Pediatric Allergy and Immunology最新文献_第8页

Effect of maternal prebiotic supplementation on human milk immunological composition: Insights from the SYMBA study. 母体补充益生元对母乳免疫成分的影响：来自 SYMBA 研究的启示。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14226

Nivedithaa Divakara, Zac Dempsey, Chitra Saraswati, Johan Garssen, Desiree Silva, Jeffrey A Keelan, Claus T Christophersen, Matthew N Cooper, Susan L Prescott, Debra J Palmer, Valerie Verhasselt, Patricia Macchiaverni

{"title":"Effect of maternal prebiotic supplementation on human milk immunological composition: Insights from the SYMBA study.","authors":"Nivedithaa Divakara, Zac Dempsey, Chitra Saraswati, Johan Garssen, Desiree Silva, Jeffrey A Keelan, Claus T Christophersen, Matthew N Cooper, Susan L Prescott, Debra J Palmer, Valerie Verhasselt, Patricia Macchiaverni","doi":"10.1111/pai.14226","DOIUrl":"10.1111/pai.14226","url":null,"abstract":"Background: Immunomodulatory proteins in human milk (HM) can shape infant immune development. However, strategies to modulate their levels are currently unknown. This study investigated whether maternal prebiotic supplementation alters the levels of immunomodulatory proteins in HM.Methods: The study was nested within the SYMBA double-blind randomized controlled trial (ACTRN12615001075572), which investigated the effects of maternal prebiotic (short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides) supplementation from <21 weeks gestation during pregnancy until 6 months postnatal during lactation on child allergic disease risk. Mother-child dyads receiving prebiotics (n = 46) or placebo (n = 54) were included in this study. We measured the levels of 24 immunomodulatory proteins in HM collected at 2, 4, and 6 months.Results: Cluster analysis showed that the overall immunomodulatory protein composition of milk samples from both groups was similar. At 2 months, HM of prebiotic-supplemented women had decreased levels of TGF-β1 and TSLP (95% CI: -17.4 [-29.68, -2.28] and -57.32 [-94.22, -4.7] respectively) and increased levels of sCD14 (95% CI: 1.81 [0.17, 3.71]), when compared to the placebo group. At 4 months, IgG1 was lower in the prebiotic group (95% CI: -1.55 [-3.55, -0.12]) compared to placebo group.Conclusion: This exploratory study shows that prebiotic consumption by lactating mothers selectively alters specific immunomodulatory proteins in HM. This finding is crucial for understanding how prebiotic dietary recommendations for pregnant and lactating women can modify the immune properties of HM and potentially influence infant health outcomes through immune support from breastfeeding.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 9","pages":"e14226"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the changing landscape of pediatric allergies in the Asia Pacific region. 驾驭亚太地区不断变化的儿科过敏症形势。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14229

Carmen Riggioni, Agnes Leung, Rachel L Peters, Phillipe Eigenmann

引用次数: 0

Editorial comment on "Six-year trend of subsequent allergic diseases following Kawasaki disease and its clinical implications: A population-based matched cohort study of 34,712 patients". 关于 "川崎病后继发过敏性疾病的六年趋势及其临床意义：对 34,712 名患者进行的基于人群的匹配队列研究"。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14248

Maria Kostara, Maria Otal-Buesa, Agnes S Y Leung, Philippe Eigenmann

引用次数: 0

Autosomal dominant TCF3 deficiency with absent B cells and a unique immunoglobulin profile. 常染色体显性 TCF3 缺乏症伴有 B 细胞缺失和独特的免疫球蛋白谱。

IF 4.4 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14246

Hanae Miyazawa,Yusuke Matsuda,Tetsujiro Shirahashi,Tomoko Toma,Taizo Wada

引用次数: 0

Vaccines and allergy: Back to the right places. 疫苗与过敏：回到正确的地方

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14236

Viviana Moschese, Davide Montin, Giorgio Ottaviano, Mayla Sgrulletti, Alessandra Beni, Giorgio Costagliola, Maria Sangerardi, Veronica Santilli, Michele Miraglia Del Giudice, Caterina Rizzo, Baldassarre Martire

引用次数: 0

Reply to Özdemir. 答复 Özdemir.

