Parasitology Research最新文献

{"title":"Identifying zoonotic risks: molecular insights into Cryptosporidium and Enterocytozoon bieneusi in pediatric cancer patients in Ahvaz, 2024.","authors":"Hanieh Makipour, Ali Haghighi, Ahmad Halakou, Dian Dayer, Saeid Bitaraf, Arta Farhadi Kia, Marzieh Abbasi Nasab, Mahnaz Mori, Roya Salehi Kahyesh, Hamed Mirjalali","doi":"10.1007/s00436-025-08500-5","DOIUrl":"10.1007/s00436-025-08500-5","url":null,"abstract":"<p><p>Opportunistic infections remain a major cause of morbidity and mortality among patients with immunodeficiency and malignancy. Cryptosporidium spp. and microsporidia, particularly Enterocytozoon bieneusi, are obligate intracellular parasites that can lead to severe complications and even death in immunocompromised individuals.In this cross-sectional study, 60 stool samples were collected from pediatric oncology patients aged 5-18 years who were hospitalized at Baghaei 2 Hospital in Ahvaz, southwestern Iran, in 2024. Following DNA extraction, molecular analysis was performed to detect the presence of Cryptosporidium spp. and E. bieneusi. For genotyping, amplification and sequencing of the 60-kDa glycoprotein (gp60) gene for Cryptosporidium spp. and the internal transcribed spacer (ITS) region for E. bieneusi were conducted. A total of 16 samples (26.6%) tested positive for either C. hominis or E. bieneusi. Co-infection with both pathogens was identified in two patients (3%). Statistical analysis revealed no significant association between gender and parasitic infection (P = 0.166), nor between the type of malignancy and presence of protozoa (P = 0.717). Genotyping of E. bieneusi showed the presence of BEB6, CHG3, D, and I genotypes, with BEB6 being the most prevalent. Subtyping of C. hominis revealed the presence of the IeA11G3T3 subtype. Overall, the molecular findings demonstrated a prevalence rate 26.6 % of parasitic infection among the studied population, with E. bieneusi being predominant. The detection of potentially zoonotic genotypes, particularly BEB6, underscores the likelihood of zoonotic transmission routes in these patients.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"55"},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neurobiological and immune serum biomarkers with Toxoplasma gondii infection in patients with schizophrenia.","authors":"Olga Abramova, Yana Zorkina, Dmitry Goncharov, Evgenia Abbazova, Marina Baranets, Alexander Berdalin, Valeriya Ushakova, Valeria Zakurazhnaya, Irina Morozova, Alexandra Ochneva, Konstantin Pavlov, Denis Andreyuk, Georgy Kostyuk, Anna Morozova","doi":"10.1007/s00436-025-08498-w","DOIUrl":"10.1007/s00436-025-08498-w","url":null,"abstract":"<p><p>Some studies suggest that Toxoplasma gondii infection may increase the risk of developing schizophrenia. Determining changes in blood biomarker concentrations may provide new insights into the underlying mechanisms associated with Toxoplasma gondii infection in schizophrenia. The aim of the study was to evaluate the concentrations of several serum neurobiological and immune parameters and to identify changes in their concentrations that could potentially be indicators of psychopathologic changes in infection. The concentration of biomarkers was determined in serum from patients with schizophrenia (uninfected n = 50, infected n = 30) and from mentally healthy volunteers (uninfected n = 51, infected n = 29) using multiplex analysis. A number of psychometric scales have been applied to assess the cognitive functioning. No significant associations were between schizophrenia and Toxoplasma gondii infection (p = 0.54; OR = 1.18; 95% CI = 0.69-2.01). However, infected patients with schizophrenia had more severe cognitive impairment compared to uninfected schizophrenia patients (PDQ-20). The group of biomarkers has been identified whose concentration changes were observed only between Toxoplasma gondii-infected healthy individuals and individuals with schizophrenia (neurobiological indicators KLK6, UCHL1, Amyloid beta 1-42 and neurogranin; anti-inflammatory cytokine IL-10; chemokines IL-8 and MIP-1 beta), but not between uninfected groups. The hypothesis was proposed that it is possible to use these indices as indicators of the development of schizophrenic psychopathology in Toxoplasma gondii infection. The associations of blood biomarker concentrations with IgA and IgM antibody levels (chemokine RANTES) and with schizophrenia symptoms (hormone-like messenger KLK6; chemokines IP-10 and GRO alpha) were found. Toxoplasma gondii reactivation leads to a decrease in negative symptomatology and reduced FGF-21 levels in patients with schizophrenia, and increased CNTF and NGF beta levels compared to the latent form.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"53"},"PeriodicalIF":1.