Parkinson's Disease最新文献

{"title":"Serum GDF-15 Levels Correlate With Motor and Nonmotor Symptom Domains and Overall Disease Severity in Patients With Parkinson's Disease.","authors":"Noriyuki Miyaue, Hayato Yabe, Mina Yasugi, Masahiro Nagai","doi":"10.1155/padi/9949931","DOIUrl":"https://doi.org/10.1155/padi/9949931","url":null,"abstract":"<p><strong>Objective: </strong>Growth differentiation factor 15 (GDF-15) has emerged as a potential biomarker for neurodegenerative diseases. Although elevated serum GDF-15 levels have been reported in Parkinson's disease (PD), their association with clinical features has not been fully characterized.</p><p><strong>Methods: </strong>We evaluated serum GDF-15 concentrations in 40 patients with PD and analyzed their relationships with clinical measures, including motor severity (MDS-UPDRS), quality of life (PDQ-39), sleep disturbances (PDSS-2), autonomic symptoms (SCOPA-AUT), and cognitive function (MoCA-J).</p><p><strong>Results: </strong>Higher serum GDF-15 levels were associated with older age and greater symptom burden across multiple domains. Significant relationships were observed with MDS-UPDRS Parts I-III and total scores, PDQ-39 summary index and bodily discomfort index, two different PDSS-2 domains (motor symptoms at night and PD symptoms at night), and SCOPA-AUT total and gastrointestinal dysfunction scores. After adjusting for age, the associations between serum GDF-15 levels and MDS-UPDRS Part II, Part III, and total scores remained significant. No sex-related differences were detected. A trend toward lower MoCA-J scores with increasing GDF-15 levels was observed but did not reach statistical significance.</p><p><strong>Conclusion: </strong>Serum GDF-15 levels are linked to both motor and nonmotor aspects of PD and may reflect overall disease burden. Further longitudinal studies are needed to determine their value for disease monitoring and prognosis.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"9949931"},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensor-Based Assessment of Asymmetry in Upper Limb Bradykinesia Among Patients With Parkinson's Disease and Scans Without Evidence of Dopaminergic Deficit (SWEDD).","authors":"Do Young Kwon, Junghyuk Ko, Yuri Kwon, Ji-Won Kim","doi":"10.1155/padi/6400390","DOIUrl":"https://doi.org/10.1155/padi/6400390","url":null,"abstract":"<p><strong>Background: </strong>Bilateral motor asymmetry is a hallmark feature of Parkinson's disease (PD). However, few studies have quantitatively examined this feature in patients with scans without evidence of dopaminergic deficit (SWEDD). This study aimed to investigate upper limb asymmetry in bradykinesia among PD and SWEDD patients using gyro sensors, focusing on finger tapping and forearm rotation task.</p><p><strong>Methods: </strong>We recruited 23 early-stage, drug-naïve PD patients, 23 SWEDD patients, and 20 age-matched healthy controls. We recorded gyro sensor signals during 15-s finger tapping and forearm rotation tasks. Bilateral asymmetry indices were calculated and compared among groups. In addition, repeated measure analysis of variance (ANOVA) was used to examine the interaction of task and group, and Spearman correlation analysis was conducted with clinical motor scores.</p><p><strong>Results: </strong>No significant group differences were found during finger tapping. However, during forearm rotation, PD patients exhibited significantly greater asymmetry than SWEDD patients in several indices, including RMS angular velocity, peak angular displacement, peak power, and total power. Task × group interaction effects were significant only in forearm rotation, and asymmetry indices from forearm rotation showed significant correlations with clinical motor scores.</p><p><strong>Conclusions: </strong>Forearm rotation is a sensitive task for detecting motor asymmetry in PD and for differentiating PD from SWEDD. These results suggest that quantitative motor asymmetry indices using wearable sensors could aid clinicians in the identification of potential SWEDD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"6400390"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13042346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a Biologically Defined Diagnosis: Incorporating Pathophysiological Measures Into Parkinson's Disease Clinical Criteria.","authors":"Angus McNamara, Laura M Carr, Irina Baetu, Mark Jenkinson, Lyndsey Collins-Praino","doi":"10.1155/padi/2703114","DOIUrl":"10.1155/padi/2703114","url":null,"abstract":"<p><p>Parkinson's