IF 7.4 1区医学

PAIN® Pub Date : 2025-05-06 DOI: 10.1097/j.pain.0000000000003614

Ying Xiong,Wen Shao,Juan Wang,Shaolin Yang,Wenzhen Zhu,Qiang Zhang

{"title":"Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides.","authors":"Ying Xiong,Wen Shao,Juan Wang,Shaolin Yang,Wenzhen Zhu,Qiang Zhang","doi":"10.1097/j.pain.0000000000003614","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003614","url":null,"abstract":"Diffusion tensor imaging can detect brain white matter changes in classical trigeminal neuralgia (TN). However, it lacks specificity for individual tissue microstructural features, such as neurite density, orientation dispersions, and extracellular edema. Neurite orientation dispersion and density imaging (NODDI), a novel diffusion magnetic resonance imaging (MRI) technique, can provide these distinct indices. We characterized brain microstructural alterations in patients with unilateral TN using NODDI and compared the difference between left- and right-side TN (LTN and RTN, respectively). Diffusion-weighted imaging was performed on 39 patients with LTN, 37 patients with RTN, and 37 healthy controls. Neurite orientation dispersion and density imaging-related indices, including the intracellular volume fraction (Vic), orientation dispersion index (ODI), and isotropic volume fraction (Fiso), were estimated and compared using tract-based spatial statistics and voxel-based region-of-interest analysis. The LTN and RTN groups exhibited microstructural abnormalities in white and gray matter as measured by decreased fractional anisotropy and Vic and elevated Fiso, respectively. These alterations were associated with clinical features and were mainly located in the frontal lobe, corona radiata, internal capsule, and thalamus. The angular variation of neurites, characterized by ODI, exhibited no significant changes between TN and control groups. Patients with classical TN of either side exhibited reduced Vic and increased Fiso, which indicated decreased density of axons and dendrites and neuroinflammatory edema in bilateral hemispheres. Neurite orientation dispersion and density imaging is a useful technique for in vivo diffusion MRI of white and gray matter in the brain, which provides additional metrics and information closely related to the tissue microstructure that merits further study of TN pathogenesis.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter microstructural associations with pain experiences in a large community sample of youth. 在大量社区青年样本中，白质微观结构与疼痛经验的关联。

IF 7.4 1区医学

PAIN® Pub Date : 2025-05-02 DOI: 10.1097/j.pain.0000000000003580

Scott A Jones,Carmen I Bango,Sara Shao,Dani Y Del Rubin,Arturo Lopez Flores,Bonnie J Nagel,Amy L Holley,Anna C Wilson

{"title":"White matter microstructural associations with pain experiences in a large community sample of youth.","authors":"Scott A Jones,Carmen I Bango,Sara Shao,Dani Y Del Rubin,Arturo Lopez Flores,Bonnie J Nagel,Amy L Holley,Anna C Wilson","doi":"10.1097/j.pain.0000000000003580","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003580","url":null,"abstract":"Pain experiences in adolescence are increasing and represent a major public health concern. However, little is known about the neurobiological phenotype of pain experiences in adolescents, particularly outside of a clinical setting. A better neurobiological understanding of pain experiences in community youth may shed light on potential vulnerabilities present before clinical diagnoses of chronic pain. This study utilized an exploratory region-of-interest approach, in a large community sample (n = 7332) of youth (ages 11-12), to examine the association between white matter microstructure, fractional anisotropy (FA) and mean diffusivity (MD), and pain experiences. Bayesian multilevel modeling was used to explore group differences (between those reporting past-month pain and those who did not), and continuous associations between pain experiences (average pain intensity, worst pain intensity, and pain-related limitations) and FA and MD. Sex differences in these effects were also explored. Analyses revealed widespread associations between pain-related limitations and lower FA and greater MD in male but not female youth. Furthermore, average pain intensity was associated with greater superior corticostriate and superior longitudinal fasciculus MD in all youth, and worst pain intensity was associated with lower inferior fronto-occipital fasciculus FA in male youth. There were no group differences in FA or MD between those with or without past-month pain. These findings suggest that white matter microstructural alterations in youth may be more related to the severity of the pain experience than to the presence or absence of pain itself, with male youth showing stronger neurobiological associations with pain-related outcomes.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project). 初级理疗护理中肌肉骨骼疼痛患者管理中的个性化决策支持：分组随机对照试验（SupportPrim 项目）。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2024-10-15 DOI: 10.1097/j.pain.0000000000003456

Fredrik Granviken, Ingebrigt Meisingset, Kerstin Bach, Anita Formo Bones, Melanie Rae Simpson, Jonathan C Hill, Danielle A van der Windt, Ottar Vasseljen

