Journal of Pineal Research最新文献_第2页

Melatonin Is Bound to a Glycolytic Protein Complex via Tdh2p During Fermentation in Saccharomyces cerevisiae 在酿酒酵母发酵过程中，褪黑素通过Tdh2p与糖酵解蛋白复合物结合。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-10 DOI: 10.1111/jpi.70131

Sandra Martín-Esteban, Joseph J. Rossi, Cristobal A. Onetto, Antonio G. Cordente, María-Jesús Torija, Gemma Beltran

{"title":"Melatonin Is Bound to a Glycolytic Protein Complex via Tdh2p During Fermentation in Saccharomyces cerevisiae","authors":"Sandra Martín-Esteban, Joseph J. Rossi, Cristobal A. Onetto, Antonio G. Cordente, María-Jesús Torija, Gemma Beltran","doi":"10.1111/jpi.70131","DOIUrl":"10.1111/jpi.70131","url":null,"abstract":"Melatonin (MEL) is a multifunctional bioactive compound known for its antioxidant properties and regulatory roles in both animal and microbial systems. Although MEL has been shown to interact with glycolytic enzymes in yeast, the molecular basis and physiological relevance of these interactions remain unclear. Here, we investigate MEL interactions with key glycolytic proteins in Saccharomyces cerevisiae during alcoholic fermentations, using CRISPR-Cas9-generated gene deletion mutants. Protein interactions in wild type and mutant strains were analysed via co-immunoprecipitation and western blotting. The fermentative behavior of single and double TDH deletion mutants was assessed in both laboratory and wine yeast strains. TDH2 and TDH3 deletions extended the lag phase and reduced GAPDH activity, while TDH1 deletion had minor effects, indicating a differential contribution of glycolytic isoenzymes to fermentation kinetics. Analysis of MEL-bound proteins revealed that Tdh2p is essential for complex formation, as its absence abolished MEL binding to other glycolytic proteins. Molecular docking predicted stable hydrogen bonds between MEL and Tdh2p, supporting a direct interaction. These results demonstrate the formation of a glycolytic protein-MEL complex and identify Tdh2p as a key mediator, providing a foundation for further studies on its physiological relevance and regulatory mechanisms.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Supplementation in Adult Patients With Atopic Dermatitis: A Randomized Clinical Trial 褪黑素补充治疗成人特应性皮炎：一项随机临床试验。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-06 DOI: 10.1111/jpi.70130

Zinat Heidari, Ghazal Gharibi, Hoorieh Alaeen, Elliyeh Ghadrdan, Ehsan Shahrestanaki, Zeynab Sadeghi-ghadi, Amirhossein Sahebkar, Maryam Daei

{"title":"Melatonin Supplementation in Adult Patients With Atopic Dermatitis: A Randomized Clinical Trial","authors":"Zinat Heidari, Ghazal Gharibi, Hoorieh Alaeen, Elliyeh Ghadrdan, Ehsan Shahrestanaki, Zeynab Sadeghi-ghadi, Amirhossein Sahebkar, Maryam Daei","doi":"10.1111/jpi.70130","DOIUrl":"10.1111/jpi.70130","url":null,"abstract":"<div>\u0000 \u0000 This study aimed to evaluate the effects of melatonin supplementation on disease severity, sleep quality, and quality of life in adult patients with atopic dermatitis (AD). This study was designed as a randomized, double-blind, placebo-controlled clinical trial involving adult patients with mild to moderate AD. Eligible participants were randomly assigned to receive either a 10 mg melatonin tablet or a matching placebo once daily for 4 weeks. The primary outcome was the severity of AD, assessed by SCORAD index at baseline and after 4 weeks of supplementation. Secondary outcomes included the intensity of pain (NPRS), pruritus severity (Pruritus-NRS), sleep quality (ADSS), and quality of life (DLQI). Eighty patients completed the study. The mean age (Standard deviation) of the patients was 33.26 (12.57) years, and 32 patients (40%) were male. The SCORAD, Pruritus-NRS, 12-PSS, ADSS, and DLQI indices improved significantly (p-values of < 0.001, 0.006, 0.011, < 0.05, and 0.003, respectively) after 4 weeks of supplementation. However, melatonin supplementation did not improve the NPRS (p-value: 0.063). No patient reported an adverse effect throughout the study. Melatonin supplementation in adult patients with mild to moderate AD effectively improved disease severity, sleep quality, and quality of life, without any reported adverse effects. However, due to limitations of our study, further research is required to confirm these findings.\u0000 </div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Melatonin Suppresses Proinflammatory Mediators in Lipopolysaccharide-Stimulated CRL1999 Cells via Targeting MAPK, NF-κB, c/EBPβ, and p300 Signaling 退黑素通过靶向MAPK、NF-κB、c/EBPβ和p300信号通路抑制脂多糖刺激的CRL1999细胞中的促炎介质。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-02 DOI: 10.1111/jpi.70128