disease is the second most common neurodegenerative disorder worldwide, as well as being the fastest-growing neurological disorder. Furthermore, PD corresponds to a significant burden on those diagnosed, their caregivers and healthcare systems, highlighting the critical need for early and accurate diagnosis. Effective diagnosis is essential not only for timely intervention but also for the development of disease-modifying treatments, which are currently unavailable for PD management. Historically, PD diagnosis and characterisation was heavily reliant on clinical presentation, which are only present after significant neurodegeneration has already occurred. Because of this, there is a consensus amongst the scientific community to transition away from clinical features and instead redefine PD diagnosis and staging based on biological presentation. This review discusses historical developments in clinical diagnostic criteria for PD as well as the role the recently developed frameworks such as SynNeurGe and the Neuronal alpha-Synuclein Disease-Integrated Staging System (NSD-ISS) will play in the further advancements of diagnostic practices. Furthermore, substantial research efforts into the pathobiology of PD have led to the development of novel in vivo assessments capable of detecting critical biomarkers of PD. Specialised imaging modalities, particularly nuclear imaging and magnetic resonance imaging, and biomarkers of α-synuclein pathology demonstrate high sensitivity and specificity for not only early diagnosis but also differential diagnosis between other parkinsonisms. Beyond diagnostic reforms, it is also important to identify markers that could serve as indicators of clinical course to aid in tailoring personalised treatment strategies. Therefore, this review also summarises key pathobiological hallmarks of PD beyond α-synuclein pathology, namely, dopaminergic denervation, copathologies and underlying indicators of neurodegeneration, such as iron deposition and neuroinflammation. Furthermore, strategies to assess such pathologies and their potential utility in the current paradigm shift towards biological characterisation are discussed.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"2703114"},"PeriodicalIF":2.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12934250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes Following Constipation Treatments Between Parkinson's Disease and Non-Parkinson's Disease Patients Evaluated by the Constipation Scoring System.","authors":"Kulthida Methawasin, Atip Krittayasingh, Kitsarawut Khuancharee, Piyanant Chonmaitree, Monton Wongwandee","doi":"10.1155/padi/1105437","DOIUrl":"https://doi.org/10.1155/padi/1105437","url":null,"abstract":"<p><strong>Objectives: </strong>The Constipation Scoring System (CSS) is a validated tool for assessing constipation severity and has been previously applied in Parkinson's disease (PD) populations. However, comparative data on post-treatment CSS outcomes between individuals with and without PD remain lacking. This study aimed to compare post-treatment constipation severity between PD and non-PD patients in real-world clinical settings, with particular focus on neurology and gastroenterology outpatient clinics.</p><p><strong>Methods: </strong>This retrospective chart review included 67 patients with PD from a neurology clinic and 50 non-PD patients with constipation from a gastroenterology clinic. Baseline characteristics were retrieved from electronic medical records. Follow-up assessments were conducted through direct or telephone interviews to evaluate constipation severity using the CSS. Additional data were collected on patients' self-reported intake of water, coffee, carbohydrates, and fiber, as well as exercise habits.</p><p><strong>Results: </strong>Post-treatment CSS scores did not differ significantly between groups (PD: 6.07 ± 3.57 vs. non-PD: 5.24 ± 2.84; <i>p</i> = 0.172), with most participants classified as having mild constipation. No significant differences were observed in daily water, coffee, or fiber intake, or in exercise habits. However, non-PD patients reported significantly higher carbohydrate intake compared to PD patients (<i>p</i> = 0.003). PD patients more frequently reported long-standing constipation symptoms (≥ 6 years) than non-PD patients (<i>p</i> < 0.001). Patterns of laxative use also differed: while sennosides were most commonly used in both groups, non-PD patients more frequently used lactulose and mucilin, whereas PD patients more commonly used Unison enemas (<i>p</i> = 0.020) and milk of magnesia (<i>p</i> = 0.070).