{"title":"Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project).","authors":"Fredrik Granviken, Ingebrigt Meisingset, Kerstin Bach, Anita Formo Bones, Melanie Rae Simpson, Jonathan C Hill, Danielle A van der Windt, Ottar Vasseljen","doi":"10.1097/j.pain.0000000000003456","DOIUrl":"10.1097/j.pain.0000000000003456","url":null,"abstract":"Abstract: We developed the SupportPrim PT clinical decision support system (CDSS) using the artificial intelligence method case-based reasoning to support personalised musculoskeletal pain management. The aim of this study was to evaluate the effectiveness of the CDSS for patients in physiotherapy practice. A cluster randomised controlled trial was conducted in primary care in Norway. We randomised 44 physiotherapists to (1) use the CDSS alongside usual care or (2) usual care alone. The CDSS provided personalised treatment recommendations based on a case base of 105 patients with positive outcomes. During the trial, the case-based reasoning system did not have an active learning capability; therefore, the case base size remained the same throughout the study. We included 724 patients presenting with neck, shoulder, back, hip, knee, or complex pain (CDSS; n = 358, usual care; n = 366). Primary outcomes were assessed with multilevel logistic regression using self-reported Global Perceived Effect (GPE) and Patient-Specific Functional Scale (PSFS). At 12 weeks, 165/298 (55.4%) patients in the intervention group and 176/321 (54.8%) in the control group reported improvement in GPE (odds ratio, 1.18; confidence interval, 0.50-2.78). For PSFS, 173/290 (59.7%) patients in the intervention group and 218/310 (70.3%) in the control group reported clinically important improvement in function (odds ratio, 0.41; confidence interval, 0.20-0.85). No significant between-group differences were found for GPE. For PSFS, there was a significant difference favouring the control group, but this was less than the prespecified difference of 15%. We identified several study limitations and recommend further investigation into artificial intelligence applications for managing musculoskeletal pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"1167-1178"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents: erratum. 中枢神经系统鞘氨醇-1-磷酸受体亚型1的激活有助于啮齿动物吗啡诱导的痛觉过敏和抗伤性耐受：勘误。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 DOI: 10.1097/j.pain.0000000000003630

Timothy M Doyle, Kali Janes, Zhoumou Chen, Peter M Grace, Emanuela Esposito, Salvatore Cuzzocrea, Tally M Largent-Milnes, William L Neumann, Linda R Watkins, Sarah Spiegel, Todd W Vanderah, Daniela Salvemini

引用次数: 0

Pharmacologically enabling the degradation of Na V 1.8 channels to reduce neuropathic pain. 通过药理作用使 NaV1.8 通道降解，从而减轻神经性疼痛。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2024-11-08 DOI: 10.1097/j.pain.0000000000003470

Molly K Martin, Raider Rodriguez, Giselle Guerrero, Garrett D Sheehan, Rasheen Powell, Amanda H Klein, Arin Bhattacharjee

{"title":"Pharmacologically enabling the degradation of Na V 1.8 channels to reduce neuropathic pain.","authors":"Molly K Martin, Raider Rodriguez, Giselle Guerrero, Garrett D Sheehan, Rasheen Powell, Amanda H Klein, Arin Bhattacharjee","doi":"10.1097/j.pain.0000000000003470","DOIUrl":"10.1097/j.pain.0000000000003470","url":null,"abstract":"Abstract: In phase II clinical trials, Na V 1.8 channels were identified as viable targets to treat acute pain. Results were modest, however, and Na V 1.8 pore blockers must be given systemically, potentially leading to adverse effects, especially during prolonged use. A local, long-lasting approach is desirable, yet local anesthetics are neither specific nor long-lasting. In lieu of a pore blocker approach, we show a pharmacological method targeting the scaffolding and degradation of Na V 1.8 channels, which attenuated neuropathic pain behavior in mice. Na V 1.8 channels interact with the WW domain-containing scaffold protein called Magi-1. WW domains are typically found in ubiquitin ligases, and Na V 1.8 channels are susceptible to degradation by ubiquitin ligases. Here, we show Na V 1.8 and MAGI-1 colocalized in human tissues. We demonstrate that a lipidated peptide derived from the Na V 1.8 WW binding domain, at sub-micromolar concentrations, inhibited rodent dorsal root ganglion neuronal firing. The peptide reduced Na V 1.8 channel immunoreactivity and tetrodotoxin-resistant currents in human dorsal root ganglion neurons. We found that the lipidated peptide attenuated neuropathic pain behaviors in mice for multiple weeks after a single injection. Our results reveal that the Na V 1.8-targeted lipidated peptide provides local and sustained analgesia, serving as a viable alternative to Na V 1.8 pore blockers.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"1191-1203"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal lumbar Urocortin 3-expressing neurons are associated with both scratching and Compound 48/80-induced sensations. 脊髓腰部表达 Urocortin 3 的神经元与搔抓和 48/80 号化合物诱发的感觉有关。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2024-10-15 DOI: 10.1097/j.pain.0000000000003435

