Pancreatology最新文献_第7页

Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor of the pancreas 骨外尤文氏肉瘤/胰腺原始神经外胚层肿瘤

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.008

Macie Enman , Niraja Shainoju Korremla , Shuko Harada, Vanessa Eulo, Sameer Al Diffalha , Vikas Dudeja

引用次数: 0

Incidence and risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE) in acute necrotizing pancreatitis (ANP) - A single center experience 急性坏死性胰腺炎（ANP）中深静脉血栓（DVT）和肺栓塞（PE）的发生率和风险因素--单中心经验

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.007

Gaurav Suryawanshi , David E. Jonason , Satish Munigala , Megan Ghai , Stuart Amateau , Nabeel Azeem , Shawn Mallery , Martin L. Freeman , Guru Trikudanathan

{"title":"Incidence and risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE) in acute necrotizing pancreatitis (ANP) - A single center experience","authors":"Gaurav Suryawanshi , David E. Jonason , Satish Munigala , Megan Ghai , Stuart Amateau , Nabeel Azeem , Shawn Mallery , Martin L. Freeman , Guru Trikudanathan","doi":"10.1016/j.pan.2024.07.007","DOIUrl":"10.1016/j.pan.2024.07.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Inflammation-induced dysregulation of the coagulation cascade and vascular stasis in hospitalized patients with acute necrotizing pancreatitis (ANP) serve as a milieu for venous thromboembolism (VTE). Deep vein thrombosis (DVT) and pulmonary embolism (PE) are often underrecognized. We evaluated the incidence and risk factors for VTE in a cohort of patients with ANP.</p></div><div><h3>Methods</h3><p>All adult patients with ANP at our center between 2009 and 2022 were followed for three months after index hospitalization and categorized into cases and controls based on development of VTE. Demographic, clinical, and radiologic characteristics during admission were compared. A multivariable analysis was done to identify independent predictors for VTE. A p value of <0.05 was taken as significant.</p></div><div><h3>Results</h3><p>Among 643 ANP patients, 512 [males-350, median age-52 years] were eligible for inclusion. VTE developed in 64 (12.5 %) patients – 28 DVT (5 %), 22 PE (4 %) and both in 14 (3 %) after a median 16 days from the diagnosis of ANP. Significant independent predictors for VTE on multivariable analysis were age ≥60 years (OR 1.91; 95 % CI 1.04–3.53), peri-pancreatic extent of necrosis (OR 7.61; 95 % CI 3.94–14.70), infected necrosis (OR 2.26; 95 % CI 1.13–4.50) and total length of stay ≥14 days (OR 4.08; 95 % CI 1.75–9.50).</p></div><div><h3>Conclusions</h3><p>The overall incidence of VTE in our cohort of patients with ANP was 12.5 %, which was usually diagnosed within one month of hospitalization. High-risk patients can be stratified based on clinical and imaging characteristics and may benefit from intensive DVT screening and prophylaxis during hospitalization and following discharge.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical impact of carbonic anhydrase 9 expression on neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma 碳酸酐酶9的表达对胰腺导管腺癌新辅助化放疗的临床影响

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.003

Taichi Terai, Satoshi Nishiwada, Minako Nagai, Kota Nakamura, Yuichiro Kohara, Satoshi Yasuda, Yasuko Matsuo, Shunsuke Doi, Takeshi Sakata, Hirokimi Kumada, Mizuki Watanabe, Masayuki Sho

