{"title":"Impact of the relationship between renal pedicles and tumors on surgical outcomes for non-high-risk abdominal neuroblastoma.","authors":"Yuki Yamamoto, Akihiro Yoneda, Osamu Miyazaki, Kimikazu Matsumoto, Satoko Yamagishi, Akinori Ichinose, Tomoya Hirokawa, Michimasa Fujiogi, Tetsuya Ishimaru, Naoki Shimojima","doi":"10.1007/s00383-024-05956-x","DOIUrl":"https://doi.org/10.1007/s00383-024-05956-x","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the impact of the relationship between renal pedicles and tumors on surgical outcomes in patients with non-high-risk abdominal neuroblastoma.</p><p><strong>Methods: </strong>We retrospectively analyzed cases of neuroblastoma without metastasis treated at our hospital between March 2002 and December 2023. Cases in which surgical resection was performed were divided into three groups according to imaging findings at the time of diagnosis and before surgery: Group E (tumor encasing renal pedicles), Group C (tumor in contact with renal pedicles), and Group S (tumor separated from renal pedicles).</p><p><strong>Results: </strong>Among 256 neuroblastoma cases diagnosed during the study period, 27 non-high-risk cases that underwent surgery for partial abdominal tumor resection or greater were included. The numbers of cases in the S group, C group, and E group, respectively, were 7, 9, and 11 at diagnosis, and 8, 14, and 5 before surgery. Renal complications (combined concurrent renal resection and post-operative renal atrophy) were seen in five E group cases at the time of diagnosis, and two C group cases and three E group cases preoperatively.</p><p><strong>Conclusion: </strong>In non-high-risk abdominal neuroblastomas, tumors encased in the renal pedicles have the highest risk of renal complications, followed by tumors in contact with the renal pedicles.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"47"},"PeriodicalIF":1.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Mokhaberi, E P Schneider, M Aftzoglou, I Hüners, M Körner, L Armbrust, D Biermann, R Kozlik-Feldmann, M Hübler, K Reinshagen, C Tomuschat
{"title":"Risk factors and surgical outcomes in pediatric patients with congenital heart disease and ischemic colitis.","authors":"N Mokhaberi, E P Schneider, M Aftzoglou, I Hüners, M Körner, L Armbrust, D Biermann, R Kozlik-Feldmann, M Hübler, K Reinshagen, C Tomuschat","doi":"10.1007/s00383-024-05950-3","DOIUrl":"10.1007/s00383-024-05950-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates risk factors and surgical outcomes in pediatric patients with congenital heart defects (CHD) who develop ischemic colitis (IC). Previous research indicates a higher IC risk in very low birth weight neonates with CHD.</p><p><strong>Methods: </strong>A retrospective analysis compared an IC-CHD group to a CHD-only group. Key variables included gestational age, birth weight, multiple pregnancies, prematurity, APGAR scores, cardiac and surgical characteristics, Aristotle-Score, and mortality rates. Surgical outcomes such as bowel resection and stoma procedures were also evaluated.</p><p><strong>Results: </strong>IC-CHD exhibited significantly lower gestational ages and birth weights, with higher rates of multiple pregnancies and prematurity. APGAR scores were notably lower. Cardiac and surgical data showed more frequent ECMO use and shorter cardiopulmonary bypass durations in the IC-CHD group. High rates of bowel resection highlighted severe gastrointestinal involvement. Mortality was significantly higher in IC-CHD with elevated Aristotle scores correlating with poorer outcomes.</p><p><strong>Conclusion: </strong>Gestational age, birth weight, and initial health status are critical in predicting IC risk and surgical outcomes in pediatric patients with CHD. The significantly higher mortality and complex surgical needs in the IC-CHD group underscore the necessity for vigilant monitoring and tailored interventions. Development of targeted therapeutic strategies adjustment for confounding factors in future studies is needed.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"48"},"PeriodicalIF":1.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ágnes Eszter Tímár, Dalma Bénes, András Terebessy, Balázs Fadgyas
