Pancreatology最新文献_第7页

Letter re: Outcomes of percutaneous endoscopic versus endoscopic transmural necrosectomy for necrotizing pancreatitis. 信re：经皮内窥镜与经壁内窥镜坏死性胰腺炎切除术的结果。

IF 2.8 2区医学

Pancreatology Pub Date : 2025-01-08 DOI: 10.1016/j.pan.2025.01.001

Saxon Connor, John Neoptolemos

引用次数: 0

Patient-derived organoids from pancreatic cancer after pancreatectomy: Feasibility and organoid take rate in treatment-naïve periampullary tumors. 胰腺切除术后胰腺癌患者来源的类器官：treatment-naïve壶腹周围肿瘤的可行性和类器官占用率。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-26 DOI: 10.1016/j.pan.2024.12.018

Marcus T T Roalsø, Marina Alexeeva, Celine Oanæs, Martin Watson, Dordi Lea, Claudia Zaharia, Hanne R Hagland, Kjetil Søreide

{"title":"Patient-derived organoids from pancreatic cancer after pancreatectomy: Feasibility and organoid take rate in treatment-naïve periampullary tumors.","authors":"Marcus T T Roalsø, Marina Alexeeva, Celine Oanæs, Martin Watson, Dordi Lea, Claudia Zaharia, Hanne R Hagland, Kjetil Søreide","doi":"10.1016/j.pan.2024.12.018","DOIUrl":"https://doi.org/10.1016/j.pan.2024.12.018","url":null,"abstract":"Background/objective: Patient-derived organoids (PDOs) have emerged as essential for ex vivo modelling for pancreatic cancer (PDAC) but reports on efficacy and organoid take rate are scarce. This study aimed to assess the feasibility of establishing PDOs from resected specimens in periampullary tumors.Methods: Patients undergoing surgery for suspected periampullary cancer were included. PDO protocol amendments were tested, with organoid take rate as outcome measure. Samples from resected specimens were processed and expanded per protocol. Pooled estimate of take rates of PDOs in PDAC was derived from literature search.Results: 23 specimens were available for PDO, of which 10 were PDAC. In 15 patients other histopathology was found: neuroendocrine tumors (NET; n = 2), neuroendocrine carcinoma (NEC; n = 1), intraductal papillary mucinous neoplasm (IPMN; n = 4), distal cholangiocarcinoma (dCCA; n = 1), ampullary carcinoma (n = 1), duodenal carcinoma (n = 1), intra-ampullary papillary tubular neoplasm (IAPN; n = 1), indeterminate PDAC/ampullary carcinoma(n = 1), and one patient with chronic inflammation/fibrosis. Organoid cultures were grown from 7 of 10 (70 %) PDAC, 1 dCCA, 1 NEC, 1 duodenal carcinoma, 1 indeterminate tumor type and 1 ampullary carcinoma (i.e. 12/18; 66.7 % across periampullary cancers). Overall take rate of PDOs was 12 of 23 (52.2 %) for all tumors. A pooled mean estimate PDO take rate of 62.3 % (95 % CI:54.8-69.3 %) was reported across available studies in the literature.Conclusion: In the current study, we found that PDOs could be established from resected pancreatic tumors in over half of resected periampullary tumors, and highest in PDACs. As such, generating a pancreatic cancer PDO biobank for translational research was feasible after cryopreservation.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic ultrasound is useful for the risk stratification of mucinous pancreatic cystic lesions: A long-term prospective study. 内镜超声对胰腺粘液性囊性病变的风险分层是有用的：一项长期前瞻性研究。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-15 DOI: 10.1016/j.pan.2024.12.006

Sahar Wesali, Antonio Molinaro, Björn Lindkvist, Per Hedenström, Riadh Sadik

{"title":"Endoscopic ultrasound is useful for the risk stratification of mucinous pancreatic cystic lesions: A long-term prospective study.","authors":"Sahar Wesali, Antonio Molinaro, Björn Lindkvist, Per Hedenström, Riadh Sadik","doi":"10.1016/j.pan.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.pan.2024.12.006","url":null,"abstract":"Objectives: The aims of this prospective observational study were to test worrisome features on endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as a stratification tool in patients with mucinous pancreatic cystic lesions (PCLs), and to assess these patients' long-term risk of adenocarcinoma and mortality.Methods: Patients with suspected PCLs on cross-sectional imaging who underwent EUS-FNA at Sahlgrenska University Hospital between February 2007 and February 2018 were consecutively enrolled. The main inclusion criterion was the final diagnosis of a mucinous PCL. The results from EUS-FNA were analyzed in the context of outcome gathered from medical records of follow-up until February 2021.Results: Of 334 patients undergoing EUS-FNA, 171 (51 %) had a final diagnosis of a mucinous PCL. 29/171 (17 %) patients were diagnosed with HGD or adenocarcinoma <6 months after EUS-FNA, with 28/29 (97 %) patients having at least one worrisome feature on EUS-FNA. A solid component in mucinous PCLs on EUS was independently associated with the presence of HGD or adenocarcinoma (OR 23.6, 95 % CI 6.1-91.6, p < .001). A total of 4/142 (3 %) patients developed adenocarcinoma during the follow-up period (median = 61.4 months). Overall, in 80/82 (98 %) of the patients without worrisome features on EUS-FNA, HGD or adenocarcinoma was not detected. Six of the 21 (29 %) patients with HGD or adenocarcinoma who underwent surgery as initial management died from pancreatic cancer during follow-up.Conclusions: EUS-FNA is useful for the risk stratification of mucinous PCLs. The low incidence of adenocarcinoma over time after a negative EUS-FNA may allow for a less resource intensive surveillance strategy.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and impact of endoscopic ultrasound utilization for suspected intraductal papillary mucinous neoplasms. 内镜超声应用于疑似导管内乳头状粘液瘤的趋势和影响。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-06 DOI: 10.1016/j.pan.2024.12.001

