Pediatric Surgery International最新文献

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Diagnostic and therapeutic yield of postoperative imaging after complicated appendicitis: a western pediatric surgery research consortium prospective study. 复杂阑尾炎术后影像学诊断和治疗率:西方儿科外科研究联盟的前瞻性研究。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-12 DOI: 10.1007/s00383-026-06672-4
Anastasia M Kahan, Michael D Traynor, Utsav M Patwardhan, Aidyn K Eldredge, Sarah B Cairo, Dane Munar, Alexandra Highet, Benjamin E Padilla, Justin H Lee, Patrick McGovern, Shannon N Acker, Catherine Dawson-Gore, Jose Diaz-Miron, Lorraine I Kelley-Quon, Jenna Lee, Stephanie D Chao, Serena Bidwell, Benjamin D Carr, Elizabeth A Fialkowski, Romeo C Ignacio, Scott S Short, Katie W Russell
{"title":"Diagnostic and therapeutic yield of postoperative imaging after complicated appendicitis: a western pediatric surgery research consortium prospective study.","authors":"Anastasia M Kahan, Michael D Traynor, Utsav M Patwardhan, Aidyn K Eldredge, Sarah B Cairo, Dane Munar, Alexandra Highet, Benjamin E Padilla, Justin H Lee, Patrick McGovern, Shannon N Acker, Catherine Dawson-Gore, Jose Diaz-Miron, Lorraine I Kelley-Quon, Jenna Lee, Stephanie D Chao, Serena Bidwell, Benjamin D Carr, Elizabeth A Fialkowski, Romeo C Ignacio, Scott S Short, Katie W Russell","doi":"10.1007/s00383-026-06672-4","DOIUrl":"10.1007/s00383-026-06672-4","url":null,"abstract":"<p><strong>Purpose: </strong>While laparoscopic appendectomy is the standard of care for acute appendicitis, postoperative imaging practices for complicated cases remains variable, and abscesses are a frequent source of morbidity. Postoperative imaging variation may influence the timing of abscess diagnosis and intervention. This study examines the association between postoperative imaging timing and both diagnostic yield (abscess detection) and therapeutic yield (intervention rate), recognizing that detection of an abscess on imaging does not always result in intervention.</p><p><strong>Methods: </strong>We conducted a prospective study of children with complicated appendicitis across nine children's hospitals (2022-2024). Patients were stratified by postoperative day (POD) of first imaging (US/CT/MRI). Primary outcomes were diagnostic yield of imaging for abscess formation and therapeutic yield for drainage or reoperation. We performed multivariable logistic regression to examine the association of POD windows and yield. Pairwise comparisons of marginal predicted probabilities were obtained with post-estimation margins and delta-method standard errors.</p><p><strong>Results: </strong>Among 2,560 patients with complicated appendicitis, 578 (22.5%) underwent postoperative abdominal imaging. Of these, 327 (56.6%) occurred prior to discharge and 251 (43.4%) after discharge. Therapeutic yield varied as a continuous function of postoperative day; LOWESS analysis demonstrated increasing probability of drainage through approximately POD7-10 followed by decline, with sliding window analysis identifying peak therapeutic yield between POD6-8 (42.3% of scans resulted in drainage). Diagnostic yield was highest when imaging occurred before POD10, while imaging after POD10 identified significantly fewer abscesses (37.2% vs. 69.2%, p < 0.001) and resulted in fewer interventions (20.0% vs. 37.2%, p < 0.001). When stratified by discharge status, pre-discharge therapeutic yield peaked between POD6-10, while post-discharge yield plateaued around POD6-8. Therapeutic yield was higher among patients imaged before discharge, who represent a clinically distinct population with persistent failure to meet discharge criteria.