</p><p><strong>Conclusion: </strong>Although constipation severity and treatment outcomes were comparable between PD and non-PD patients, PD patients more often experienced long-standing symptoms and demonstrated distinct patterns of laxative use. Prospective studies are warranted to evaluate standardized treatment protocols to better clarify treatment outcomes and inform clinical practice.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"1105437"},"PeriodicalIF":2.2,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of a Digital Social Forum in a Parkinson's Disease Risk Cohort: A Thematic Analysis of Forum Messages.","authors":"Laura J Smith, Janusiya Jeyaganesh, Xiancheng Li, Aneet Gill, Anette Schrag, Brook Huxford, Cristina Simonet, Laura Pérez-Carbonell, Alastair J Noyce, Anna De Simoni","doi":"10.1155/padi/7537110","DOIUrl":"10.1155/padi/7537110","url":null,"abstract":"<p><strong>Background: </strong>Reduced social engagement is associated with increased risk of incident Parkinson's disease (PD). Online peer support provides opportunities to develop new social connections. A digital social forum was recently embedded within PREDICT-PD, an online UK cohort study that stratifies participants for risk of future PD, to explore the feasibility of digital social engagement as an intervention to modify PD risk.</p><p><strong>Objective: </strong>This study reports on the content of messages exchanged on the forum to better understand how this was used and experienced.</p><p><strong>Methods: </strong>364 public posts from 218 distinct users were analysed using thematic analysis.</p><p><strong>Results: </strong>Members created a sense of community through disclosing personal information and reaching out to others. Experiences were shared in relation to symptom appraisal, emotional impacts and routes to diagnosis. Practical advice, resources and information were exchanged to aid symptom management and proactive lifestyle changes. Users discussed their aspirations for timely diagnosis and treatment within healthcare, further research funding to aid prevention and treatment, and greater awareness of PD within society. Technical issues with the forum were reported, and accessibility was viewed as a potential barrier.</p><p><strong>Conclusions: </strong>The online forum provided a peer support environment for people with similar health experiences to connect, exchange information and emotional support, and engage in discussions around political and social issues unique to PD. This highlights the potential of leveraging online peer support to promote social engagement in prodromal PD. Further research is needed to examine the effect on PD risk and develop accessible technologies.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"7537110"},"PeriodicalIF":2.2,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of Australians Living With Parkinson's Disease.","authors":"Alycia Messing, Warren Bartik, Megan J Hobbs, Deborah Apthorp","doi":"10.1155/padi/2661657","DOIUrl":"10.1155/padi/2661657","url":null,"abstract":"<p><p>This study explores the healthcare experiences of Australians with Parkinson's disease, focusing on healthcare access, symptom management and support networks. Despite the body of research on the experiences of PwPD, there is limited understanding of the specific challenges faced by Australians in accessing and navigating healthcare services. A national survey was conducted, and free-text responses to an optional open-ended question were analysed using thematic analysis to identify key themes in healthcare experiences and barriers. Seven themes were identified: Navigating Healthcare, Diagnostic Experiences, Symptom Experience and Management, Optimism and Resilience, Knowledge and Understanding of Parkinson's Disease, Necessitated Self-Advocacy, and Community-Driven Support. Participants reported difficulties in obtaining timely diagnoses, navigating healthcare services and accessing specialised care. Information gaps and inadequate patient-provider communication were also noted. Peer support networks were highlighted as crucial for coping and resilience, with a notable shift away from traditional familial support structures. Findings underscore systemic challenges in healthcare access and communication for Australian PwPD and suggest that enhancing peer support networks and improving care pathways could strengthen disease management and support.