Parkinson's Disease最新文献

{"title":"Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson's Disease.","authors":"Wei Quan,&nbsp;Jia Li,&nbsp;Li Liu,&nbsp;Qinghui Zhang,&nbsp;Yidan Qin,&nbsp;Xiaochen Pei,&nbsp;Jiajun Chen","doi":"10.1155/2021/9919129","DOIUrl":"https://doi.org/10.1155/2021/9919129","url":null,"abstract":"<p><p>This study aimed to explore the N6-methyladenosine (m6A) modification genes involved in the pathogenesis of Parkinson's disease (PD) through data analysis of the two data sets GSE120306 and GSE22491 in the GEO database and further explore its influence on cell phenotype in PD. We analyzed the differentially expressed genes and function enrichment analysis of the two sets of data and found that the expression of the m6A-modification gene <i>HNRNPC</i> was significantly downregulated in the PD group, and it played an important role in DNA metabolism, RNA metabolism, and RNA processing and may be involved in PD. Then, we constructed the <i>HNRNPC</i> differential expression cell line to study the role of this gene in the pathogenesis of PD. The results showed that overexpression of <i>HNRNPC</i> can promote the proliferation of PC12 cells, inhibit their apoptosis, and inhibit the expression of inflammatory factors IFN-<i>β</i>, IL-6, and TNF-<i>α</i>, suggesting that <i>HNRNPC</i> may cause PD by inhibiting the proliferation of dopaminergic nerve cells, promoting their apoptosis, and causing immune inflammation. Our study also has certain limitations. For example, the data of the experimental group and the validation group come from different cell types, and the data of the experimental group involve individuals with G2019S <i>LRRK2</i> mutations. In addition, due to the low expression of <i>HNRNPC</i> in PC12 cells, we used the method of overexpressing this gene to study its function. All these factors may cause our conclusions to be biased. Therefore, more research is still needed to corroborate it in the future.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"9919129"},"PeriodicalIF":3.2,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Dopaminergic Denervation and the Progression of Autonomic Dysfunctions in Different Clinical Subtypes of Parkinson's Disease.","authors":"Eun Hye Jeong,&nbsp;Mun Kyung Sunwoo,&nbsp;Sung Wook Hyung,&nbsp;Sun-Ku Han,&nbsp;Jae Yong Lee","doi":"10.1155/2021/2268651","DOIUrl":"https://doi.org/10.1155/2021/2268651","url":null,"abstract":"<p><strong>Background: </strong>Autonomic dysfunctions occur in the early stage of Parkinson's disease (PD) and impact the quality of life during the progression of the disease. In this study, we evaluated the serial progression of autonomic dysfunctions between different subtypes of a prospective PD cohort.</p><p><strong>Materials and methods: </strong>From the Parkinson's Progression Markers Initiative (PPMI) database, 325 PD patients (age: 61.2 ± 9.7, M : F = 215 : 110) were enrolled. Patients were subgrouped into tremor-dominant (TD), indeterminate, and postural instability and gait disorder (PIGD) subtypes. The progression of autonomic dysfunctions and dopaminergic denervation from I-123 FP-CIT SPECT images of each group were analyzed and compared at baseline, 12 months, 24 months, and 48 months of follow-up periods.</p><p><strong>Results: </strong>The SCOPA-AUT score of the indeterminate subtype was significantly higher than that of the TD subtype (<i>P</i> < 0.05) at baseline and was significantly higher than that of both TD and PIGD subtypes (<i>P</i> < 0.05) at 48 months. The indeterminate subtype had the most significant correlation between the aggravation of dopaminergic denervation in I-123 FP-CIT SPECT images and the increase of SCOPA-AUT scores during 48 months of follow-up (<i>r</i> = 0.56, <i>P</i> < 0.01).