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Awake Percutaneous Cervical Cordotomy in Patients With Cancer: A Technical Report. 清醒经皮宫颈Cordotomy在癌症患者中的应用:一份技术报告。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-06-01 DOI: 10.1111/papr.70159
Adinda P Pradhana, Hans Timmerman, Egbert J M Klarenbeek, Martijn L Verstraaten, Ruud Stellema, Anna K L Reyners, André P Wolff
{"title":"Awake Percutaneous Cervical Cordotomy in Patients With Cancer: A Technical Report.","authors":"Adinda P Pradhana, Hans Timmerman, Egbert J M Klarenbeek, Martijn L Verstraaten, Ruud Stellema, Anna K L Reyners, André P Wolff","doi":"10.1111/papr.70159","DOIUrl":"10.1111/papr.70159","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous cervical cordotomy (PCC) is a minimally invasive radiofrequency procedure for intractable unilateral cancer pain. Commonly performed under conscious sedation, awake PCC enables real-time patient feedback, potentially improving targeting precision and expanding eligibility for patients in whom sedation poses risks.</p><p><strong>Method and technique: </strong>This article presents the structured protocol for awake PCC implemented at our center, including pre-procedural training, positioning, fluoroscopic guidance, impedance monitoring, sensory and motoric testing, lesioning strategy, and aftercare. The key principle is to create the smallest effective lesion, applied incrementally until spinothalamic tract disruption is confirmed.</p><p><strong>Discussion: </strong>In our experience, awake PCC enables precise targeting and has yielded up to 90% success in pain relief. The approach requires substantial preparation, including training for both patient and team to ensure cooperation, clear communication, and tolerance of brief intraoperative discomfort. Although these demands can be challenging, we have found awake PCC to be a safe and effective last-resort option for patients facing devastating pain.</p><p><strong>Conclusion: </strong>This technical note provides a practical and stepwise approach to awake PCC. It may assist clinicians in adopting or refining the technique.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 5","pages":"e70159"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Pain Researcher and Clinician Perceptions of Complementary, Alternative, and Integrative Medicine: A Large-Scale, International Cross-Sectional Survey. 探索疼痛研究人员和临床医生对补充、替代和综合医学的看法:一项大规模的国际横断面调查。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70140
Jeremy Y Ng, Dennis Anheyer, Holger Cramer
{"title":"Exploring Pain Researcher and Clinician Perceptions of Complementary, Alternative, and Integrative Medicine: A Large-Scale, International Cross-Sectional Survey.","authors":"Jeremy Y Ng, Dennis Anheyer, Holger Cramer","doi":"10.1111/papr.70140","DOIUrl":"10.1111/papr.70140","url":null,"abstract":"<p><strong>Introduction: </strong>Complementary, alternative, and integrative medicine (CAIM) has gained popularity among patients experiencing pain, used alongside conventional medical treatments. This study aimed to explore the perceptions of pain clinicians and researchers on CAIM interventions.</p><p><strong>Methods: </strong>An anonymous, online survey was distributed to 46,223 authors who had published pain-related research in MEDLINE-indexed journals. The survey included multiple-choice questions and open-ended sections to gather detailed opinions.</p><p><strong>Results: </strong>A total of 1024 participants responded, 900 of which were eligible to participate; most identified as either pain researchers (n = 435/900, 48.33%) or both researchers and clinicians (n = 398/900, 44.22%). Many held senior positions (n = 549/892, 61.55%). Among the CAIM modalities, mind-body therapies such as meditation, yoga, and biofeedback were viewed as the most promising for pain prevention, treatment, and management, with 68.47% (n = 569/831) of participants endorsing these approaches. While (n = 341/777, 43.89%) of the respondents believed that most CAIM therapies are safe, only 25.55% (n = 198/775) disagreed with the idea that such therapies are effective. There was broad agreement on the need for more research into CAIM therapies, with 45.88% (n = 356/776) agreeing and 42.53% (n = 330/776) strongly agreeing that further investigation is valuable. Additionally, many respondents supported the inclusion of CAIM training in clinician education, either through formal programs (n = 361/778, 46.40%) or supplementary courses (n = 409/776, 52.71%).</p><p><strong>Conclusions: </strong>Mind-body therapies received the most positive feedback, while biofield therapies were met with the most skepticism. These findings highlight the interest in CAIM among pain researchers and clinicians and emphasize the need for more research and education tailored to this area.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70140"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Topographical, Sensory, and Temporal Characteristics of Pain in Parkinson's Disease: A Cross-Sectional Survey. 帕金森病疼痛的地形、感觉和时间特征:一项横断面调查。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70142
Anthony Mezzini, Saravana Kumar, Sue Sharrad, Joanne Harmon, Marion Eckert
