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Praziquantel efficacy, urinary and intestinal schistosomiasis reinfection - a systematic review. 吡喹酮疗效、尿路和肠道血吸虫病再感染——一项系统综述。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-10-01 Epub Date: 2022-11-17 DOI: 10.1080/20477724.2022.2145070
Isaac Frimpong Aboagye, Yvonne Abena Afadua Addison
{"title":"Praziquantel efficacy, urinary and intestinal schistosomiasis reinfection - a systematic review.","authors":"Isaac Frimpong Aboagye, Yvonne Abena Afadua Addison","doi":"10.1080/20477724.2022.2145070","DOIUrl":"10.1080/20477724.2022.2145070","url":null,"abstract":"<p><p>Praziquantel (PZQ) has been extensively used as the drug of choice for the treatment of schistosomiasis on account of its safety and effectiveness against all major forms of schistosomiasis. However, low cure rate, reduced susceptibility of <i>Schistosoma mansoni</i> to PZQ and treatment failures in <i>S</i>. <i>haematobium</i> infections have been reported, raising concerns about its efficacy. Using the search terms, 'praziquantel efficacy, schistosomiasis, school children, reinfection' as well as defined inclusion criteria, and guided by the PRISMA guidelines, articles from 2001 to 2022 were selected from the PubMed and Google Scholar databases and reviewed to assess their importance to the research question. This review assessed the efficacy of PZQ against schistosomiasis and reinfection rates following treatment of <i>Schistosoma</i> infections in children. Majority of both intestinal and urinary schistosomiasis studies reported comparable egg reduction rates (ERRs) of 94.2% to 99.9% and 91.9% to 98%, respectively. However, ERRs suggestive of sub-optimal PZQ efficacy as well as generally high and comparable cure rates for intestinal (81.2%-99.1%) and urinary (79%-93.7%) schistosomiasis studies were reported. Schistosomiasis reinfection rates varied widely for urinary (8.1%-39.6%) and intestinal (13.9%-63.4%) studies within eight to 28 weeks following PZQ treatment. Praziquantel treatment of urinary and intestinal schistosomiasis should be accompanied by the provision of potable water, toilet, and recreational facilities to reduce reinfection and egg reduction rates and increase cure rate to expedite schistosomiasis elimination.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 7","pages":"623-630"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Epidemiology of free-living amoebae infections in Africa: a review. 非洲自由生活阿米巴感染的流行病学:综述。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2022-12-22 DOI: 10.1080/20477724.2022.2160890
Giovanni D Milanez, Karlo B Carlos, Mary Erika Adao, Bernadette B Ayson, Ariela V Dicon, Rhonette Anne M Gahol, Sharmaine Kaye S Lacre, Franchesca Pauline E Marquez, April Jane M Perez, Panagiotis Karanis
{"title":"Epidemiology of free-living amoebae infections in Africa: a review.","authors":"Giovanni D Milanez, Karlo B Carlos, Mary Erika Adao, Bernadette B Ayson, Ariela V Dicon, Rhonette Anne M Gahol, Sharmaine Kaye S Lacre, Franchesca Pauline E Marquez, April Jane M Perez, Panagiotis Karanis","doi":"10.1080/20477724.2022.2160890","DOIUrl":"10.1080/20477724.2022.2160890","url":null,"abstract":"<p><p>FLA-related conditions are a rare medical occurrence. Despite their rarity, they are considered a public health concern for two reasons: the absence of a regular treatment regimen in the case of central nervous system infections and the fast progression of the symptoms leading to fatal outcomes. A total of 358 articles were retrieved from different databases (91 from PubMed, 26 from NCBI, 138 from Academia, 102 from Science Direct, and one from IJMED). 7 (46.6%) clinical cases came from Egypt, 2 (13.3%) cases of FLA infection came from Nigeria, 3 (20%) cases came from the Gambia, and 1 (6.6%) case was reported from African countries like Algeria, Tunisia, South Africa, and Zambia. Medical conditions caused by free-living amoeba are considered significant public health concerns. These ubiquitous organisms can cause both fatal and debilitating health conditions. Immediate diagnosis of cases and proper hygienic practices are necessary to provide direct medical intervention. They may be the key to reducing the morbidity and mortality rates from FLA-acquired infections. Although several government-led initiatives have been implemented to mitigate a plethora of parasitic diseases, the case of FLA-related conditions in African countries has yet to be realized.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"527-534"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10165513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Routine blood parameters of dengue infected children and adults. A meta-analysis. 登革热感染儿童和成人的常规血液参数。荟萃分析。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2023-01-02 DOI: 10.1080/20477724.2022.2161864