Lillian Wang, Priyanka Vatsavayi, Shounak Majumder, Ferga C Gleeson, Elizabeth Rajan, Barham K Abu Dayyeh, Andrew C Storm, Shifa Umar, Saran T Velaga, William S Harmsen, Santhi S Vege, Vinay Chandrasekhara

{"title":"Trends and impact of endoscopic ultrasound utilization for suspected intraductal papillary mucinous neoplasms.","authors":"Lillian Wang, Priyanka Vatsavayi, Shounak Majumder, Ferga C Gleeson, Elizabeth Rajan, Barham K Abu Dayyeh, Andrew C Storm, Shifa Umar, Saran T Velaga, William S Harmsen, Santhi S Vege, Vinay Chandrasekhara","doi":"10.1016/j.pan.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.pan.2024.12.001","url":null,"abstract":"Background: Multiple management guidelines for intraductal papillary mucinous neoplasms (IPMNs) have been published to improve risk stratification and resource utilization. This study aims to evaluate trends in endoscopic ultrasound (EUS) use and agreement between cross-sectional imaging and EUS for specific pancreas cystic lesion (PCL) features.Methods: This retrospective cohort study included consecutive adults undergoing EUS for suspected IPMN detected with cross-sectional imaging (CT/MRCP) between 2013 and 2015 (Cohort 1) and 2018-2020 (Cohort 2). Clinical, radiographic, EUS, cytologic, and outcomes data were collected. IPMN were defined as high-risk/worrisome (having any Fukuoka high risk (HR) or worrisome feature (WF)), low risk (cyst size 10-29.9 mm, without Fukuoka HR or WF), or very low risk (cyst size <10 mm, without Fukuoka HR or WF). Chi-square, Fisher's exact test, Wilcoxon rank-sum test and Kappa statistics were used. Impact of the COVID-19 pandemic was assessed via post-hoc sensitivity analysis.Results: Of 711 patients, 292 (41.1 %) were in Cohort 1. More patients in Cohort 1 underwent EUS for non-high risk/non-worrisome PCL on pre-EUS imaging (65.8 % vs. 54.9 %, P < 0.01). Good agreement between pre-EUS imaging and EUS for WF (84.1 %) and HR (96.6 %) was seen. EUS-FNA impacted surveillance and surgical referral in 29.5 % (P = 0.51). Median surveillance duration was 917 days (IQR 367, 1439 days), during which pancreatic ductal adenocarcinoma (PDAC) was diagnosed in 7.5 % (P = 0.11).Conclusions: In this series EUS over-utilization for low risk IPMN improved over time reflecting more conservative guidelines, without changing PDAC diagnosis rates. There was good agreement between cross-sectional imaging and EUS for specific PCL features.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmacytoid dendritic cells reduce acinar cell regeneration via IL33 and IFNA in an autoimmune pancreatitis model

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-05 DOI: 10.1016/j.pan.2024.05.030

Elisabeth Orgler , Nicole Schreiner , Hellen Ishikawa-Ankerhold , Lisa Fahr , Georg Beyer , Julia Mayerle , Ivonne Regel

引用次数: 0

Characterization of the immune microenvironment of pancreatic ductal adenocarcinoma and its precursor lesions with deep learning

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-05 DOI: 10.1016/j.pan.2024.05.086

Manuel Michels , Lena Haeberle , Marie Schulte , Carolin Mueller , Sebastian Haensch , Martin Schlensog , Friederike Opitz , Irene Esposito

引用次数: 0

Minimal-invasive methods show more benefit compared to opioids for pain management in unresectable pancreatic cancer – systematic review and meta-analysis

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-05 DOI: 10.1016/j.pan.2024.05.064

Ioana-Irina Rezuș , Ioana Creangă-Murariu , Anett Rancz , Oghosa Clinton Ibude , Mahmoud Obeidat , Renata Papp , Daniel Sandor Veres , Bogdan-Ionel Tamba , Peter Hegyi , Brigitta Teutsch

引用次数: 0

Misfolding trypsinogen mutant causes chronic pancreatitis in a preclinical mouse model

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-05 DOI: 10.1016/j.pan.2024.05.018

Mate Sandor , Alexandra Demcsak , Balazs Csaba Nemeth , Miklos Sahin-Toth

引用次数: 0

Minimallyinvasive spleen-preserving distal pancreatectomy in obese patients: factors associated with clinically relevant pancreatic fistula

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-05 DOI: 10.1016/j.pan.2024.05.005

Fabio Ausania , Carolina González-Abós , Filippo Landi , Dp Collaborative Group , Luca Morelli , P. Cristoforo Giulianotti

引用次数: 0

Metabolic syndrome and hypertension individually worsen the outcome of acute pancreatitis: a systematic review and meta-analysis

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-05 DOI: 10.1016/j.pan.2024.05.092

Dalma Dobszai , Mahmoud Obeidat , Eszter Szalai , Dániel Veres , Luca Havelda , Renáta Papp , Alim Choi , Bettina Budai , Dominika Csajbók , Péter Hegyi , Andrea Szentesi

引用次数: 0