{"title":"The Topographical, Sensory, and Temporal Characteristics of Pain in Parkinson's Disease: A Cross-Sectional Survey.","authors":"Anthony Mezzini, Saravana Kumar, Sue Sharrad, Joanne Harmon, Marion Eckert","doi":"10.1111/papr.70142","DOIUrl":"10.1111/papr.70142","url":null,"abstract":"<p><strong>Background: </strong>Pain in Parkinson's disease (PD) manifests clinically in a variety of ways and several pain types have been identified, however, their characteristics have not been extensively studied.</p><p><strong>Objective: </strong>To describe the characteristics of common pain types in people with PD.</p><p><strong>Methods: </strong>A survey of people with PD that experience pain symptoms was conducted. Participants were recruited using a combination of sampling methods. The survey questions focused on collecting information about the topographical, sensory, and temporal characteristics of pain. Descriptive statistics were used to report results.</p><p><strong>Results: </strong>Two hundred and sixteen participants were included in the data analyses. A median of 5 (interquartile range [IQR] 4-7) pain types were experienced by participants. Pain was commonly localized in the lower limbs but often affected several different body segments. Acute attacks of pain were characteristic for many participants in most pain types and were typically frequent (two to six times per week or more) and prolonged (minutes to hours). Periods of pain accentuation were most likely to occur in the morning, evening, and night and appear to be associated with PD medication pharmacology and a variety of exacerbating and ameliorating factors. Fluctuations in pain were found to range from mild to severe in all pain types.</p><p><strong>Conclusions: </strong>This study makes a valuable contribution to the existing literature by providing the most detailed assessment of the topographical, sensory, and temporal characteristics of common PD pain types to date that may be used to guide clinical diagnosis and treatment.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70142"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12979705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients. 反复射频热凝治疗三叉神经痛的疗效和安全性。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70148
Antti J Luikku, Sara Matikka, Sami Heikkinen, Anssi Lipponen, Katja Luostarinen, Timo Koivisto, Ville Leinonen, Jukka Huttunen, Henna-Kaisa Jyrkkänen
{"title":"Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients.","authors":"Antti J Luikku, Sara Matikka, Sami Heikkinen, Anssi Lipponen, Katja Luostarinen, Timo Koivisto, Ville Leinonen, Jukka Huttunen, Henna-Kaisa Jyrkkänen","doi":"10.1111/papr.70148","DOIUrl":"10.1111/papr.70148","url":null,"abstract":"<p><strong>Background: </strong>Trigeminal neuralgia (TN) is a pain condition characterized by paroxysmal, electric shock-like facial pain, affecting one or more areas of the branches. Approximately 33%-50% of patients require invasive treatment. Radiofrequency thermocoagulation (RFTC) is an established method for managing drug-resistant and chronic TN. This study evaluates treatment response quality and complication rates in repeated RFTC procedures for TN patients.</p><p><strong>Methods: </strong>In this retrospective analysis, patient records were extracted from the electronic medical records of Kuopio University Hospital, using the trigeminal neuralgia diagnosis code and the procedure code for thermal destruction of a cranial nerve. Data collected included sex, age, treatment outcomes at 3-month follow-up, presence of complications, technical details, and procedural success for each intervention.</p><p><strong>Results: </strong>Data from 140 patients were analyzed. An excellent or good response was observed in 79% of patients after the first procedure, 62.9% after the second, and 42.3% after the third. Complication rates were 15.7%, 19.6%, and 42.9%, respectively. Logistic regression analysis showed that complication risk was significantly associated with tertiary procedure and female sex. Development of painful post-traumatic trigeminal neuropathy (PTTN) was more common after repeated interventions; 1.4% after the first, 3.1% after the second, and 13.8% after the third procedure.</p><p><strong>Conclusions: </strong>RFTC is an effective and safe method for treatment for persistent trigeminal neuralgia when conservative treatment fails. However, its benefits diminish, and risks increase with each additional procedure, particularly the third. Based on these findings, reintervention should generally be limited to a single repeat procedure.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70148"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dr. Gabor Bela Racz-A Life of Impact and Innovation. Gabor Bela racz博士——影响与创新的一生。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70152
Carl Noe
{"title":"Dr. Gabor Bela Racz-A Life of Impact and Innovation.","authors":"Carl Noe","doi":"10.1111/papr.70152","DOIUrl":"https://doi.org/10.1111/papr.70152","url":null,"abstract":"","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70152"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First Treatment of a Sacroiliitis Patient Using Fluoroscopy Guided High Intensity Focused Ultrasound for Sacroiliitis. 透视引导下高强度聚焦超声治疗骶髂炎患者的首次治疗。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70134