{"title":"RETRACTION: Melatonin Suppresses Proinflammatory Mediators in Lipopolysaccharide-Stimulated CRL1999 Cells via Targeting MAPK, NF-κB, c/EBPβ, and p300 Signaling","authors":"","doi":"10.1111/jpi.70128","DOIUrl":"10.1111/jpi.70128","url":null,"abstract":"RETRACTION: D. Shi, X. Xiao, J. Wang, L. Liu, W. Chen, L. Fu, F. Xie, W. Huang, and W. Deng, “Melatonin Suppresses Proinflammatory Mediators in Lipopolysaccharide-Stimulated CRL1999 Cells via Targeting MAPK, NF-κB, c/EBPβ, and p300 Signaling,” Journal of Pineal Research 53, no. 2 (2012): 154–165, https://doi.org/10.1111/j.1600-079X.2012.00982.x.The above article, published online on 30 January 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns that three of the four bands in the IL-1β image in Figure 1D were copied and presented as the COX-2 image in Figure 2B. An investigation by the publisher confirmed this duplication and also confirmed that the GAPDH control bands had been reused in both figures.The authors responded to an inquiry by the publisher, but they could not supply all of the original data for the article to validate the data. The retraction has been agreed to because the evidence of image duplication and manipulation in the article compromises the editors’ confidence in the results presented. The authors were informed about the retraction.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Matrix Metalloproteinase-9 Activity and Expression Is Reduced by Melatonin During Prevention of Ethanol-Induced Gastric Ulcer in Mice 关注表达：褪黑素在预防乙醇性胃溃疡过程中降低基质金属蛋白酶-9活性和表达

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-02 DOI: 10.1111/jpi.70127

{"title":"EXPRESSION OF CONCERN: Matrix Metalloproteinase-9 Activity and Expression Is Reduced by Melatonin During Prevention of Ethanol-Induced Gastric Ulcer in Mice","authors":"","doi":"10.1111/jpi.70127","DOIUrl":"10.1111/jpi.70127","url":null,"abstract":"EXPRESSION OF CONCERN: S. Swarnakar, A. Mishra, K. Ganguly, and A. V. Sharma, “Matrix Metalloproteinase-9 Activity and Expression Is Reduced by Melatonin During Prevention of Ethanol-Induced Gastric Ulcer in Mice,” Journal of Pineal Research 43, no. 1 (2007): 56–64, doi.org/10.1111/j.1600-079X.2007.00443.x.This Expression of Concern is for the above article, published online on 17 April 2007 in Wiley Online Library (wileyonlinelibrary. com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. The Expression of Concern has been agreed due to concerns raised by third parties. Specifically, overlapping areas have been identified between panels D (erroneously labelled as “B” in the published article) and F of Figure 1, despite the panels present different scientific contexts. Due to the time elapsed since the original publication, the authors were unable to retrieve the raw data underlying the figure. They state that the images show a different distribution of cells within the lumen, which they argue supports that the panels were not taken from or processed using the same tissue section. However, this clarification was deemed insufficient to resolve the concerns, as the similarities observed between the panels were considered too extensive to be coincidental, supporting the conclusion that the images likely originate from the same tissue section. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147323979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway 关注的表达：褪黑素通过调节基质金属蛋白酶-3和凋亡通路来预防子宫内膜异位症。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-02 DOI: 10.1111/jpi.70126

