Panminerva medicaPub Date : 2025-06-01Epub Date: 2025-03-27DOI: 10.23736/S0031-0808.25.05268-1
Ashlyn M O'Leary, Christopher R D'Angelo
{"title":"Mantle cell lymphoma: from pathogenesis to treatment for 2024 and beyond.","authors":"Ashlyn M O'Leary, Christopher R D'Angelo","doi":"10.23736/S0031-0808.25.05268-1","DOIUrl":"10.23736/S0031-0808.25.05268-1","url":null,"abstract":"<p><p>Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma with multiple subtypes including classical mantle cell lymphoma (cMCL), the leukemic variant of mantle cell lymphoma (LV-MCL), and in situ mantle cell neoplasia (ISMCN). Their clinical presentations differ significantly and range from indolent to very aggressive. The defining genetic feature and chief oncogenic mechanism of MCL involves the t(11;14)(q13;q32) translocation, which results in a fusion of the gene that encodes cyclin D1 (CCND1) and the immunoglobulin heavy chain gene (IGH). As a result of significant variation between subtypes, treatment approaches and prognoses of this disease vary drastically. Current treatment options for MCL range from observation to conventional chemotherapy with or without subsequent stem cell transplantation, to targeted immunotherapies against key molecular targets. The role of stem cell transplant has become more debatable for frontline consolidation therapy. Earlier incorporation of Bruton's tyrosine kinase (BTK) inhibitors is being strongly considered for frontline therapy. Chimeric antigen receptor therapy (CAR-T) therapies have become established treatment options for relapsed/refractory disease. Ongoing frontiers involve optimal management of TP53 mutated MCL and those relapsing with CNS involvement. Novel therapeutic approaches including the development of non-covalent BTK inhibitors and bispecific antibody therapy carry significant promise to further improve outcomes across all subtypes of this disease.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"59-71"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-06-01Epub Date: 2024-02-27DOI: 10.23736/S0031-0808.24.05106-1
Xi Yin, Naifeng He
{"title":"The influencing factors of elderly health based on data analysis.","authors":"Xi Yin, Naifeng He","doi":"10.23736/S0031-0808.24.05106-1","DOIUrl":"10.23736/S0031-0808.24.05106-1","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"123-125"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-06-01Epub Date: 2025-02-18DOI: 10.23736/S0031-0808.25.05295-4
Francesco Scaglione, Giorgio Ciprandi
{"title":"Ketoprofen and its lysine salt in managing children with fever: evidence emerging from comparative trials.","authors":"Francesco Scaglione, Giorgio Ciprandi","doi":"10.23736/S0031-0808.25.05295-4","DOIUrl":"10.23736/S0031-0808.25.05295-4","url":null,"abstract":"<p><p>Fever usually is a physiological response to infectious/inflammatory acute events. Namely, fever has positive benefits contrasting noxious agents. However, when fever causes discomfort, it is better to relieve symptoms associated to fever. Antipyretics mainly are non-steroidal anti-inflammatory agents (NSAIDs) and acetaminophen. The NSAIDs class includes many molecules. The most used NSAID to relieve fever is ibuprofen. However, ketoprofen also provides interesting pharmacological characteristics. In particular, salifying ketoprofen with lysine, such as ketoprofen lysine salt (KLS), provides a better and quicker absorption then acid ketoprofen and reduces side effects. The present paper considers the comparative pediatric studies between ketoprofen or KLS and other antipyretics, mainly concerning ibuprofen and acetaminophen. The results showed that ketoprofen and KLS are valuable option in managing children with fever.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"101-107"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-06-01DOI: 10.23736/S0031-0808.25.05314-5
Yeduvaka Madhuri, Qazi Saifullah, Manisha Pandey, Subrat K Bhattamisra