</p><p><strong>Conclusion: </strong>Postoperative imaging performed before POD10 demonstrated the highest diagnostic and therapeutic yield for detecting intra-abdominal abscess following appendectomy for complicated appendicitis. Therapeutic yield for postoperative imaging peaked between POD 6-8. Imaging performed after POD10 was significantly less likely to identify drainable collections. Among patients who re-present after discharge, imaging yield declines after POD10, which may inform the timing and modality of imaging in this population, balancing diagnostic utility against radiation exposure. Diagnosing an abscess does not always lead to intervention; clinicians should prioritize the POD6-8 window to maximize actionable yield.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Outcomes of bovine jugular vein versus porcine valved conduits for right ventricle to pulmonary artery connection". 对“牛颈静脉与猪瓣膜导管连接右心室与肺动脉的结果”的评论。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-12 DOI: 10.1007/s00383-026-06678-y
Tahir Ullah, Hamza Nasir
{"title":"Comment on \"Outcomes of bovine jugular vein versus porcine valved conduits for right ventricle to pulmonary artery connection\".","authors":"Tahir Ullah, Hamza Nasir","doi":"10.1007/s00383-026-06678-y","DOIUrl":"10.1007/s00383-026-06678-y","url":null,"abstract":"","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indocyanine green fluorescence-guided transumbilical three-port laparoscopic suprainguinal varicocelectomy with testicular artery and lymphatic preservation for pediatric varicocele: a retrospective cohort study. 吲哚菁绿荧光引导下经脐三孔腹腔镜腹股沟上精索静脉曲张切除术保留睾丸动脉和淋巴治疗小儿精索静脉曲张:一项回顾性队列研究。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-12 DOI: 10.1007/s00383-026-06669-z
Yang Zhao, Yanpei Yang, Xiaowei Zhang, Kuan Lu, Lifei Ma, Tian Tao, Xiaoguang Zhou, Yuandong Tao, Huixia Zhou
{"title":"Indocyanine green fluorescence-guided transumbilical three-port laparoscopic suprainguinal varicocelectomy with testicular artery and lymphatic preservation for pediatric varicocele: a retrospective cohort study.","authors":"Yang Zhao, Yanpei Yang, Xiaowei Zhang, Kuan Lu, Lifei Ma, Tian Tao, Xiaoguang Zhou, Yuandong Tao, Huixia Zhou","doi":"10.1007/s00383-026-06669-z","DOIUrl":"10.1007/s00383-026-06669-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the technical feasibility and short-term perioperative and cosmetic outcomes of indocyanine green (ICG) fluorescence-guided transumbilical three-port laparoscopic suprainguinal varicocelectomy with testicular artery and lymphatic preservation in pediatric patients, and to describe changes in testicular volume and testicular volume discrepancy (TVD) at 6 months after surgery.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on pediatric patients with varicocele who underwent surgical treatment at our institution between January 2023 and December 2024. All patients underwent ICG fluorescence-guided transumbilical three-port laparoscopic suprainguinal varicocelectomy with testicular artery and lymphatic preservation. Perioperative outcomes, postoperative complications, cosmetic outcomes, and ultrasonographic testicular-volume measurements were analyzed. Paired preoperative and 6-month postoperative testicular-volume measurements were compared.</p><p><strong>Results: </strong>All 42 procedures were completed laparoscopically without conversion or intraoperative complications. The median operative time was 26 min, median estimated blood loss was 2 mL, and postoperative hospital stay was 1 day. Lymphatic vessels were visualized and preserved in all patients. During a median follow-up of 11 months, no hydrocele, recurrent varicocele, testicular atrophy, or Doppler-detected venous reflux was observed. At 3 months, the median Vancouver Scar Scale score was 1; 31 patients (73.8%) were very satisfied and 11 (26.2%) were satisfied with the cosmetic outcome. At 6 months, mean ipsilateral testicular volume increased from 9.45 to 10.84 mL, while mean TVD decreased from 14.92% to 7.65%.</p><p><strong>Conclusion: </strong>ICG fluorescence-guided transumbilical three-port laparoscopic suprainguinal varicocelectomy with testicular artery and lymphatic preservation was technically feasible in this retrospective cohort and was associated with favorable short-term perioperative and cosmetic outcomes.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neighborhood socioeconomic opportunity and clinical presentation, recurrence, and longitudinal treatment intensity in adolescent pilonidal disease. 青少年毛鞘疾病的社区社会经济机会与临床表现、复发和纵向治疗强度。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-12 DOI: 10.1007/s00383-026-06673-3