{"title":"EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway","authors":"","doi":"10.1111/jpi.70126","DOIUrl":"10.1111/jpi.70126","url":null,"abstract":"EXPRESSION OF CONCERN: S. Paul, P. Bhattacharya, P. D. Mahapatra, and S. Swarnakar, “Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway,” Journal of Pineal Research 49, no. 2 (2010): 156–168, https://doi.org/10.1111/j.1600-079X.2010.00780.x.This Expression of Concern is for the above article, published online on 02 August 2010 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. The Expression of Concern has been agreed due to concerns raised by third parties. Specifically, the features of the sections presented in Figure 6 (A), (B), and (C) were found to closely resemble those of small intestine rather than endometrial (uterine) tissue in mice. Due to the time elapsed since publication, the authors were unable to retrieve the raw data underlying the images. Despite the authors highlighting several features in their clarification to support that the images represent uterine tissue from a surgically induced mouse endometriosis model—such as morphological details of uterine glands, stroma, blood vessels, and expected cycle-related changes—they also acknowledge that the possibility of having reported a different tissue type cannot be fully ruled out. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating Melatonin Safety: Fact, Fiction, and Confounders 导航褪黑素安全：事实，虚构和混淆。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-01 DOI: 10.1111/jpi.70129

Alessandro Colitta, Francy Cruz-Sanabria, Simone Bruno, Ugo Faraguna

引用次数: 0

Can Morning Light Phase Advance Human Melatonin Rhythms in Less Than 24 h? 晨光能在不到24小时内促进人体褪黑激素节律吗？

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-03-01 DOI: 10.1111/jpi.70134

Clara López-Velasco, Carolin Franziska Reichert, Christian Cajochen

{"title":"Can Morning Light Phase Advance Human Melatonin Rhythms in Less Than 24 h?","authors":"Clara López-Velasco, Carolin Franziska Reichert, Christian Cajochen","doi":"10.1111/jpi.70134","DOIUrl":"10.1111/jpi.70134","url":null,"abstract":"Light is the primary cue that synchronises the human circadian system to the 24-h day, advancing or delaying circadian rhythms depending on its timing. While it is known that morning light induces phase advances, most studies assess the timing of dim-light melatonin onset (DLMO) in the subsequent circadian cycle, over 24 h after the light intervention. However, it is unclear whether these phase advances occur within the same circadian cycle as the light intervention or the next one. This narrative review addresses the question of whether morning light can phase-advance human melatonin rhythms in less than 24 h. To answer this question, we review studies that use same-day or single-cycle protocols, in which light exposure and post-intervention DLMO assessment occur within the same 24-h period. To compare light interventions across studies, melanopic equivalent daylight illuminance (mEDI) values were estimated and related to the magnitude of the observed phase advance. The reviewed research suggests that modest phase advances of 10-30 min can be achieved within the same circadian cycle if light is delivered shortly after waking up in the morning. This is particularly effective if the light is bright, blue-enriched, or if it is delivered for a long time (over 1 h). There was a statistical trend (r = 0.51, p = 0.06) towards a positive association between the mEDI of the light intervention and the magnitude of the phase advance. Overall, same-day phase-advances seem possible but not well characterised, and more targeted work is needed to determine whether morning light can phase-advance human melatonin rhythms in less than 24 h. If this is confirmed, the length of circadian protocols could be reduced, accelerating the clinical use of treatments for circadian rhythms sleep-wake disorder.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":"e70134"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin and Its Derivatives Counteract the Ultraviolet B Radiation-Induced Damage in Human and Porcine Skin Ex Vivo 关注表达：褪黑素及其衍生物在体外抵消紫外线B辐射引起的人类和猪皮肤损伤。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-24 DOI: 10.1111/jpi.70111

