High seropositivity against NDO-LID in a group of household contacts of leprosy patients. Are we close to leprosy elimination in Colombia?

IF 4.9 4区医学 Q1 PARASITOLOGY

Pathogens and Global Health Pub Date : 2023-12-01 Epub Date: 2023-05-25 DOI:10.1080/20477724.2023.2217405

Héctor Serrano-Coll, Mónica Muñoz, Juan Camilo Beltrán, Nora Cardona-Castro

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引用次数: 0

Abstract

Introduction: Leprosy is a chronic infectious disease caused by two mycobacteria (Mycobacterium leprae and Mycobacterium lepromatosis). The household contacts (HHC) of leprosy index cases are at higher risk of being infected with these mycobacteria. Therefore, serological testing in HHC would be an effective strategy to eliminate leprosy in Colombia.

Objective: To determine the seroprevalence and factors associated with the infection by M. leprae in HHC.

Methods: An observational study was conducted in 428 HHC located in the Colombian Caribbean, Andean, Pacific, and Amazonian regions. We evaluated the seropositivity and titrations of IgM, IgG, and protein A against NDO-LID.

Results: The evaluated HHC showed high seropositivity, precisely 36.9% anti-NDO-LID IgM, 28.3% anti-NDO-LID IgG, and 47.7% protein A. Furthermore, Protein A showed a greater capacity to detect infected individuals than other anti-NDO-LID conjugates (p < 0.0001). This study did not show differences in the seropositivity according to sex or age of the HHC (p > 0.05). Higher seropositivity for IgM was evidenced mainly in HHC located in the Colombian Pacific region (p 0.001). This research did not show differences in the seropositivity for these serological tests between HHC of PB or MB leprosy patients (p > 0.05).

Conclusion: Leprosy transmission is still active between Colombian HHC. Consequently, controlling leprosy transmission in this population is fundamental to eradicating this disease.

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麻风病患者的一组家庭接触者中NDO-LID的高血清阳性率。哥伦比亚的麻风病即将消灭吗？

简介：麻风病是由两种分枝杆菌（麻风分枝杆菌和麻风分枝杆菌）引起的慢性传染病。麻风指数病例的家庭接触者感染这些分枝杆菌的风险更高。因此，在HHC进行血清学检测将是消除哥伦比亚麻风病的有效策略。目的：了解麻风分枝杆菌在HHC的血清流行情况及相关因素。方法：对位于哥伦比亚加勒比海、安第斯、太平洋和亚马逊地区的428个HHC进行了观察性研究。我们评估了针对NDO-LID的血清阳性率和IgM、IgG和蛋白A的滴定。结果：所评估的HHC显示出高血清阳性率，准确地说是36.9%的抗NDO LID IgM，28.3%的抗NDO LID IgG和47.7%的蛋白A。此外，蛋白A比其他抗NDO-LID偶联物显示出更大的检测感染个体的能力（p p > 0.05）。IgM的较高血清阳性率主要在哥伦比亚太平洋地区的HHC中得到证明（p 0.001）。该研究没有显示PB或MB麻风病患者的HHC在这些血清学测试的血清阳性率方面的差异（p > 结论：麻风病在哥伦比亚HHC之间的传播仍然活跃。因此，控制麻风病在这一人群中的传播是根除这种疾病的根本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.