Anam N Ehsan, Claire Abrajano, Bill Chiu
{"title":"Neighborhood socioeconomic opportunity and clinical presentation, recurrence, and longitudinal treatment intensity in adolescent pilonidal disease.","authors":"Anam N Ehsan, Claire Abrajano, Bill Chiu","doi":"10.1007/s00383-026-06673-3","DOIUrl":"10.1007/s00383-026-06673-3","url":null,"abstract":"<p><strong>Background: </strong>Pilonidal disease is a chronic inflammatory condition of adolescence requiring sustained outpatient management, yet the impact of neighborhood-level social determinants of health on disease course and treatment intensity remains unclear.</p><p><strong>Method: </strong>We conducted a retrospective cohort study of adolescents evaluated for pilonidal disease at a high-volume specialty clinic from 2019 to 2024. Residential addresses were geocoded and linked to census tract-level socioeconomic opportunity using the California Healthy Places Index (HPI). HPI was analyzed continuously, by quintiles, and using a prespecified lowest-quintile (Q1) threshold contrast. Outcomes included disease stage at presentation, symptom duration, recurrence, receipt of laser epilation, and number of completed laser sessions. Multivariable models adjusted for age and sex; treatment intensity models additionally adjusted for stage and recurrence.</p><p><strong>Results: </strong>Among 393 adolescents (median age 17.0 years[IQR:15.3-18.8]), neighborhood opportunity was not associated with disease severity, symptom duration, recurrence, or receipt of laser therapy. However, among laser recipients (92%), Q1 residence was independently associated with fewer completed laser sessions (adjusted IRR:0.78; 95% CI:0.65-0.93), reflecting approximately 22% lower treatment intensity.</p><p><strong>Conclusions: </strong>Neighborhood-level social determinants were associated with reduced continuity of ambulatory surgical care, reflected by lower longitudinal laser treatment intensity, suggesting structural influences on continuity of ambulatory surgical care rather than biologic disease trajectory.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and clinical outcomes of postoperative small bowel obstruction after neonatal abdominal surgery: a single-center retrospective study. 新生儿腹部手术后小肠梗阻的发生率和临床结局:单中心回顾性研究
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-09 DOI: 10.1007/s00383-026-06676-0
Masahiro Fukuhara, Hiroaki Matsumoto, Yasuyuki Uchida
{"title":"Incidence and clinical outcomes of postoperative small bowel obstruction after neonatal abdominal surgery: a single-center retrospective study.","authors":"Masahiro Fukuhara, Hiroaki Matsumoto, Yasuyuki Uchida","doi":"10.1007/s00383-026-06676-0","DOIUrl":"10.1007/s00383-026-06676-0","url":null,"abstract":"<p><strong>Purpose: </strong>The long-term incidence and clinical course of neonatal abdominal surgery remain unclear. We evaluated the incidence, management, and outcomes of postoperative SBO following neonatal abdominal surgery.</p><p><strong>Methods: </strong>We retrospectively reviewed the records of neonates who underwent abdominal surgery within 30 days of birth in 2000-2025. Patients with postoperative SBO were identified, and their clinical characteristics, treatment, and outcomes were analyzed. The cumulative incidence was estimated using a competing risk analysis, with death before SBO treated as a competing event.