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring real-time PCR techniques for diagnosing leishmaniasis: key insights from a systematic review.","authors":"José Bryan Rihs, Mariana Teixeira Vilela, Janete Soares Coelho Dos Santos, Sérgio Caldas, Rodrigo Souza Leite, Marcos Paulo Gomes Mol","doi":"10.1007/s00436-025-08503-2","DOIUrl":"10.1007/s00436-025-08503-2","url":null,"abstract":"<p><p>Real-time PCR (qPCR) has emerged as a promising alternative to be used in the diagnosis of leishmaniasis. However, a consensus on the standardized approach for this purpose is yet to be established. This systematic review aims to highlight relevant aspects for the development of possible consensus protocols. The study included publications from January 2011 to July 2023 using different databases. Studies focusing on qPCR standardization for the diagnosis of leishmaniasis were included. The collected data encompassed study group details, geographical locations, sample types and quantities, molecular targets, and qPCR methodologies, which were subsequently pooled and analyzed. Forty-three studies conducted in diverse regions of the world were included. The majority were visceral leishmaniasis, followed by cutaneous leishmaniasis and post-kala-azar dermal leishmaniasis. Overall, invasive samples demonstrated higher sensitivity (> 90%) compared to non-invasive samples (< 90%), but both exhibited high specificity (> 85%). Furthermore, the kDNA minicircle was identified as the most promising molecular target, with a discreet preference for the use of TaqMan probes over SYBR Green. Various qPCR approaches have exhibited promising results in the diagnosis of leishmaniasis. However, further studies exploring non-invasive sampling techniques in conjunction with appropriate molecular targets are essential to establish efficient and reliable diagnostic techniques.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"54"},"PeriodicalIF":1.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional annotation and analysis of the hard tick Dermacentor nuttalli midgut genes.","authors":"Hejia Ma, Lijun Jia, Jian Feng, Tianshuai Li, Chao Li, Jixu Li, Xuenan Xuan, Yali Sun","doi":"10.1007/s00436-025-08480-6","DOIUrl":"https://doi.org/10.1007/s00436-025-08480-6","url":null,"abstract":"<p><p>Ticks are hematophagous vectors that transmit a variety of pathogens, posing significant threats to the health of both humans and animals. Tick midgut proteins play essential roles in blood digestion, feeding, toxic waste processing, and pathogen transmission. Dermacentor nuttalli is the primary vector of tick-borne pathogens, including rickettsioses in the Qinghai-Tibet Plateau. However, there is a lack of genomic, transcriptomic, and proteomic information regarding the biology of D. nuttalli. In this study, we assembled and compared the midgut transcriptomes of female D. nuttalli ticks at 0, 24, 48, 72, and 96 h during blood feeding, identifying the genes with differentially regulated expression following feeding. The obtained data were compiled and annotated in multiple databases including Nr, NT, PFAM, KOG, KEGG, and GO. The high-quality clean readings of midgut tissue at the different blood-feeding times were recorded as 22,524,912, 23,752,325, 20,377,718, 21,300,710, and 20,378,658, respectively. The transcripts were classified into eight large categories, including immunogenic proteases (8.37%), protease inhibitors (0.85%), transporters (3.96%), ligand binding proteins (1.98%), ribosomal function proteins (0.94%), heat shock proteins (0.30%), other proteases and miscellaneous proteins (57.61%), and unknown proteins (26.00%). Significant differences were observed in the genes obtained at 0, 24, 48, 72, and 96 h during blood feeding. The differentially expressed genes include catalytic proteins that play an important role in accelerating biochemical reactions, binding activity proteins which are involved in various molecular interactions, and proteins that actively participate in multiple metabolic pathways and cellular processes. Notably, the gene expression in the midgut of D. nuttalli shows dynamic changes every 24 h throughout the blood-feeding process. This change may represent an equivalent strategy of antigenic variation for ticks, designed to protect their essential feeding function against the host's immune system. The tick antigens identified in this study may serve as promising candidates for the development of effective vaccines or as drug targets for acaricides.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"52"},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction, expression, and characterization of scFv fragment against Fasciola gigantica cathepsin L1H.","authors":"Phawiya Suksomboon, Komsil Rattanasroi, Supawadee Osotprasit, Supanan Chansap, Apichai Prachasuphap, Panadda Dhepakson, Pornanan Kueakhai, Narin Changklungmoa","doi":"10.1007/s00436-025-08499-9","DOIUrl":"https://doi.org/10.1007/s00436-025-08499-9","url":null,"abstract":"<p><p>Fasciola spp. infection is a significant zoonotic disease. Fasciola gigantica cathepsin L1H (FgCathL1H) is expressed across the life stages of Fasciola gigantica: newly excysted juvenile (NEJ), juvenile, and adult. An emerging tool for diagnosing fasciolosis in humans and cattle involves single-chain variable fragments (scFv) antibodies. These