{"title":"Clinical impact of carbonic anhydrase 9 expression on neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma","authors":"Taichi Terai, Satoshi Nishiwada, Minako Nagai, Kota Nakamura, Yuichiro Kohara, Satoshi Yasuda, Yasuko Matsuo, Shunsuke Doi, Takeshi Sakata, Hirokimi Kumada, Mizuki Watanabe, Masayuki Sho","doi":"10.1016/j.pan.2024.08.003","DOIUrl":"10.1016/j.pan.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><p>PDAC cells upregulate carbonic anhydrase 9 (CA9) expression in order to survive in hypoxic tumor environments, which plays a key role in tumor progression. However, the relationship between CA9 expression and preoperative treatment has not been clarified. We evaluated the clinical impact of CA9 expression on the efficacy of neoadjuvant chemoradiotherapy (NACRT) in pancreatic ductal adenocarcinoma (PDAC).</p></div><div><h3>Methods</h3><p>We investigated CA9 expression in 273 surgical specimens and 20 serum samples obtained from patients with PDAC and evaluated their clinical outcomes. We analyzed the function of CA9 using human pancreatic cancer cell lines.</p></div><div><h3>Results</h3><p>CA9 was positively expressed in 36.2 % of patients who underwent NACRT, which was significantly lower than those who underwent upfront surgery (US) (58.9 %, p < 0.001). Interestingly, patients who were CA9-positive in the US group had a significantly poorer prognosis than that of those in the NACRT group (median survival time [MST], 21.5 months vs. 49.2 months, p < 0.001), while there was no significant difference between patients who were CA9-negative in the US and NACRT groups (MST, 45.8 months vs. 46.3 months, p = 0.357). Moreover, serum CA9 levels tended to correlate positively with CA9 expression in cancer tissues. In-vitro experiments demonstrated that CA9 expression was reduced after treatments with radiation and chemoradiation therapy (RT/CRT), and that CA9 knockdown suppressed the impact of RT/CRT on cancer cell proliferation.</p></div><div><h3>Conclusions</h3><p>CA9 may act as a target molecule for RT/CRT, highlighting its clinical importance as a valuable biomarker for more stringent indications for NACRT.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early discharge of patients with mild acute pancreatitis – A scoping review 轻度急性胰腺炎患者的早期出院--范围综述。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.006

Niels Kant , Astrid Beij , Robert C. Verdonk , Jeanin E. van Hooft , Rogier P. Voermans , Marcel B.W. Spanier , Carine J.M. Doggen , Dutch Pancreatitis Study Group

{"title":"Early discharge of patients with mild acute pancreatitis – A scoping review","authors":"Niels Kant , Astrid Beij , Robert C. Verdonk , Jeanin E. van Hooft , Rogier P. Voermans , Marcel B.W. Spanier , Carine J.M. Doggen , Dutch Pancreatitis Study Group","doi":"10.1016/j.pan.2024.08.006","DOIUrl":"10.1016/j.pan.2024.08.006","url":null,"abstract":"<div><h3>Background</h3><p>Acute pancreatitis is a common disease that is usually mild and self-limiting. Early discharge of patients with mild acute pancreatitis, with the use of supporting outpatient services including remote monitoring or smartphone applications, might be safe and could reduce the healthcare demand. The objective of this review was to provide a comprehensive overview of existing strategies aimed at facilitating early discharge of patients diagnosed with mild acute pancreatitis and to assess clinical outcomes, feasibility and costs associated with these strategies.</p></div><div><h3>Methods</h3><p>PubMed, Cochrane, Embase, and Web of Science were systematically searched, to identify studies that evaluated strategies to reduce the length of hospital stay in patients with mild acute pancreatitis.</p></div><div><h3>Results</h3><p>Five studies, including 84 to 419 patients each, were identified and described three different early discharge protocols. The early discharge strategies resulted in a median length of hospital stay of a minimum of 6 to a maximum of 23 h in these studies. Early discharge compared to usual care did not result in increased 30-day readmissions. Additionally, no occurrences of complications or mortality were observed in either group. A significant reduction in overall costs was reported ranging from 43.1 % to 85.4 %.</p></div><div><h3>Conclusions</h3><p>Early discharge of patients with mild acute pancreatitis seems both feasible and safe. Further studies are warranted, since focus on safe early discharge could significantly reduce inpatient healthcare utilization and associated costs.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1424390324007026/pdfft?md5=2df967a8b7463b91caa4565670405fc3&pid=1-s2.0-S1424390324007026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving diagnostic accuracy of hidden pancreatic tumors on endoscopic ultrasound: Insights and methodological concerns on pancreatic juice cytology 提高内镜超声对隐匿性胰腺肿瘤的诊断准确性：胰液细胞学的启示和方法学问题。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.011