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"2661657"},"PeriodicalIF":2.2,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Discrimination and Proprioceptive Impairment in Parkinson's Disease: Evidence for Distinct Sensory Dysfunction Mechanisms.","authors":"Annika Junge, Jens Volkmann, Daniel Zeller, Thorsten M Odorfer","doi":"10.1155/padi/8849526","DOIUrl":"10.1155/padi/8849526","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is characterized by motor symptoms but also includes nonmotor impairments such as sensory disturbances. Temporal discrimination (TD) deficits have been repeatedly demonstrated, while proprioceptive dysfunction is also common in PD. The exact significance of these alterations, and whether they represent related aspects of a common pathophysiological process, remains elusive.</p><p><strong>Methods: </strong>We investigated somatosensory and kinesthetic TD as well as proprioceptive accuracy in 20 PD patients and compared 20 age- and sex-matched healthy controls (HCs). Somatosensory TD threshold (STDT) was assessed using paired cutaneous electrical stimuli and TD motor thresholds (TDMTs) by electrically induced wrist flexions. Proprioception was measured with two tasks requiring wrist flexion to predefined angles (LED task) or to reproduce angular ranges (ARROW task), without visual feedback. Clinical assessment comprised MDS-UPDRS III, Hoehn and Yahr stage, levodopa dosage, and disease duration.</p><p><strong>Results: </strong>PD patients exhibited significantly elevated thresholds compared to HC for both STDT (120.3 ± 42.3 ms vs. 80.8 ± 17.1 ms, <i>p</i> = 0.001) and TDMT (107.1 ± 43.7 ms vs. 77.0 ± 16.3 ms, <i>p</i> = 0.011). Proprioceptive errors were also higher in PD for the LED (6.7° ± 2.2° vs. 3.2° ± 1.9°, <i>p</i> < 0.001) and ARROW tasks (14.2° ± 3.4° vs. 2.1° ± 0.8°,<i>p</i> < 0.001). No significant correlations were observed between TD, proprioceptive measures, or clinical severity indices.</p><p><strong>Conclusions: </strong>PD patients show pronounced impairments in both TD and proprioceptive accuracy, confirming sensory processing deficits beyond motor dysfunction. The absence of correlations suggests distinct mechanisms, highlighting the need for further neurophysiological research.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"8849526"},"PeriodicalIF":2.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12866330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Views and Experiences of Online Exercise Groups for People With Parkinson's Disease: A Qualitative Study.","authors":"James Alexander, Caroline Appel, Yiota Constantinou, Anette Schrag","doi":"10.1155/padi/9816558","DOIUrl":"10.1155/padi/9816558","url":null,"abstract":"<p><strong>Background: </strong>Online exercise groups for people with Parkinson's disease (PwP) are increasing in popularity, but little is known about PwP's experiences with them.</p><p><strong>Objective: </strong>To explore the views and experiences of PwP who have utilised Parkinson's disease-specific online exercise groups.</p><p><strong>Methods: </strong>A qualitative study utilising semistructured interviews and thematic analysis in a purposive sample of PwP who had participated in an online exercise group.</p><p><strong>Results: </strong>Nine participants (5 females) with a mean age of 69.5 (63-78) years and a mean disease duration of 9.1 (3-20) years participated. Analysis revealed three overarching themes: <i>'Considerations of online exercise groups for PwP</i>', which highlighted the pros and cons of attending online exercise classes; '<i>Online exercise class qualities'</i>, including the importance of a tailored approach, clearly communicated aims and the importance of a well-informed instructor; and '<i>Accessibility'</i>, which included considerations of convenience of access, costs and technological access.</p><p><strong>Conclusion: </strong>Online exercise groups may play an important role in future Parkinson's disease management by offering greater access to exercise. They may also perpetuate inequalities for PwP and lack the social engagement many PwP seek. Hybrid group exercise, a combination of online and face-to-face classes, could provide this. Providers must develop classes that are tailored to PwP and delivered by well-informed instructors.