</p><p><strong>Results: </strong>Among 312 neonates, 19 (6.1%) developed postoperative SBO, with 29 SBO events. The median interval from the initial surgery to the first SBO was 10.9 months, and 11 patients (57.9%) developed SBO within 1 year. During the first SBO episode, surgical intervention was required in 10 patients (52.6%). Bowel resection was required in 4 (21.1%). Seven patients developed recurrence (36.8%). No deaths occurred during SBO treatment. The cumulative incidence at 1, 5, 10, and 20 years was 4.6%, 7.3%, 8.1%, and 13.2%, respectively.</p><p><strong>Conclusion: </strong>SBO after neonatal abdominal surgery frequently occurs within 1 year, but the risk persists for a long time. The high surgical intervention and recurrence rates support its importance as a long-term complication of after neonatal abdominal surgery.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent biliary atresia and intestinal atresia: a systematic review of clinical characteristics, pathogenesis, management, and outcomes. 并发胆道闭锁和肠闭锁:临床特征、发病机制、管理和结果的系统综述。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-09 DOI: 10.1007/s00383-026-06665-3
Zaheer Hasan, Ramjee Prasad, Om Prakash Purbey, Md Mokarram Ali, Vinit Kumar Thakur, Ramdhani Yadav, Vijayendra Kumar
{"title":"Concurrent biliary atresia and intestinal atresia: a systematic review of clinical characteristics, pathogenesis, management, and outcomes.","authors":"Zaheer Hasan, Ramjee Prasad, Om Prakash Purbey, Md Mokarram Ali, Vinit Kumar Thakur, Ramdhani Yadav, Vijayendra Kumar","doi":"10.1007/s00383-026-06665-3","DOIUrl":"10.1007/s00383-026-06665-3","url":null,"abstract":"<p><strong>Purpose: </strong>The coexistence of biliary atresia (BA) and intestinal atresia (IA) is exceptionally rare. Delayed recognition of BA in neonates undergoing surgery for IA may adversely affect outcomes. This systematic review aimed to evaluate the available evidence regarding the clinical presentation, pathogenesis, management strategies, and outcomes of patients with concurrent BA and IA.</p><p><strong>Methods: </strong>A systematic literature search of PubMed, MEDLINE, and Google Scholar was conducted for studies published up to December 2025. Relevant studies encompassing case reports, case series, and retrospective reviews were identified. Data regarding demographics, type of intestinal atresia, associated anomalies, diagnostic methods, surgical management, and outcomes were extracted.</p><p><strong>Results: </strong>Fifteen studies comprising 98 patients met inclusion criteria. The association of BA with IA is rare, affecting 0.5-5% of BA patients. Duodenal atresia (DA) represents the most common intestinal association (0-1.5% of BA), followed by jejunoileal atresia (JIA) (0.5-5%). Among 98 identified cases, mortality exceeds 50% in combined presentations. Early Kasai portoenterostomy (KPE) before 60 days improves outcomes, but concomitant short bowel limits Roux-en-Y limb length, increasing cholangitis risk.</p><p><strong>Conclusions: </strong>Concurrent BA and IA represent a rare but severe neonatal condition associated with substantial morbidity and mortality. Careful biliary assessment during IA surgery, prompt investigation of persistent cholestasis, and timely Kasai portoenterostomy are essential for improving outcomes.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-adjusted shock index vs. reverse shock index multiplied by Glasgow Coma Scale to evaluate mortality in pediatric trauma: a systematic literature review and meta-analysis. 年龄调整休克指数与逆休克指数乘以格拉斯哥昏迷量表评估儿科创伤死亡率:系统文献回顾和荟萃分析
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-08 DOI: 10.1007/s00383-026-06662-6
Natalia Alexandra Fonseca Páez, Álvaro Andrés Trujillo Ceballos, Javier Aguilar Mejía, Miguel Andrés Cañón Plazas