Gary Kk Low, Sam Froze Jiee, Retneswari Masilamani, Selvanaayagam Shanmuganathan, Pramila Rai, Mitali Manda, Osamudiamen Favour Omosumwen, Jackob Kagize, Alex I Gavino, Aizad Azahar, Mohammed Abdulrazzaq Jabbar
{"title":"Routine blood parameters of dengue infected children and adults. A meta-analysis.","authors":"Gary Kk Low, Sam Froze Jiee, Retneswari Masilamani, Selvanaayagam Shanmuganathan, Pramila Rai, Mitali Manda, Osamudiamen Favour Omosumwen, Jackob Kagize, Alex I Gavino, Aizad Azahar, Mohammed Abdulrazzaq Jabbar","doi":"10.1080/20477724.2022.2161864","DOIUrl":"10.1080/20477724.2022.2161864","url":null,"abstract":"<p><p>The World Health Organization (WHO) has revised dengue case classification in 2009 to better reflect the severity of the disease. However, there was no comprehensive meta-analysis of pooled routine blood parameters according to the age or the categories of the 2009 WHO classification. This study aimed to meta-analyze the routine blood parameters of dengue infected children and adults. Electronic search was performed with eligible articles included for review. Meta-analysis was conducted for six blood parameters stratified into children, adults and all ages, which were further grouped into the three 2009 WHO case classifications (dengue without warning signs, DwoWS; dengue with warning signs, DwWS; severe dengue, SD), non-severe dengue (non-SD) and 'All' cases. A total of 55 articles were included in the meta-analysis. Fifteen studies were conducted in the children's age category, 31 studies in the adult category and nine studies in all ages. The four selected pooled blood parameters for children were white blood cell (WBC) (×10<sup>3</sup>/L) with 5.11 (SD), 5.64 (DwWS), 5.52 (DwoWS) and 4.68 (Non-SD) hematocrit (HCT) (%) with 36.78 (SD), 40.70 (DwWS), 35.00 (DwoWS) and 29.78 (Non-SD) platelet (PLT) (×10<sup>3</sup>/µL) with 78.66 (SD), 108.01 (DwWS), 153.47 (DwoWS) and 108.29 (non-SD); and aspartate aminotransferase (AST) (/µL) with 248.88 (SD), 170.83 (DwWS), 83.24 (DwoWS) and 102.99 (non-SD). For adult, WBC were 4.96 (SD), 6.44 (DwWS), 7.74 (DwoWS) and 3.61 (non-SD); HCT were 39.50 (SD), 39.00 (DwWS), 37.45 (DwoWS) and 41.68 (non-SD); PLT were 49.62 (SD), 96.60 (DwWS), 114.37 (DwoWS) and 71.13 (non-SD); and AST were 399.50 (SD), 141.01 (DwWS), 96.19 (DwoWS) and 118.13 (non-SD). These blood parameters could not differentiate between each dengue severity according to the WHO 2009 classification, SD, DwoWS, DwWS and non-SD, because the timing of blood drawing was not known and there was an overlapping confidence interval among the clinical classification. Hence, these pooled blood parameter values could not be used to guide clinicians in management and did not correlate with severity as in previous scientific literatures and guidelines.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"565-589"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of air pollutants in dengue fever incidence: evidence from two southern cities in Taiwan. 空气污染物在登革热发病中的作用:台湾两个南部城市的证据。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2022-10-19 DOI: 10.1080/20477724.2022.2135711
Hao-Chun Lu, Fang-Yu Lin, Yao-Huei Huang, Yu-Tung Kao, El-Wui Loh