Ruth Gur, Tal Harel, Paz Kelmer, Roee Sheinfeld, Oded Jacobi, Itay Goor-Aryeh, Lior Ungar
{"title":"First Treatment of a Sacroiliitis Patient Using Fluoroscopy Guided High Intensity Focused Ultrasound for Sacroiliitis.","authors":"Ruth Gur, Tal Harel, Paz Kelmer, Roee Sheinfeld, Oded Jacobi, Itay Goor-Aryeh, Lior Ungar","doi":"10.1111/papr.70134","DOIUrl":"10.1111/papr.70134","url":null,"abstract":"<p><strong>Background: </strong>Sacroiliitis is a debilitating condition causing significant lower back pain. Current treatment options, including medication, physical therapy, and invasive procedures, have limitations. High-intensity focused ultrasound (HIFU) offers a noninvasive, image-guided approach to treat chronic pain. In this study, we aimed to evaluate the safety and efficacy of HIFU for the treatment of sacroiliitis in patients with sacroiliac joint (SIJ) pain.</p><p><strong>Methods: </strong>A single-arm, open-label, pilot study was conducted on eight patients with SIJ pain. HIFU treatments were performed using a fluoroscopy-guided system. Primary outcomes included pain intensity, functional disability, and quality of life.</p><p><strong>Results: </strong>The HIFU procedure was well-tolerated, with no significant adverse events reported. Patients demonstrated a statistically significant reduction in pain intensity (p < 0.005) along with a nonsignificant improvement in functional disability and quality of life over the 6-month follow-up period. Additionally, MRI imaging confirmed precise ablation of the targeted tissue.</p><p><strong>Conclusion: </strong>HIFU shows potential as a noninvasive treatment option for sacroiliitis. However, additional larger-scale studies are needed to further explore these findings and refine treatment parameters.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70134"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sphenopalatine Ganglion Radiofrequency Ablation for Severe Facial Rosacea Manifestations. 蝶腭神经节射频消融术治疗严重面部酒渣鼻。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70151
Leonardo Kapural, Lasha-Georgi Esebua, Neil Poddar, Carmen Bekavac, Gil Yosipovitch
{"title":"Sphenopalatine Ganglion Radiofrequency Ablation for Severe Facial Rosacea Manifestations.","authors":"Leonardo Kapural, Lasha-Georgi Esebua, Neil Poddar, Carmen Bekavac, Gil Yosipovitch","doi":"10.1111/papr.70151","DOIUrl":"10.1111/papr.70151","url":null,"abstract":"<p><strong>Background: </strong>Rosacea is an inflammatory, persistent erythema that can present under several clinical subtypes. Recently, a neurogenic type of rosacea has been suggested that can be associated with chronic pain and headaches.</p><p><strong>Aims: </strong>Here we describe a successful interventional treatment for severe, likely neurogenic rosacea associated with severe migraines previously treated using various conservative approaches.</p><p><strong>Materials and methods: </strong>Radiofrequency ablation of the sphenopalatine ganglion (SPG) was completed for the patient's primary chronic pain problem, severe migraine headaches.</p><p><strong>Results: </strong>Completion of the left-sided ganglion denervation resulted in resolution of left facial rosacea symptoms/signs. After the right radiofrequency denervation (about 2 weeks later), rosacea signs/symptoms disappeared from the right side of the patient's face as well. Twelve months following the sphenopalatine radiofrequency ablation, the patient is still rosacea-free.</p><p><strong>Conclusion: </strong>A larger case series is needed to assess the efficacy of sphenopalatine radiofrequency ablation in long-term management of the facial subtype of rosacea.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70151"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptomatic Spontaneous Intracranial Hypotension Caused by a Cerebrospinal Fluid Leak at the C1-C2 Level of the Spine Sealed With an Epidural Blood Patch-Case Series and Review of Literature. 硬膜外血贴片封闭的C1-C2段脑脊液漏致自发性症状性颅内低血压病例系列及文献复习
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-04-01 DOI: 10.1111/papr.70139
Ivan Afonin, Grzegorz Turek, Adrian Drożdż, Paweł Obierzyński, Mateusz Ząbek, Mirosław Ząbek
{"title":"Symptomatic Spontaneous Intracranial Hypotension Caused by a Cerebrospinal Fluid Leak at the C1-C2 Level of the Spine Sealed With an Epidural Blood Patch-Case Series and Review of Literature.","authors":"Ivan Afonin, Grzegorz Turek, Adrian Drożdż, Paweł Obierzyński, Mateusz Ząbek, Mirosław Ząbek","doi":"10.1111/papr.70139","DOIUrl":"10.1111/papr.70139","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous intracranial hypotension (SIH) is a disorder caused by low cerebrospinal fluid (CSF) pressure due to a CSF leak located anywhere within the neuroaxis. Risk factors include trauma, degenerative disc disease, and especially connective tissue disorders. In most cases, SIH presents with orthostatic headache, worsening when upright and characteristic radiological features as diffuse pachymeningeal enhancement on MRI [4, 6]. There are a lot of publications concerning treatment of CSF leaks located in the lumbar and thoracic spine, but only scant information regarding treatment and its outcomes of CSF leaks in the upper cervical spine, e.g., C1-2.