Panminerva medica最新文献_第10页

Poorly differentiated thyroid carcinoma: molecular, clinico-pathological hallmarks and therapeutic perspectives. 分化不良的甲状腺癌：分子、临床病理特征和治疗前景。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0031-0808.23.05040-1

V. Cirello, C. Gambale, Alyaksandr V. Nikitski, Chie Masaki, João Roque, Carla Colombo

{"title":"Poorly differentiated thyroid carcinoma: molecular, clinico-pathological hallmarks and therapeutic perspectives.","authors":"V. Cirello, C. Gambale, Alyaksandr V. Nikitski, Chie Masaki, João Roque, Carla Colombo","doi":"10.23736/S0031-0808.23.05040-1","DOIUrl":"https://doi.org/10.23736/S0031-0808.23.05040-1","url":null,"abstract":"Poorly differentiated thyroid carcinoma (PDTC) is a rare and extremely aggressive tumor, accounting for about 2-15% of all thyroid cancer. PDTC has a distinct biological behavior compared to well-differentiated and anaplastic thyroid carcinoma and, in last years, it has been classified as a separate entity from both anatomopathological and clinical points of view. Nevertheless, there is still a lack of consensus among clinicians regarding inclusion criteria and definition of PDTC that affects its diagnosis and clinical management. Due to its rarity and difficulty in classification compared to other tumors, very few studies are available to date and series often include different histotypes in addition to PDTC. This review focuses on main studies concerning PDTC summarizing the evolution in the definition of its diagnosis criteria, clinicopathological features, management, and outcome. The data available confirm that the pathological evaluation and classification of PDTC are crucial and should therefore be standardized. Since the clinical presentation and prognosis of PDTC may vary widely depending on the different stage of the disease at diagnosis, the patient's management may differ in treatment and should be tailored to each patient. Finally, this review discusses advances in molecular insights of PDTC that, together with the implementation of both in vitro and in vivo models, will provide valuable insights into biological mechanisms of progression, metastasis, and invasion of this aggressive thyroid carcinoma. Further studies on larger, carefully selected series are needed to better assess the peculiar features of PDTC and to better define its management by focusing on the best diagnostic and therapeutic approaches.","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":"428 5","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle quality assessment in COVID-19 survivors: agreement between echointensity and stiffness. COVID-19 存活者的肌肉质量评估：回声密度与僵硬度之间的一致性。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0031-0808.24.05122-X

Sarah Damanti, M. Cilla, Bruno Tuscano, Chiara Pomaranzi, Valeria Tiraferri, Rebecka Papaioannu, Giacomo Ponta, R. De Lorenzo, Filippo Chiabrando, G. Vitali, M. Tresoldi, Patrizia Rovere Querini

引用次数: 0

Application efficacy of multi-segment posterior osteotomy in improving adolescent Scheuermann kyphosis deformity. 多段后截骨术在改善青少年谢尔曼脊柱后凸畸形中的应用效果。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0031-0808.24.05153-X

Shuai Zheng, Pan Zhou, Shuangjiang Liu, Renjie Qin, Guanyuan Chen, Zhiwei You, Genlong Jiao

引用次数: 0

Exploration of diagnosis and treatment plans for diffuse panbronchiolitis combined with familial aplastic anemia. 探讨弥漫性全细支气管炎合并家族性再生障碍性贫血的诊断和治疗方案。

IF 4.3 4区医学

Panminerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0031-0808.24.05134-6

Huiqin He, Jiabin Qian, Xin Lyu

引用次数: 0

Acquired double-anaplastic lymphoma kinase rearrangement in lung adenocarcinoma after systemic chemotherapy. 全身化疗后肺腺癌中获得性双无性淋巴瘤激酶重排。