Cytotoxic, Anti-bacterial, and Wound-healing Activity of Prenylated Phenols from the Kurdish Traditional Medicinal Plant Onobrychis Carduchorum (Fabaceae)
M. Clericuzio, F. Hussain, H. I. M. Amin, E. Bona, E. Gamalero, Novello Giorgia, R. Lappano, M. Talia, M. Maggiolini, Miriam Bazzicalupo, L. Cornara
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引用次数: 2
Abstract
Abstract Onobrychis carduchorum (Fabaceae) is a plant widely employed in Kurdish traditional medicine to cure wounds, inflammations, and other skin diseases. We could isolate ten different polyphenols from the acetone extract of this plant: 1–4 are isoflavones, having a genistein skeleton; 5–7 are flavanones, having a naringenin skeleton; and 8–10 are prenylated dihydro-stilbenes. In particular, 8–10 have been isolated, so far, only from Glycyrrhiza glabra (liquorice). Many of the above prenylated phenols showed significant toxicity on some human breast cancer cell lines, and a relevant growth inhibition of Staphylococcus aureus strains. In addition, 9 and 10 had marked wound healing activity. It is suggested that these bioactivities are responsible, at least partly, for the plant’s traditional use.
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