</p><p><strong>Conclusions: </strong>Autonomic dysfunctions were most severe in the indeterminate subtype throughout the 48 months of the follow-up period, with a significant correlation with dopaminergic denervation. We suggest a positive relationship between dopaminergic denervation and autonomic dysfunctions of the indeterminate subtype, beginning from the early stage of PD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"2268651"},"PeriodicalIF":3.2,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39695019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of <i>α</i>-Synuclein Evolvability for Autosomal Recessive Parkinson's Disease.","authors":"Jianshe Wei,&nbsp;Gilbert Ho,&nbsp;Yoshiki Takamatsu,&nbsp;Eliezer Masliah,&nbsp;Makoto Hashimoto","doi":"10.1155/2021/6318067","DOIUrl":"https://doi.org/10.1155/2021/6318067","url":null,"abstract":"<p><p>The majority of Parkinson's disease (PD) is sporadic in elderly and is characterized by <i>α</i>-synuclein (<i>α</i>S) aggregation and other alterations involving mitochondria, ubiquitin-proteasome, and autophagy. The remaining are familial PD associated with gene mutations of either autosomal dominant or recessive inheritances. However, the former ones are similar to sporadic PD, and the latter ones are accompanied by impaired mitophagy during the reproductive stage. Since no radical therapies are available for PD, the objective of this paper is to discuss a mechanistic role for amyloidogenic evolvability, a putative physiological function of <i>α</i>S, among PD subtypes, and the potential relevance to therapy. Presumably, <i>α</i>S evolvability might benefit familial PD due to autosomal dominant genes and also sporadic PD during reproduction, which may manifest as neurodegenerative diseases through antagonistic pleiotropy mechanism in aging. Indeed, there are some reports describing that <i>α</i>S prevents apoptosis and mitochondrial alteration under the oxidative stress conditions, notwithstanding myriads of papers on the neuropathology of <i>α</i>S. Importantly, <i>β</i>-synuclein (<i>β</i>S), the nonamyloidogenic homologue of <i>α</i>S, might buffer against evolvability of <i>α</i>S protofibrils associated with neurotoxicity. Finally, it is intriguing to predict that increased <i>α</i>S evolvability through suppression of <i>β</i>S expression might protect against autosomal recessive PD. Collectively, further studies are warranted to better understand <i>α</i>S evolvability in PD pathogenesis, leading to rational therapy development.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"6318067"},"PeriodicalIF":3.2,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39776290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Patients with Parkinson's Disease in Intensive Care Units: A Cohort Study.","authors":"Álvaro Réa-Neto,&nbsp;Bruna C Dal Vesco,&nbsp;Rafaella S Bernardelli,&nbsp;Aline M Kametani,&nbsp;Mirella C Oliveira,&nbsp;Hélio A G Teive","doi":"10.1155/2021/2948323","DOIUrl":"https://doi.org/10.1155/2021/2948323","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease affects approximately 1% of the worldwide population older than 60 years. This number is estimated to double by 2030, increasing the global burden of the disease. Patients with Parkinson's disease are hospitalized 1.5 times more frequently and for longer periods than those without the disease, increasing health-related costs.</p><p><strong>Objective: </strong>To compare the characteristics and outcome of patients with and without Parkinson's disease admitted to intensive care units (ICUs).</p><p><strong>Methods: </strong>Historical cohort study of ICU admissions in a Brazilian city over 18 years. All patients with Parkinson's disease identified were matched for age, sex, year, and place of hospitalization with patients without the disease randomly selected from the same database.</p><p><strong>Results: </strong>The study included 231 patients with Parkinson's disease (PD group) and 462 controls without the disease (NPD group). Compared with patients in the NPD group, those in the PD group were more frequently admitted with lower level of consciousness and increased APACHE II severity score but required less frequently vasoactive drugs. In total, 42.4% of the patients in the PD group were admitted to the ICUs due to sepsis or trauma. Although these patients had longer hospital stay, the mortality rates were comparable between groups. Parkinson's disease was not associated with mortality, even when controlled for associated factors of disease severity.</p><p><strong>Conclusion: </strong>Although patients with Parkinson's disease were admitted with higher severity scores and remained in the ICU for a longer time, their mortality rate was not higher than that in patients without the disease.