2: Aloe vera gel application; and group 3: scaling and root planing only.\u0000 Clinical periodontal variables included the assessment of plaque scores,\u0000 bleeding on probing, probing depth, and clinical attachment level gain. Plaque\u0000 samples were collected to estimate microbial counts of Tannerella\u0000 forsythia (T. forsythia) and Porphyromonas gingivalis\u0000 (P. gingivalis). All measurements were recorded at baseline, 3 mo,\u0000 and 6 mo. Statistical analysis of the given data was performed using the\u0000 chi-squared test and ANOVA for clinical periodontal and microbiological data.\u0000 Eighty-seven patients completed the trial. Bleeding on probing showed a\u0000 significant reduction in group 2 compared with the other groups (p <\u0000 0.001). Group 1 showed a statistically significant reduction in probing depth\u0000 and gain in clinical attachment level when compared to group 2 and group 3 (p\u0000 < 0.05). Group 1 showed a statistically significant reduction in the\u0000 counts of T. forsythia and P. gingivalis over a period of 3 mo (p\u0000 < 0.05). The reduction was seen for T. forsythia only following 6\u0000 mo (p < 0.05). Group 2 showed a significant reduction for only T.\u0000 forsythia at 3 mo (p < 0.05). Both antimicrobial photodynamic\u0000 therapy and Aloe vera gel helped in reducing periodontal inflammation.\u0000 Aloe vera gel showed additional benefit in reducing bleeding scores,\u0000 while antimicrobial photodynamic therapy showed additional enhanced activity\u0000 against periodontal pathogens and periodontal attachment level gain.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115668409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cytotoxic, Anti-bacterial, and Wound-healing Activity of Prenylated Phenols from the Kurdish Traditional Medicinal Plant Onobrychis Carduchorum (Fabaceae) 库尔德传统药用植物豆科油松烯基化酚的细胞毒、抗菌和伤口愈合活性

Planta Medica International Open Pub Date : 2020-06-05 DOI: 10.1055/a-1174-1197

M. Clericuzio, F. Hussain, H. I. M. Amin, E. Bona, E. Gamalero, Novello Giorgia, R. Lappano, M. Talia, M. Maggiolini, Miriam Bazzicalupo, L. Cornara

引用次数: 2

Anti-inflammatory Potential of Macamides Isolated from Yellow Tubers of Mashua (Tropaeolum Tuberosum) 番荔枝黄块茎中玛卡酰胺类化合物的抗炎活性研究

Planta Medica International Open Pub Date : 2020-05-18 DOI: 10.1055/a-1159-4242

Luis Apaza Ticona, María Rodríguez Coballes, G. Potente, Ángel Rumbero Sánchez

{"title":"Anti-inflammatory Potential of Macamides Isolated from Yellow Tubers of Mashua (Tropaeolum Tuberosum)","authors":"Luis Apaza Ticona, María Rodríguez Coballes, G. Potente, Ángel Rumbero Sánchez","doi":"10.1055/a-1159-4242","DOIUrl":"https://doi.org/10.1055/a-1159-4242","url":null,"abstract":"Abstract Although Tropaeolum tuberosum tubers have been consumed cooked as a folk remedy for the treatment of skin, lungs, liver and kidneys diseases, these uses have very limited scientific basis. Therefore, this article develops a phytochemical analysis of the yellow tubers of T. tuberosum with the objective to assess whether the isolated compounds have anti-inflammatory potential in the CCD-1109Sk, MRC-5 and RWPE-1 cell lines. We performed an extraction of T. tuberosum tubers using different organic solvents, followed by a bioguided chromatographic separation. Four macamides were identified by LC/MS techniques, but only N-benzyllinoleamide (1) and N-benzyloleamide (2) were isolated and elucidated by NMR/MS techniques, given that they were present in a larger proportion in the tubers. The anti-inflammatory potential of macamides was evaluated by the inhibition of NF-κB and STAT3 activation. Both compounds displayed inhibition of NF-κB activation with IC50 values of 2.28±0.54 µM; 3.66±0.34 µM and 4.48±0.29 µM for compound (1) and 6.50±0.75 µM; 7.74±0.19 µM and 8.37 ±0.09 µM for compound (2) in CCD-1109Sk, MRC-5 and RWPE-1 cell lines, respectively. Moreover, both compounds inhibited the STAT3 activation with IC50 of 0.61±0.76 µM; 1.24±0.05 µM and 2.10±0.12 µM for compound (1) and 5.49±0.31 µM; 7.73 ±0.94 µM and 7.79±0.30 µM for compound (2). Therefore, isolated macamides of T. tuberosum tubers showed promising anti-inflammatory effects, suggesting a possible beneficial use to combat inflammatory processes of skin, lung and prostate.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"76 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120870621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B 肝素包被脂质体提高叔帕酮B的抗疟原虫活性和降低毒性

