Pain physician最新文献

{"title":"Short-Term Efficacy of Multimodal Drug Combinations in Ultrasound-Guided Thoracic Paravertebral Block for Zoster-Associated Pain: Methodological Reflections.","authors":"Maria Paula Bernal-Vargas, Carlos Eduardo Restrepo-Garces","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E755-E756"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Comparison of Local Anesthetic Concentration in Pericapsular Nerve Group (PENG) Block for Total Hip Arthroplasty Under Spinal Anesthesia: A Randomized Controlled Trial\".","authors":"Dr Reena","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E745"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Response to Comments on \"Evaluating the Efficacy of GCSB-5 in Lumbar Disc Herniation: A Randomized Controlled Trial\".","authors":"Min Cheol Chang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E741"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Response to Comment on \"Cervical Erector Spinae Plane Block vs. Epidural Steroid Injection for Cervical Radicular Pain: A Clinical Trial\".","authors":"Sajede Salehi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E753-E754"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Repsonse to \"Short-Term Efficacy of Multimodal Drug Combinations in Ultrasound-Guided Thoracic Paravertebral Block for Zoster-Associated Pain: Methodological Reflections\".","authors":"Dan Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E757"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative Therapies in the Management of Chronic Low Back Pain from Evidence to Practice: An Analytical Summary of the 2025 Comprehensive Evidence-Based Guidelines.","authors":"Laxmaiah Manchikanti, Annu Navani, Sheldon Jordan, Mahendra R Sanapati, Sairam Atluri, Navneet Boddu, Kenneth D Candido, Alan D Kaye","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Regenerative medicine is an evolving medical subspecialty dedicated to enhancing the body's natural healing mechanisms to repair or to replace damaged tissues. By using autologous or allogeneic biologics, it offers the potential to restore function where conventional therapies have shown limited success. While this field holds great promise and continues to generate enthusiasm among both patients and clinicians, it remains in early stages of clinical validation. Therefore, it must be approached with careful optimism and responsible application, ensuring that its presentation, promotion, and use in clinical settings are grounded in evidence and ethical standards. In 2025, the American Society of Interventional Pain Physicians (ASIPP) published updated comprehensive evidence-based guidelines.</p><p><strong>Study design: </strong>Summary and structured synthesis of a multidisciplinary, evidence-based clinical practice guideline developed by systematic literature review, dual-instrument methodologic quality appraisal, Grading of Recommendations Assessment, Development, and Evaluation (GRADE) certainty assessment, and modified Delphi consensus.</p><p><strong>Objectives: </strong>The present investigation summarizes the 2025 updated comprehensive evidence-based guidelines for regenerative therapies in the management of chronic low back pain published by ASIPP. The critical and analytical summary is organized around these recommendations, presenting for each underlying evidence, the assigned evidence level, the consensus-based clinical recommendation, and the practical consequences for patient selection, product preparation and dosing, procedural technique, regulatory compliance, and informed consent.</p><p><strong>Methods: </strong>A multidisciplinary panel convened by ASIPP defined key clinical questions, reviewed relevant literature, formulated evidence-based statements, and reached consensus through structured discussion and formal voting. Methodologic quality of randomized trials was assessed with Cochrane review criteria and the Interventional Pain Management Techniques - Quality Appraisal of Reliability and Risk of Bias (IPM-QRB) instrument; nonrandomized studies were assessed with the Risk of Bias in Non-Randomized Studies of Exposure (ROBINS-E) tool and IPM-QRBNR. Evidence was graded on the 5-level modified ASIPP scale and appraised for certainty under GRADE. Consensus required at least 80% agreement among eligible panelists without a primary conflict of interest.