Parasitology Research最新文献

{"title":"Immunomodulatory and anti-inflammatory effects of fluvoxamine during the intestinal phase of Trichinella spiralis infection in mice.","authors":"Wesam M A Elgendy, Ahmad A Othman, Nema A Soliman, Nivin Baiomy, Dina M El-Guindy, Dina I Elgendy","doi":"10.1007/s00436-025-08553-6","DOIUrl":"10.1007/s00436-025-08553-6","url":null,"abstract":"<p><p>Trichinellosis is a meat-borne zoonosis of ubiquitous distribution. The severity is variable, and fatalities may occur. Immune-mediated inflammation plays an important role in the pathogenesis of the disease. Thus, safe and effective compounds with anti-inflammatory properties are needed. Our study was designed to evaluate the effects of fluvoxamine as an adjuvant to albendazole during the intestinal and migratory phases of trichinellosis. Therefore, Trichinella spiralis-infected mice were treated with either fluvoxamine, albendazole, or a combination of both drugs. Notably, the parasite burden was reduced in the intestines and muscles of fluvoxamine-treated mice compared to the infected control, denoting a detrimental effect of the drug against Trichinella spiralis. Moreover, in comparison with the infected control, there was a marked improvement in intestinal and muscle inflammation with the treatment, evidenced by the reduction in COX-2 and TNF-α and the decrement of inflammatory infiltrates in tissues. The expression of iNOS was also reduced in the muscles. Treatment with fluvoxamine alleviated the oxidative stress in the intestines and muscles with a reduction in malondialdehyde and H₂O₂ and an increase in reduced glutathione levels. Finally, fluvoxamine moderated the immune response, as evidenced by the downregulation of the levels of IL-4 and IFN-γ and the increase of those of IL-10 in tissues. Characteristically, all these beneficial effects were maximal in mice receiving the combined treatment. In conclusion, fluvoxamine administration during the early phase of trichinellosis exhibited immunomodulatory and anti-inflammatory activities that potentiated the efficacy of albendazole. Therefore, fluvoxamine could be considered a useful adjuvant treatment in trichinellosis.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 10","pages":"112"},"PeriodicalIF":2.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parasitic gastritis in wild sunda pangolins (Manis Javanica), Singapore.","authors":"Shin Min Chong, Kei Chloe Tan, Delia Hwee Hoon Chua, Liesbeth Frias, Chiharu Okumura","doi":"10.1007/s00436-025-08567-0","DOIUrl":"10.1007/s00436-025-08567-0","url":null,"abstract":"<p><p>Gastrointestinal parasites have been reported in wild Sunda pangolins (Manis javanica), but the clinical significance of such detections is often unknown. This report describes pathological lesions in the stomachs of two dead wild Sunda pangolins caused by Gendrespirura sp.. Gross and histopathological examination showed gastritis and hyperkeratosis in infected animals. Morphological identification confirmed the presence of Gendrespirura sp., and molecular analysis revealed a close phylogenetic relationship with the genus Gendrespirura, supporting placement within the family Habronematidae. This report highlights the pathological significance of parasite infections in wild pangolins in Singapore, further advancing our understanding of the natural biology and parasitology of wild Sunda pangolins, and the effects of these infections on the health and conservation of this critically endangered species.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 10","pages":"111"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anisakid biodiversity in two young harbour seals (Phoca vitulina L.) from coastal South-West Norway.","authors":"Paolo Cipriani, Lucilla Giulietti, Marialetizia Palomba, Veronica Rodriguez Fernandez, Simonetta Mattiucci, Arne Bjørge, Arne Levsen, Miguel Bao","doi":"10.1007/s00436-025-08559-0","DOIUrl":"10.1007/s00436-025-08559-0","url":null,"abstract":"<p><p>Anisakid nematodes are widespread marine parasites with complex life cycles involving invertebrates and fish as intermediate or transport hosts, and marine mammals as definitive hosts. Despite their ecological importance, and the zoonotic potential associated with the larval stages found in fish, recent data on anisakid species diversity in pinnipeds from Norwegian waters remain scarce. In this study, we investigated anisakid infections in two juvenile harbour seals (Phoca vitulina) stranded along the southern coast of Norway. Gastrointestinal nematodes were collected, morphologically classified to the genus level, and subsequently identified to species level through molecular analyses of mitochondrial (mtDNA cox2) and nuclear (rDNA ITS) markers.Five anisakid species were identified: Contracaecum osculatum sp. A (reported here for the first time in harbour seals), C. osculatum (sensu stricto), Phocanema decipiens (s.s.), P. krabbei, and Anisakis simplex (s.s.). The latter species was found in unexpectedly high abundance and in fully developed adult stages in one of the seals. Notably, these adult A. simplex (s.s.) exhibited large body size, in contrast with previous studies reporting either absence or minimal presence of adults in harbour seals. The underlying mechanisms promoting growth and reproductive development of A. simplex (s.s.) in this