{"title":"Age-adjusted shock index vs. reverse shock index multiplied by Glasgow Coma Scale to evaluate mortality in pediatric trauma: a systematic literature review and meta-analysis.","authors":"Natalia Alexandra Fonseca Páez, Álvaro Andrés Trujillo Ceballos, Javier Aguilar Mejía, Miguel Andrés Cañón Plazas","doi":"10.1007/s00383-026-06662-6","DOIUrl":"10.1007/s00383-026-06662-6","url":null,"abstract":"<p><strong>Objective: </strong>Early identification of high-risk pediatric trauma patients is essential for timely intervention. The Shock Index, Pediatric Age-adjusted (SIPA) and the reverse Shock Index multiplied by Glasgow Coma Scale (rSIG, including rSIM variants) are commonly studied physiologic scores that have not been systematically compared. This study evaluated and compared the performance of SIPA and rSIG/rSIM for predicting mortality in pediatric trauma, and secondarily, blood product transfusion and other resource-use outcomes.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed PRISMA 2020 and was registered in PROSPERO (CRD42025641021). Five databases were searched from inception to September 10, 2025. Observational studies including trauma patients younger than 18 years that reported SIPA and/or rSIG/rSIM in relation to mortality and/or secondary outcomes were eligible. Screening and data extraction were performed in duplicate. Risk of bias was assessed using the Newcastle-Ottawa Scale. Random-effects models (DerSimonian-Laird, with restricted maximum likelihood sensitivity analysis) synthesized odds ratios (ORs). Subgroup analyses compared SIPA versus rSIG/rSIM, and publication bias was explored using funnel plots and Egger's test.</p><p><strong>Results: </strong>Thirty-three studies were included qualitatively. Fourteen studies (n = 352,871) contributed to the mortality meta-analysis. The pooled effect favored rSIG/rSIM over SIPA for mortality (OR for SIPA vs. rSIG/rSIM = 0.19; 95% CI, 0.08-0.42; P < 0.001), with substantial heterogeneity (I²=98.8%), which was markedly lower within the rSIG/rSIM subgroup (I²=22.6%) than SIPA (I²=99.0%; between-subgroup difference, P = 0.019). Eleven studies contributed to transfusion outcomes; both indices captured increased transfusion risk (OR for SIPA vs. rSIG/rSIM = 0.28; 95% CI, 0.18-0.42; P < 0.001), without a significant SIPA-rSIG/rSIM contrast (P = 0.149). Egger's tests did not suggest small-study effects for either outcome.</p><p><strong>Conclusion: </strong>Indices incorporating neurologic status (rSIG/rSIM) showed a stronger and more consistent association with mortality than SIPA in pediatric trauma, supporting rSIG/rSIM for early mortality risk stratification when the Glasgow Coma Scale is reliably measured. SIPA remains informative for transfusion and resource-use enrichment.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic landmark models predicting native liver survival after kasai portoenterostomy: a bicentric study. 动态地标模型预测kasai门肠造口术后原生肝脏存活:一项双中心研究。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-07 DOI: 10.1007/s00383-026-06661-7
Yu Meng, Qianhui Yang, Xin Li, Pu Yu, Qi Ji, Yuqiang Chen, Zhijie Liu, Chen Yu, Yilin Zhao, Yaqiong Qiu, Hui Zhang, Yuan Yang, Xiqian Xiong, Cong Zhang, Jianghua Zhan
{"title":"Dynamic landmark models predicting native liver survival after kasai portoenterostomy: a bicentric study.","authors":"Yu Meng, Qianhui Yang, Xin Li, Pu Yu, Qi Ji, Yuqiang Chen, Zhijie Liu, Chen Yu, Yilin Zhao, Yaqiong Qiu, Hui Zhang, Yuan Yang, Xiqian Xiong, Cong Zhang, Jianghua Zhan","doi":"10.1007/s00383-026-06661-7","DOIUrl":"10.1007/s00383-026-06661-7","url":null,"abstract":"<p><strong>Objectives: </strong>Native liver survival (NLS) after Kasai portoenterostomy (KPE) for biliary atresia (BA) is highly heterogeneous, and clinically practical approaches that update prognostic estimates across prespecified postoperative follow-up time points remain limited.