{"title":"Inguinal hernioplasty in children-open or laparoscopic?: A retrospective cohort study of 1,072 cases.","authors":"Ágnes Eszter Tímár, Dalma Bénes, András Terebessy, Balázs Fadgyas","doi":"10.1007/s00383-024-05943-2","DOIUrl":"https://doi.org/10.1007/s00383-024-05943-2","url":null,"abstract":"<p><strong>Purpose: </strong>The most common surgical intervention in childhood is inguinal hernioplasty. The advantage of laparoscopic approach is still questionable, therefore our aim was to compare open hernia repair (OHR) and PIRS (Percutaneous Internal Ring Suturing) technique at the authors' institute.</p><p><strong>Methods: </strong>An observational retrospective cohort study was conducted between 2013 and 2021. Patients were included with hernioplasties under 18 years. The number of contralateral patent processus vaginalis, length of hospital stay, complications and recurrences were analysed.</p><p><strong>Results: </strong>1,072 surgeries were performed (OHR: 836, PIRS: 236) in 959 patients with the mean age of 4.2 years. During the study period 86 incarcerated hernias were treated: 85/86 following successful reduction with postponed surgery (77 open and eight PIRS) and 1/86 acute (open) surgery. Only six complications (OHR: 5, PIRS: 1, p = 0.86) and 22 recurrences were registered (open:15, PIRS: 7, p = 0.22). The average length of hospital stay was 1.13 days (OHR: 1.3, PIRS: 1.13 days, p = 0.82). PIRS identified contralateral patent processus vaginalis in 22.45% of cases initially diagnosed as unilateral.</p><p><strong>Conclusions: </strong>Our findings indicate that both techniques are equally safe, with no statistically significant differences observed in terms of hospital stay duration, recurrence rates, or complication rates.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"45"},"PeriodicalIF":1.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk factors associated with neonatal pneumothorax in the neonatal intensive care unit: 10 years of experience in a single-center.","authors":"H Madenci, M Uysal","doi":"10.1007/s00383-024-05939-y","DOIUrl":"https://doi.org/10.1007/s00383-024-05939-y","url":null,"abstract":"<p><strong>Background: </strong>We aimed to evaluate the epidemiological characteristics, risk factors and prognostic factors affecting the clinical follow-up of patients who underwent tube thoracostomy due to pneumothorax in the neonatal intensive care unit of our hospital.</p><p><strong>Methods: </strong>In our study; 54 cases with neonatal pneumothorax underwent tube thoracostomy followed up in the neonatal intensive care unit between April 2014 and March 2023 were retrospectively analyzed.</p><p><strong>Results: </strong>The gestational age of the cases was between 28 and 38 weeks; 24 (44.4%) were premature and 30 (55.6%) were 36 weeks and above. Of the cases included in the study, 35 (64.8%) had primary lung disease and 19 (35.2%) had other anomalies accompanying pneumothorax. Mechanical ventilation was needed in 35 (64.8%) of the 54 cases included in the study. While all patients who did not require mechanical ventilation recovered, 10 of 35 patients (28.6%) who required mechanical ventilation died. The body weight of 10 of these 35 cases (28.6%) was 2500 g or less.</p><p><strong>Conclusion: </strong>It was determined that accompanying primary lung disease, the need to connect to a ventilator, and bilateral pneumothorax significantly affected mortality and prognosis in premature babies, especially those weighing less than 2500 g, who were followed in the neonatal intensive care unit.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"46"},"PeriodicalIF":1.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Association between nighttime/weekend visits and patient outcomes in children with blunt liver and spleen injuries.","authors":"Hiraku Funakoshi, Shogo Shirane, Morihiro Katsura","doi":"10.1007/s00383-024-05936-1","DOIUrl":"https://doi.org/10.1007/s00383-024-05936-1","url":null,"abstract":"","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"43"},"PeriodicalIF":1.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiyi Zhang, Jiayu Yan, Jun Yan, Liuming Huang, Yajun Chen, Xin Ni
{"title":"Surgical management of children with Burkitt's lymphoma involving the gastrointestinal tract.","authors":"Zhiyi Zhang, Jiayu Yan, Jun Yan, Liuming Huang, Yajun Chen, Xin Ni","doi":"10.1007/s00383-024-05955-y","DOIUrl":"https://doi.org/10.1007/s00383-024-05955-y","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical characteristics and surgical management of children with Burkitt's lymphoma (BL) involving the gastrointestinal tract.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 87 pediatric patients diagnosed with BL involving the gastrointestinal tract and treated surgically at Beijing Children's Hospital (2008-2022). All patients were histopathologically confirmed with BL and diagnosed with gastrointestinal involvement through imaging studies and surgery. Clinical data were reviewed and analyzed.