Pancreatology最新文献

{"title":"Pylorus preservation after total pancreatectomy: a systematic review and meta-analysis","authors":"Mohamed Ali Chaouch ,&nbsp;Heithem Jeddou ,&nbsp;Edouard Wasiekewski ,&nbsp;Marie Livin ,&nbsp;Raffaele Vincenzo De Rosa ,&nbsp;Antoine Castel ,&nbsp;Aude Merdrignac ,&nbsp;Fabien Robin ,&nbsp;Laurent Sulpice","doi":"10.1016/j.pan.2025.08.013","DOIUrl":"10.1016/j.pan.2025.08.013","url":null,"abstract":"<div><h3>Background</h3><div>Total pancreatectomy (TP) is a major surgical procedure often associated with significant morbidity. Pylorus preservation (PP) during TP aims to minimize postoperative complications, particularly delayed gastric emptying (DGE), while maintaining gastrointestinal function. However, their impact remains controversial. This study systematically reviewed and analyzed the outcomes of TP with and without pylorus preservation.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted following the PRISMA and AMSTAR 2 guidelines. Randomized controlled trials and controlled clinical trials comparing TP with PP (PP group) and TP without PP (non-PP group) were included. The primary outcome analyzed was delayed gastric emptying (DGE), while the secondary outcomes included morbidity, anastomotic ulcer, cholangitis, blood loss, operative time, and hospital stay.</div></div><div><h3>Results</h3><div>Four eligible studies (167 patients, 93 PP, and 74 non-PP) were included. No significant differences were found between the PP and non-PP groups in terms of DGE (OR = 1.35, 95 % CI [0.41, 4.44], p = 0.62), overall morbidity (OR = 1.21, 95 % CI [0.38, 3.85], p = 0.75), anastomotic ulcer (OR = 0.99, 95 % CI [0.15, 6.61], p = 0.99), cholangitis (OR = 1.47, 95 % CI [0.07, 31.53], p = 0.8), or blood loss (MD = 18.89, 95 % CI [-164.98, 202.76], p = 0.84). The PP group had a significantly shorter operative time than the non-PP group (MD = −0.62, 95 % CI [-0.90, −0.33], p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>PP during TP can reduce operative time but does not significantly impact postoperative outcomes, such as DGE, morbidity, or hospital stay. More prospective studies are needed to confirm these findings and to explore the potential benefits of PP in minimally invasive surgical approaches.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 959-966"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study identifies FUT2 rs601338 polymorphism linking intra-pancreatic fat deposition to chronic pancreatitis","authors":"Haotian Chen ,&nbsp;Xiaoyin Bai ,&nbsp;Zhengye Liu ,&nbsp;Hanze Du ,&nbsp;Xiaoli Chen ,&nbsp;Dong Wu ,&nbsp;Jiarui Mi","doi":"10.1016/j.pan.2025.07.407","DOIUrl":"10.1016/j.pan.2025.07.407","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Pancreas fat deposition, measured by pancreatic proton density fat fraction (PDFF) in the MRI, has emerged as a critical area of research within the metabolic field. However, its genetic basis and how genetic predisposition impacts the pancreatic disorders remain poorly understood.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We conducted a genome-wide association study (GWAS) in 20,040 European individuals (excluding those with acute/chronic pancreatitis and pancreatic cancer) from the UK Biobank. Subsequent post-GWAS analyses including colocalization, transcriptome-wide association studies (TWAS) and integrative analysis with single-cell transcriptomics were employed to identify genetic loci and prioritize genes enriched in pancreatic tissue. Regression models and interaction analyses were used to assess the impact of candidate genetic variant on the risk of pancreatic disorders.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Our analyses identified 44 independent significant genetic variants near 14 protein-coding genes, including &lt;em&gt;FUT2&lt;/em&gt;, &lt;em&gt;CBFA2T2&lt;/em&gt;, &lt;em&gt;FAF1&lt;/em&gt;, &lt;em&gt;MAMSTR&lt;/em&gt;, &lt;em&gt;SGMS1&lt;/em&gt;, &lt;em&gt;CSNK2A1&lt;/em&gt;, &lt;em&gt;CEBPB&lt;/em&gt;, and &lt;em&gt;CEBPG&lt;/em&gt;. Genetic colocalization and transcriptome-wide association studies (TWAS) confirmed the essential roles of &lt;em&gt;FUT2&lt;/em&gt; and &lt;em&gt;CBFA2T3&lt;/em&gt; in the pancreas. Single-cell transcriptomics showed high &lt;em&gt;FUT2&lt;/em&gt; expression specifically in the exocrine pancreas (acinar and ductal cells). Notably, the polymorphism rs601338 in the &lt;em&gt;FUT2&lt;/em&gt; exon region can cause a stop gain mutation in protein translation. Regression analysis revealed that the rs601338 AA genotype was significantly associated with an increased risk of chronic pancreatitis (CP) across all populations