</p><p><strong>Methods: </strong>In this retrospective bicentric cohort study (training, n = 168; validation, n = 80), Cox proportional hazards landmark models were developed at five prespecified time points (preoperative and 2 weeks, 1, 3, and 6 months post-KPE) using a LASSO/Boruta dual-algorithm intersection approach with variance inflation factor (VIF)-based collinearity pruning. Internal validation used 500-replicate bootstrap resampling; external validation was performed in an independent cohort.</p><p><strong>Results: </strong>Preoperative and 2-week models showed limited discrimination (C-index ≤0.576). The 3-month two-variable model (TBA + TBil clearance ratio [TBil-CR]) achieved a training C-index of 0.812 (optimism 0.003) and an external C-index of 0.778 (95% CI 0.679-0.878). Risk stratification yielded a 35-percentage-point difference in 2-year cumulative event rates (41.7% vs. 7.0%; log-rank P < 0.001), consistently reproduced in the validation cohort. TBil-CR HR declined progressively across postoperative landmarks, and its single-variable C-index exceeded the jaundice clearance criterion by 0.103 at 3 months.</p><p><strong>Conclusions: </strong>A parsimonious two-variable landmark model incorporating TBil-CR and TBA at 3 months post-KPE accurately predicts long-term NLS in children with BA, outperforming traditional binary bilirubin thresholds.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-Operative Ketorolac in Children After Crohn's Ileocecectomy. 克罗恩回盲切除术后儿童用酮咯酸治疗。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-10-05 DOI: 10.1007/s00383-026-06660-8
Kara Kennedy, Rosa Hwang, Camryn Krumbhaar, Yunliang Zhao, Chris Penney, Keith Baxelbaum, Elana Mitchel, Andrew Grossman, Peter Mattei
{"title":"Post-Operative Ketorolac in Children After Crohn's Ileocecectomy.","authors":"Kara Kennedy, Rosa Hwang, Camryn Krumbhaar, Yunliang Zhao, Chris Penney, Keith Baxelbaum, Elana Mitchel, Andrew Grossman, Peter Mattei","doi":"10.1007/s00383-026-06660-8","DOIUrl":"10.1007/s00383-026-06660-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate complications and flare rates in children with Crohn's disease who received ketorolac following ileocecectomy.</p><p><strong>Methods: </strong>Electronic medical record data of patients < 18 years with Crohn's disease undergoing ileocecectomy at a single institution from 1/1/2013-9/1/2023 were retrospectively reviewed. Demographics, operative course, 30-day complications, and Crohn's flares, small bowel obstructions (SBO), and strictures within two years were collected. Patients who received post-operative ketorolac were compared to those who did not.</p><p><strong>Results: </strong>191 patients met criteria. 169(88.5%) received ketorolac and 22(11.5%) did not. Median age was 15.9[14.2, 17.8] years. Age, sex, pre-operative steroid use, biologic use, and labs were similar between groups. The majority (97.9%) were laparoscopic-assisted. Post-operatively, ketorolac-exposed patients required significantly less opioids (17.0[3.9, 35.2] morphine milli-equivalents vs. 39.7[8.4, 58.7], p = 0.048). Length of stay, days to first flatus, and days to ambulation were similar. There were 18(9.4%) 30-day complications, with no differences between groups. There was no difference in the number of Crohn's flares (3(1.8%) vs. 1(4.5%), p = 0.39), SBOs (8(4.7%) vs. 0(0%), p = 0.6), or strictures (1(0.6%) vs. 0(0%), p > 0.99).</p><p><strong>Conclusion: </strong>In this single-institution analysis, no association between post-operative ketorolac and Crohn's flares was detected, though further study is required. Patients who receive ketorolac may benefit from decreased opioid consumption.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Between technique and virtue: a bioethical reflection on the management of patients with anorectal malformations. 在技术与美德之间:肛肠畸形患者治疗的生物伦理学思考。
IF 1.8 3区 医学
Pediatric Surgery International Pub Date : 2026-09-29 DOI: 10.1007/s00383-026-06649-3
Catalina Correa, Clara Cossio-Uribe
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