</p><p><strong>Results: </strong>Among 87 patients, 79 were male and 8 were female, with an average age of 6.8 ± 3.3 years. Predominant clinical manifestations included abdominal pain (74/87, 85.1%) and abdominal mass (45/87, 51.7%). The ileocecal region (31/87, 35.6%) was the most frequent involvement site. The presence of intussusception (58/87, 66.7%) was the main indication for surgery, of which 56 (56/58, 96.6%) underwent enterectomy and anastomosis. Twenty-two (22/87, 25.3%) patients underwent surgery for abdominal mass, with 15 (15/22, 68.2%) receiving an open biopsy. During the follow-up period, 2 patients (2/83, 2.4%) experienced recurrence, 4 patients (4/83, 4.8%) required reoperation, and no deaths were reported.</p><p><strong>Conclusion: </strong>The main surgical indications for gastrointestinal BL are intussusception and abdominal mass. Surgery plays a crucial role in resolving intussusception, clarifying the diagnosis, and ultimately facilitating the timely initiation of chemotherapy without delay.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"44"},"PeriodicalIF":1.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medium- to long-term outcomes of seton placement for fistula-in-ano in children: the experience of 103 patients from a single institution.","authors":"Shaobo Yang, Cheng Xie, Yanlei Huang, Shan Zheng","doi":"10.1007/s00383-024-05932-5","DOIUrl":"https://doi.org/10.1007/s00383-024-05932-5","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the efficacy of seton placement for anal fistula in children.</p><p><strong>Methods: </strong>The clinical data of children with anal fistula treated by seton placement admitted from January 2017 to September 2022 were retrospectively analyzed. Our primary treatments for perianal abscess (PA) are conservative treatment and drainage. Patients with systemic and inflammatory bowel diseases were excluded.</p><p><strong>Results: </strong>The median follow-up time of these patients was 23 (6-58) months, and the median onset age was 16 (3-156) months. Among the 103 patients, 75 with a single fistula and 20 with a double fistula were treated by primary seton placement. Seven patients with multiple fistulas were treated using staged seton placement, and one case using primary seton placement. A total of 97 patients experienced good healing, four patients experienced poor healing and healed after dressing change and debridement, and two patients with multiple fistulas who experienced recurrence underwent a second seton placement. The average healing time was four (1-10) weeks.</p><p><strong>Conclusion: </strong>The medium- to long-term outcome of seton placement indicates that this procedure is safe and effective in the treatment of anal fistula in children.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"42"},"PeriodicalIF":1.5,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trephination for primary pediatric pilonidal sinus disease: medium term functional and recurrence outcome of a large cohort.","authors":"Catalin Iacob, Eleonora Niazov, Osnat Zmora","doi":"10.1007/s00383-024-05941-4","DOIUrl":"https://doi.org/10.1007/s00383-024-05941-4","url":null,"abstract":"<p><strong>Purpose: </strong>Minimal incision procedures have been recommended for pediatric pilonidal sinus disease, based on small studies with short follow-up. We aimed to describe medium-term outcomes of trephination in a large cohort.</p><p><strong>Methods: </strong>Retrospective chart review and additional concluding telephone interviews for all children who underwent primary trephination in our institution over 5.5 years, collecting demographic and clinical data, and updated functional and recurrence outcome data.</p><p><strong>Results: </strong>100 patients were included. Median follow-up time was 31.4 (16.2-52.8) months. Post-operative analgesics were used for 1.25 (0-4) days, sick days were 7 (3-11), and time to full activity was 14 (14-30) days. Recurrent pain, discharge, and abscess/es were reported by 37%, 35%, and 15% of patients, with 80-85% occurring within the first post-operative year. Reoperation rate was 18%, with 95% occurring within 2 years. No significant associations were found between demographic or clinical characteristics and either functional or recurrence medium-term outcomes.</p><p><strong>Conclusion: </strong>Trephination carries excellent functional outcome with less favorable medium-term efficacy for the treatment of primary pediatric pilonidal sinus disease. Most adverse outcomes, including reoperations, occur within the first two years.