host species remain unclear, but may involve a combination of host-specific physiological traits, environmental factors, and parasite phenotypic plasticity. Gross pathological examination revealed multiple gastric and intestinal ulcers in the same seal, including seven crateriform lesions consistent with ulcerative gastritis and enteritis, associated with nematode attachment and feeding. These findings expand the current knowledge on anisakid diversity in P. vitulina and provide novel evidence of its role as a definitive host for A. simplex (s.s.) in Norwegian coastal waters. Furthermore, the results suggest that competitive interactions among anisakid species, combined with ecological and physiological host factors, may facilitate the development and maturation of A. simplex (s.s.) in harbour seals. Further studies are warranted to assess the frequency and health implications of such infections in wild pinniped populations.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"110"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular responses in rainbow trout Oncorhynchus mykiss to experimental Anisakis simplex infection.","authors":"Kaan Kumas, Bahram Sayyaf Dezfuli, Emanuela Franchella, Yajiao Duan, Per Walter Kania, Kurt Buchmann","doi":"10.1007/s00436-025-08565-2","DOIUrl":"10.1007/s00436-025-08565-2","url":null,"abstract":"<p><p>Fish in wild and cultured populations may be infected with numerous types of pathogens but the host responses vary dependent on both host and parasite species. The present study demonstrates how an experimental infection with endoparasitic nematode larvae (Anisakis simplex) induces cellular and humoral immune responses in rainbow trout Oncorhynchus mykiss. The nematode larvae invaded the peritoneal cavity of the fish following oral administration and became encapsulated by a range of host cells including macrophages, neutrophils, mast cells, fibroblasts, and lymphocytes. The main part (92.7%) of the recovered larvae was located in the body cavity and 51.3% along the pyloric caeca with only few in or on the stomach, liver, spleen, swim bladder, and musculature. The cellular reaction was documented by transmission electron microscopy (TEM) and histochemistry. Real time quantitative PCR (qPCR) showed that a series of immune-relevant genes in the host spleen became regulated by the infection. Thus, A. simplex induced downregulation of immune-genes (encoding IgD and lysozyme) and upregulation of the gene encoding the immune-regulating cytokine IL-10. Nematode molecules influencing the antiparasitic host reactions are discussed.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"109"},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albendazole treatment efficacy and predictors of success in combating soil-transmitted helminth infections in school children of Central Tigray, Northern Ethiopia.","authors":"Yemane Tadesse Desta, Mesfin Tesfay, Mulugeta Tilahun, Teklemichael Tesfay, Haftom Kahsay Abrha","doi":"10.1007/s00436-025-08546-5","DOIUrl":"10.1007/s00436-025-08546-5","url":null,"abstract":"<p><p>The present study evaluated the efficacy of albendazole in treating soil-transmitted helminth infections among school children aged 6 to 15 years in three districts of Central Tigray, Ethiopia. A total of 1020 elementary school children were screened from three schools using Kato-Katz and microscopic detection techniques. Of these, 35.2% (359/1020) of children were infected with one or more soil-transmitted helminths and were treated with 400 mg albendazole. The efficacy of the drug was assessed by measuring the percentage reduction in helminth egg counts using Kato-Katz. Albendazole was most effective against hookworm, with overall 94.1% egg reduction rates (ERRs), 3 weeks post-treatment followed by A. lumbricoides and T. trichiura, with overall ERRs of 83.9% and 31%, respectively. Analysis of factors affecting albendazole treatment success revealed that the age of respondents, source of drinking water, and infection intensity at baseline were significant predictors of treatment success. School children 6-8 years old showed higher ERRs, while those using stream water for drinking purposes and with multiple parasite infections at baseline had lower probability of ERRs. These findings demonstrate the varying efficacy of albendazole across different STH infections and geographical locations, calling a more refined research to enhance treatment approaches for A. lumbricoides and T. trichiura. This study underscores the need for context-specific therapeutic intervention to enhance treatment success in endemic areas.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"108"},"PeriodicalIF":2.