{"title":"Role of air pollutants in dengue fever incidence: evidence from two southern cities in Taiwan.","authors":"Hao-Chun Lu,&nbsp;Fang-Yu Lin,&nbsp;Yao-Huei Huang,&nbsp;Yu-Tung Kao,&nbsp;El-Wui Loh","doi":"10.1080/20477724.2022.2135711","DOIUrl":"10.1080/20477724.2022.2135711","url":null,"abstract":"<p><p>Air pollution may be involved in spreading dengue fever (DF) besides rainfalls and warmer temperatures. While particulate matter (PM), especially those with diameter of 10 μm (PM10) or 2.5 μm or less (PM25), and NO2 increase the risk of coronavirus 2 infection, their roles in triggering DF remain unclear. We explored if air pollution factors predict DF incidence in addition to the classic climate factors. Public databases and DF records of two southern cities in Taiwan were used in regression analyses. Month order, PM10 minimum, PM2.5 minimum, and precipitation days were retained in the enter mode model, and SO2 minimum, O3 maximum, and CO minimum were retained in the stepwise forward mode model in addition to month order, PM10 minimum, PM2.5 minimum, and precipitation days. While PM2.5 minimum showed a negative contribution to the monthly DF incidence, other variables showed the opposite effects. The sustain of month order, PM10 minimum, PM2.5 minimum, and precipitation days in both regression models confirms the role of classic climate factors and illustrates a potential biological role of the air pollutants in the life cycle of mosquito vectors and dengue virus and possibly human immune status. Future DF prevention should concern the contribution of air pollution besides the classic climate factors.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"596-604"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10220268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Aristotle - Ἀριστοτέλης (ARISTOTÉLĒS, 384/3- 322/1 BCE) The revelation of tuberculosis in his zoological works. 亚里士多德-Ἀριστοτ ης (ARISTOTÉLĒS,公元前384/3- 322/1)在他的动物学著作中揭示了结核病。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2022-12-02 DOI: 10.1080/20477724.2022.2143164
M Cilione, M Martini, F Zampieri, N Riccardi, F Brigo, V Gazzaniga
{"title":"Aristotle - Ἀριστοτέλης (ARISTOTÉLĒS, 384/3- 322/1 BCE) The revelation of tuberculosis in his zoological works.","authors":"M Cilione, M Martini, F Zampieri, N Riccardi, F Brigo, V Gazzaniga","doi":"10.1080/20477724.2022.2143164","DOIUrl":"10.1080/20477724.2022.2143164","url":null,"abstract":"ABSTRACT One of the most challenging issues with the sources of ancient medicine is to be able to identify the correspondence between the diseases we know today and those reported in ancient medical texts. Ancient diseases’ definitions rarely help us, and the symptoms described often correspond to more than one disease. This is especially true about tuberculosis, a disease that historians of medicine habitually associates with the Greek words phthi(n)o (φθίνω), verb, phthisis/phthoe (φθίσις/φθόη), noun, phthinodes/phthisikos (φθινώδης/φθισικός), adjective, all etymologically linked to an Indo-European root that expresses the idea of consumption in a broad sense. This article aims to analyze a group of Greek words, branchos/branchia (βράγχος/βράγχια), krauros/kraurao (κραῦρος/κραυράω), and katarreo (καταρρέω), that appear in nosological contexts very close to the infectious disease that today we call tuberculosis. Moreover, the paper aims to focus on the transmission pathways of TB being via animal-human contact and some ancient strategies to cure it. The symptoms, transmission pathways and therapeutic approach of tuberculosis belong to a homogeneous pathological picture that emerges from a set of texts that date back to the period between the fifth century BC and the second century AD.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"605-610"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10220280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities between Latinx migrants and Spanish natives in COVID-19 outcome in Madrid. 马德里 COVID-19 结果中拉美移民与西班牙本地人之间的差异。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2023-02-12 DOI: 10.1080/20477724.2023.2174295
Begoña de Dios, Asunción Pérez-Jacoiste, Antonio Lalueza, Guillermo Maestro, Ana García-Reyne, Manuel Lizasoain, Carlos Lumbreras