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"2948323"},"PeriodicalIF":3.2,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39624198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pareidolia in Parkinson's Disease and Multiple System Atrophy.","authors":"Kentaro Kurumada,&nbsp;Atsuhiko Sugiyama,&nbsp;Shigeki Hirano,&nbsp;Tatsuya Yamamoto,&nbsp;Yoshitaka Yamanaka,&nbsp;Nobuyuki Araki,&nbsp;Masatsugu Yakiyama,&nbsp;Miki Yoshitake,&nbsp;Satoshi Kuwabara","doi":"10.1155/2021/2704755","DOIUrl":"https://doi.org/10.1155/2021/2704755","url":null,"abstract":"<p><p>Pareidolia is a visual illusion of meaningful objects that arise from ambiguous forms embedded in visual scenes. Previous studies showed that pareidolias are frequently observed in patients with Parkinson's disease (PD) as well as dementia with Lewy bodies. However, whether pareidolias are useful for differentiating PD from other neurodegenerative parkinsonism disorders including multiple system atrophy (MSA) is unclear. The noise pareidolia test (NPT) was performed in 40 and 48 patients with PD and MSA, respectively. A receiver operating characteristic (ROC) curve analysis was used to evaluate sensitivity and specificity. Results of neuropsychological tests were also compared between patients with PD with and without pareidolias. Visual hallucinations were present in none of the subjects. Pareidolic response in the NPT was observed in 47.5% and 18.8% of patients with PD and MSA, respectively. The number of pareidolic responses in patients with PD was significantly larger compared with patients with MSA (<i>P</i>=0.001). ROC curve analyses showed the sensitivity and specificity at 33% and 98%, respectively. Among patients with PD, those with pareidolias demonstrated higher State-Trait Anxiety Inventory-state (<i>P</i>=0.044) and State-Trait Anxiety Inventory-trait (<i>P</i>=0.044) than those without pareidolias. Pareidolias can be found in patients with PD without visual hallucinations, and the pareidolia test may be a highly specific test for differentiating PD from MSA. Thus, anxiety may be associated with pareidolias in patients with PD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"2704755"},"PeriodicalIF":3.2,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effects of Estradiol plus Lithium Chloride via Anti-Apoptosis and Neurogenesis Pathway in <i>In Vitro</i> and <i>In Vivo</i> Parkinson's Disease Models.","authors":"Yung-Shih Lee,&nbsp;Chien-Wei Feng,&nbsp;Mei-Yu Peng,&nbsp;Te-Fu Chan,&nbsp;Yu-Chieh Chen","doi":"10.1155/2021/3064892","DOIUrl":"https://doi.org/10.1155/2021/3064892","url":null,"abstract":"<p><p>Few pharmaceutical agents for slowing Parkinson's disease (PD) progression existed, especially for perimenopause females. The current general medications are mostly hormone replacement therapy and may have some side effects. Therefore, there is an urgent need for a novel treatment for PD. This study examined the possibility of estradiol plus lithium chloride (LiCl), one of the metal halides used as an alternative to salt. We showed that the combination of LiCl and estradiol could enhance neurogenesis proteins GAP-43 and N-myc in the human neuronal-like cells. We also further confirmed the neurogenesis activity in zebrafish. LiCl and LiCl plus estradiol could enhance 6-OHDA-induced upregulation of TGase-2b and Rho A mRNA expression. Besides, LiCl plus estradiol showed a synergic effect in anti-apoptotic activity. LiCl plus estradiol protected SH-SY5Y cells and zebrafish against 6-OHDA-induced damage on neurons than LiCl or estradiol alone groups via p-P38, p-Akt, Bcl-2, and caspase-3 cascade. The potential for developing this combination as a candidate treatment for PD is discussed.