Parkinson's Disease最新文献

{"title":"Diagnostic Accuracy of Machine Learning-Assisted MRI for Mild Cognitive Impairment in Parkinson's Disease: A Systematic Review and Meta-Analysis.","authors":"Feng Zhang, Liangqing Guo, Lin Liu, Xiaochun Han","doi":"10.1155/padi/2079341","DOIUrl":"https://doi.org/10.1155/padi/2079341","url":null,"abstract":"<p><p>To evaluate the diagnostic accuracy of machine learning-assisted magnetic resonance imaging (MRI) in detecting cognitive impairment among Parkinson's disease (PD) patients through a systematic review and meta-analysis. We systematically searched for studies that applied machine learning algorithms to MRI data for diagnosing PD with mild cognitive impairment (PD-MCI). Data were extracted and synthesized to calculate pooled sensitivity, specificity, positive likelihood ratio (PLR) and negative diagnostic likelihood ratio (NLR), and diagnostic odds ratios (DOR). A bivariate random-effects model and summary receiver operating characteristic (SROC) curves were employed for statistical analysis. The quality of studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) instrument. The publication bias was investigated through Deeks' funnel plot. All statistical analyses were conducted using Stata 14.0. The pooled sensitivity and specificity for diagnosing PD-MCI using machine learning-assisted MRI were 0.82 (95% CI: 0.75-0.87) and 0.81 (95% CI: 0.73-0.87), respectively. The PLR was 4.28 (95% CI: 2.93-6.27), and the NLR was 0.23 (95% CI: 0.16-0.32), indicating a high diagnostic accuracy. The area under the curve (AUC) for the SROC was 0.85 (95% CI: 0.82-0.88). Quality assessment using the QUADAS-2 tool showed a predominantly low risk of bias among the studies, and the Deeks' funnel plot suggested no significant publication bias (<i>p</i>=0.30). In summary, the MRI combined with machine learning for diagnosing PD-MCI achieved high accuracy with the pooled sensitivity of 82% and specificity of 81%.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"2079341"},"PeriodicalIF":2.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method of Tremor Levodopa Responsiveness Assessment and Its Correlation With Clinical Factors in Parkinson's Disease: Outcomes of the Acute Levodopa Challenge Test.","authors":"Fangfei Li, Shaosong Xing, Yusha Cui, Lingyan Ma, Rui Yan, Genliang Liu, Tao Feng","doi":"10.1155/padi/9923049","DOIUrl":"10.1155/padi/9923049","url":null,"abstract":"<p><p><b>Objectives:</b> Levodopa remains the most effective treatment for Parkinson's disease (PD); however, tremor reactions to dopaminergic medications show significant variance among patients with PD. This study aimed to assess the different methodologies employed to determine the dopamine responsiveness of tremors and their association with the clinical characteristics of PD. <b>Methods:</b> Patients with PD and tremors were evaluated using the acute levodopa challenge test (LCT). Tremor levodopa responsiveness (LR) was calculated using the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) scores during OFF and ON periods. Tremor LR was calculated in two formats: absolute difference in tremor scores (OFF-ON), termed aLR, and percentage change in tremor scores, termed %LR and calculated as ([OFF-ON]/OFF100%). Independent variables were compared between the better tremor response to levodopa and poorer tremor response to levodopa groups based on the tremor change rate median score. Additionally, the effect of the tremor LR calculation method was correlated with clinical measures. <b>Results:</b> This study enrolled 188 patients with PD who displayed tremors, of whom 98 (52%) showed better tremor response to levodopa. We identified a moderately negative correlation between tremor aLR and the rigidity-to-tremor score ratio (<i>r</i> = 0.40) during the OFF period, in addition to positive correlations between tremor aLR and the tremor score (<i>r</i> = 0.75), rest tremor score (<i>r</i> = 0.75), motor score (<i>r</i> = 0.42), postural and kinetic tremor score (<i>r</i> = 0.30), and tremor score-to-disease duration ratio (<i>r</i> = 0.30) of the UPDRS-III during OFF periods. The tremor %LR showed no significant relationship with any of the tested variables. <b>Conclusions:</b> The aLR, rather than the %LR, is a more effective assessment method for evaluating the efficacy of levodopa for treating tremors in PD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"9923049"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Mechanisms and Clinical Evidence for Acupuncture in Parkinson's Disease: A Systematic Review.","authors":"Jinting Li, Minmin Wu, Wenjing Song, Jiongliang Zhang, Luwen Zhu","doi":"10.1155/padi/9739567","DOIUrl":"10.1155/padi/9739567","url":null,"abstract":"<p><p>Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and the mainstay of treatment is dopamine replacement therapy; however, its beneficial effects tend to wane over time as the disease progresses. Many patients seek complementary therapies to alleviate motor and nonmotor symptoms associated with PD, and the efficacy of acupuncture as a commonly used complementary and alternative therapy for PD remains controversial. In this review, we systematically examine randomized controlled trials and mechanistic studies on acupuncture for PD over the past 12 years. The findings indicate that acupuncture improves both motor and nonmotor symptoms. We also found that the mechanisms underlying the effects of acupuncture on PD may involve connectomics, modulation of dopamine and glutamate systems, regulation of the gut-brain axis, organelle homeostasis, and molecular and signaling pathway modulation. This review proposes a multitarget neuroprotection hypothesis to provide a theoretical basis for standardized acupuncture research.