{"title":"An overview of recent developments in clinical trials of anti-diabetic drugs.","authors":"Yeduvaka Madhuri, Qazi Saifullah, Manisha Pandey, Subrat K Bhattamisra","doi":"10.23736/S0031-0808.25.05314-5","DOIUrl":"10.23736/S0031-0808.25.05314-5","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder affecting over 90% of diabetes patients worldwide. The condition is driven by genetic predispositions, environmental factors, obesity, and physical inactivity. Pharmacological treatments range from metformin to newer agents, including GLP-1 analogues and SGLT-2 inhibitors, which target different aspects of glucose metabolism. The review highlights advancements in clinical trials for T2DM treatments, focusing on recent and ongoing research. Clinical trial data were sourced from ClinicalTrials.gov, and the search criteria focused on trials that were published with monotherapy of T2DM having results within the last six years, specifically from 2019 to 2024. The clinical trials of the patients under the age group of adults (18 to 64 years) and older adults (>64 years) were included. The data are mentioned in inverse chronological order with respect to study duration. The clinical trial data suggest promising results in managing hemoglobin A1c and body weight. However, adverse events such as cardiovascular, gastrointestinal, and bone-related issues and other issues such as diabetic ketoacidosis and pancreatitis were reported in some cases. Dulaglutide, tripeptide, and oral insulin showed promising therapeutic effects in clinical trials. Despite significant progress, the management of T2DM remains challenging, emphasizing the need for ongoing innovation in treatment approaches to improve patient quality of life and reduce the global burden of the disease.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":"67 2","pages":"87-100"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-03-01Epub Date: 2025-03-12DOI: 10.23736/S0031-0808.25.05296-6
Giorgio Ciprandi, Francesco Scaglione
{"title":"Ketoprofen and ketoprofen lysine salt in managing children with mild-moderate acute pain: evidence emerging from comparative trials.","authors":"Giorgio Ciprandi, Francesco Scaglione","doi":"10.23736/S0031-0808.25.05296-6","DOIUrl":"10.23736/S0031-0808.25.05296-6","url":null,"abstract":"<p><p>Acute pain is a common symptom experienced by all children. Pain may be due to different causes, but inflammatory pain is the most common. In addition, infectious diseases are characterized by an inflammatory reaction. As a result, inflammatory pain, including pain associated with infections, should be preferably relieved by non-steroidal anti-inflammatory drugs (NSAIDs). In this regard, ketoprofen and ketoprofen lysine salt represent a valuable option also in children with mild-moderate acute pain. This paper presents and discusses the comparative studies between ketoprofen or KLS and other analgesics, mainly concerning ibuprofen and acetaminophen. The results showed that ketoprofen and KLS are an effective, safe, and rapid strategy in relieving mild-moderate acute pain in children.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"46-51"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-03-01Epub Date: 2025-03-27DOI: 10.23736/S0031-0808.25.05198-5
Neil G Docherty
{"title":"Perspectives on the profiling of renal risk in obesity.","authors":"Neil G Docherty","doi":"10.23736/S0031-0808.25.05198-5","DOIUrl":"10.23736/S0031-0808.25.05198-5","url":null,"abstract":"<p><p>With the formal designation of obesity as a primary disease process, early detection of its end-organ consequences and the prognostication of long-term risk will become an important aspect of its clinical management. Obesity is increasingly recognized as a treatable risk factor for chronic kidney disease. However, profiling of kidney health and estimation of renal risk remain relatively underemphasized in obesity and nephrology care guidelines. The establishment of clinical protocols that facilitate the detection of early-stage renal impairment in obesity and incorporate profiling of an individual's risk of progression, could help guide