</p><p><strong>Results: </strong>Thirty-five authors contributed and 33 participated in the formal consensus process. Nineteen recommendations were generated, all achieving 100% agreement. Effectiveness recommendations were graded by anatomical target: lumbar intradiscal injections of platelet-rich plasma (PRP) and of bone marrow aspirate concentrate (BMAC) each carry Level III, fair evidence with a moderate consensus-based recommendation; lumbar epidura","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E531-E552"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric Analysis of the Corpus Callosum in Relation to Adult Migraine: Association with Disease Duration and Clinical Disability.","authors":"Pinar Ozturk, Cile Aktan, Dilek Kilic","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Migraine is increasingly recognized as a disorder associated with widespread neuroanatomical and white-matter alterations rather than a purely episodic pain condition. The corpus callosum, the largest interhemispheric commissural tract, plays a critical role in sensory integration, pain modulation, and interhemispheric connectivity. Structural alterations of the corpus callosum may therefore reflect cumulative neurobiological effects of chronic migraine.</p><p><strong>Objectives: </strong>To compare corpus callosum morphometric characteristics between adult patients with migraine and controls without migraine and to investigate the associations between callosal morphology and clinical disease burden, including migraine duration, age at onset, attack frequency, and migraine-related disability.</p><p><strong>Study design: </strong>Single-center, cross-sectional observational study.</p><p><strong>Setting: </strong>Tertiary referral neurology center with retrospective magnetic resonance imaging evaluation and prospective clinical assessment.</p><p><strong>Methods: </strong>A total of 101 adult patients diagnosed with migraine according to ICHD-3 criteria and 101 age- and gender-matched controls without migraine were included in our study. Morphometric measurements of the corpus callosum were obtained from midsagittal fluid-attenuated inversion recovery magnetic resonance images using the Witelson segmentation method, assessing genu, truncus, and splenium thickness, as well as anteroposterior length. Group comparisons were performed using the Mann-Whitney U test and the Welch t test, as appropriate. Associations between callosal measurements and clinical variables, including disease duration, age at migraine onset, attack frequency, and Migraine Disability Assessment Scores, were analyzed using the Spearman rank correlation. A receiver operating characteristic analysis was conducted to evaluate the discriminative ability of callosal measurements.</p><p><strong>Results: </strong>Compared with controls, patients with migraine had statistically significant reduced mean (SD) thickness of the genu (10.41 [1.35] mm vs 11.43 [1.08] mm), truncus (5.91 [0.73] mm vs 6.68 [0.84] mm), and splenium (10.73 [1.16] mm vs 11.13 [1.16] mm) all P < 0.05; anteroposterior length did not differ significantly. Within the migraine group, genu thickness correlated positively with age at onset (r = 0.33) and Migraine Disability Assessment Score (r = 0.37) and negatively with disease duration (r = -0.30). Attack frequency showed no significant association with any morphometric parameter. A receiver operating characteristic analysis showed a modest discriminatory performance for genu and truncus thickness.</p><p><strong>Limitations: </strong>Our study's cross-sectional design precludes causal inference. Also, morphometric measurements were limited to a 2-dimensional assessment thereby making us unable to conduct diffusion or volumetric analyses.</","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E717-E724"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Burst Spinal Cord Stimulation Versus Those of Paravertebral Block on Thoracic Subacute Herpetic Neuralgia: A Propensity Score-Matched Retrospective Cohort Study.","authors":"Xiao-Kai Zhou, Min Yang, Yun-Qing Zhu, Shi-Yu Zhu, Zhong-Yun Wang, Yin-Bing Pan, Jian-Jun Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Subacute herpetic neuralgia (SHN) is a form of neuropathic pain often accompanied by breakthrough pain (BTP) and paresthesia, leading to impairments in the quality of patients' lives. Although burst spinal cord stimulation (burst-SCS) and thoracic paravertebral block (TPVB) are commonly used in the management of thoracic SHN, the comparative effectiveness of these procedures remains unclear.</p><p><strong>Objectives: </strong>This study aimed to compare the clinical effects of burst-SCS to those of TPVB in patients with thoracic SHN.</p><p><strong>Study design: </strong>A single-center, retrospective cohort study.</p><p><strong>Setting: </strong>The First Affiliated Hospital with Nanjing Medical University, People's Republic of China.</p><p><strong>Methods: </strong>This retrospective cohort study included 382 patients with thoracic SHN. These individuals were identified through the electronic medical record system. Patients were assigned into either the burst-SCS group or the TPVB group, depending on the intervention they received. Propensity score matching (PSM) was applied to balance baseline characteristics between the 2 groups. Pain intensity, efficacy assessment, incidence of postherpetic neuralgia (PHN), mean number of BTP episodes per day, area and severity of touch-evoked pain, sleep quality, and medication use were assessed at baseline (T0), at discharge (T1), and at one month (T2), 3 months (T3), 6 months (T4), and 12 months (T5) after treatment.