{"title":"Disparities between Latinx migrants and Spanish natives in COVID-19 outcome in Madrid.","authors":"Begoña de Dios, Asunción Pérez-Jacoiste, Antonio Lalueza, Guillermo Maestro, Ana García-Reyne, Manuel Lizasoain, Carlos Lumbreras","doi":"10.1080/20477724.2023.2174295","DOIUrl":"10.1080/20477724.2023.2174295","url":null,"abstract":"<p><p>Previous studies have suggested an increased susceptibility of COVID-19 among certain populations. We analyzed whether COVID-19 presentation and mortality differ between Latinx migrants and Spanish natives.</p><p><strong>Methods and materials: </strong>COVID-19 patients between 35-64 years old admitted between January 26th-May-5th 2020 were reviewed. Demographics, major comorbidities, symptoms, signs and analytical parameters on admission were recorded. Respiratory failure was defined as PaO2/FiO2 ≤ 200 mmHg, noninvasive or invasive mechanical ventilation requirement at any time during hospitalization. A propensity score (PS) adjustment was created between Latinx and Spanish. A multivariable logistic regression model adjusted by the PS was performed to evaluate the effects of different variables on mortality.</p><p><strong>Results: </strong>894 patients: 425 (47.5%) Latinx and 469 (52.5%) Spanish natives were included. Latinx were younger (50 vs 55 years <i>p</i> < 0.001) and had less comorbidities (29.4% vs 55.0% <i>p</i> < 0.001) than Spanish natives. More often they exhibited fever (22.1% vs 9.8% <i>p</i> = 0.018) and had higher inflammatory markers (PCR) (11.3 mg/dl vs 7.7 mg/dl <i>p</i> < 0.001). Mortality seemed lower among Latinx (4.7% vs 8.7%, <i>p</i> = 0.017). No association was found between ethnicity and mortality. Respiratory failure [OR = 23.978 (CI 95% 9.4-60.1) <i>p</i> < 0.001], LDH [OR (per unitary increment) = 1.002; CI95% (1.000-1.004;<i>p</i> = 0.036] and PCR [OR (per unitary increment) = 1.044 (CI95% 1.06-1.08); <i>p</i> = 0.02] were independently associated to mortality.</p><p><strong>Conclusions: </strong>We were unable to identify significant ethnic disparities between Latinx and Spanish natives in terms of COVID-19 mortality. Universal access to the health care system in Spain may have contributed to a better outcome of Latinx patients. Differences previously described might be a consequence of socioeconomic disparities.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"590-595"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10165540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applicability of the Mexican ovitrap system for Aedes vector surveillance in Colombia. 墨西哥诱蚊诱卵器系统在哥伦比亚监测伊蚊病媒的适用性。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2022-11-16 DOI: 10.1080/20477724.2022.2146049
Eduardo Wright, Maria Angelica Carrillo, David Matamoros, Rocío Cárdenas Sanchez, Johanna Yañez, Giusseppe Di Lorenzo, Juan Manuel Villa, Axel Kroeger
{"title":"Applicability of the Mexican ovitrap system for Aedes vector surveillance in Colombia.","authors":"Eduardo Wright, Maria Angelica Carrillo, David Matamoros, Rocío Cárdenas Sanchez, Johanna Yañez, Giusseppe Di Lorenzo, Juan Manuel Villa, Axel Kroeger","doi":"10.1080/20477724.2022.2146049","DOIUrl":"10.1080/20477724.2022.2146049","url":null,"abstract":"<p><p>Ovitraps can detect Aedes vectors at an early stage and can serve as an alarm indicator for outbreak prediction. This study aimed to summarize the available literature about the ovitrap system and to determine its feasibility, required resources and costs when installing and maintaining this vector surveillance system in the municipality of Los Patios, Colombia. A scoping review to assess the role of ovitraps as a tool for Aedes vector surveillance was conducted. The subsequent fieldwork consisted of mapping the municipality, manufacturing, and installing 40 ovitraps in 10 blocks, revising them weekly for 4 weeks by two half-time employed vector control technicians, and carrying out a cost analysis. A total of 38 studies were included in this review showing that ovitraps had a better performance than other entomological surveillance methods and a positive correlation with other entomological and disease variables. From the field results over 4 weeks, a high proportion of positive ovitraps (80%, 90%, 75%, 97.5%) and positive blocks (100%) as well as a good acceptance by house owners (76.9%), were identified. Operational indicators such as average installation time of the ovitraps (10h15 m), weekly reading and reinstallation (on average 7h27 m) and the cost of the intervention (COL$1,142,304.47/US$297) were calculated. Literature shows that ovitraps are sensitive to detect the presence of Aedes mosquitoes, providing data efficiently and timely for outbreak prediction. The field testing showed it is an affordable and feasible method in the context of a Colombian municipality and similar endemic areas.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"554-564"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10518271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of rapid and robust availability of epidemiological data for real-time mapping of the risk of avian influenza A (H5N1) spread. 快速、可靠地提供流行病学数据对于实时绘制甲型禽流感(H5N1)传播风险图的重要性。