in full adjustment model (OR 1.26 [95 % CI 1.07–1.48], p &lt; 0.001; HR 1.24 [95 % CI 1.03–1.50], p &lt; 0.001). Subgroup analyses revealed population-specific patterns: in Europeans, the AA genotype showed significant associations in logistic regression, while in non-Europeans, both GA and AA genotypes exhibited positive trends, with AA achieving statistical significance (OR 1.20 [95 % CI 1.01–1.41], p = 0.034). Sex-stratified analyses showed significant associations in elevated risk of CP in males (OR 1.33 [95 % CI 1.08–1.62], p = 0.006; HR 1.31 [95 % CI 1.04–1.67], p = 0.025) but not females with full adjustment. Interaction analysis indicated a synergistic effect of current smoking and the rs6031218 AA genotype on CP risk, while COX-2 inhibitor treatment might reduce CP risk in rs6031218 AA individuals.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study identified novel genetic variants for pancreatic PDFF and confirmed related genes functions in the pancreas. These findings emphasize the need for regular surveillance of pancreatic fat deposition in the population with a high genetic risk based on &lt;em&gt;FUT2&lt;/em&gt; polymorphism, which could facilitate risk stratification and tailored therapeutic approaches for ","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 868-877"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining oligo-recurrence criteria for locoregional intervention in pancreatic ductal adenocarcinoma: A multidisciplinary era perspective","authors":"Takao Ohtsuka ,&nbsp;Daisuke Hashimoto ,&nbsp;Franz Apodaca Torrez","doi":"10.1016/j.pan.2025.08.020","DOIUrl":"10.1016/j.pan.2025.08.020","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 815-816"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of Intraductal Papillary Mucinous Neoplasms (IPMN) is possible after 5 years of follow-up","authors":"Mirko D'Onofrio ,&nbsp;Riccardo De Robertis Lombardi ,&nbsp;Nicolò Cardobi ,&nbsp;Beatrice Mascarin ,&nbsp;Francesca Baratta ,&nbsp;Antonio Pea ,&nbsp;Antonio Amodio ,&nbsp;Luca Frulloni ,&nbsp;Roberto Salvia","doi":"10.1016/j.pan.2025.07.411","DOIUrl":"10.1016/j.pan.2025.07.411","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 912-918"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality-of-life in long-term survivors after pancreatico-duodenectomy with clinical nurse specialist and dietitian led multi-professional support","authors":"Roshna Nangial ,&nbsp;Mary E. Phillips ,&nbsp;Adam E. Frampton ,&nbsp;Kathryn H. Hart","doi":"10.1016/j.pan.2025.07.413","DOIUrl":"10.1016/j.pan.2025.07.413","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 980-982"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of coronavirus disease 2019 on the clinical outcomes of acute pancreatitis: a nationwide observational study in Japan","authors":"Tomoo Manaka ,&nbsp;Kunio Tarasawa ,&nbsp;Tetsuya Takikawa ,&nbsp;Kazuhiro Kikuta ,&nbsp;Ryotaro Matsumoto ,&nbsp;Yu Tanaka ,&nbsp;Takanori Sano ,&nbsp;Shin Hamada ,&nbsp;Shin Miura ,&nbsp;Kiyoshi Kume ,&nbsp;Kenji Fujimori ,&nbsp;Kiyohide Fushimi ,&nbsp;Atsushi Masamune","doi":"10.1016/j.pan.2025.08.010","DOIUrl":"10.1016/j.pan.2025.08.010","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Acute pancreatitis (AP) is a major gastrointestinal disorder with an increasing global incidence. However, the impact of coronavirus disease 2019 (COVID-19) on AP remains unclear, particularly in Japan. This study aimed to investigate the association between AP and COVID-19, including the influence of comorbidities, using a Japanese nationwide administrative database.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with AP who were hospitalized between April 2020 and March 2023, registered in the Diagnosis Procedure Combination database. Patients were classified into COVID-19-negative and COVID-19-positive groups. Propensity score matching was performed to adjust for potential confounders in the analysis of factors associated with severe AP.</div></div><div><h3>Results</h3><div>Among 65,770 patients with AP, 548 (0.8 %) were COVID-19-positive, with COVID-19 recorded as a comorbidity at admission in 345 patients and as a secondary diagnosis during hospitalization in 203 patients. Compared with the COVID-19-negative group, the COVID-19-positive group had a higher proportion of severe AP (42.0 % vs. 30.2 %), intensive care unit admissions (4.6 % vs. 2.7 %), mechanical ventilation (5.5 % vs. 2.5 %), interventions for local complications (3.3 % vs. 1.8 %), and in-hospital mortality (5.0 % vs. 2.5 %). After propensity score matching, COVID-19 positivity and renal disease were associated with severe AP. When stratified by the timing of COVID-19 diagnosis, patients diagnosed during hospitalization were older, had longer hospital stays, and experienced higher in-hospital mortality compared with those without COVID-19 or those diagnosed at admission.