</p><p><strong>Results: </strong>After PSM, 72 matched pairs were generated, with baseline characteristics well balanced between the 2 groups. From T1 to T5, the burst-SCS group demonstrated significantly greater improvement in visual analog scale (VAS) scores than did the TPVB group. Additionally, the cure rate was significantly higher in the burst-SCS group from T1 to T5, as was the response rate at T1 and T2. Moreover, the incidence of PHN was markedly lower in the burst-SCS group than in the TPVB group at T3. Both the area and severity of touch-evoked pain were significantly lower in the burst-SCS group than in the TPVB group from T1 to T5. This finding was consistent with the reduction in the mean number of BTP episodes per day from T1 to T3. At certain follow-up time points, patients in the burst-SCS group exhibited better sleep quality and lower pregabalin consumption than did those in the TPVB group. However, no significant difference was observed between the 2 groups in oral morphine equivalent dosage.</p><p><strong>Limitations: </strong>The study design was retrospective and nonrandomized. The findings should not be extrapolated to zoster-associated pain involving other anatomical regions or different disease stages.</p><p><strong>Conclusion: </strong>Both short-term burst-SCS and TPVB were effective in relieving pain and improving sleep quality for patients with thoracic SHN; however, burst-SCS was associated with more favorable clinical outcomes.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E679-E690"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASIPP Letters to CMS.","authors":"Asipp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E761-E772"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Treatment Success After Intercostal Nerve Radiofrequency for Intercostal Neuralgia: A Retrospective.","authors":"Kaan Yavuz, Mesut Bakir, Esra Bayburtluoglu, Bedri Ilcan, Nureddin Teker, Sebnem Rumeli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Intercostal neuralgia, which is characterized by neuropathic pain along the distribution of the intercostal nerves (ICNs), can impair patients' quality of life substantially. ICN-targeted radiofrequency (RF) treatment is used increasingly in current practice; however, data on factors that predict the success of such treatments remain limited.</p><p><strong>Objectives: </strong>This study aims to evaluate factors associated with treatment success in patients with intercostal neuralgia who underwent ICN-targeted RF treatment.</p><p><strong>Study design: </strong>A retrospective cohort study.</p><p><strong>Setting: </strong>A single-center retrospective study conducted at Mersin University Faculty of Medicine Hospital.</p><p><strong>Methods: </strong>This retrospective chart review included adults who had post-traumatic, postherpetic, or idiopathic intercostal neuralgia and underwent ultrasound-guided conventional radiofrequency ablation (CRF) or pulsed radiofrequency treatment (PRF) on their ICNs between January 1, 2018, and May 30, 2025. Pain intensity (measured on the NRS-11) was assessed at baseline and at 3 and 6 months after the procedure. The primary outcome was the 6-month treatment response (according to IMMPACT criteria: ≥ 50% pain reduction or a ≥ 4-point decrease in NRS score from its baseline counterpart). Group comparisons and multivariable logistic regression were performed to evaluate the outcomes and predictors of response.</p><p><strong>Results: </strong>Sixty patients were included in the analysis (CRF, n = 31; PRF, n = 29). At both 3 and 6 months, mean NRS scores were significantly lower in the CRF group than in the PRF group (3 months: 2.77 ± 1.80 vs 5.83 ± 2.55; P < 0.001; 6 months: 2.81 ± 1.93 vs 6.31 ± 2.34; P < 0.001). In the multivariable model, which included age, gender, presence of allodynia, baseline NRS score, and RF modality, only RF modality was identified as an independent predictor of treatment response (OR 9.395; 95% CI 2.363-37.359; P = 0.001).</p><p><strong>Limitations: </strong>The single-center setting, relatively small sample size, and retrospective study design.</p><p><strong>Conclusions: </strong>Ultrasound-guided intercostal CRF may provide clinically meaningful analgesia for patients with refractory intercostal neuralgia. Although both modalities were associated with short-term pain improvement, CRF produced significantly more sustained pain reduction at 3 and 6 months and emerged as the sole independent predictor of treatment success.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 6","pages":"E671-E677"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}