IF 4.9 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2023-06-20 DOI: 10.1080/20477724.2023.2228055
Francesco Branda, Sandra Mazzoli
{"title":"The importance of rapid and robust availability of epidemiological data for real-time mapping of the risk of avian influenza A (H5N1) spread.","authors":"Francesco Branda, Sandra Mazzoli","doi":"10.1080/20477724.2023.2228055","DOIUrl":"10.1080/20477724.2023.2228055","url":null,"abstract":"","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"521-524"},"PeriodicalIF":4.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molnupiravir as the COVID-19 panacea: false beliefs in low- and middle-income countries. 将 Molnupiravir 作为 COVID-19 的灵丹妙药:中低收入国家的错误观念。
IF 4.9 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2023-07-03 DOI: 10.1080/20477724.2023.2232593
Ngoc-Ha Tran, Nguyen Khoi Quan, Van Phu Tran, Dang Nguyen, Ngoc Phuong Hong Tao, Nguyen Ngoc Hoang Linh, Nguyen Tien Huy
{"title":"Molnupiravir as the COVID-19 panacea: false beliefs in low- and middle-income countries.","authors":"Ngoc-Ha Tran, Nguyen Khoi Quan, Van Phu Tran, Dang Nguyen, Ngoc Phuong Hong Tao, Nguyen Ngoc Hoang Linh, Nguyen Tien Huy","doi":"10.1080/20477724.2023.2232593","DOIUrl":"10.1080/20477724.2023.2232593","url":null,"abstract":"","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"525-526"},"PeriodicalIF":4.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal plants as a source of antiparasitics: an overview of experimental studies. 药用植物作为抗寄生虫药物的来源:实验研究综述。
IF 3.4 4区 医学
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2023-02-20 DOI: 10.1080/20477724.2023.2179454
Sandamalie Ranasinghe, Anthony Armson, Alan J Lymbery, Alireza Zahedi, Amanda Ash
{"title":"Medicinal plants as a source of antiparasitics: an overview of experimental studies.","authors":"Sandamalie Ranasinghe, Anthony Armson, Alan J Lymbery, Alireza Zahedi, Amanda Ash","doi":"10.1080/20477724.2023.2179454","DOIUrl":"10.1080/20477724.2023.2179454","url":null,"abstract":"<p><p>Despite advances in modern human and veterinary medicine, gastrointestinal (GI) parasitic infections remain a significant health issue worldwide, mainly in developing countries. Increasing evidence of the multi-drug resistance of these parasites and the side effects of currently available synthetic drugs have led to increased research on alternative medicines to treat parasitic infections. The exploration of potential botanical antiparasitics, which are inexpensive and abundant, may be a promising alternative in this context. This study summarizes the <i>in vitro</i>/<i>in vivo</i> antiparasitic efficacy of different medicinal plants and their components against GI parasites. Published literature from 1990-2020 was retrieved from Google Scholar, Web of Science, PubMed and Scopus. A total of 68 plant species belonging to 32 families have been evaluated as antiparasitic agents against GI parasites worldwide. The majority of studies (70%) were conducted <i>in vitro</i>. Most plants were from the Fabaceae family (53%, <i>n</i> = 18). Methanol (37%, <i>n</i> = 35) was the most used solvent. Leaf (22%, <i>n</i> = 16) was the most used plant part, followed by seed and rhizome (each 12%, <i>n</i> = 9). These studies suggest that herbal medicines hold a great scope for new drug discoveries against parasitic diseases and that the derivatives of these plants are useful structures for drug synthesis and bioactivity optimization.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 6","pages":"535-553"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10220768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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