</div></div><div><h3>Conclusions</h3><div>Patients with concurrent COVID-19 infection, particularly those diagnosed during hospitalization, are at increased risk of severe AP and in-hospital mortality compared to those without COVID-19.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 823-831"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-standing Pseudopapillary Neoplasm of the Pancreas and G6PD Deficiency","authors":"Idriss Hussein Musa ,&nbsp;Adil A. AL-Zadjali ,&nbsp;Babar Rehmani ,&nbsp;Asem Shalaby ,&nbsp;Faiza H.AL. Hajri ,&nbsp;Shahzad Younas ,&nbsp;Tasneem M.AL. Muhthoori","doi":"10.1016/j.pan.2025.07.009","DOIUrl":"10.1016/j.pan.2025.07.009","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 991-993"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor Regarding “Perilesional Branch Duct Dilation as a Hallmark MRCP Feature for Differentiating High-Grade PanIN from Low-Grade PanIN”","authors":"Kentaro Yamao ,&nbsp;Yasuo Takehara ,&nbsp;Hiroshi Ogawa ,&nbsp;Jun Nakahodo ,&nbsp;Ryuki Minami ,&nbsp;Ryota Sagami ,&nbsp;Hidefumi Nishikiori ,&nbsp;Hidekazu Takahashi ,&nbsp;Yoshihisa Takada ,&nbsp;Tadashi Iida ,&nbsp;Yasuyuki Mizutani ,&nbsp;Takuya Ishikawa ,&nbsp;Hiroki Kawashima","doi":"10.1016/j.pan.2025.08.004","DOIUrl":"10.1016/j.pan.2025.08.004","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 989-990"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of FOLFIRINOX versus gemcitabine plus nab-paclitaxel in patients with early recurrent pancreatic cancer after adjuvant S-1 treatment: A propensity score-matched analysis","authors":"Naohiro Okano ,&nbsp;Kentaro Sakamaki ,&nbsp;Takafumi Mie ,&nbsp;Kazuo Watanabe ,&nbsp;Satoshi Kobayashi ,&nbsp;Akiko Todaka ,&nbsp;Yuko Suzuki ,&nbsp;Hidetoshi Kitamura ,&nbsp;Kazunari Tanaka ,&nbsp;Kei Nakagawa ,&nbsp;Keiko Kamei ,&nbsp;Kumiko Umemoto ,&nbsp;Nobuaki Azemoto ,&nbsp;Yasuyuki Kawamoto ,&nbsp;Hiroaki Yanagimoto ,&nbsp;Kunihiro Tsuji ,&nbsp;Hiroshi Imaoka ,&nbsp;Takeshi Terashima ,&nbsp;Chigusa Morizane ,&nbsp;Masafumi Ikeda ,&nbsp;Junji Furuse","doi":"10.1016/j.pan.2025.08.017","DOIUrl":"10.1016/j.pan.2025.08.017","url":null,"abstract":"<div><h3>Background</h3><div>Oral fluoropyrimidine, S-1 is the standard adjuvant chemotherapy for patients with resected pancreatic cancer (PC) in Japan. Patients experiencing early recurrence are typically treated with 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (GnP), which are commonly used in patients with advanced PC. However, no clinical studies have compared these regimens in this particular population.</div></div><div><h3>Methods</h3><div>This multicenter retrospective study included PC patients who experienced recurrence within six months of the last S-1 administration, including those who had recurrence during the treatment. Patients were treated with either FOLFIRINOX or GnP between December 2013 and 2018. The primary endpoint was overall survival (OS), with secondary endpoints of progression-free survival (PFS), objective response, and serious adverse events (SAEs). Propensity score-matched (PSM) analysis was performed to reduce potential confounding factors between the two groups.</div></div><div><h3>Results</h3><div>A total of 284 patients from 32 institutions were enrolled. After PSM, 43 patients from each group were compared. Some patient characteristics remained imbalanced between the matched pairs. The GnP group was associated improved OS compared to FOLFIRINOX group (median, 14.5 vs. 11.1 months; hazard ratio [HR], 0.61; 95 % confidence interval [CI], 0.38–0.97). While PFS tended to be longer in the GnP group (median, 7.1 vs. 5.1 months), this difference did not reach statistical significance (HR, 0.65; 95 % CI, 0.41–1.02). The objective response and observed SAEs in the GnP/FOLFIRINOX groups were 20/19 % and 14/19 % respectively.</div></div><div><h3>Conclusions</h3><div>GnP was associated with improved OS compared to FOLFIRINOX for patients with early recurrence after adjuvant S-1.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 6","pages":"Pages 950-958"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding \"Predictors of acute pancreatitis in patients treated with GLP-1 receptor agonists for weight management\".","authors":"Jinyu Wu, Wen Wang, Kuncheng Yang","doi":"10.1016/j.pan.2025.08.019","DOIUrl":"https://doi.org/10.1016/j.pan.2025.08.019","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}