antibodies, consisting of linked variable regions of heavy chains (VHs) and light chains (VLs), retain binding specificity and affinity. This study aims to construct, express, and characterize an scFv antibody for use in a diagnostic kit for fasciolosis. The study successfully constructed and expressed recombinant scFv antibody genes derived from mouse spleen cells in Escherichia coli HB2151. Specific VH and VL fragments targeting recombinant FgCathL1H were amplified, inserted into a phagemid vector (pCANTAB5E), and transformed into E. coli TG1. Infection with the M13KO7 helper phage produced recombinant phages, and scFv clones with a high binding capacity were selected through three rounds of bio-panning. The expression of scFv proteins was induced with 1 mM IPTG, yielding antibodies detectable in the culture supernatant and periplasmic space. The indirect ELISA revealed strong binding in 10 scFv phage clones, which were sequenced and analyzed via computer-guided homology modeling and showed a similar classification to CDR1-3, consisting of VHs and VLs. The scFv DNA construct was approximately 747 bp in length. The SDS-PAGE, ELISA, and western blot confirmed the specificity of the scFv clone 1B, particularly at ~ 29 kDa. Docking studies showed epitopes on the scFv interacting with FgCathL1H. This scFv reacted specifically with F. gigantica antigens at 36 kDa (whole body (WB) of metacercaria and NEJ) and ~ 28 kDa (WB of 4-week-old juveniles and adults, and adult excretory-secretory protein (ES)). Immunolocalization showed positive staining in the cecal epithelium. Thus, scFv anti-rFgCathL1H shows promise for diagnosing fasciolosis.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"51"},"PeriodicalIF":1.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular detection of Leishmania donovani, Dirofilaria sp. \"hongkongensis,\" and Wolbachia spp. in the dog population from tribal settlements of Western Ghats, Kerala, India.","authors":"Prasanta Saini, B Sivalaxmi, H A Haritha, P A Fathima, Harish Kumar Shah, P M Ajithlal, Manju Rahi","doi":"10.1007/s00436-025-08481-5","DOIUrl":"https://doi.org/10.1007/s00436-025-08481-5","url":null,"abstract":"<p><p>Leishmaniasis and dirofilariasis are significant emerging zoonotic diseases. This study aimed to assess the prevalence of single and co-infections involving Leishmania donovani, Dirofilaria sp. \"hongkongensis\", and Wolbachia spp. among dogs from the Kani tribal settlements of Western Ghats, Kerala. In July 2023, blood samples from 75 dogs were collected and analyzed using microscopy, serology, and molecular diagnostics. Molecular analysis using kDNA-PCR and ITS1 PCR identified leishmaniasis in 39 out of 75 dog samples (52.0% [95% CI, 40.2 to 63.7], with phylogenetic analysis confirming the species as L. donovani. Additionally, 19 out of 75 dog samples (25.3% [95% CI, 16.0 to 36.7]) produced a ~ 720 bp band for nematode-specific COI amplification, which was confirmed as Dirofilaria sp. \"hongkongensis\". Among the 19 Dirofilaria-positive samples, 14 (73.7% [95% CI, 48.8 to 90.9]) tested positive for Wolbachia using the wsp primer. Among the 75 dogs screened, 12 (16% [95% CI, 08.6 to 26.3]) were co-infected with Leishmania and Dirofilaria, while 9 (12% [95% CI, 05.6 to 21.6]) were co-infected with all three parasites: L. donovani, Dirofilaria sp. \"hongkongensis\", and Wolbachia spp. The findings suggest that Kerala is gradually becoming more vulnerable to zoonoses like leishmaniasis and dirofilariasis emphasizing the need for prompt intervention and prevention measures. These results underscore the critical need for continued development of multi-pathogen detection methods, not only in regions where multiple diseases are endemic but also in areas where such diseases may emerge.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"50"},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culicoides species of Palaearctic region in Afrotropical region: comments on two recent publications on Culicoides species present in Ethiopia.","authors":"Denis Augot, Christine Millot, Leila Hadj-Henni","doi":"10.1007/s00436-025-08496-y","DOIUrl":"https://doi.org/10.1007/s00436-025-08496-y","url":null,"abstract":"<p><p>Biting midges are key vectors that can transmit different pathogens to mammals and birds. In Ethiopia, two studies showed the diversity of Culicoides species in several districts based on morphological characters. For this, the same identification key was used for Afrotropical and Palaearctic Culicoides fauna. Consequently, results are incomplete and erroneous. It is misleading to state that a universal identification key is available.