{"title":"EXPRESSION OF CONCERN: Melatonin and Its Derivatives Counteract the Ultraviolet B Radiation-Induced Damage in Human and Porcine Skin Ex Vivo","authors":"","doi":"10.1111/jpi.70111","DOIUrl":"10.1111/jpi.70111","url":null,"abstract":"EXPRESSION OF CONCERN: C. Skobowiat, A. A. Brożyna, Z. Janjetovic, S. Jeayeng, A. S. W. Oak, T.-K. Kim, U. Panich, R. J. Reiter, A. T. Slominski, “Melatonin and its Derivatives Counteract the Ultraviolet B Radiation-Induced Damage in Human and Porcine Skin Ex Vivo,” Journal of Pineal Research 65, no. 2 (2018): e12501, https://doi.org/10.1111/jpi.12501.This Expression of Concern is for the above article, published online on 27 April 2018 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. Concerns have been raised by a third party regarding multiple images included in this article. The University of Alabama at Birmingham is currently investigating these concerns. This Expression of Concern has been published in order to alert readers to these concerns while the investigation is ongoing. The publisher will publish a final notice regarding this investigation once a determination has been reached. The authors were informed of this Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii 褪黑素通过阻止纳米塑料的摄取和激活白芍抗氧化系统来防御氧化应激。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-23 DOI: 10.1111/jpi.70117

Zhipeng Sheng, Zhaoyu Hou, Jiasong Meng, Daqiu Zhao, Jun Tao

{"title":"Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii","authors":"Zhipeng Sheng, Zhaoyu Hou, Jiasong Meng, Daqiu Zhao, Jun Tao","doi":"10.1111/jpi.70117","DOIUrl":"10.1111/jpi.70117","url":null,"abstract":"<div>\u0000 \u0000 As emerging pollutants of global concern, the toxicity of polystyrene nanoplastics (PS-NPs) in plants has received widespread attention, but little is known about how to alleviate their adverse impacts on wood plants. In Paeonia ostii, PS-NPs could be uptood by roots, transported and accumulated in stems and leaves, and induced oxidative stress and negatively affected plant growth. Exogenous melatonin application has for the first time shown to reduce the cell wall porosity to prevent PS-NPs from entering the cells via inhibiting the expression of genes associated with expansins, ultimately decreasd PS-NPs accumulation. And exogenous melatonin also activated the antioxidant system to scavenge reactive oxygen species (ROS) and alleviated the adverse impacts of PS-NPs on plant growth. Moreover, increasing endogenous melatonin by overexpressing N-acetylserotonin-O-methyltransferase gene obtained the similar results as mentioned above. And the transgenic plants uptook and accumulated relatively lower levels of PS-NPs by reducing the cell wall porosity, and induced lower ROS accumulation by activating the antioxidant system. Collectively, these results suggested that melatonin could defend against the oxidative stress caused by PS-NPs via preventing their uptake and activating the antioxidant system in P. ostii, which highlighted that melatonin can be used to protect plants in the nanoplastic-polluted environments.</div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC-1β: In Vivo and In Vitro Studies 关注表达：褪黑素通过激活PGC-1β来保护横断主动脉收缩引起的病理性心肌肥大：体内和体外研究。

IF 6.3 1区医学

Journal of Pineal Research Pub Date : 2026-02-19 DOI: 10.1111/jpi.70119

{"title":"EXPRESSION OF CONCERN: Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC-1β: In Vivo and In Vitro Studies","authors":"","doi":"10.1111/jpi.70119","DOIUrl":"10.1111/jpi.70119","url":null,"abstract":"EXPRESSION OF CONCERN: M. Zhai, Z. Liu, B. Zhang, L. Jing, B. Li, K. Li, X. Chen, M. Zhang, B. Yu, K. Ren, Y. Yang, W. Yi, J. Yang, J. Liu, D. Yi, H. Liang, Z. Jin, R. J. Reiter, W. Duan, and S. Yu, “Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC-1β: In Vivo and In Vitro Studies,” Journal of Pineal Research 63, no. 3 (2017): e12433, https://doi.org/10.1111/jpi.12433.This Expression of Concern is for the above article, published online on 14 July 2017 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns of image overlap between the 4 wk TAC image and the 8 wk Sham + Mel image in Figure 2D. An investigation by the publisher confirmed this concern and also found overlap between the Perivascular (8 wk) and Interstitial (8 wk) images in Figure 4A. The authors did not respond to an inquiry and request for original data by the publisher, and as such the data in this article related to the concerns cannot be validated. This Expression of Concern has been published in order to inform and alert readers about the concerns of image overlap in Figures 2D and 4A. The authors were informed of this Expression of Concern.","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 2","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146224626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0