Marina C M Franck, Hannah M Weman, Mikaela M Ceder, Aikeremu Ahemaiti, Katharina Henriksson, Erica Bengtsson, Kajsa A Magnusson, Harmen K Koning, Caroline Öhman-Mägi, Malin C Lagerström

{"title":"Spinal lumbar Urocortin 3-expressing neurons are associated with both scratching and Compound 48/80-induced sensations.","authors":"Marina C M Franck, Hannah M Weman, Mikaela M Ceder, Aikeremu Ahemaiti, Katharina Henriksson, Erica Bengtsson, Kajsa A Magnusson, Harmen K Koning, Caroline Öhman-Mägi, Malin C Lagerström","doi":"10.1097/j.pain.0000000000003435","DOIUrl":"10.1097/j.pain.0000000000003435","url":null,"abstract":"Abstract: Urocortin 3 is a neuropeptide that belongs to the corticotropin-releasing hormone family and is involved in mechanosensation and stress regulation. In this study, we show that Urocortin 3 marks a population of excitatory neurons in the mouse spinal cord, divided into 2 nonoverlapping subpopulations expressing protein kinase C gamma or calretinin/calbindin 2, populations previously associated with mechanosensation. Electrophysiological experiments demonstrated that lumbar spinal Urocortin 3 neurons receive both glycinergic and GABAergic local tonic inhibition, and monosynaptic inputs from both Aβ and C fibers, which could be confirmed by retrograde trans-synaptic rabies tracing. Furthermore, fos analyses showed that subpopulations of lumbar Urocortin 3 neurons are activated by artificial scratching or Compound 48/80-induced sensations. Chemogenetic activation of lumbar Urocortin 3-Cre neurons evoked a targeted biting/licking behavior towards the corresponding dermatome and chemogenetic inhibition decreased Compound 48/80-induced behavior. Hence, spinal lumbar Urocortin 3 neurons represent a mechanically associated population with roles in both scratching and Compound 48/80-induced sensations.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"1070-1087"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A call to action to integrate best practice assessment of sexual orientation and gender identity in pain research and clinical care. 呼吁采取行动，在疼痛研究和临床护理中纳入对性取向和性别认同的最佳实践评估。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2024-12-13 DOI: 10.1097/j.pain.0000000000003481

Lauren E Harrison, Katelynn E Boerner, William Black, Sarah Nelson, Melissa Santos, Laura E Simons, Emily O Wakefield, Jacqueline N Warner, Anna C Wilson, Anna Zajacova

引用次数: 0

Predicting chronic post-traumatic head and neck pain: the role of bedside parameters. 预测慢性创伤后头颈部疼痛：床边参数的作用。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2024-09-27 DOI: 10.1097/j.pain.0000000000003431

Roni Ramon-Gonen, Yelena Granovsky, Shahar Shelly

{"title":"Predicting chronic post-traumatic head and neck pain: the role of bedside parameters.","authors":"Roni Ramon-Gonen, Yelena Granovsky, Shahar Shelly","doi":"10.1097/j.pain.0000000000003431","DOIUrl":"10.1097/j.pain.0000000000003431","url":null,"abstract":"Abstract: Traumatic brain injury (TBI) annually impacts 69 million individuals worldwide. Mild TBI constitutes approximately 90% of all TBIs. Chronic pain post-mTBI occurs in 29% to 58% of patients. This study aims to introduce a predictive model for chronic pain development in individuals diagnosed with mild traumatic brain injury (mTBI) immediately postinjury. We included individuals who had sustained mTBI in motor vehicle accident (MVA). All patients had initial assessments within the first 72 hours (representing the subacute period) after the injury and performed follow-ups for 1 year. Machine learning model was applied to the integrated measures of clinical pain, pain-related psychological parameters, mTBI clinical signs, and sociodemographic information. This study included 203 patients experiencing acute head or neck pain attributable to mTBI post-MVA. We categorized these patients into 2 groups: patients who progressed to develop chronic head or neck pain (n = 89, 43.8%) and patients who recovered (low/mild pain) (n = 114, 56.2%). Severity of the subacute neck pain, number of painful body areas, and education years were identified as the most significant factors predicting chronic pain. The optimized predictive model demonstrated high efficacy, with an accuracy of 83%, a sensitivity of 92%, and an area under the receiver operating characteristic curve of 0.8. Our findings indicate feasibility in predicting chronic post-MVA pain within the critical 72-hour window postinjury using simple bedside metrics. This approach offers a promising avenue for the early detection of individuals at increased risk for chronic pain, enabling the implementation of targeted early interventions.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"1050-1059"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ronald Dubner: pioneer in pain research, founding member of the International Association for the Study of Pain, and former Editor-in-Chief of PAIN. Ronald Dubner：疼痛研究的先驱，国际疼痛研究协会的创始成员，pain杂志的前主编。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.1097/j.pain.0000000000003548