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"9739567"},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Identification of Inflammation-Related TF-mRNA-miRNA Coexpression Network and Immune Infiltration in Parkinson's Disease.","authors":"Zhuzhen Shen, Jieli Zhang, Xiuna Jing, Enxiang Tao","doi":"10.1155/padi/2323585","DOIUrl":"https://doi.org/10.1155/padi/2323585","url":null,"abstract":"<p><p><b>Background:</b> Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Inflammation, marked by the infiltration of inflammatory mediators and the proliferation of inflammatory cells, is closely linked to PD. This study aims to identify and validate inflammation-related biomarkers in PD and construct a TF-mRNA-miRNA coexpression network through bioinformatics analysis. <b>Methods:</b> The PD-associated dataset GSE7621 and inflammation-related genes were downloaded from the GEO Database and GeneCards platform to obtain inflammation-related differential expression genes (IRDEGs). The key IRDEGs were generated by PPI network analysis. The gene expression levels of the key IRDEGs were validated by blood samples from PD patients using QPCR analysis. We utilized the ENCODE, hTFtarget, CHEA, miRWALK, and miRDB databases to obtain upstream and downstream molecular network models for constructing the TF-mRNA-miRNA interaction network of the key IRDEGs. Finally, based on CIBERSORT algorithm, the associations between IRDEs and immune cell infiltration were investigated. <b>Results:</b> A total of four key IRDEGs (CXCR4, LEP, SLC18A2, and TAC1) were screened and validated. Through biological function analysis, key-related pathways and coexpression networks of PD were identified. These genes may be closely related to the onset of PD. Additionally, we found that increased CD4 T-cell infiltration might be associated with the occurrence of PD. <b>Conclusions:</b> We identified four potential inflammation-related treatment target and constructed a TF-mRNA-miRNA regulatory network. This information provides an initial basis for understanding the complex PD regulatory mechanisms.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"2323585"},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Regional Burden of Parkinson's Disease in Kazakhstan 2014-2021: Insights From National Health Data.","authors":"Ruslan Akhmedullin, Arnur Gusmanov, Gulnur Zhakhina, Byron Crape, Temirgali Aimyshev, Yuliya Semenova, Gaziz Kyrgyzbay, Abduzhappar Gaipov","doi":"10.1155/padi/4317554","DOIUrl":"https://doi.org/10.1155/padi/4317554","url":null,"abstract":"<p><p><b>Background:</b> This study explores the burden of Parkinson's disease (PD) in Kazakhstan, the largest country in Central Asia, a region where data on neurological disorders are notably sparse. <b>Methods:</b> Utilizing data from Kazakhstan's Unified National Electronic Health System during 2014-2021, the study investigates the epidemiology, disability-adjusted life years (DALYs), and survival outcomes in a cohort of PD patients. The authors employed Cox proportional hazards regression models and Kaplan-Meier analysis, alongside sensitivity analyses, to assess the impact of demographic factors, hypertension, and the Charlson Comorbidity Index (CCI) on survival. <b>Results:</b> The study cohort included 10,125 patients, revealing a tenfold increase in PD prevalence during the study period. Mortality rates varied significantly, with the highest rates observed in the eldest age group (137.05 per 1000 person-years). PD contributed to a loss of 156.12 DALYs per 100,000 population, primarily driven by years of life lost. The analysis identified an increased risk of all-cause mortality among males (adjusted hazard ratio (aHR) 1.6; 1.5-1.8), older individuals (aHR 1.05; 1.04-1.06), those with higher CCIs, and individuals of Kazakh ethnicity. Interestingly, patients with comorbid hypertension had a higher probability of survival (aHR 0.67; 0.60-0.73). <b>Conclusion:</b> This study is the first of its kind in Central Asia to examine the burden of PD using a large-scale outpatient registry. The findings underscore the need for targeted interventions to address the growing burden of PD, particularly among males and ethnic Kazakhs. Additionally, further research is needed to explore the inverse association between hypertension and survival in the PD cohort.