</p><p><strong>Case series: </strong>Three women presented with persistent headaches, worsening when standing, lasting weeks to months. Two reported cervical pain, one had double vision, and all experienced dizziness. Symptoms resolved in recumbency. All had connective tissue disorders: patient 1 had systemic lupus erythematosus (SLE) and Sjögren's syndrome, patient 2 had polymyositis, and patient 3 was under observation for SLE. The MRI showed typical SIH features, and the cervical spine MRI was unremarkable except for spinal longitudinal epidural collection (SLEC) in two patients. CT-myelography identified CSF leaks at C1-2 in all cases. Epidural blood patching (EBP) at C1-2 under CT guidance resolved symptoms, with only one patient experiencing a brief post-procedural headache. At 3 months' follow-up, all patients remained symptom-free. Repeated CT-myelography in one patient showed no residual CSF leak.</p><p><strong>Conclusions: </strong>SIH is a very rare and frequently misdiagnosed condition. Administration of EBP at the C1-2 level of the spine is troublesome; therefore, it should be performed under guidance of computed tomography. All three patients were discharged symptom free within 24-72 h.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 4","pages":"e70139"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the Letter Commenting on: "Twenty-One-Year Experience With Cervical Diagnostic Blocks and Denervation: A Study of 1031 Cases at a Single Institution". 对“21年宫颈诊断阻滞和去神经治疗经验:一所医院1031例病例的研究”评论函的回应。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-03-01 DOI: 10.1111/papr.70135
Thomas Mirland, Lara Chow Yuen, Nathalie Van Cutsem, José Cravo, Olivier Duranteau, Turgay Tuna
{"title":"Response to the Letter Commenting on: \"Twenty-One-Year Experience With Cervical Diagnostic Blocks and Denervation: A Study of 1031 Cases at a Single Institution\".","authors":"Thomas Mirland, Lara Chow Yuen, Nathalie Van Cutsem, José Cravo, Olivier Duranteau, Turgay Tuna","doi":"10.1111/papr.70135","DOIUrl":"https://doi.org/10.1111/papr.70135","url":null,"abstract":"","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 3","pages":"e70135"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Glossopharyngeal Neuralgia: A Systematic Review. 舌咽神经痛的治疗:系统回顾。
IF 2.7 3区 医学
Pain Practice Pub Date : 2026-03-01 DOI: 10.1111/papr.70144
Marcelo A Rohde, Lorenzo Gabriel A Viera, Aline O S Meneses, Helena F S Rypl, Laura P Nunes, Victor Hugo W Annes, Amauri Dalla-Corte
{"title":"Treatment of Glossopharyngeal Neuralgia: A Systematic Review.","authors":"Marcelo A Rohde, Lorenzo Gabriel A Viera, Aline O S Meneses, Helena F S Rypl, Laura P Nunes, Victor Hugo W Annes, Amauri Dalla-Corte","doi":"10.1111/papr.70144","DOIUrl":"10.1111/papr.70144","url":null,"abstract":"<p><strong>Introduction: </strong>Glossopharyngeal neuralgia (GPN) is a rare neuropathy characterized by paroxysmal, unilateral, and severe pain episodes affecting the throat, tonsils, base of the tongue, and pharynx. Its management remains challenging due to the absence of standardized treatment protocols and the limited availability of high-quality comparative studies.</p><p><strong>Objective: </strong>To review and compare the effectiveness and safety of available treatments for GPN.</p><p><strong>Methods: </strong>A systematic review was conducted, analyzing studies published in the last decade that evaluated GPN treatments. Searches were performed in PubMed, SCIELO, and the Regional Portal of BVS. Studies were assessed for quality, risk of bias, and key outcomes, including pain relief and adverse effects.</p><p><strong>Results: </strong>Twenty-six studies, comprising 973 patients, were included. Seven treatment modalities were analyzed. Microvascular decompression (MVD) demonstrated the highest efficacy and durability, with an immediate pain relief rate exceeding 86.7% and exhibiting the lowest recurrence rates. Alternative treatments, including gamma knife radiosurgery, radiofrequency thermocoagulation, and pulsed radiofrequency, showed initial pain relief but had higher recurrence rates over time. The posterior inferior cerebellar artery was the most frequently involved vessel in cases with vascular compression.</p><p><strong>Conclusion: </strong>MVD is the preferred first-line surgical treatment when pharmacological therapy fails, vascular compression is present, and the patient is a suitable candidate for surgery. In cases where MVD is contraindicated or vascular compression is absent, alternative treatments should be considered based on individual patient factors, balancing efficacy and long-term outcomes. Further high-quality studies are needed to refine treatment strategies for GPN.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"26 3","pages":"e70144"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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