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"9816558"},"PeriodicalIF":2.2,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12848610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue-Inducing Protocols in Parkinson's Disease: Implications for Gait Assessment and Rehabilitation: A Systematic Review.","authors":"Mahdi Majlesi, Elaheh Azadian, Nader Farahpour, Rezvan Bakhtiarian, Hadi Nobari","doi":"10.1155/padi/8822220","DOIUrl":"10.1155/padi/8822220","url":null,"abstract":"<p><strong>Background: </strong>Fatigue is a common and disabling nonmotor symptom of Parkinson's disease (PD), which significantly impacts gait and overall mobility. In spite of its clinical significance, the biomechanical consequences of different fatigue induction protocols on gait performance in PD are not yet well understood.</p><p><strong>Objective: </strong>To systematically review fatigue induction protocols in gait studies of individuals with PD and to examine how different types of fatigue (local, general, and cognitive) and assessment methods influence gait outcomes.</p><p><strong>Methods: </strong>In accordance with PRISMA guidelines registered under PROSPERO (CRD420251038246), five databases were systematically searched from January 2004 to March 2025. Seven studies met the inclusion criteria and were reviewed and analyzed through descriptive synthesis.</p><p><strong>Results: </strong>Repeated sit-to-stand tasks were the most effective in inducing lower-limb fatigue and produced consistent changes in gait, including reduced stride length, slower speed, and impaired turning. General aerobic or functional tasks had inconsistent effects, and no study directly tested cognitive fatigue on gait. Fatigue assessment methods varied widely, including force decline, perceived exertion, and fatigue scales. Gait outcome measures were also heterogeneous, limiting comparability.</p><p><strong>Conclusion: </strong>Targeted lower-limb fatigue protocols are effective in revealing gait impairments in PD. There is a clear need for standardized fatigue induction procedures and gait evaluation methods to improve consistency and comparability across research. Clinically, assessing gait under fatigue conditions may uncover subtle mobility impairments and inform more personalized rehabilitation strategies.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2026 ","pages":"8822220"},"PeriodicalIF":2.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12771624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Participation Among American Indian and Alaskan Native Individuals Living With Parkinson's Disease.","authors":"Jacob D Jones, Yenny Valenzuela, Melissa Pacheco, Lonnie Nelson","doi":"10.1155/padi/3207928","DOIUrl":"10.1155/padi/3207928","url":null,"abstract":"<p><strong>Background: </strong>There is a notable gap in racial and ethnic representation in Parkinson's disease (PD) research, particularly among American Indian and Alaska Native (AIAN) populations, despite a higher prevalence of PD in these groups. This study investigated research participation among AIAN individuals in terms of perceived access to research opportunities, willingness to participate, and potential concerns about participation.</p><p><strong>Methods: </strong>Data were obtained from the online Fox Insight (FI) study. A total sample of 4412 individuals who self-reported their race as White (<i>n</i> = 4363) or AIAN (<i>n</i> = 49) were selected. The Attitudes and Beliefs Regarding Research and Genetic Testing for PD survey was administered to assess participants' attitudes and knowledge about the research process, opportunities, and preferences.</p><p><strong>Results: </strong>A significantly smaller proportion of AIAN individuals (34.7%) reported concurrent or past participation in PD research compared with White non-AIAN participants (52.9%). Despite this lower participation rate and limited knowledge of research opportunities, a large majority of AIAN individuals (89.8%) expressed a willingness to participate in research. Additionally, both AIAN and White non-AIAN participants reported similar rates of concerns about research participation. Among AIAN individuals, the most common barriers were distance from research site, transportation, and time commitments.</p><p><strong>Conclusion: </strong>These findings highlight that low research participation among AIAN individuals may be more associated with low engagement from the research community rather than unwillingness or relatively greater research concerns. Building stronger partnerships with tribal communities and involving community leaders to build trust may improve research representation among AIAN populations.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"3207928"},"PeriodicalIF":2.2,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}