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14243

Lanye Hu, Youjin Li

引用次数: 0

Association between phthalate exposure and risk of allergic rhinitis in children: A systematic review and meta-analysis. 邻苯二甲酸盐暴露与儿童过敏性鼻炎风险之间的关系：系统回顾和荟萃分析。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14230

Yeonghun Oh, Soo-Jong Hong, Yong Joo Park, In-Hwan Baek

{"title":"Association between phthalate exposure and risk of allergic rhinitis in children: A systematic review and meta-analysis.","authors":"Yeonghun Oh, Soo-Jong Hong, Yong Joo Park, In-Hwan Baek","doi":"10.1111/pai.14230","DOIUrl":"10.1111/pai.14230","url":null,"abstract":"Phthalates are ubiquitous in diverse environments and have been linked to a myriad of detrimental health outcomes. However, the association between phthalate exposure and allergic rhinitis (AR) remains unclear. To address this knowledge gap, we conducted a systematic review and meta-analysis to comprehensively evaluate the relationship between phthalate exposure and childhood AR risk. We searched the Cumulative Index to Nursing and Allied Health Literature, Excerpta Medica Database, and PubMed to collect relevant studies and estimated pooled odds ratios (OR) and 95% confidence intervals (CI) for risk estimation. Ultimately, 18 articles, including seven cross-sectional, seven case-control, and four prospective cohort studies, were selected for our systematic review and meta-analysis. Our pooled data revealed a significant association between di-2-ethylhexyl phthalate (DEHP) exposure in children's urine and AR risk (OR = 1.188; 95% CI = 1.016-1.389). Additionally, prenatal exposure to combined phthalates and their metabolites in maternal urine was significantly associated with the risk of childhood AR (OR = 1.041; 95% CI = 1.003-1.081), although specific types of phthalates and their metabolites were not significant. Furthermore, we examined environmental phthalate exposure in household dust and found no significant association with AR risk (OR = 1.021; 95% CI = 0.980-1.065). Our findings underscore the potential hazardous effects of phthalates on childhood AR and offer valuable insights into its pathogenesis and prevention.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 9","pages":"e14230"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern: The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial. 表达关切：服用褪黑素对特应性皮炎患儿疾病严重程度和睡眠质量的影响：随机、双盲、安慰剂对照试验。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14224

引用次数: 0

Reply to Ching-Heng Tsai and Lien-Chung Wei. 答复 Ching-Heng Tsai 和 Lien-Chung Wei。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14249

Josh Lawson, Minyoung Kim, Parisa Jandaghi, Donna Goodridge, Lloyd Balbuena, Don Cockcroft, Darryl Adamko, Ulfat Khanam

引用次数: 0

Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. 孕早期体重指数、孕产妇体重增加与儿童哮喘和过敏性疾病。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-09-01 DOI: 10.1111/pai.14240

Vincent Ojwang', Bright I Nwaru, Takkinen Hanna-Mari, Tapanainen Heli, Minna Kaila, Suvi Ahonen, Onni Niemelä, Anna-Maija Haapala, Jorma Ilonen, Jorma Toppari, Heikki Hyöty, Riitta Veijola, Mikael Knip, Suvi M Virtanen

{"title":"Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children.","authors":"Vincent Ojwang', Bright I Nwaru, Takkinen Hanna-Mari, Tapanainen Heli, Minna Kaila, Suvi Ahonen, Onni Niemelä, Anna-Maija Haapala, Jorma Ilonen, Jorma Toppari, Heikki Hyöty, Riitta Veijola, Mikael Knip, Suvi M Virtanen","doi":"10.1111/pai.14240","DOIUrl":"https://doi.org/10.1111/pai.14240","url":null,"abstract":"Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear.Methods: We analyzed data from 3176 mother-child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children.Results: Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42-0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13-1.96]) by 5 years of age.Conclusion: Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 9","pages":"e14240"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0