Barry J Sessle

{"title":"Ronald Dubner: pioneer in pain research, founding member of the International Association for the Study of Pain, and former Editor-in-Chief of PAIN.","authors":"Barry J Sessle","doi":"10.1097/j.pain.0000000000003548","DOIUrl":"10.1097/j.pain.0000000000003548","url":null,"abstract":"Abstract: Ronald Dubner (1934-2023) was a \"giant\" in the field of pain. His more than 5 decades of research programs at the US National Institutes of Health and the University of Maryland resulted in important discoveries that considerably advanced our understanding of the neural and nonneural processes underlying acute and chronic pain and their behavioral and clinical correlates. Through his multidisciplinary and translational research approaches, his novel findings as well as his training as a dentist and neuroscientist, Ron was able to bring to the attention of the pain field the clinical implications of these findings and thereby positively influence the clinical management of pain. Also especially notable were his mentorship of numerous pain scientists and clinicians, many of whom went on to develop their own research programs that significantly benefitted the pain field. Ron also played leadership roles in the International Association for the Study of Pain and other scientific organizations, and his editorial positions for the PAIN journal significantly and positively influenced the journal's stature and its impact on the pain field. This article, which is part of the journal's series this year that is celebrating its 50th anniversary, highlights Ron's research and related activities during his years at the National Institutes of Health and University of Maryland and includes comments that Ron himself made about these activities. The article also considers his background and personal attributes that underpinned the many contributions that Ron Dubner made to the pain field, including those to the International Association for the Study of Pain and PAIN .","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"977-987"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood maltreatment and chronic "all over" body pain in adulthood: a counterfactual analysis using UK Biobank. 童年虐待与成年后 "全身 "慢性疼痛：利用英国生物数据库进行的反事实分析。

IF 5.9 1区医学

PAIN® Pub Date : 2025-05-01 Epub Date: 2024-11-15 DOI: 10.1097/j.pain.0000000000003457

Kate A Timmins, Tim G Hales, Gary J Macfarlane

{"title":"Childhood maltreatment and chronic \"all over\" body pain in adulthood: a counterfactual analysis using UK Biobank.","authors":"Kate A Timmins, Tim G Hales, Gary J Macfarlane","doi":"10.1097/j.pain.0000000000003457","DOIUrl":"10.1097/j.pain.0000000000003457","url":null,"abstract":"Abstract: Evidence linking adverse childhood experiences and chronic pain in adulthood is largely cross-sectional, potentially subject to recall bias and does not allow exploration of mediating pathways. We analysed a large population-based cohort (UK Biobank) using a causal framework, to determine if childhood maltreatment is related to chronic \"all over\" body pain in adulthood. We used doubly robust estimation with inverse probability weights to estimate the difference in risk of chronic pain \"all over\" between those exposed/not exposed to childhood maltreatment (abuse or neglect). In addition, we looked at interaction with adult stressful life events and examined mediation using inverse odds weighting in a generalized linear model. Using cases with complete data (n = 118,347), the risk of chronic \"all over\" body pain was higher in the exposed (6.3%, 95% confidence interval [CI] 6.0%-6.5%) than in the unexposed (4.0%; 95% CI 3.8%-4.2%). This difference remained in analyses stratified by sex. Conversely, when analyses were repeated with a negative control exposure, childhood sunburn, risk differences were 0.8% in women (95% CI 0.3%-1.3%) and 0.5% in men (95% CI 0.1%-0.9%). Childhood maltreatment and adult life events had similar effects, and there was a supra-additive risk (1.2%; 95% CI 0.6-1.7) when experiencing both. In mediation analyses, the total effect was a relative risk of 1.57 (95% CI 1.49-1.66), while the estimated indirect effect via all mediators was relative risk 1.16 (95% CI 1.14-1.18). Reducing childhood maltreatment would likely prevent cases of chronic widespread pain in adulthood. Stressful adult events and mediators may offer opportunities for intervention.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"1204-1211"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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