Planta Medica International Open Pub Date : 2020-05-01 DOI: 10.1055/a-1158-0569

A. Ledoux, L. Mamede, C. Palazzo, T. Furst, O. Jansen, P. de Tullio, Védaste Kagisha, Hélène Pendeville, M. Fillet, G. Piel, M. Frédérich

{"title":"Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B","authors":"A. Ledoux, L. Mamede, C. Palazzo, T. Furst, O. Jansen, P. de Tullio, Védaste Kagisha, Hélène Pendeville, M. Fillet, G. Piel, M. Frédérich","doi":"10.1055/a-1158-0569","DOIUrl":"https://doi.org/10.1055/a-1158-0569","url":null,"abstract":"Abstract Poupartone B is an alkyl cyclohexenone derivative isolated from Poupartia borbonica. This compound demonstrated promising antimalarial activity (IC50 < 1 µg/mL), however, it was not devoid of toxicity. Thus, to reduce the adverse side effects of this natural bioactive molecule, a delivery strategy involving a nanostructure was formulated. Additionally, poupartone B-loaded liposomes were coated with heparin, a glycosaminoglycan that is known to target proteins on the surface of Plasmodium falciparum-infected red blood cells. The quantification of the compound in the formulation was performed by HPLC-DAD, while heparin was quantitated by 1H NMR spectroscopy. The liposomes’ antiplasmodial activity was tested on artemisinin-resistant P. falciparum isolate, and toxicity was evaluated on human HeLa cells and zebrafish embryos. Throughout this research, the formulation demonstrated higher antiplasmodial activities against both P. falciparum strains and a significant decrease of in vitro toxicity. The formulation improved the selectivity index 2 times in vitro and proved to be 3 times less toxic than the compound alone in the zebrafish embryo acute toxicity test. Hence, the use of this strategy to deliver natural products in Plasmodium-infected cells, particularly those with a narrow therapeutic margin, is proposed.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129831126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Quantification of Cannabinoids in Cannabis Oil Using GC/MS: Method Development, Validation, and Application to Commercially Available Preparations in Argentina GC/MS定量测定大麻油中的大麻素:方法开发、验证及在阿根廷市售制剂中的应用

Planta Medica International Open Pub Date : 2020-05-01 DOI: 10.1055/a-1155-6613

Nicolás Fernández, Laura Jorgelina Carreras, Rafael Antonio Larcher, A. Ridolfi, P. N. Quiroga

{"title":"Quantification of Cannabinoids in Cannabis Oil Using GC/MS: Method Development, Validation, and Application to Commercially Available Preparations in Argentina","authors":"Nicolás Fernández, Laura Jorgelina Carreras, Rafael Antonio Larcher, A. Ridolfi, P. N. Quiroga","doi":"10.1055/a-1155-6613","DOIUrl":"https://doi.org/10.1055/a-1155-6613","url":null,"abstract":"Abstract The medicinal use of cannabis oil is increasing all over the world. Few analytical methods for the quantification of cannabinoids have been validated using internationally accredited guidelines. This work describes the development and validation of a selective and sensitive gas chromatography-mass spectrometry method for the qualitative analysis of the main cannabinoids, namely cannabidiolic acid, tetrahydrocannabinolic acid, cannabigerol, and cannabichromene as well as quantitative determination of cannabidiol, Δ9-tetrahydrocannabinol, and cannabinol, present in cannabis oils. The method was fully validated according to Food and Drug Administration and International Conference on Harmonization guidelines. A linear range of 0.1–30 μg/mL was obtained for CBD and Δ9-THC and 0.034–11.7 μg/mL for CBN, presenting determination coefficients above 0.99. The lower limits of quantification ranged from 0.034 to 0.1 μg/mL. The intra- and inter-day precision, calculated in terms of relative standard deviation, were 3.9–13.8 and 4.7–14.1%, respectively. Extraction efficiency at lower limits of quantification was 95–103%. Verification of method validity was performed with authentic cannabis oil samples. To our knowledge, this is the first method available in Argentina, validated according to international guidelines, for quantification of CBD, Δ9-THC, and CBN in cannabis oil. The primary application of this method is to differentiate between cannabis oils with high or low content of Δ9-THC, CBD, or mixed Δ9-THC/CBD. This is of fundamental importance for the patient and so that the physicians can carry out a suitable therapy.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124542529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia 曼陀罗挥发油内酯的抗氧化、细胞毒和乙酰胆碱酯酶抑制活性