strategies to break the causal association between obesity and chronic kidney disease. Currently, checks on kidney health in patients with obesity are prompted due to the presence of obesity complications such as cardiovascular and/or metabolic disease and routine screening relies upon the use of estimated glomerular filtration rate equations. Ample evidence exists to demonstrate that these equations are of limited utility in the setting of excess body weight and intentional weight loss. The present article presents the case that an expanded model of renal risk profiling should be developed for obesity medicine, suggesting feasible means of incorporating important risk factors and biomarker profiling alongside a more targeted assessment of directly measured GFR and renal functional reserve in at risk patients. The development of such a model or variation thereof should be prioritized to guide the targeted deployment of obesity treatments with proven reno-protective effects.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"27-36"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-03-01Epub Date: 2024-12-20DOI: 10.23736/S0031-0808.24.05277-7
Iginio Colaiori, Giuseppe Biondi-Zoccai, Luigi Spadafora, Marco Bernardi, Antonio Aloia, Marco Ancona, Gianfranco Aprigliano, Emanuele Barbato, Cesare Baldi, Carlo Briguori, Paolo Buja, Mauro Cadeddu, Gavino Casu, Alberto De Caterina, Francesco De Felice, Ciro De Simone, Luca Donazzan, Fabio Ferranti, Nicoletta Franco, Achille Gaspardone, Ervis Hiso, Massimo Leoncini, Angelo Leone, Stefano Lucreziotti, Massimo Mancone, Lucia Marinucci, Mauro Maioli, Matteo Montorfano, Salvatore Musarò, Tullio Niglio, Andrea Picchi, Arnaldo Poli, Gerlando Preti, Flavio L Ribichini, Andrea Rolandi, Enrico Romagnoli, Giuseppe M Sangiorgi, Federica Serino, Pierluigi Soldà, Gianluca Tiberti, Fabrizio Tomai, Francesco Tomassini, Fabrizio Ugo, Giovanni Esposito, Francesco Saia, Francesco Versaci
{"title":"Regional disparities in the management and outcomes of ST-elevation myocardial infarction: an Italian analysis focusing on time-dependent reperfusion networks and in-hospital logistics.","authors":"Iginio Colaiori, Giuseppe Biondi-Zoccai, Luigi Spadafora, Marco Bernardi, Antonio Aloia, Marco Ancona, Gianfranco Aprigliano, Emanuele Barbato, Cesare Baldi, Carlo Briguori, Paolo Buja, Mauro Cadeddu, Gavino Casu, Alberto De Caterina, Francesco De Felice, Ciro De Simone, Luca Donazzan, Fabio Ferranti, Nicoletta Franco, Achille Gaspardone, Ervis Hiso, Massimo Leoncini, Angelo Leone, Stefano Lucreziotti, Massimo Mancone, Lucia Marinucci, Mauro Maioli, Matteo Montorfano, Salvatore Musarò, Tullio Niglio, Andrea Picchi, Arnaldo Poli, Gerlando Preti, Flavio L Ribichini, Andrea Rolandi, Enrico Romagnoli, Giuseppe M Sangiorgi, Federica Serino, Pierluigi Soldà, Gianluca Tiberti, Fabrizio Tomai, Francesco Tomassini, Fabrizio Ugo, Giovanni Esposito, Francesco Saia, Francesco Versaci","doi":"10.23736/S0031-0808.24.05277-7","DOIUrl":"10.23736/S0031-0808.24.05277-7","url":null,"abstract":"<p><strong>Background: </strong>Prompt reperfusion is critical for patients with ST-segment elevation myocardial infarction (STEMI) to improve outcomes. Yet, variability in regional healthcare delivery may influence treatment times and patient outcomes. We thus aimed at evaluating differences in management and outcomes of STEMI patients across Northern, Central, and Southern Italy, focusing on time-dependent reperfusion and in-hospital logistics.</p><p><strong>Methods: </strong>A prospective observational study conducted from September 1<sup>st</sup> to 25<sup>th</sup>, 2023, including 554 STEMI patients treated at high-volume hub centers operating 24/7. Data were collected through structured surveys completed by catheterization laboratory directors across different Italian regions. Primary outcomes included door-to-balloon (DTB) time, time from symptom onset to balloon inflation, and regional disparities in pre- and post-PCI management. Secondary outcomes included in-hospital mortality, discharge destinations, and medication regimens.