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"49"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of deltamethrin resistance in Rhipicephalus microplus populations on communal farms of South Africa.","authors":"William Diymba Dzemo, Songezo Mavundela","doi":"10.1007/s00436-025-08493-1","DOIUrl":"https://doi.org/10.1007/s00436-025-08493-1","url":null,"abstract":"<p><p>This study was conducted to assess the progression of deltamethrin resistance in Rhipicephalus (B.) microplus populations over a 5-year period, from 2019 to 2023, on selected communal farms in the Eastern Cape Province, South Africa. Ticks were collected from three communal farms with a documented history of deltamethrin resistance in R. (B.) microplus populations in 2019. The sampled tick populations were tested for resistance using the adult immersion test (AIT). The data generated from the AIT indicated deltamethrin resistance, with oviposition inhibition percentages ≤ 95% at both the manufacturer's recommended dose and twice the recommended dose. These findings confirm the establishment of deltamethrin resistance in R. (B.) microplus populations on the communal farms within the KSD local municipality, following over a decade of frequent and continuous use of this acaricide. Ticks on cattle, along with their control and acaricide resistance in tick populations, pose a significant threat to livestock production on communal farms in South Africa.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"48"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemosporidian and trypanosomatid diversity in a high-latitude island ecosystem, including the first record of Zelonia in the Nearctic.","authors":"Jacqueline Savage, Jaclyn Santos, Paul R Sweet, Spencer C Galen","doi":"10.1007/s00436-025-08490-4","DOIUrl":"https://doi.org/10.1007/s00436-025-08490-4","url":null,"abstract":"<p><p>Biodiversity surveys remain a critical tool for characterizing the global species richness of parasites. In high-latitude regions of the world, characterizing parasite biodiversity is of particular importance due to the rapid rate at which the climate is changing and potentially shifting parasite distributions and abundances. We sampled a bird community on Prince of Wales Island in southern Alaska, United States, to test for the abundance and richness of haemosporidian and trypanosomatid parasites in this understudied region. We tested for parasites in 67 archived tissue samples of 18 bird species, of which five had not been previously tested for haemosporidians and 11 had not been sampled for trypanosomatids using molecular methods. We recovered two novel mitochondrial genetic lineages of haemosporidians (genera Haemoproteus and Leucocytozoon), and three novel 18S rRNA genotypes belonging to Trypanosoma of uncertain species-level affinities. Surprisingly, we also identified a trypanosomatid from the genus Zelonia, a group of monoxenous parasites of insects, from an avian tissue. While this anomalous record may have been the result of environmental contamination, it nonetheless reflects the first record of Zelonia in the entire Nearctic region.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"47"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First confirmation of the chicken eyeworm, Oxyspirura mansoni, as a causative pathogen of human cutaneous larva migrans by morphological and molecular evidence.","authors":"Pham Doanh, Hoang Hien, Bui Dung, Yukifumi Nawa","doi":"10.1007/s00436-025-08473-5","DOIUrl":"https://doi.org/10.1007/s00436-025-08473-5","url":null,"abstract":"<p><p>Human larva migrans is a zoonotic disease caused by larvae of various nematode species, with all previously confirmed pathogens originating from mammalian reservoirs. In 2020, a case series in Vietnam reported instances of cutaneous larva migrans caused by avian eyeworm larvae of the Oxyspirura genus. This nematode genus, belonging to the Thelaziidae family, includes 84 species that mainly parasitize the eyes of various bird species. They utilize different arthropod intermediate hosts, such as cockroaches, grasshoppers, and crickets, in their life cycle. Although the 18S sequences of the larvae were analyzed, the precise identification of the pathogen at the species level remains inconclusive. This study aims to identify the exact causative agent at the species level by analyzing larvae from a patient and adult eyeworms collected from chickens raised in his family using morphological and molecular methods. Molecular analysis of 18S rDNA, ITS2, and cox1 sequences revealed genetic identity between the larva from the patient and adult eyeworms from chickens, as well as with Oxyspirura mansoni from Thailand and Bangladesh. Additionally, morphological examinations further confirmed the adult chicken eyeworms as Oxyspirura mansoni. These findings confirm that O. mansoni larvae are responsible for human larva migrans, marking the first confirmation of nematode larvae from birds (chickens) as a pathogen causing an emerging neglected tropical disease in humans. Given the widespread distribution of this nematode, further research is crucial to investigate this neglected disease, not only in Vietnam but also in other regions. Understanding appropriate treatments and transmission routes is essential to prevent infections in both chickens and humans.</p>","PeriodicalId":19968,"journal":{"name":"Parasitology Research","volume":"124 5","pages":"46"},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}