Muhammad Hammad Zaheer, Hamza Zaheer, Saad Hassan, Muhammad Abdullah

引用次数: 0

What's in the life of children with chronic pancreatitis? 慢性胰腺炎患儿的生活是怎样的？

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.012

Aliye Uc, Mark E. Lowe

引用次数: 0

The role of aspirin in the prevention of pancreatic cancer: A nested case-control study in the UK Biobank 阿司匹林在预防胰腺癌中的作用：英国生物库中的巢式病例对照研究。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.005

George R. Buckland , Sam A. Wilding , Declan McDonnell , Zaed Z.R. Hamady

{"title":"The role of aspirin in the prevention of pancreatic cancer: A nested case-control study in the UK Biobank","authors":"George R. Buckland , Sam A. Wilding , Declan McDonnell , Zaed Z.R. Hamady","doi":"10.1016/j.pan.2024.08.005","DOIUrl":"10.1016/j.pan.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><p>Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) usage has been associated with pancreatic ductal adenocarcinoma (PDAC) prevention, though epidemiological data have not reliably demonstrated this. The aim of this study is to identify if aspirin and other NSAIDs are effective in the primary prevention of PDAC in a large UK prospective cohort.</p></div><div><h3>Methods</h3><p>A nested case-control study was conducted using the UK Biobank cohort. Incident PDAC cases (n = 1129 of whom 239 (21.2 %) were using aspirin) were age and sex-matched with cancer-free controls (n = 8822 of whom 1752 (19.9 %) were using aspirin). Conditional logistic regression models were used to generate odds ratios (ORs) and 95 % confidence intervals (CI) for risk of PDAC with and without regular use of aspirin, non-aspirin NSAIDs and all NSAIDs respectively. Exploratory analyses were carried out assessing interactions with diabetes mellitus (DM) as a condition with increased pancreatic cancer risk.</p></div><div><h3>Results</h3><p>Regular aspirin use at initial recruitment was independently associated with a decreased risk of PDAC (OR [95 % CI] = 0.80 [0.68–0.95] <em>P</em> = 0.01). Regular non-aspirin NSAID use was not associated with a risk reduction of PDAC (OR [95 % CI] = 1.01 [0.84–1.23] <em>P</em> = 0.88). Exploratory analyses showed that in those with DM; regular aspirin use reduced risk of PDAC (OR [95 % CI] = 0.60 [0.42–0.85] <em>P</em> = 0.004) compared to non-use.</p></div><div><h3>Discussion</h3><p>Regular aspirin use is associated with a reduction in risk of PDAC. The reduced risk is more apparent in participants with DM.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors of fatigue and its association with quality of life among patients with chronic pancreatitis: A cross-sectional study. 慢性胰腺炎患者疲劳的发生率、风险因素及其与生活质量的关系：一项横断面研究

IF 2.8 2区医学

Pancreatology Pub Date : 2024-08-22 DOI: 10.1016/j.pan.2024.08.016

Hamna Ameen, F N U Hafeezullah

引用次数: 0

Letter to the editor: Prevalence and risk factors of fatigue and its association with quality of life among patients with chronic pancreatitis: A cross-sectional study. 致编辑的信慢性胰腺炎患者疲劳的发生率和风险因素及其与生活质量的关系：一项横断面研究。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-07-05 DOI: 10.1016/j.pan.2024.07.002

Hamza Yousuf Ibrahim, Shehdev Meghwar

引用次数: 0

Response to the letter to the editor regarding “The timing of endoscopic necrosectomy: More questions than answers” 对 "内窥镜坏死切除术的时机：问题多于答案

IF 2.8 2区医学

Pancreatology Pub Date : 2024-06-13 DOI: 10.1016/j.pan.2024.06.007

Qing Liu, Jian Yang, Junwen Zhang

引用次数: 0