</p><p><strong>Results: </strong>The median DTB time was consistent across regions (30 minutes; IQR: 20-50 minutes). Significant regional disparities were however noted in time from symptom onset to balloon inflation, with Southern and Island regions experiencing longer median times (180 minutes) compared to Central (170 minutes) and Northern (154 minutes) regions (P<0.01). We also found a significant reduction in DTB time associated with ECG teletransmission from ambulances (mean reduction of 25 minutes, P=0.03). In-hospital mortality rates were similar across regions (P=0.83).</p><p><strong>Conclusions: </strong>This comprehensive nationwide analysis highlights significant regional disparities in the management and treatment timelines of STEMI patients in Italy. Despite these differences, in-hospital care was consistently timely across regions, suggesting that pre-hospital logistics critically influence overall treatment times. Enhanced pre-hospital ECG teletransmission could further optimize reperfusion times, potentially improving patient outcomes.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"1-9"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-03-01Epub Date: 2023-11-10DOI: 10.23736/S0031-0808.23.04943-1
Peng Lü, Feng Wu, Feng Li, Kanglian Zhu, Fengqin Shi
{"title":"Diosgenin inhibits the proliferation and migration of MCF-7 breast cancer cells through the demethylation of miR-145 gene.","authors":"Peng Lü, Feng Wu, Feng Li, Kanglian Zhu, Fengqin Shi","doi":"10.23736/S0031-0808.23.04943-1","DOIUrl":"10.23736/S0031-0808.23.04943-1","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"55-56"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panminerva medicaPub Date : 2025-03-01Epub Date: 2024-12-20DOI: 10.23736/S0031-0808.24.05269-8
Dev Desai, Darshilkumar Maheta, Siddharth P Agrawal, Abhijay B Shah, Akx Panchal, Hetvi Shah, Wilbert S Aronow
{"title":"Comparative efficacy and safety of colchicine and interleukin-1 antagonists in recurrent pericarditis: a network meta-analysis.","authors":"Dev Desai, Darshilkumar Maheta, Siddharth P Agrawal, Abhijay B Shah, Akx Panchal, Hetvi Shah, Wilbert S Aronow","doi":"10.23736/S0031-0808.24.05269-8","DOIUrl":"10.23736/S0031-0808.24.05269-8","url":null,"abstract":"<p><strong>Introduction: </strong>Despite advancement of therapeutic approaches to recurrent pericarditis, it poses notable challenges to its' management. As per the current guidelines, colchicine is the first line therapy, although, non-conventional treatments like interleukin-1 (IL-1) antagonists (rilonacept, anakinra, goflikicept) are progressively utilized for refractory cases.</p><p><strong>Evidence acquisition: </strong>A comprehensive electronic search identified relevant literature across multiple databases, focusing on recurrence rates and adverse effects associated with each treatment regimen.</p><p><strong>Evidence synthesis: </strong>Eleven studies (6 on colchicine, 5 on IL-1 antagonists) involving 1053 patients were included. Colchicine significantly reduced recurrence risk by 63% (OR 0.37, 95% CI 0.27-0.52). IL-1 antagonists demonstrated superior efficacy: anakinra reduced recurrence by 98% (OR 0.02, 95% CI 0.01-0.07), rilonacept by 98% (OR 0.02, 95% CI 0.01-0.07), and goflikicept by 99% (OR 0.01, 95% CI 0.00-0.05). Adverse effects were comparable between colchicine and IL-1 antagonists except for rilonacept, which showed a higher risk (OR 5.70, 95% CI 2.13-15.27).</p><p><strong>Conclusions: </strong>IL-1 antagonists significantly reduce recurrent pericarditis episodes compared to colchicine, with anakinra, rilonacept, and goflikicept demonstrating high efficacy and acceptable safety profiles. These findings support their consideration as alternative therapies in colchicine-refractory cases of recurrent pericarditis. Further studies are warranted to refine treatment guidelines and optimize patient outcomes.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"37-45"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}