Planta Medica International Open Pub Date : 2020-05-01 DOI: 10.1055/a-1156-4229

Christian Jasso, A. Nieto-Camacho, M. Ramírez-Apan, Mahinda Martínez, E. Maldonado

引用次数: 3

Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera 大翅末叶的抗炎、解热、镇痛和保肝作用的评价

Planta Medica International Open Pub Date : 2020-04-23 DOI: 10.1055/a-1142-7072

Mahamane Haïdara, A. Dénou, M. Haddad, A. Camara, K. Traoré, A. Aubouy, G. Bourdy, R. Sanogo

{"title":"Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera","authors":"Mahamane Haïdara, A. Dénou, M. Haddad, A. Camara, K. Traoré, A. Aubouy, G. Bourdy, R. Sanogo","doi":"10.1055/a-1142-7072","DOIUrl":"https://doi.org/10.1055/a-1142-7072","url":null,"abstract":"Abstract In Mali, improved traditional medicines [“Médicaments Traditionnels Améliorés”] are prepared from traditionally used medicinal plants. Recently, the Department of Traditional Medicine has identified Terminalia macroptera Guill. & Perr. (Combretaceae) as a potential candidate for an improved traditional medicine. T. macroptera is a West African medicinal plant used in Mali against various health disorders, with more than 30 different indications mentioned by traditional healers, including hepatitis, gonorrhea, fever, pain relief, and various infectious diseases (Helicobacter pylori-associated diseases). To date, validation of most of the biological activities of has been mainly carried out in vitro, except for antimalarial activities. In this study, the potential anti-inflammatory, antipyretic, analgesic, and hepatoprotective properties of T. macroptera were investigated in different murine models. Administration of T. macroptera ethanolic root and leaf extracts in rats significantly reduced pyrexia, pain, inflammation, and hepatic marker enzymes such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in the different murine models used (p<0.05). A phytochemical screening of T. macroptera revealed the presence of tannins, flavonoids, saponins, anthracene derivatives, sterols, triterpenes, and sugars in both leaf and root extracts as the main phytochemical compounds. This was confirmed by qualitative analysis, liquid chromatography coupled with high-resolution mass spectrometry. T. macroptera extracts demonstrated interesting in vivo antipyretic, analgesic, anti-inflammatory, and hepatoprotective activities. Therefore, T. macroptera should be proposed and further evaluated as a potential improved traditional medicine for the treatment of liver-related disorders and for the relief of pain and fever.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"07 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130222874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Untargeted Metabolomics Profiling and Global Semi-quantitation of a Prescription Chinese Herbal Medicine Formula Yinqiaosan Using UPLC-QTOF-MS with a Single Exogenous Reference Internal Standard 单外源内标UPLC-QTOF-MS对中药复方银翘散的非靶向代谢组学分析及整体半定量分析

Planta Medica International Open Pub Date : 2020-04-21 DOI: 10.1055/a-1141-0119

Yachun Shu, Chandana Mannem, Gang Xu, Shashank Gorityala, Xiao Liu, Yan Xu

{"title":"Untargeted Metabolomics Profiling and Global Semi-quantitation of a Prescription Chinese Herbal Medicine Formula Yinqiaosan Using UPLC-QTOF-MS with a Single Exogenous Reference Internal Standard","authors":"Yachun Shu, Chandana Mannem, Gang Xu, Shashank Gorityala, Xiao Liu, Yan Xu","doi":"10.1055/a-1141-0119","DOIUrl":"https://doi.org/10.1055/a-1141-0119","url":null,"abstract":"Abstract Yinqiaosan is a classic Chinese herbal medicine formula that has been used to treat various bacterial and viral infections by Chinese medicine doctors for over two centuries. In this work, we developed a comprehensive qualitative and quantitative method for identification, quantitation, and quality assessment of chemical constituents of Yinqiaosan formula in four different preparation forms (i.e., decoction, granule, pill, and tablet), which employed ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry with a single exogenous reference internal standard for untargeted metabolomics profiling and global semiquantitative analysis. The use of a single exogenous reference internal standard permitted not only qualitative and quantitative analyses of multiple herbal components in a single instrument run, but also cross-comparison of chemical contents in between all four Yinqiaosan preparation forms. The acquired mass chromatograms were analyzed, quantitated, and compared using multivariate data analysis for similarities and differences of chemical constituents in four Yinqiaosan preparation forms. For the first time, we were able to identify over 100 chemical constituents from each preparation form using the available database. Among the 49 commonly identified compounds in the 4 Yinqiaosan preparation forms, 16 have been reported to have pharmacological activities, which may be used in a network pharmacology study of Yinqiaosan for exploring the underlying mechanism of the herbal formula.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121859744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression 塔拉单宁通过调节黑色素形成酶和黑素体转运蛋白的表达来调节色素沉着