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"3064892"},"PeriodicalIF":3.2,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39579796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic Changes in Brain Hemodynamics in Patients with Parkinson's Disease and Risk Factors for Cerebrovascular Disease: A Pilot Study.","authors":"Rodrigo Tavares Brisson,&nbsp;Rita de Cássia Leite Fernandes,&nbsp;Josevânia Fulgêncio de Lima Arruda,&nbsp;Liene Duarte Silva,&nbsp;Marco Antônio Sales Dantas de Lima,&nbsp;Ana Lucia Zuma Rosso","doi":"10.1155/2021/1713496","DOIUrl":"https://doi.org/10.1155/2021/1713496","url":null,"abstract":"<p><p>Recent epidemiological studies have revealed a correlation between atypical features and worse functional outcomes in Parkinson's disease (PD) patients with cerebrovascular disease (CVD). We aimed to evaluate the brain hemodynamics of PD patients with risk factors for CVD using Doppler ultrasonography. In this prospective pilot study, we randomly included 27 outpatients diagnosed with PD. Transcranial color-coded sonography (TCCS) examinations were performed, obtaining measurements of middle cerebral artery mean flow velocities (Vm), the resistance index (RI), and the pulsatility index (PI). The breath-holding index (BHI) was used to assess cerebrovascular reactivity (cVR). Standardized functional scales (UPDRS III, Hoehn & Yahr scale, and MoCA) were administered. The patients were divided into two groups: those with two or more vascular risk factors (PDvasc) and those with fewer than two vascular risk factors (PDnvasc). Patients in the PDvasc group showed higher PI (1.00 vs. 0.85; <i>p</i>=0.020), RI (0.59 vs. 0.5; <i>p</i>=0.05), H&Y mean (2.4 vs. 1.4; <i>p</i>=0.036), higher frequency of altered cVR (90.9% vs. 25.0%; <i>p</i>=0.001), and lower BHI (0.46 vs. 1.01; <i>p</i>=0.027). We also divided the patients in other two groups: one with patients with classical and another with akinetic-rigid PD clinical type. Patients with the akinetic-rigid type of PD had significantly higher RI (0.60 vs. 0.51; <i>p</i>=0.03), PI (0.99 vs. 0.77; <i>p</i>=0.03), higher frequency of altered cVR (80% vs. 35%; <i>p</i>=0.02), and lower BHI (0.48 vs. 0.96; <i>p</i>=0.05) than patients with classic-type PD. We concluded that TCCS displays impaired cerebrovascular reactivity and a more severe disease pattern in Parkinsonian patients with two or more risk factors for CVD and in the akinetic-rigid type. Doppler ultrasonography may be a useful tool in a clinical setting to investigate PD patients.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"1713496"},"PeriodicalIF":3.2,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39520889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current State of Parkinsonism in West Africa: A Systematic Review.","authors":"Jude T Quarshie,&nbsp;Esther N Mensah,&nbsp;Osbourne Quaye,&nbsp;Anastasia R Aikins","doi":"10.1155/2021/7479423","DOIUrl":"https://doi.org/10.1155/2021/7479423","url":null,"abstract":"Parkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism. However, there is not enough data on the prevalence, symptoms, and management of the disorder in West African patients. This systematic review examines the current state of parkinsonism in West Africa by discussing its epidemiology, symptomatology, and treatment. We searched PubMed, BioMed Central, and AJOL databases from January 2000 to December 2020 for studies on parkinsonism conducted in West African countries. We included 32 studies in this review: 23 from Nigeria, 5 from Ghana, and 1 each from Benin, Mali, Niger, and Senegal. Out of the 32 reviewed studies, 11 focused on the prevalence of parkinsonism, 4 examined the genetics of Parkinson's disease (PD), and 17 described the symptomatology and therapy of parkinsonism. The prevalence of parkinsonism in West Africa ranges from 6.0% to 8.3% of neurologic admissions/consultations. The estimated crude prevalence of PD in West Africa varies from 15 to 572 per 100,000 people. Thus far, no pathogenic genetic variants have been associated with PD in the region. Levodopa is frequently used singly or in combination with other medications to manage parkinsonian symptoms, which is consistent with reports from other African regions. Most of the reviewed studies focused only on PD, limiting assessment of other forms of parkinsonism. Almost all the prevalence studies were hospital-based and monocentric, making it impossible to accurately estimate the true prevalence of parkinsonism in West Africa. Larger community-based prevalence studies are recommended to enable accurate quantification of disease burden. Future genetic investigations should consider a wider array of gene mutations associated with parkinsonism. Moreover, public health surveillance strategies