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"4317554"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water Physical Exercise Program (WPEP) Using High-Intensity Interval Training in Individuals With Parkinson's Disease: A Clinical Trial Protocol.","authors":"Luís Henrique Paladini, Giovanna Cristina Leveck, Tainá Christinelli, Juliana Siega, André Eduardo Falcoski Doliny, Paulo Cesar Barauce Bento, Vera Lúcia Israel","doi":"10.1155/padi/1946207","DOIUrl":"https://doi.org/10.1155/padi/1946207","url":null,"abstract":"<p><p><b>Introduction:</b> Parkinson's disease (PD) is a chronic, neurodegenerative disease of the central nervous system (CNS). Complications in PD are related to impaired cardiorespiratory capacity, and the presence of motor and nonmotor symptoms, such as reduced cardiorespiratory fitness, decreased respiratory muscle strength and lung volumes and capacities, bradykinesia, muscle rigidity, attenuation of strength and lower limb muscle power, sleep disorders, anxiety, and depressive symptoms. The practice of high-intensity exercise and the examination of the aquatic environment may help to minimize these symptoms and slow disease progression. <b>Objective:</b> To develop a water physical exercise program (WPEP) focusing on high-intensity interval training (HIIT) for individuals with DP. <b>Methods:</b> This is a protocol for a single blinded controlled clinical trial. The sample will consist of individuals with PD between Stages 1 and 4 on the Hoehn and Yahr (HY) Scale, divided into a control group and a WPEP group (which will participate in the WPEP). The outcomes will be divided into three categories: cardiorespiratory, motor, and nonmotor aspects. The WPEP will last 12 weeks, and the intervention will take place two times a week, with a duration of approximately 35 min, with an interval between 48 and 72 h between training sessions for muscle recovery, for a total of 24 sessions. It is expected that this study will establish parameters for prescribing and monitoring a WPEP for individuals with PD Stages 1-4 on the HY scale, enhancing the practice of exercise prescription. <b>Trial Registration:</b> Brazilian Register of Clinical Trials: RBR-3hp5yvh.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"1946207"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress: A New Pathophysiological Pathway in Parkinson's Disease and a Potential Target of the Brain-Sport Crosstalk.","authors":"Stefano Caproni, Alessio Di Fonzo, Carlo Colosimo","doi":"10.1155/padi/6691390","DOIUrl":"10.1155/padi/6691390","url":null,"abstract":"<p><p>Oxidative stress (OS), a condition that occurs when the balance between reactive oxygen species production and antioxidant defense mechanisms is disrupted, has been implicated in the pathogenesis of several neurological conditions, including neurodegenerative and vascular disorders. Ferroptosis is a mechanism mediating OS-induced damage, with growing evidence of specific involvement in both Parkinson's disease (PD) and ischemic stroke. Regular physical activity may have an antioxidant effect by increasing the production and activity of nonenzymatic and enzymatic antioxidants. Among the biological mediators of physical activity, irisin may act as an agent capable of inducing systemic changes and crossing the brain-blood barrier. This review aims to describe the main role of OS in the pathophysiology of PD, highlighting putative neurodegenerative mechanisms and emphasizing the potential targeting by physical activity as a possible shared preventive and symptomatic treatment approach.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"6691390"},"PeriodicalIF":2.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clozapine for Quetiapine-Refractory Psychosis in Parkinson's Disease: A Long-Term Single-Center Retrospective Study.","authors":"Walter Pirker","doi":"10.1155/padi/1068722","DOIUrl":"https://doi.org/10.1155/padi/1068722","url":null,"abstract":"<p><p><b>Background:</b> Hallucinations and delusions are severe long-term complications of Parkinson's disease (PD). Clozapine is the only antipsychotic with proven efficacy in PD psychosis (PDPsy) available outside the United States but apprehensions about its adverse event profile result in a substantial underuse of clozapine. <b>Objectives:</b> To investigate the practical use and long-term efficacy of clozapine in severe psychotic disorders in PD. <b>Methods:</b> In this retrospective study, the author used data collected over a period of 20 years and included all PD patients under his care, who were treated with clozapine for psychotic disorders. <b>Results:</b> During the observation period, 41 PD patients (38 with PDPsy, 2 with psychotic depression, and one with schizoaffective disorder) were started on clozapine. They had responded poorly or only transiently to quetiapine. An overnight switch to clozapine was tolerated in most. Maximum clozapine doses ranged from 12.5 to 150 mg (72.9 ± 29.9 mg). A significant reduction in psychotic symptoms was achieved in 2 days to 6 months. Among the cases tolerating clozapine, 10 had a full, 25 had a good, 3 had a moderate, and 2 had a poor clinical response to clozapine. Treatment lasted up to 12 years. The long-term response was full or good in 23, moderate in 3, and poor in 2 patients. <b>Conclusions:</b> Clozapine is often effective in the treatment of psychotic disorders in PD including PDPsy poorly or only transiently responding to quetiapine. Side effects including agranulocytosis are manageable in the majority of cases. Clozapine treatment should not be delayed if other measures against PDPsy prove ineffective.