Planta Medica International Open Pub Date : 2020-04-01 DOI: 10.1055/a-1141-0151

Myra O. Villareal, Thanyanan Chaochaiphat, Meriem Bejaoui, Kozo Sato, H. Isoda

{"title":"Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression","authors":"Myra O. Villareal, Thanyanan Chaochaiphat, Meriem Bejaoui, Kozo Sato, H. Isoda","doi":"10.1055/a-1141-0151","DOIUrl":"https://doi.org/10.1055/a-1141-0151","url":null,"abstract":"Abstract The skin color is imparted by the pigment melanin produced in the melanosomes of melanocytes, through the catalytic action of melanogenesis enzymes tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase. Disruptions in the melanogenesis process may result to hypopigmentation, as observed in cutaneous postinflammatory conditions. Here, the bioactivity of tara tannin, specifically on melanogenesis, was evaluated in vitro using human epidermal melanocytes (HEM) and B16F10 murine melanoma cells in order to determine the possibility that it may be used as a treatment against hypopigmentation. The melanin content of tara tannin-treated B16F10 cells and the expression level of melanogenesis enzymes and melanosome transport proteins were determined. To elucidate the underlying mechanism of tara tannin’s effect on melanogenesis, DNA microarray analysis was performed. Tara tannin significantly increased melanogenesis in both murine and human pigment cell models by upregulating melanogenesis-associated enzymes’ (tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase) protein and mRNA expression levels, as well as the melanosome transport proteins (myosin Va and RAB27A) expression, both attributed to increased microphthalmia-associated transcription factor (MITF) expression. Global gene expression analysis results revealed the modulation of genes (p≤0.05; fold-change ≥2.0 and ≤−2.0) that are under the transcriptional regulation of MITF and genes relevant for MAPK signaling, metabolic pathways, and cell cycle. Tara tannin has a significant effective melanogenesis-promoting effect, making it a potential therapeutic agent against hypopigmentation disorders. This is the first report on the melanogenesis regulatory effect of tara tannin in vitro.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126542274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Core Imprinting: An Alternative and Economic Approach for Depleting Pyrrolizidine Alkaloids in Herbal Extracts 核心印迹法:一种消耗草药提取物中吡咯利西啶类生物碱的替代经济方法

Planta Medica International Open Pub Date : 2020-03-18 DOI: 10.1055/a-1121-4868

T. Kopp, Mona Abdel-Tawab, B. Mizaikoff

{"title":"Core Imprinting: An Alternative and Economic Approach for Depleting Pyrrolizidine Alkaloids in Herbal Extracts","authors":"T. Kopp, Mona Abdel-Tawab, B. Mizaikoff","doi":"10.1055/a-1121-4868","DOIUrl":"https://doi.org/10.1055/a-1121-4868","url":null,"abstract":"Abstract Due to the high toxicity of pyrrolizidine alkaloids, in 2011, the German Federal Institute of Risk Assessment recommended that their daily intake limit should be no more than 0.007 µg/kg body weight. The risk of ingesting these substances in herbal preparations, either from their inherent presence in plants or through contamination with pyrrolizidine alkaloid-containing weeds, should not be underestimated. A promising molecular imprinted polymer was developed previously to minimise exposure to these compounds. Due to the high costs of the template and the risk of template bleeding, an alternative and more economic pyrrolizidine alkaloid depleting strategy is still required. Core imprinting, which focuses on the most important structural element in the target molecule, was investigated using triethylamine and tetraethylammonium as easily available and cheap alternative templates. The suitability of core imprinting was demonstrated using a pyrrolizidine alkaloid standard solution if an excess of an alternative template compared to monocrotaline was used for imprinting. Matrix trials in pyrrolizidine alkaloid-spiked Mentha piperita, Chelidonium majus, Glycyrrhiza glabra, and Matricaria chamomilla extracts containing Echium vulgare revealed better pyrrolizidine alkaloid binding than demonstrated for the original molecular imprinted polymer. Echimidine and echimidine-N-oxide were depleted in the range of 31.8–70.0 and 26.1–45.1%, respectively. However, solvent-dependent differences in pyrrolizidine alkaloid binding and inherent plant analytical marker compounds were observed. Hence, binding of analytical marker compounds was better minimised in methanolic than in ethanolic extracts. The present study reveals core imprinting to be an economic alternative approach for depleting pyrrolizidine alkaloids in plant extracts.","PeriodicalId":199864,"journal":{"name":"Planta Medica International Open","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125255190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3