should be established to monitor the epidemiology of the disorder.","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"7479423"},"PeriodicalIF":3.2,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39505601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Potential Core Genes in Parkinson's Disease Using Bioinformatics Analysis.","authors":"Wei Quan,&nbsp;Jia Li,&nbsp;Xiya Jin,&nbsp;Li Liu,&nbsp;Qinghui Zhang,&nbsp;Yidan Qin,&nbsp;Xiaochen Pei,&nbsp;Jiajun Chen","doi":"10.1155/2021/1690341","DOIUrl":"https://doi.org/10.1155/2021/1690341","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore new core genes related to the occurrence of Parkinson's disease (PD) and core genes that can lead to the progression of PD.</p><p><strong>Methods: </strong>The expression profile data of GSE42966, which contained six substantia nigra tissues isolated from normal individuals and nine substantia nigra tissues isolated from patients with PD, were obtained from Gene Expression Omnibus. Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis and protein-protein interaction (PPI) network construction. We then identified 10 hub genes and analyzed their expression in different Braak stages.</p><p><strong>Results: </strong>A total of 773 DEGs were identified that were significantly enriched in metabolic pathways. Ten hub genes were identified through the PPI network, namely, <i>GNG3</i>, <i>MAPK1</i>, <i>FPR1</i>, <i>ATP5B</i>, <i>GNG2</i>, <i>PRKACA</i>, <i>HRAS</i>, <i>HSPA8</i>, <i>PSAP</i>, and <i>GABBR2</i>. The expression of <i>HRAS</i> was different in patients with PD with Braak stages 3 and 4.</p><p><strong>Conclusion: </strong>These 10 hub genes and the metabolic pathways they are enriched in may be involved in the pathogenesis of PD. <i>HRAS</i> may have potential value in predicting the progression of PD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"1690341"},"PeriodicalIF":3.2,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39466061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson's Disease.","authors":"Bei Luo,&nbsp;Yue Lu,&nbsp;Chang Qiu,&nbsp;Wenwen Dong,&nbsp;Chen Xue,&nbsp;Dongming Liu,&nbsp;Li Zhang,&nbsp;Weiguo Liu,&nbsp;Wenbin Zhang","doi":"10.1155/2021/2711365","DOIUrl":"https://doi.org/10.1155/2021/2711365","url":null,"abstract":"<p><strong>Background: </strong>Patients with Parkinson's disease (PD) undergoing deep brain electrode implantation experience a temporary improvement in motor symptoms before the electrical stimulation begins. We usually call this the microlesion effect (MLE), but the mechanism behind it is not clear.</p><p><strong>Purpose: </strong>This study aimed to assess the alterations in brain functions at the regional and whole-brain levels, using regional homogeneity (ReHo) and functional connectivity (FC), during the postoperative microlesion period after deep brain stimulation (DBS) in PD patients.</p><p><strong>Method: </strong>Resting-state functional MRI data were collected from 27 PD patients before and after the first day of DBS and 12 healthy controls (HCs) in this study. The ReHo in combination with FC analysis was used to investigate the alterations of regional brain activity in all the subjects.</p><p><strong>Results: </strong>There were increased ReHo in the basal ganglia-thalamocortical circuit (left supplementary motor area and bilateral paracentral lobule), whereas decreased ReHo in the default mode network (DMN) (left angular gyrus, bilateral precuneus), prefrontal cortex (bilateral middle frontal gyrus), and the cerebello-thalamocortical (CTC) circuit (Cerebellum_crus2/1_L) after DBS. In addition, we also found abnormal FC in the lingual gyrus, cerebellum, and DMN.</p><p><strong>Conclusion: </strong>Microlesion of the thalamus caused by electrode implantation can alter the activity of the basal ganglia-thalamocortical circuit, prefrontal cortex, DMN, and CTC circuit and induce abnormal FC in the lingual gyrus, cerebellum, prefrontal cortex, and DMN among PD patients. The findings of this study contribute to the understanding of the mechanism of MLE.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"2711365"},"PeriodicalIF":3.2,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39409941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}