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"39"},"PeriodicalIF":1.5,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing the risk factors for surgical site infections after anal reconstruction surgery in patients with anorectal malformations: a retrospective analysis.","authors":"Shinichiro Yokoyama, Daisuke Ishii, Soma Sakamura, Insu Kawahara, Satsuki Hashimoto, Yuka Kumata, Takahiro Korai, Kazuyoshi Okumura, Momoko Ara, Takafumi Kondo, Riku Ishimura, Ryo Takahashi, Shoichi Tsuzaka, Masashi Minato, Go Ohba, Hiroshi Yamamoto, Shohei Honda, Hisayuki Miyagi, Akihiro Nui","doi":"10.1007/s00383-024-05953-0","DOIUrl":"https://doi.org/10.1007/s00383-024-05953-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify surgical site infection (SSI) risk factors after anal reconstruction surgery in patients with anorectal malformations (ARMs).</p><p><strong>Methods: </strong>This retrospective analysis from January 2013 to December 2022, including all pediatric surgical facilities in Hokkaido, Japan, examined consecutive patients with ARMs, excluding cloacal cases, regarding perioperative and SSI factors during their initial anal reconstruction surgeries.</p><p><strong>Results: </strong>This study involved 157 cases of major clinical groups and 7 cases of rare/regional variants, among whom 4% developed SSIs. SSIs occurrence varied by type and was primarily observed from the neo-anus to the perineal region. Organ/space SSIs occurred in rectourethral fistula (prostatic/bulbar) and perineal (cutaneous) fistula type. Surgical procedures were abdominal sacroperineal rectoplasty, posterior sagittal anorectoplasty, laparoscopic-assisted anorectal pull-through, cutback anoplasty, and Pott's anoplasty, varied based on the ARM type and facility. In perineal (cutaneous) fistula, vestibular fistula, and anal stenosis cases, a significant association was observed between perianal muscle division and SSIs in patients aged > 4 months (p = 0.04). No significant SSI factors were found in other ARM types.</p><p><strong>Conclusion: </strong>The choice of procedure as an interventional perioperative factor is suggested to be associated with SSIs. These findings may contribute to making informed decisions regarding surgical procedures in such cases.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"41"},"PeriodicalIF":1.5,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Jank, M Kraljevic, A Ozturk Aptekmann, D Patel, M Boettcher, R LeDuc, R Keijzer
{"title":"Validation and in silico function prediction of circtial1 as a novel marker of abnormal lung development in nitrofen-induced congenital diaphragmatic hernia (CDH).","authors":"M Jank, M Kraljevic, A Ozturk Aptekmann, D Patel, M Boettcher, R LeDuc, R Keijzer","doi":"10.1007/s00383-024-05911-w","DOIUrl":"https://doi.org/10.1007/s00383-024-05911-w","url":null,"abstract":"<p><strong>Purpose: </strong>Circular RNAs (circRNAs) are stable, non-coding RNAs with tissue- and developmental-specific expression making them suitable biomarkers for congenital anomalies. Current circRNA discovery pipelines have focused on human and mouse. We aim to bridge this gap by combining bioinformatics resources and used circtial1 as a model candidate in the nitrofen rat model of congenital diaphragmatic hernia (CDH).</p><p><strong>Methods: </strong>Circtial1 backsplice junction sequences from a microarray were used to predict mature circRNA sequences and downstream pathways by miRNA interactions using CRAFT and circAtlas. We validated circtial1 expression using conventional PCR, amplicon sequencing, RT-Qpcr, and Basescope™ in situ hybridization.</p><p><strong>Results: </strong>Expression of parental gene tial1 was decreased in nitrofen-induced lungs at embryonic day (E)15 (p = 0.004) and E21 (p = 0.008), while at E18, there was no significant difference (p = 0.65). At E21, circtial1 expression did not differ between CDH and control lungs (p = 0.07); however, there was a decreased expression in male pups (p = 0.0167). In situ hybridization confirmed low circtial1 expression. CircRNA::miRNA::mRNA interactions revealed pathway enrichment for inflammation/infection and neuron function/development.</p><p><strong>Conclusion: </strong>For the first time, we report circRNA profiling in nitrofen-induced CDH with a sex-specific expression of circtial1. Current bioinformatics tools have significant challenges, but can guide hypothesis formation on their biological role.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"40"},"PeriodicalIF":1.5,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}