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetic diversity of tick species in selected areas of Qinghai Province.","authors":"Xuelian Chen, Zhi Li, Xueyong Zhang, Hong Duo, Xiuying Shen, Yijun Ma, Yong Fu, Zhihong Guo","doi":"10.1007/s00436-025-08556-3","DOIUrl":"10.1007/s00436-025-08556-3","url":null,"abstract":"<p><p>The purpose of this study was to evaluate the genetic diversity of ticks from free-ranging hosts in some areas of Qinghai Province and perform a phylogenetic analysis among different geographical populations, in order to establish a foundation for the prevention and control of ticks and tick-borne diseases in Qinghai Province. In March and April 2024, a total of 935 ticks were collected from goats, yaks, and horses in Jianzha and Haiyan counties. The tick species were identified by taxonomic key and 16S ribosomal RNA (16S rRNA) sequencing, and haplotype analysis, phylogenetic tree construction, and genetic differentiation index were performed using DNASP v.6, Popart, MEGA 11, and Arlequin v.3.5 software. The 935 collected tick samples belonged to three categories: Haemaphysalis spp., including H. qinghaiensis (n = 525) and H. danieli (n = 199); Dermacentor spp., containing D. nuttalli (n = 8) and D. silvarum (n = 201); and Hyalomma marginatum (n = 2), which was first identified in Qinghai Province. Haplotype and nucleotide polymorphism analyses indicated that there were 19 haplotypes in H. danieli, with haplotype H13 as the dominant haplotype (119/199); six haplotypes in D. nuttalli, with H3 and H4 haplotypes as the dominant haplotypes (4/8); and 20 haplotypes in D. silvarum, with H1 as the dominant haplotype (149/201). The genetic differentiation of D. silvarum, H. danieli, and D. nuttalli occurred both within and among populations. The phylogenetic analysis revealed that the tick species obtained from this study formed clades with the corresponding tick populations. These findings show that the tick species in Jianzha and Haiyan in Qinghai Province underwent population expansion and exhibited enhanced genetic diversity, providing a vital basis for understanding the distribution of ticks and tick-borne diseases in Qinghai Province.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"107"},"PeriodicalIF":2.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxocariasis, risk and protective factors, and mental health difficulties in early childhood: a comparison of marginalised Roma communities and the majority population.","authors":"Daniela Fiľakovská Bobáková, Zuzana Kalinova, Elena Hatalová, Monika Halanova","doi":"10.1007/s00436-025-08557-2","DOIUrl":"10.1007/s00436-025-08557-2","url":null,"abstract":"<p><p>Toxocariasis is a parasitic infection that poses significant health risks to children, particularly in marginalised populations with limited access to sanitation and healthcare. This study aimed to compare the occurrence of toxocariasis in early childhood between a group of children from the Slovak majority population and from marginalised Roma communities (MRCs), explore potential risk and protective factors and the association with mental health difficulties in early childhood. Cross-sectional data were obtained from mothers, and blood samples of their children aged 14-21 months were collected during the first wave of the longitudinal RomaREACH study. A total of 88 blood samples from children were analysed: 49 children from the Slovak Majority population and 39 from MRCs. Anti-Toxocara canis IgG antibodies were detected in serum samples using an enzyme-linked immunosorbent assay (ELISA). Though it was not statistically significant, seropositivity for Toxocara canis was more often observed in children from MRCs (35.9%) than in the majority population (20.4%). The absence of running water in households significantly increases the risk of Toxocara infection in children, whereas a longer duration of breastfeeding decreases it. Children seropositive for Toxocara canis showed higher levels of early mental health difficulties even when controlled for MRC residence. These results indicate the need for integrated public health interventions targeting parasitic infections in susceptible populations. Improving access to sanitation, promoting breastfeeding, and strengthening the preventive and educational role of early childhood health services are critical strategies to reduce the risk of exposure to Toxocara spp. eggs and mitigate its potential impact on child health and development.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"106"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and genetic polymorphisms in Rhipicephalus sanguineus (Latreille 1806) from the Iberian Peninsula.","authors":"F Rosa, M F Caeiro, M Carvalho, D Dias, F Pina-Martins","doi":"10.1007/s00436-025-08550-9","DOIUrl":"10.1007/s00436-025-08550-9","url":null,"abstract":"<p><p>Rhipicephalus sanguineus is a tick species characterized by high intraspecific variability, even among populations occupying the same habitats. This study investigated whether two distinct phenotypes of R. sanguineus, collected from four geographically separated regions, are associated with specific nucleotide polymorphisms in the mitochondrial cox1 and 16S rRNA gene regions-markers commonly employed in phylogenetic analyses. Morphometric analysis based on established criteria clearly distinguished two morphotypes-Morphotype 1 and Morphotype 2-with statistically significant differences. This morphological differentiation was supported by phylogenetic and genetic divergence analyses, primarily based on mitochondrial cox1 sequences, which revealed six polymorphic sites within the analyzed fragment. Among the identified haplotypes, two-Haplotype 2a and Haplotype 2b-were consistently associated with Morphotype 2. This genetic segregation was confirmed in extended analyses including reference isolates (morphologically and/or genetically defined either as R. sanguineus or R. hibericus). These analyses also demonstrated a close phylogenetic relationship between Morphotype 1 and the R. sanguineus neotype, as well as between R. hibericus and both morphotypes. Although the 16S rRNA marker exhibited lower resolution, it still effectively distinguished the two morphotypes and corroborated the haplotype assignments established by the cox1 phylogeny. The observed genetic divergence (p-distance of 1% in cox1 gene) and the phylogenetic relationship between R. sanguineus and R. hibericus confirmed that R. sanguineus is a polymorphic species, with well-defined haplo-morphotypes, and that R. hibericus is not genetically distinguishable from R. sanguineus.