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"1068722"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystatin C Secretion in Blood Derivatives and Cellular Models of Idiopathic Parkinson's Disease.","authors":"Kathleen Mommaerts, Anna S Monzel, Alise Zagare, Sarah L Nickels, Nico J Diederich, Laura Longhino, William Mathieson, Paul M A Antony, Fay Betsou, Jens C Schwamborn","doi":"10.1155/padi/5149071","DOIUrl":"10.1155/padi/5149071","url":null,"abstract":"<p><p>Parkinson's disease is an age-related progressive neurodegenerative disorder. A large majority of Parkinson's disease patients have an unknown etiology, which is classified as idiopathic Parkinson's disease. Generating disease models directly from idiopathic Parkinson's disease patients may improve the understanding of the disease pathology. Both neuroprotective and neurodegenerative roles have been suggested for cystatin C in neurodegenerative disease. In Parkinson's disease, investigations assessing cystatin C levels in different types of biospecimens such as blood, cerebrospinal fluid, and in vitro models have had conflicting results. We present a study assessing cystatin C levels in different biospecimen types originating from the same subjects. Using a sandwich ELISA, we compared cystatin C concentration in blood derivatives (plasma and serum) and culture media of derived models (stem cells, neuroepithelial stem cells, and midbrain organoids) of three idiopathic Parkinson's disease and three age-matched healthy control subjects with the same <i>CST3</i> genotype. Genotyping analyses confirmed that all subjects were homozygous AA. The identity of the derived models was confirmed using immunohistochemical staining. Secreted cystatin C concentration was measured in each biospecimen tested. No statistically significant differences in cystatin C concentrations were found between the subjects in any of the biospecimen types. As a personalized marker, a higher cystatin C concentration was shown for some individual patients in the culture medium of midbrain organoids, suggesting a potential involvement in Parkinson's disease physiopathology. This proof of concept demonstrates that cystatin C is secreted by various idiopathic Parkinson's disease cell models, including midbrain organoids, which in turn suggests that cystatin C secretion by midbrain organoids might be pertinent in neurodegenerative disease research.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2025 ","pages":"5149071"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Markers and Risk of Parkinson's Disease: A Population-Based Analysis.","authors":"Hongping Wang, Wenqiang Li, Qun Lai, Qian Huang, Hao Ding, Zhiping Deng","doi":"10.1155/padi/4192853","DOIUrl":"https://doi.org/10.1155/padi/4192853","url":null,"abstract":"<p><p><b>Objected:</b> Parkinson's disease (PD) is an important cause of neurological dysfunction, and the aim of this study was to explore whether neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic inflammatory response (SIRI), and systemic immune inflammation (SII) are associated with the risk of developing PD. Based on this, we may identify people at high risk for PD and intervene early. <b>Method:</b> Our study included 31,480 participants from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2018. Basic information and inflammation-related indicators were obtained by questionnaires and laboratory tests, respectively. NLR, PLR, LMR, SIRI, SII, and PD risk were analyzed using weighted logistic regression models. <b>Results:</b> There were 261 and 31,219 in the PD and non-PD groups, respectively, and the prevalence of PD was 0.83%. Separate analyses of NLR and PLR were conducted after fully adjusting for confounding factors. According to our analysis, there was an increased risk of PD for both NLR and PLR in the higher level group (Q4) as compared with the lower level group (Q1) (OR = 1.83 and 95% confidence interval (CI) = 1.09-3.07, and OR = 1.92 and 95% CI = 1.20-3.08). However, we did not find similar relationships in LMR, SIRI, and SII. <b>Conclusions:</b> There was a significant association between elevated levels of NLR, PLR, and PD risk, while LMR, SIRI, and SII were not statistically significant. It suggests that NLR or PLR could be used to screen people at risk of PD at an early stage. It is essential to conduct more large-scale prospective studies to investigate the role that NLR and PLR play in PD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":"2024 ","pages":"4192853"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}