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"105"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential susceptibility of human placental trophoblasts to Trypanosoma cruzi infection.","authors":"Paula Andrea Marín, Ana Milena Murillo Giraldo, Ana María Mejia-Jaramillo, Omar Triana-Chávez, Santiago Pemberty, Ana María Vásquez","doi":"10.1007/s00436-025-08552-7","DOIUrl":"10.1007/s00436-025-08552-7","url":null,"abstract":"<p><p>Congenital transmission is a key route for Trypanosoma cruzi infection, yet the cellular mechanisms enabling congenital transmission remains poorly understood. This study evaluated the susceptibility of different trophoblast cell line models to T. cruzi infection and compared infectivity patterns among TcI strains compared to Y strain (TcII). The BeWo cell line was used to model cytotrophoblast (CT) and syncytiotrophoblast (ST) cells, while the HTR-8/SVneo cells modeled extravillous trophoblasts (EVTs). Three Colombian TcI strains and one TcII strain were cultured and differentiated into infective trypomastigotes. Infection rates, intracellular parasite replication, trypomastigote release, cell viability, hormone secretion, apoptosis, and ultrastructural characteristics were studied. Significant differences in infection susceptibility among trophoblast types were observed. BeWo CT-like cells were highly permissive to infection, whereas ST-like cells exhibited strong resistance, potentially due to intrinsic defense mechanisms. HTR-8/SVneo showed moderate susceptibility, supporting persistent replication and trypomastigote release. Infection impaired cell viability and disrupted endocrine functions such as hCG secretion, with cell-type-specific effects. Parasite strains also differed in infectivity. Strain Υ demonstrated high infectivity and cytotoxic effects. In contrast, SN3 and GAL61S strains exhibited slower intracellular development and lower release of trypomastigotes. Strain SA showed early infectivity but limited replication. These findings highlight the differential susceptibility of trophoblast subtypes to T. cruzi infection and the variability in strain virulence. Further insight into placental defense mechanisms and parasite-host interactions is essential for understanding congenital transmission and developing targeted preventive strategies.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"104"},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence and risk factors associated with Cystic echinococcosis among nomadic, rural, and urban communities in Northwestern Iran.","authors":"Sakhavat Abolhasani, Towhid Babazadeh, Khalil Maleki Chollou, Ali Bahadori, Yavar Rostami, Hannaneh Arabpour, Zahra Mirzapoor, Sanaz Hayati, Nasim Taheri, Hanane Moqadam, Soghra Valizadeh, Hamed Behniafar","doi":"10.1007/s00436-025-08555-4","DOIUrl":"10.1007/s00436-025-08555-4","url":null,"abstract":"<p><p>Hydatid disease or hydatid cysticercosis is a zoonotic disease caused by the tapeworm Echinococcus granulosus. Dogs are definitive hosts, while humans and livestock, such as sheep and cattle, are intermediate hosts for the parasite. Infection occurs when contaminated food is ingested. This neglected disease is prevalent in temperate regions, mainly where sheep farming is common, with seroprevalence in Iran ranging from 1.6% to over 20%. The current study assesses human CE prevalence among various demographics in East Azerbaijan, Iran. This cross-sectional study was conducted on 1912 individuals aged 10 or older from urban, rural, and nomadic populations. To identify Anti-E. granulosus IgG, the ELISA technique was employed. Probable risk factors were recorded using a questionnaire prior to serum collection. At last, the multiple logistic regression model was employed to assess the correlation between seroprevalence rates and variables. The study found a seroprevalence rate of approximately 4% (95% CI 3.15%-4.91%), with 77 individuals testing positive for hydatidosis. Significant risk factors included nomadic and rural living conditions (OR = 2.059, 95% CI = 1.270-3.337), contact with dogs (OR = 2.30; 95% CI 1.42-3.75), and occupations in agriculture, animal husbandry, and housekeeping (OR = 1.244, 95% CI = 1.068-1.450). Results directed towards actual living conditions being the main contributors to the prevalence of the disease and occupational exposure reflect the vulnerability of the nomads due to their limited access to healthcare and hygiene measures. The present study indicates the urgent need to undertake targeted public health interventions that improve awareness and preventive strategies among high-risk groups.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 9","pages":"103"},"PeriodicalIF":2.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}